Aissam Ikmi

Aissam Ikmi

@aikmi.bsky.social

Group Leader @EMBL. We study the design principles of "early" animals using cnidarians.

421 followers208 following15 posts

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Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex... @embl.org

cell.comDeciphering mechanical determinants of morphological evolutionA comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these m...
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Aissam Ikmi reposted

Aissam Ikmi reposted

Double preprint! 👇 Check out our latest studies on timing, heterogeneity and collective behaviour (with a fun tiny bonus on evolution!) 1. www.biorxiv.org/content/10.6... 2. arxiv.org/abs/2605.13234

biorxiv.orgCellular timing heterogeneity regulates phase transitions in living matterRigidity transitions govern tissue organization in ways reminiscent of inert materials. Yet, living tissues are composed of active units with autonomous timing mechanisms, raising the question whether...
Lena Schindler@lena-schindler.bsky.social

I am thrilled to share my PhD work with @nicolettapetridou.bsky.social @embl.org: www.biorxiv.org/cgi/content/... A fun collaboration with Bernat Corominas-Murtra, Adrián Aguirre-Tamaral, @bart-smeets.bsky.social , Jef Vanghel and Tom Belpaire! Read the story in the comments below ⤵️

Aissam Ikmi reposted

Aissam Ikmi reposted

Hi Cnidarian Enthusiasts! Friendly reminder that Cnidofest 2026 will take place at the Marine Biological Laboratory in Woods Hole, MA, September 23-27. The abstract submission deadline is July 1 and the registration deadline is September 2. Submit and find full details at www.cnidofest.org

cnidofest.orgCnidofestCnidofest is a biennial meeting of scientists interested in developing and using cnidarians as model systems to study molecular and cellular biology, developmental biology, neurobiology, and comparati...

Aissam Ikmi reposted

How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...

Aissam Ikmi reposted

Glad to see this out in its final form! www.nature.com/articles/s41... What changed since the preprint? Wonderful experiments disentangling the effect of receptor binding vs tissue porosity on Nodal diffusion, plus one of the smoothest review experiences! Thanks @natcellbio.nature.com & reviewers 🙏

nature.comTissue rigidity phase transition shapes morphogen gradients - Nature Cell BiologyAutorino et al. report a feedback loop between Nodal signalling and tissue phase transitions in zebrafish embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which l...
Nicoletta Petridou@nicolettapetridou.bsky.social

Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org

Aissam Ikmi reposted

21st century dev bio at its best! I can't help but point out that not one but two Bruker microscopes (Acquifer IM, MuVi) were used for gentle&long term time lapse imaging of developing Nematostella here. No need to mount your invertebrate (cnidaria, planaria, crustaceans), we can do the time lapse!

Aissam Ikmi@aikmi.bsky.social

We thought we were just studying mesoglea biogenesis…Turns out Nematostella has been hiding a sophisticated backup pressure valve! Work driven by the talented PhD student Soham Basu! @embl.org‬ www.biorxiv.org/content/10.1...

Aissam Ikmi reposted

A press release on our latest work on shape diversity in cnidarians. @embl.org

EMBL@embl.org

A sea anemone looks very different from a coral, despite belonging to the same broad biological group. A new study from EMBL researchers and their colleagues sheds new light on how diversity arises in body shapes in the animal world. www.embl.org/news/science...

Aissam Ikmi reposted

How do #sponges coordinate their bodies despite lacking neurons and true muscles? We show that sponges use monoamines to control water flow in their canals — reminiscent of how adrenaline regulates blood vessels. My PhD story, now on BioRxiv: www.biorxiv.org/content/10.6... #Evolution

Aissam Ikmi reposted

We’re looking for a new team member! 🚀 Only 3 more weeks to apply to the fantastic Vienna BioCenter PhD program

Vienna BioCenter Scientific Training@vbcscitraining.bsky.social

Our Spring PhD call is OPEN! 30+ fully funded positions across diverse life science disciplines. Explore projects in Stem Cells, Development: www.vbcphd.at Apply by 9 April 2025 Institute of Molecular Biotechnology, Max Perutz Labs Vienna, IMP, Gregor Mendel Institute of Molecular Plant Biology

Aissam Ikmi reposted

🔥Exciting new paper from the Ikmi group @embl.org! The authors identified a set of mesoscale mechanical modules that can be used to predict species-specific shapes by combining a comparative analysis of cnidarian larval morphogenesis with active surface theory #morphogenesis #cnidaria

Aissam Ikmi@aikmi.bsky.social

Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex... @embl.org

Aissam Ikmi reposted

Aissam Ikmi reposted

Amazing to see this study finally out! Proud to have contributed to the active surface modelling of cnidaria morphogenesis across species and huge congrats to Richard, Nicolas, and all authors! #morphogenesis #activematter #nematicorder #evolution

