Philippe Bastin&#x27;s Lab

21 Sept

Great start of the 14th meeting on cilia, flagella and centrosomes (CFC2026) in Aussois with exciting talks of Maya Sarieddine, Jérémy Vincent, Amandine Hecquet, Sarah de Freitas and Vincent Gache, with plenty of questions and debates! Looking forward to two more exciting days!

24 July

There is more than cilia beating in the establishment of left-right symmetry! Proud to have contributed to this beautiful study by Amaia Ochandorena Saa @meilhacsigolene.bsky.social where Thierry Blisnick imaged mouse node by SEM doi/10.1126/sciadv.adx6486 @pasteur.fr @institutimagine.bsky.social

@spyroslytras.bsky.social

27 July

It's asymmetry of course, not symmetry!

Philippe Bastin's Lab reposted

Spyros Lytras

23 July

Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!

Antigen Evolution & Design Lab@antigenevo.bsky.social

🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st

8 July

Another long-term project finally completed! Solving (well we think) the contribution of the IFT-A complex in anterograde transport. www.biorxiv.org/content/10.6... Congratulations to Adeline Mallet, Thierry Blisnick, @ebertiaux.bsky.social, Cécile Fort, Manuel Majrouh and Sylvain Trépout!

26 June

So lucky to work with such a great and enthusiastic team 😀 Congratulations to all for insightful talks and lively discussions! Watch this space for the laureate of the best title...

Christine Girard-Blanc@chrisgirardb.bsky.social

Very nice lab retreat of @bastinlab.bsky.social in Île de Ré ! Lot of science and fun 😍

youtube.comMicrotubules | Scientific Animated Short Film 2026YouTube video by Drawing Intelligence

26 June

Beautiful videos nicely explaining microtubules! Congratulations to Renaud Chabrier and Casten Janke 👍 www.youtube.com/watch?v=dVbv...

Philippe Bastin's Lab reposted

Melanie Bonhivers

@mbonhivers.bsky.social

12 June

The CNRS has opened a Junior Professor Chair (CPJ) call in Parasitology, and the Microbiologie Fondamentale et Pathogénicité (MFP, Bordeaux) laboratory is among the potential host institutions. More information: www.insb.cnrs.fr/fr/cnrsinfo/... #Parasitology #Protozoology #ResearchJobs #CNRS

insb.cnrs.frJunior Professor Chairs (CPJ) 2026 – CNRS BiologyCNRS Biology is recruiting researchers through its Junior Professor Chair (CPJ) program, subject to final approval by the French Ministry of Higher Ed

Philippe Bastin's Lab reposted

Development

@dev-journal.bsky.social

Sigolène Meilhac @meilhacsigolene.bsky.social will be speaking on "Congenital structural heart defects" at our Journal Meeting in the UK this September #HumanDev26 Register to attend: biologists.com/meetings/dev... Abstract deadline: 12 June 2026

@chrisgirardb.bsky.social Christine’s first manuscript is on BioRXiv! She investigated the CCDC40 protein in trypanosomes with superb expansion images and unexpected findings! www.biorxiv.org/content/10.6...

Even more striking, despite not swimming, they divide and grow normally, which seems to contradict the role of flagellum motility in cytokinesis. We propose a model based on flagellum length and attachment to explain this unexpected finding. Let us know what you think, feedback is welcome!

Many thanks to all involved, especially @vincelouv.bsky.social and @centriolelab.bsky.social for iU-ExM training!

Depletion by RNAi led to spectacular phenotypes with disruption of inter-doublet connections, loss of multiple flagellar components and inhibition of motility

Strikingly, flagella are too short! They incorporate tubulin too slowly and fail to elongate beyond 7 µm. Furthermore they acquire the FLAM8 maturation marker too quickly and lose the locking protein CEP164C much faster!

The project was initiated by Thierry Blisnick following discussions with @meilhacsigolene.bsky.social and Amaia Ochendorena Saa who were using the CCDC40 mutant to investigate cilia contribution cilia to left-right asymmetry www.biorxiv.org/content/10.6.... Thierry did scanning EM of the mouse node

With iterative-UExM, she revealed the repetitive pattern of CCDC40 associated to the 96nm repeat

10 June

Great science at our symposium “Grand challenges on vector-borne diseases” @pasteur.fr last week, showing the richness, diversity and creativity of the field, with original strategies to control vector populations and transmission. Many thanks to all speakers for exceptional presentations!

