The Lambrechts Lab

The Lambrechts Lab

@lambrechtslab.bsky.social

Research unit @pasteur.fr investigating arbovirus transmission by mosquitoes.

356 followers171 following38 posts

The Lambrechts Lab reposted

Andrea Gloria-Soria
@agloriasoria.bsky.social

Check our latest paper on #aegypti! Online now.

Molecular Ecology@molecology.bsky.social

Out in MEC! How does genetic variation help mosquitoes adapt to contrasting environments? A new study investigates genetic diversity and introgression in Saudi Arabian populations of Aedes aegypti. @wileyecology.bsky.social Read more: buff.ly/igMkyT9

buff.lyIntrogression Shapes Genetic Variation Associated With Humid Environments in <fc><fi>Aedes aegypti</fi></fc> Mosquitoes From Saudi ArabiaIntrogression between genetically distinct populations generates variation that may promote adaptation to diverse environmental conditions. In the mosquito Aedes aegypti, the forest-associated…

The Lambrechts Lab reposted

Spyros Lytras
@spyroslytras.bsky.social

Come work on exciting AI for biology projects in Paris!! 🇫🇷 Details and application below, deadline sept 1st!

Antigen Evolution & Design Lab@antigenevo.bsky.social

🚨 JOB ALERT🚨 We are very excited to be hiring the lab's ✨very first postdoc✨! Work on new AI technologies for decoding antigen protein evolution in a fresh research environment, at the heart of Paris 🇫🇷 Details & link to apply: research.pasteur.fr/en/job/postd... Deadline: Sep 1st

The Lambrechts Lab reposted

Shicheng Guo
@shihcheng.bsky.social

Flavivirus infectivity in mosquitoes like Aedes aegypti is shaped by mosquito-capsid interactions, shedding light on species-specific vector traits. PMID:41639463, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10100-x #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

doi.orgMosquito–capsid interactions contribute to flavivirus vector specificity | NatureMultiple mosquito species serve as competent vectors to carry and transmit numerous flaviviruses1,2. Several long-standing scientific questions remain to be answered, including identification of the fundamental factors that facilitate flavivirus infectivity in mosquitoes and the genetic basis that contributes to the naturally occurring interspecies specificity of mosquitoes to flaviviruses3–8, such as Aedes aegypti mosquitoes to dengue virus (DENV). Here we report that circulating mature virions are inactivated by the acidity of mosquito haemolymph; thus, extracellular vesicles carrying replication-competent viral nucleocapsids serve as the predominant means of intercellular viral dissemination. Mechanistically, mosquito valosin-containing protein (VCP) binds to the viral capsid, thereby allowing the incorporation of nucleocapsids into extracellular vesicles. The capsid of a flavivirus (such as DENV) selectively binds to the VCP of its natural vector (Ae. aegypti), but not to that of a

The Lambrechts Lab reposted

Nelson Lau Lab
@nelson-lau-lab.bsky.social

At last! Please check out our study now published @natcomms.nature.com on the #virus small #RNAs profiles across Aedes aegypti #mosquitoes from labs and around the world: www.nature.com/articles/s41...

nature.comSmall RNA genomics of Aedes aegypti mosquitoes discovers infectious viruses that trigger an RNA interference response - Nature CommunicationsThis study is a small RNA genomics survey from global Aedes aegypti mosquito samples, and detected replicating viruses. This study then isolated several mosquito viruses into cell cultures to show tha...
The Lambrechts Lab
@lambrechtslab.bsky.social

WOW! 😳

Karim Majzoub@karimaj.bsky.social

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it. A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

sciencedirect.comDeltaviruses spread through a viral Trojan HorseHepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…
The Lambrechts Lab
@lambrechtslab.bsky.social

🚨 We're hiring! A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

research.pasteur.frPostdoctoral position in mosquito population genomics at Institut Pasteur in Paris - ResearchThe Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...
The Lambrechts Lab
@lambrechtslab.bsky.social

🚨 A #postdoc position is available @lambrechtslab.bsky.social @pasteur.fr ➡️ Come join our team to investigate the #genomic variations underlying the adaptive potential and vectorial capacity of Aedes aegypti #mosquitoes 🦟 More details at this link: research.pasteur.fr/b/1Cov

research.pasteur.frPostdoctoral position in mosquito population genomics at Institut Pasteur in Paris - ResearchThe Insect-Virus Interactions Unit is looking for a postdoctoral researcher to investigate the genomic variations underlying a mosquito’s capacity to transmit human arboviruses. Description Our resear...

The Lambrechts Lab reposted

Simon Cauchemez
@scauchemez.bsky.social

Two postdoc positions for a number of exciting epidemic modelling projects opening in my Unit at @pasteur.fr in beautiful Paris. Deadline for applications: 13th April. More details at the following link: research.pasteur.fr/job/two-post...

research.pasteur.frTwo postdoctoral positions in epidemic modelling - ResearchJob description We are recruiting 2 postdocs to contribute to research projects in the Mathematical Modelling of Infectious Diseases Unit, at Institut Pasteur in Paris. The postdocs will develop state...
The Lambrechts Lab
@lambrechtslab.bsky.social

🦟 🦠 Notre équipe et celle de @simonlorierelab.bsky.social au sein du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr avons élucidé les déterminants génétiques viraux de la transmissibilité du #virus #Zika par le #moustique Aedes aegypti

CNRS Écologie & Environnement@cnrsecologie.bsky.social

#RésultatScientifique🔎 Une étude publiée dans Nature Communications analysent pourquoi les moustiques transmettent plus efficacement les souches africaines du virus Zika que les souches asiatiques. ➡️ www.inee.cnrs.fr/fr/cnrsinfo/...

