Bryan Roth

First human trials of designer protein therapies stun US neuroscientists cen.acs.org/biological-c...

"...psychedelic-related psychosis, although rare, represents a clinically relevant phenomenon, particularly among individuals with identifiable vulnerabilities.." journals.sagepub.com/doi/10.1177/...

Single Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression jamanetwork.com/journals/jam...

Go Tar Heels!!

Go Tar Heels!!

New in PN: In defense of empathy "Being aware of other people’s feelings, sensitive to them, and able to put yourself in another person’s shoes is pretty much essential for humans to function as a community. But the current conservative project has zero room for that sort of thing."

Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression | Science Signaling www.science.org/doi/10.1126/...

Improving optogenetic control over Gi/o-coupled receptor signaling by optimized GIRK channel expression | Science Signaling www.science.org/doi/10.1126/...

An acetylcholine-inhibited sleep-active hippocampal interneuron orchestrates memory consolidation: Neuron www.cell.com/neuron/fullt...

An acetylcholine-inhibited sleep-active hippocampal interneuron orchestrates memory consolidation: Neuron www.cell.com/neuron/fullt...

An opioid efficacy switch for reversible optical control of analgesia: Cell www.cell.com/cell/fulltex...

We posted a preprint on all-to-all functional mapping of a cortical microcircuit in vivo. biorxiv.org/content/10.6... Yitong Qi developed molecular tools, optics, and protocols for massively parallel optogenetic stimulation and voltage imaging during animal behavior.

Winter Brain Enthusiasts, are you concerned that you've missed your chance to submit a poster for #WCBR2027? FEAR NOT!!!! We are extending the deadline to October 20th, 2026 so you can submit your amazing science! www.winterbrain.org

PTPRS mediates invasion of tetanus neurotoxin into the central nervous system: Cell www.cell.com/cell/fulltex...

WOW!! A cross-species AAV platform for precise microglial interrogation: Neuron www.cell.com/neuron/fullt...

Also:”.. These findings indicate that the serotonergic psychedelic DOI induces species- and sex-specific behavioral effects in rodent models, with a robust 5-HT2AR dependence noted for DOI-evoked HTRs and ESRs.” Just not mPfc-specific.

Interesting read...Persisting perceptual abnormalities in psychedelic users are associated with conditioned hallucinations and impaired sensory processing www.biorxiv.org/content/10.6...

This is huge--NIMH will allocate $$$ to fund, essentially, clinical trial networks for #psychedelics and other rapidly-acting psychoactives (#ketamine #mdma ) grants.nih.gov/grants/guide...

Pharmacokinetic properties of Ogerin and its regulation of post-ischemia signaling in mice https://www.biorxiv.org/content/10.64898/2026.10.02.754522v1

Amazing (to me)! Implications for ongoing human chemogenetic trials in China targeting ACC for pain? Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain: Neuron www.cell.com/neuron/fullt...

My (unpleasant) thoughts regarding psychedelics.... zendudest.substack.com/p/what-keeps...

Long overdue…I like that Nagel was included !

Long overdue…I like that Nagel was included !

Suuuuper interesting, I was not tracking this. The judge found the law criminalizing noncitizen voting is a voter qualification statute, and therefore outside of Congress’s power. Surprisingly, this is an issue of first impression! Decision is here: storage.courtlistener.com/recap/gov.us...

As I've been saying: "In this nationally representative cross-sectional survey of US adults, self-attributed adverse outcomes were most frequent among respondents reporting ibogaine or 5-MeO-DMT use." jamanetwork.com/journals/jam...

Whoo hoo!! www.med.unc.edu/intranet/202...

Cool!! Systematic identification of p11 as a signaling modulator across the GPCRome | Science Advances www.science.org/doi/10.1126/...

Wow!!

Ordinarily the sex lives of politicians I ignore or shrug away…”ordinarily”

The RAMP3 proximity interactor MYO6 determines spatiotemporal signaling of the GPCR CLR in lymphatic endothelial cells | Science Signaling www.science.org/doi/10.1126/...

Published: 16 September 2026 Development of a random background to understand ligand optimization www.nature.com/articles/s41...

Published: 16 September 2026 Development of a random background to understand ligand optimization www.nature.com/articles/s41...

My father and I along with my brother are vets. I’m an independent while they are fiercely democratic.

L’Shanah tova to all who celebrate. Maybe this year will be better than the last.

My analysis of $CMPS most recent data: --Strong 1 WK response --Relatively quick loss of efficacy --2nd dose helps --Modest differences at later stage --NO PLACEBO GROUP FOR THIRD PHASE

My analysis of $CMPS most recent data: --Strong 1 WK response --Relatively quick loss of efficacy --2nd dose helps --Modest differences at later stage --NO PLACEBO GROUP FOR THIRD PHASE

Astrocytes mediate the dopaminergic modulation of tonic GABAergic signaling in substantia nigra | Science Advances www.science.org/doi/10.1126/...

Cool www.pnas.org/doi/10.1073/...

"This case demonstrates the limited effectiveness and lack of knowledge on HPPD treatments as well as the need for longitudinal assessments in management." #psychedelics onlinelibrary.wiley.com/doi/10.1155/...

New mouse models for psychedelic studies pubmed.ncbi.nlm.nih.gov/42649266/

Nice perspective! www.nature.com/articles/s41...

Btw Shokat was hhmi funded (mainly) but heck give nci credit!

Was it pre-printed?

I became a strict vegetarian nearly 40 years ago. A simple act with enormous consequences if followed by most of us to decrease the CO2 increases. Are y’all vegetarian (those who take global warming seriously)?? If not, are your concerns genuine?

Must read #psychedelics library.samhsa.gov/sites/defaul...

My behavioral neuroscience lab at Northeastern is looking to recruit two new research techs! Job description and link to apply is here: northeastern.wd1.myworkdayjobs.com/careers/job/...

Activation of G12-type G proteins in pancreatic β cells protects against impaired glucose homeostasis | Science Advances www.science.org/doi/10.1126/...

Interoceptive effects of N1-substituted lysergamides in rats: Role of agonist affinity at 5-hydroxytryptamine receptors and in vivo metabolism to lysergic acid diethylamide - The Journal of Pharmacology and Experimental Therapeutics jpet.aspetjournals.org/article/S002...

LSD May Lead to a New Kind of Medicine www.youtube.com/watch?v=lkMt...

"Together these preclinical findings reveal a regionally specific molecular pathway in male mice that should be further investigated as a possible target to reduce fear-based symptoms of adolescent maltreatment." www.nature.com/articles/s41...

DO NOTHING! zendudest.substack.com/p/how-to-suc...