10 June

Also a big thank you to Mallory Perrin-Wolf and her team for fantastic support, to Laurence Isnard Emma Lepretre for the exhibit with tsetse fly and mosquito models and to Geneviève Milon for having brought back to life Edouard Chatton’s magnificent drawings.

4 June

Getting redy for the symposium tomorrow... @pasteur.fr

Philippe Bastin's Lab reposted

Mohamed-Ali HAKIMI

@hakimi.bsky.social

2 June

📢 Save the date! Join us on July 2, 2026, at IAB (#Grenoble) for: 🔬 Parasite Life Cycles Unveiled: Sex, Regulation and Host Adaptation 4 leading scientists will discuss parasite development and host–parasite interactions. 🥙 Free attendance + Lebanese lunch Register: forms.gle/a5fdoVPqgNq3...

Philippe Bastin's Lab reposted

ParasitesRule

@parasitesrule.org

27 May

Registration and abstract submission are now open for the 2026 Kinetoplastid Molecular Cell Biology Meeting (KMCB). @rmc9z.bsky.social @omarharb.org 🗓 September 8–12, 2026 ⏰Abstract deadline June 22 Submit your abstract and register at parasitesrule.com/kmcb #KMCB #Parasitology #Kinetoplastids

21 May

Lovely time at Antwerp University for the joint meeting of the Belgian Society for Parasitology and Protistology and the Dutch society for Parasitology. Many thanks to Sarah Hendrickx for the invitation!

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

So, we are finally coming up with this (probably too complicated) model, suggestions welcome! Would KIN2B be the ancestor of all IFT kinesins? Or is it a degenerate version of another kinesin?

Many thanks to the efforts of all lab members and collaborators over 25 years! 👍

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

So, we thought that KIN2A was the major IFT carrier and yet its knockout gave little phenotype in T. brucei and L. mexicana, KIN2B being able to take over! While looking minor in abundance, KIN2B turned out to be essential for flagellum construction and KO could not be obtained in trypanosomes!

Daniel Abbühl then developed Cas9 marker-free approach with sufficiently high efficiency to monitor impact of gene disruption and with @chrisgirardb.bsky.social revealed that KIN2B was indeed essential for flagellum construction in T. brucei as in L. mexicana

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

Aline tried multiple combination of IFT and kinesins but while single tagging worked, double tagging failed multiple times, possibly because of steric hindrance. Fortunately, the combination KIN2B/IFT140 worked out and gave the solution: only a handful of KIN2B shift IFT proteins to the tip

We were reinsured to hear that Jack Sunter, Ziyin Wang, Cécile Fort and @zephyris-science.bsky.social made similar observations in Leishmania mexicana

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

Moara Lemos went to Munich to initiate some in vitro work in the team of Zeynep Ökten, Augustine Cleetus developed this further and revealed the peculiarities of each trypanosome kinesin, which can walk on mammalian microtubules

Thanks to the heroic effort of Aline Alves, we finally revealed that KIN2A and KIN2B show different localisation and different trafficking profiles. But neither of them as sufficient to explain the actual frequency of IFT trafficking while their addition looked too abundant!

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

Combined KIN2A and KIN2B knockdown showed that they were involved in IFT and flagellar length control, @ebertiaux.bsky.social picked up by developing the grow-and-lock model doi.org/10.1016/j.cu... Related findings were made by the group of @mattwelchlab.bsky.social https://doi:10.1242/jcs.129213

Slava Yurchenko and Kika Pašuthová produced a detailed phylogenomic analysis to find out that KIN2A and KIN2B were specific to Euglenozoa (both parasitic and free-living organisms) and that KAP was missing in all of them

Flagella can be assembled by IFT without the canonical heterotrimeric kinesin! Grab a cup of tea or coffee and follow a story that started 25 years ago

bioRxiv Cell Biology@biorxiv-cellbio.bsky.social

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

@lindakohl.bsky.social then post-doc in the lab reassembled the first kinesin gene in 2001 (at that time, the genome was not complete). She knocked it down but no phenotype was visible in contrast to other IFT genes clearly involved in flagellum construction link.springer.com/article/10.1...