Aissam Ikmi@aikmi.bsky.social

Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex... @embl.org

Aissam Ikmi reposted

New Preprint! When one enhancer allele changes another's regulatory output, is that bad? We found it could be a feature — interallelic cis-regulatory dominance buffers outputs AND enables evolutionary innovation. Two for one! Led by @ottilie.bsky.social from @embl.org doi: doi.org/10.64898/202...

doi.orgInterallelic cis-regulatory dominance promotes robustness and evolutionary innovationDominance is a central principle of genetics, yet the mechanistic basis and the evolutionary consequences of dominance arising from cis-regulatory variation remain poorly understood. We examined the evolutionary trajectories of a pleiotropic developmental enhancer in Drosophila . A genotype–phenotype map between D. melanogaster and D. simulans enhancer sequences reveals extensive epistasis, and many homozygous evolutionary paths reduce transcriptional output. In heterozygotes, however, regulatory dominance masks variants that reduce gene expression, potentially relaxing evolutionary constraints. Using allele-specific reporters and imaging, we show that this dominance arises from interallelic interactions (also known as transvection) reinforced by transcriptional hubs. Importantly, this enhancer dominance is cell-type specific, raising the possibility that it conceals deleterious effects in essential tissues while revealing novel, ectopic activity in others. Interallelic regulatory hubs may therefore expand the range of mutational paths available to diploid genomes while preserving essential transcriptional output. ### Competing Interest Statement The authors have declared no competing interest.

Aissam Ikmi reposted

Aissam Ikmi reposted

Our Special Issue on Lifelong Development #LifelongDevSI is now complete! Guest edited by Meri Huch and Mansi Srivastava, it contains 26 research and review-type articles. On the cover: the dorsal vasculature of an adult zebrafish's first gill arch. See Preußner et al. doi.org/10.1242/dev....

Great having you at @embl.org, Michel! Inspiring science, great discussions, and a fantastic perspective on quantitative evo-devo.

The Milinkovitch-Tzika lab@lanevol.bsky.social

Wonderful visit to @embl.org Heidelberg! Grateful to Alexandre Aulehla and @aikmi.bsky.social for the invitation and to all the group leaders, post-docs and students for the stimulating discussions. Amazing science and a great community! #EMBL #ScienceTalk #DevelopmentalBiology

Had the pleasure of working with @mohannad-dardiry.bsky.social to rethink what it means to develop for life. Many thanks to @dev-journal.bsky.social! @embl.org #LifelongDevSI

dardiry.bsky.socialBluesky
Development@dev-journal.bsky.social

Phenotypic plasticity as the foundation of lifelong development In this #LifelongDevSI Hypothesis, @mohannad-dardiry.bsky.social & @aikmi.bsky.social (@embl.org) challenge the paradigm of organismal terminal differentiation doi.org/10.1242/dev....

Aissam Ikmi reposted

Want to help us image and understand those incredible samples Felix just collected at UBC - and many more? 2 more days to apply! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... #ExM #PlanetaryCellBiology 🧪🧬🔬🌍🌱🦠

embl.wd103.myworkdayjobs.comResearch Technician - Expansion MicroscopyWe are seeking a highly motivated research technician to join the Dey Group. The Dey Group studies the evolution and diversity of cell division mechanisms across the eukaryotic tree, using comparative...
Felix Mikus@fmikus.bsky.social

Two weeks at @ubcbotany.bsky.social are coming to an end, marking the 2nd trip for our @moorefound.bsky.social project @dudinlab.bsky.social @gautamdey.bsky.social & T. Richards. Thanks for hosting @pjkeelinglab.bsky.social, @fburki.bsky.social and most importantly Denis Tikhonenkov & Vittorio!

Aissam Ikmi reposted

Aissam Ikmi reposted

Here our latest work on how morphogens trigger tissue phase transitions to tune their own length-scales and time-scales - An exciting collaboration with @zhvas.bsky.social @dianakhorom.bsky.social Bernat Corominas-Murtra and heroic experiments by the incredible @cami-autorino.bsky.social @embl.org

Camilla Autorino@cami-autorino.bsky.social

🔔 Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨ “A closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 🔁 📶 🔗 www.biorxiv.org/content/10.1... #devbio #biophysics 🧵⤵️

Aissam Ikmi reposted

Aissam Ikmi reposted

EMBL scientists have used sea anemones to study how animals restore their shape following major injuries. The results show how, in regenerating animals, systemic molecular and cellular changes help in regaining the original shape. 🪄 www.embl.org/news/science... 🧪 #MolBiol

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