Andy Hickl

Andy Hickl

@andyhickl.bsky.social

CTO, AllenInstitute.org. Advisor, Fathom.org. He/him. Working at intersection of AI and biology.

945 followers1.6K following1.8K posts

Andy Hickl reposted

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

We're looking for a visionary leader to help drive this effort. As Director of Studio D3, you’ll shape the future of data-driven discovery at the Allen Institute, guiding a team at the cutting edge of computation and biology. 🧪

Here at the Allen Institute, our teams get to work with some of the largest biological datasets ever collected. But data alone isn’t enough. We need bold theoretical models, innovative analytical frameworks, and scalable computational methods to extract the principles that govern life.

That’s where Studio D3 comes in. Studio D3 brings together world-class theoreticians, computational biologists, and engineers to turn data into discovery. From decoding cellular organization to building #AI-driven models of biological function, the work we do transforms our understanding of life.

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Given that nearly 3 billion people worldwide live with brain diseases—ranging from Alzheimer’s and Parkinson’s to ADHD and depression—our priority should be expanding access to effective treatments, not restricting them. 🧪

Instead of undermining established therapies, we should be investing in understanding the root causes of these conditions and developing new ways to prevent and treat them. 🧪

The story of this climate data resource should serve as a cautionary tale: we need to act as a community to ensure vital datasets and analytics platforms are safe from political shifts. We should start planning for the self-sustaining, resilient infrastructure needed to protect scientific work

What AI should exist — but doesn’t yet — to transform biology? The Paul G. Allen Frontiers Group has launched the Ask Anything, Change Everything campaign to gather bold ideas on how AI can revolutionize our understanding of fundamental biology. alleninstitute.org/ask-anything...

alleninstitute.orgAsk Anything Change EverythingSubmissions are open for ideas of how artificial intelligence (AI) could unlock discoveries that advance our knowledge of fundamental biology.

This is your chance to shape the future of AI-driven discovery. If you have an idea — big or small — that could push the boundaries of what’s possible, we want to hear it. Submit your ideas and be part of the conversation. Let’s build the future together.

Using smaller, open-source models like Llama-3.1-8B, Aviary achieves expert-level performance at 100x lower inference costs compared to frontier LLMs. A major leap for accessible, scalable AI in science.

Andy Hickl reposted

Andy Hickl reposted

Meet ACE - a new tool for comparing annotations across Allen Institute transcriptomic taxonomies! Join us for a webinar on how to use it in your #neuroscience research, incl. studies using our Alzheimer's datasets. 📆 Dec. 18, 9:30am PT 💻 Webinar 🎟️ alleninstitute.org/events/cell_... #neuroskyence

alleninstitute.orgCell Type Taxonomies A-Z: Webinar SeriesWebinar series covering everything and anything cell types starting in January 2024. Hosted by the Allen Institute.

Andy Hickl reposted

alleninstitute.org/careers/inte... Internships and Postbac opportunities open at the Allen Institute, applications close January 7th 2025. Great opportunity for anyone interested in life sciences research or science-support careers. Spread the word!

alleninstitute.orgInternship & Postbaccalaureate ProgramsStudents and early-career professionals in lab research, biology, neuroscience, immunology, and others should apply for our internships and fellowships.

Cool Yule read: this article highlights how behavioral diversity in artificial intelligence “teams” can significantly enhance problem-solving & adaptability, something that could change how we approach challenges in (AI) research. 🧪 arxiv.org/abs/2412.16244

arxiv.orgNeural diversity is key to collective artificial learningMany of the world's most pressing issues, such as climate change and global peace, require complex collective problem-solving skills. Recent studies indicate that diversity in individuals' behaviors i...

I’m so stealing this idea. Such a cool way to ensure #deib is built into a team’s mindset. Thanks for sharing, @sarahstern.bsky.social

Sarah Stern@sarahstern.bsky.social

At (most) lab meetings we have a “moment for diversity” where that week’s presenter either tells us about their culture or presents some topic related to diversity and inclusion. This week I chose to spend a few minutes talking about Rita Levi-Montalcini. en.m.wikipedia.org/wiki/Rita_Le...

I used to spend about half my time thinking about ways we can better understand how to use AI in #biology — but increasingly, I’m worried about how about how we scale platforms to cope with data volumes 🧪🧵

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Although the volumes are large, scaling in life sciences is similar to other industries. Institutions should focus on cloud for scalable data storage, AI/ML for faster insights, and standardized data formats to streamline workflows.

I used to spend about half my time thinking about ways we can better understand how to use AI in #biology — but increasingly, I’m worried about how about how we scale platforms to cope with data volumes 🧪🧵

@jshendure.bsky.social and team continually blow me away

allen institute@alleninstitute.org

What if we could read the diary of a cell? Researchers from around the world, including #SeaSynBio's @jshendure.bsky.social, share with @nytimes.com' @carlzimmer.bsky.social their vision for how an emerging suite of technologies could change how we study life. 🔗 www.nytimes.com/2024/11/25/s...

Moravec’s Paradox is such a fascinating concept: today’s AI can tackle complex tasks like reasoning or drug discovery—things that push human limits. But it still struggles with what humans find simple, like picking up a coffee cup. Biology & AI remind us how differently intelligence can evolve. 🧪

This is a great fellowship for any postdoc who wants to work with #neuro data in a nurturing environment at @alleninstitute.bsky.social. Deadline is approaching!

Andy Hickl@andyhickl.bsky.social

My team at @alleninstitute.bsky.social is fortunate to be sponsored by the Shanahan Foundation to offer fellowships in data-driven #neuroscience. Apply by December 16! #postdocs #mlsky https://alleninstitute.org/careers/internships-and-postbac/shanahan-foundation-fellowship/

Andy Hickl reposted

Tom suggests replacing the logic of prereg -> confirmation with the logic of train/validation/test splits. The place this approach is really, really needed is in historical data — where we can never get another equivalent sample! Our ordinary understanding of replication is broken there.

Tom Carpenter, PhD@tcarpenter.bsky.social

Example: you split the data into 2 sets. You run several analyses in one part. You grok it many ways. You do subdivide that into folds to find analyses that minimize error in folds when slopes are estimated from others. When you have an analysis you like, you independently confirm in the other set

I ran nearly 8,900 of my tweets through ChatGPT to analyze patterns in my digital footprint. It revealed insights into my political affiliation, career history, and personal life. Here’s what I learned. 🧵🤖

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Demographically, ChatGPT guessed I’m in my 40s, married, and a parent—and it got it right. Tweets about helping my kids with games or reflecting on family moments highlight how my professional and personal priorities overlap.

I ran nearly 8,900 of my tweets through ChatGPT to analyze patterns in my digital footprint. It revealed insights into my political affiliation, career history, and personal life. Here’s what I learned. 🧵🤖

ChatGPT inferred that I lean progressive, based on posts about fairness, collaboration, and ethical technology. While my tweets don’t focus heavily on politics, my tone and retweets suggest values aligned with equality and innovation.

The analysis estimated that I’ve held multiple roles in AI and technology leadership, citing mentions of Vulcan Inc. and collaborations on cutting-edge machine learning projects. It traced career milestones I’d casually shared online.

Stuff like: Strengthening Lab Safety: we can follow and promote robust biosecurity protocols in daily research, or Engaging in Public Dialogue: Share your work openly to foster understanding and build trust.