@biorxiv-cellbio.bsky.social

Later on, @sabsalon.bsky.social was the first one to visualise IFT in T. brucei upon overexpression of GFP::IFT52 (with an analogical camera!). www.molbiolcell.org/doi/10.1091/... All IFT proteins could be imaged but neither endogenous tagging nor overexpression gave clear results for KIN2A/KIN2B

Philippe Bastin's Lab reposted

bioRxiv Cell Biology

13 May

Life without heterotrimeric kinesins: trypanosomatids use a combination of homodimeric kinesin-2 motors to drive intraflagellar transport https://www.biorxiv.org/content/10.64898/2026.05.12.724483v1

Philippe Bastin's Lab reposted

Laura Cantini

@cantinilab.bsky.social

12 May

📢 We are recruiting! We are looking for postdoctoral researchers to join my team at @pasteur.fr (research.pasteur.fr/en/team/mach...). We develop AI methods to infer cellular dynamics and gene regulation. If you are interested, send me an email with your CV. We look forward to hearing from you!

research.pasteur.frMachine Learning for integrative genomics – ResearchSingle-cell high-throughput sequencing, a major breakthrough in life sciences, allows to access the integrated molecular profiles of thousands of cells in a single experiment. This abundance of data p...

Philippe Bastin's Lab reposted

Royal Microscopical Society

@royalmicrosoc.bsky.social

12 May

We are very pleased to announce Prof. Paul Guichard and Dr. Virginie Hamel @centriolelab.bsky.social as joint winners of the RMS Award for Light Microscopy 🔬 👏 🏅 Huge congratulations to both! Read more about Paul and Virginie's achievements: www.rms.org.uk/resource/pro...

Philippe Bastin's Lab reposted

CNRS Biologie

@cnrsbiologie.bsky.social

29 Apr

🔬 Étudier l’organisation tridimensionnelle des génomes Les travaux de @rkoszul.bsky.social, médaille d’argent du @cnrs.fr, apportent des réponses clés sur des processus fondamentaux ! 👋 @pasteur.fr 👉 Lire le portrait : buff.ly/KyFOrjq

buff.lybuff.ly

Philippe Bastin's Lab reposted

Joachim Frank

@joachim123.bsky.social

29 Apr

I came here in 1975. I'm a Nobel Prize-winning scientist born in Germany during WWII, came here in 1975 thinking there was no way fascism could take hold in this country. I was wrong. I don't not want to be book-ended by two fascist regimes. We will stand up and set things right.

Kristian G. Andersen@kgandersen.bsky.social

Choice words from Dr. Szostak here. And while I am no Nobel Prize-winning scientist, I identify with the same quandary as an immigrant, moving here in 2009 and (proudly) becoming a citizen in 2023. I, too, don't recognize that country anymore 😢🇺🇸🧳🛫. newsletter.ofthebrave.org/p/im-a-nobel...

newsletter.ofthebrave.orgI’m a Nobel Prize-winning immigrant. I can no longer recognize this country.Attacks on science and immigrants are destroying America.

Philippe Bastin's Lab reposted

The Lambrechts Lab

@lambrechtslab.bsky.social

23 Apr

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

research.pasteur.frPostdoctoral position in mosquito population genomics at Institut Pasteur in Paris - ResearchThe Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...

@susanagodinho.bsky.social

23 Apr

A brilliant scientist and such a nice guy 😢

Institut Pasteur | 130 years of biomedical research@pasteur.fr

Institut Pasteur mourns the passing of Philippe Bousso, a renowned immunologist, head of the Dynamics of Immune Responses unit and director of the Immunology Department. His pioneering imaging work transformed our understanding of immune cells in vivo. 1/3

Philippe Bastin's Lab reposted

Susana Godinho

22 Apr

Our flagship conference celebrating everything centrosomes and cilia returns this year and it promises to be another exceptional scientific event in the beautiful city of Lausanne, 1–4 September. 👉 Abstract submission+registration deadline 1 June Don’t miss the opportunity to share your research 🤩

Philippe Bastin's Lab reposted

Mill_lab

@cilialab.bsky.social

20 Apr

Tuesday is finally our next big session on all things #cilia, #centrosomes & gloriously kick-ass #CellBiology. Free, open to all aficionados, and frankly no excuse not to join. 👀 Unregistered? Easily fixed 👇 www.eventbrite.co.uk/e/bscb-genso...

eventbrite.co.ukBSCB GenSoc UK Cilia and Centrosome Network e-Symposia SeriesBSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

Mill_lab@cilialab.bsky.social

Just over two weeks until our 55th @bscb-official.bsky.social @gensocuk.bsky.social @ukcilianetwork.bsky.social e-symposium Tuesday April 21st 2026 15:00-17:45 BST! Join us for 6 talks from the latest rising talent!! Free & open to all. Register: www.eventbrite.co.uk/e/bscb-genso... 1/2

eventbrite.comBSCB GenSoc UK Cilia and Centrosome Network e-Symposia SeriesBSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series