Soragni:Lab

Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n news.cuanschutz.edu/dbmi/cu-ansc...

One of the many things I love about @ascbiology.bsky.social ,my favorite scientific society, is that it recognizes there are many ways to contribute to science, including mentoring, education, outreach and advocacy. This year's Fellows represent that. 1/n www.ascb.org/society-news...

Happy Fourth of July. A reminder that democracy, like science, depends on care, integrity, and collective responsibility. Let us all do our part

Truer words were never spoken. Really important session on cancer prevention and screening with a focus on policies #AACR26

First AACR Meeting ever as a non-UCLA affiliate, big changes and so excited for what’s ahead. If you see me around, stop to say hi 👋 #AACR 26

Artemis astronauts now sharing photos of the moon they have taken with their iPhones. The lights are switched off on the spaceship so they can take photos better.

Just learned the Artemis II team is getting a better lunch than I am. Well then.. www.youtube.com/watch?v=m3kR...

Cancer research, dismantled. Only *35* grants awarded so far in FY26. NCI stats for new and competitive grant renewals from: grant-witness.us/funding_curv...

There is barely any money going out the door as is

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

We're hiring villagers! We are looking for a lab technician to help us discover how gene-by-environment interactions shape the developing brain via in vitro cell villages. Please DM me or visit our website at mfwellslab dot com for more info. Deadline to apply is March 11th: tinyurl.com/34seyjaj

On the side of small gripes: I'll never find reasonable to be asked to be online at 5am to review grants especially now that paylines are gone-and so are grants. It's unreasonably burdensome for all, even more so for those getting children ready for/to school. If the goal is inclusion, 5am is not it

That's right. Worse than Pointless www.nytimes.com/2026/02/23/o...

This is a graph of the death of US science.

It's a tragedy. I hope no one thinks that we are over the hump. This is quite literally how federally supported science goes extinct.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers. The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

Finally, today's offering! www.biorxiv.org/content/10.6... This began life as a very different project which failed because we couldn't agree on defining eqtl sharing across cohorts. So two young members of the lab dug deeply into this - first @ijbeasley.bsky.social, then @patrickgibbs.bsky.social

New version of our preprint on bioRxiv about bioRxiv up. Now that’s what I call a revision – 6 years after the first version! It has new data about our progress and highlights from a massive user survey. 1/n www.biorxiv.org/content/10.1...

A nationally recognized leader in patient-derived tumor organoids and functional precision oncology has arrived at CU! Welcome, Alice Soragni, PhD (@alice.soragnilab.com) 👋 ⬇️ https://news.cuanschutz.edu/dbmi/alice-soragni-joins-university-colorado-anschutz

This is an interesting article for those beginning down the cryoEM route for structure determination from the perspective of a crystallography lab. Not giving up on crystallography yet 😜 but I honestly can't think of a single crystallography lab now that isn't also using CryoEM in some capacity.

Nature 🤝 Ornithology .. who knew .. www.nature.com/natcities/

This is 252 R01s, only. The math is quite devastating

This may end up being a hot take, but two things can be true at once: the new SciENcv is a pain, and it won't really affect things too much as most reviewers (...check notes...) actually use google/google scholar/REPORTER already

Cells come in many shapes and sizes, with diverse physiological functions. But how do #organelles and their interaction networks remodel during #differentiation of stem cells into different cell types? Here’s what we discovered about neuronal differentiation: 1/13

Congrats to all the authors! #ARTNetPublication

Of so many things to be infuriated about, this is perhaps my biggest gripe. Pancreatic cancer patients, who face a future without hope, are being denied a potential game-changing therapy www.mskcc.org/news/can-mrn...

Proud of this review on centering models and next gen techs to address and prevent acquired resistance in cancer. Cements the work that our working group within @nciartnet.org has done over the last couple years, glad it resonated with people

This city has a way

With so much going on, in life and country, I have not been here as much as I used to. Posting about this big career change and reading the reactions, comments, and jokes, made me feel right back at home. Y'all know me too well. This space, like Twitter in the before time, is something else

Really nice article describing the molecular mimicry behind VITT in a very accessible manner. Original paper here: www.nejm.org/doi/full/10.... We all learned something, in this process.

I have a 166,000 word, ~700 page document of how NOT OK scientists have been in the last year.

I will never stop advocating for an edit button

Schools are back, and so am I. Happy new year everyone May this year be.. different

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...