The Lambrechts Lab
@lambrechtslab.bsky.social

🦟 🦠 Notre équipe du laboratoire "Génomique Évolutive, Modélisation et Santé" (GEMS) @cnrsecologie.bsky.social @pasteur.fr a identifié un gène clé impliqué dans la sensibilité du #moustique Aedes aegypti au #virus de la #dengue www.inee.cnrs.fr/fr/cnrsinfo/...

inee.cnrs.frUn gène antiviral découvert chez les moustiques favorise la transmission de la denguePourquoi certains moustiques sont-ils plus susceptibles de transmettre la dengue que d’autres ?

The Lambrechts Lab reposted

David Bikard
@dbikard.bsky.social

Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!

The Lambrechts Lab reposted

Thomas Vial
@tompvial.bsky.social

Kicking off the new year with mosquitoes, metabolomics, & arboviruses! 🥳 🦟Our new preprint is out! We mapped the metabolism of the Aedes aegypti mosquito across its life cycle to find new ways to fight dengue virus. Check it out on: doi.org/10.64898/202... #VectorBiology #Metabolomics #Mosquito

doi.orgStage-resolved metabolomics reveals the methionine cycle as a key regulator of Aedes aegypti development and dengue virus susceptibilityDevelopmental transitions in the mosquito Aedes aegypti are central to vector competence and disease transmission, yet the underlying metabolic programs remain poorly defined. Here, we use untargeted ...
The Lambrechts Lab
@lambrechtslab.bsky.social

Exciting opportunity @pasteur.fr for junior scientists aiming to create their research group !

Institut Pasteur | 130 years of biomedical research@pasteur.fr

🔬 Call to create junior research groups at the Institut Pasteur Focus: Infectious diseases, host-microbe interactions, vaccines Special interest: AI methodologies 📅 Deadline: Feb 9, 2026 👥 2-12 years post-PhD Apply now 📝 research.pasteur.fr/en/call/crea... #JobOpportunity #Research

research.pasteur.frCreation of new junior research groups at the Institut Pasteur - Call for applications 2026 - ResearchThe Institut Pasteur is launching an international call to recruit new junior research group leaders leveraging cutting-edge transdisciplinary approaches to exploring infectious diseases, host-microbe...

The Lambrechts Lab reposted

Institut Pasteur | 130 years of biomedical research
@pasteur.fr

🦟 Can we "pasteurize" mosquitoes to stop dengue & Zika? Sarah Merkling @merklinglab.bsky.social uses AI + CRISPR to analyze stomach cells and understand why some mosquitoes spread viruses while others don't. Goal: Make disease-carrying mosquitoes harmless. #Zika #Dengue

pasteur.frSarah Merkling wants to "pasteurize" mosquitoes!At the Institut Pasteur, Sarah Merkling's research focuses on a topic that is still largely unknown: interactions between mosquitoes and viruses. She boldly devises novel strategies based on state-of-...

The Lambrechts Lab reposted

Nature Microbiology
@natmicrobiol.nature.com

OUT NOW! - Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes 🍄🧲🦟☠️ By Dan Tang, Jun Cao, Raymond Leger, Jianhua Huang, Weiguo Fang & colleagues. www.nature.com/articles/s41...

nature.comEngineered Metarhizium fungi produce longifolene to attract and kill mosquitoes - Nature MicrobiologyInsects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

The Lambrechts Lab reposted

Natural History Museum, London
@nhm-london.bsky.social

A long-held myth about a mosquito evolving in the London Underground has been debunked! 🦟 The insect gained notoriety in the Second World War, when it fed on Londoners seeking shelter in the rail tunnels during the Blitz. Discover its true origin story.👇 www.nhm.ac.uk/discover/new...

nhm.ac.ukOrigins of the London Underground mosquito revealed | Natural History MuseumNew research reveals that these insects likely evolved in the Mediterranean basin more than 1,000 years ago.
The Lambrechts Lab
@lambrechtslab.bsky.social

🚨 New preprint alert! We have developed a targeted amplicon sequencing panel for Aedes aegypti. We believe it is a powerful and cost-effective tool for studying #mosquito #population #genetics. Curious how it matches up to WGS? Check out our preprint to find out! www.biorxiv.org/content/10.1...

biorxiv.orgA targeted amplicon sequencing panel for cost-effective high-throughput genotyping of Aedes aegyptiThe mosquito Aedes aegypti is the primary vector for several medically significant arboviruses, including dengue, Zika, chikungunya, and yellow fever. Studying the genetic diversity of Ae. aegypti is ...

The Lambrechts Lab reposted

Princeton University
@princeton.edu

A study by researchers at Princeton, @pasteur.fr, and @ucsandiego.bsky.social reveals that Africa’s low rates of Zika virus outbreaks may be due to a surprising factor: the genetic makeup of local mosquito populations.

environment.princeton.eduMosquito Genetics May Explain Why Zika Virus Outbreaks Are Rare in Africa – But Climate Change Could Shift the Balance - High Meadows Environmental InstituteA new study reveals that Africa’s low rates of Zika virus outbreaks may be due to a surprising factor: the genetic makeup of local mosquito populations. Research by scientists at the High Meadows Envi...
The Lambrechts Lab
@lambrechtslab.bsky.social

Huge thanks to @gonzalezlabbcn.bsky.social for her invaluable contribution as a member of Alexander Bergman's PhD jury and for the stimulating discussions that ensued. It was a great opportunity to chat about #transposons in #mosquitoes and #Drosophila!

Pepi (Josefa) González@gonzalezlabbcn.bsky.social

Discussing mosquitoes and fruitflies #transposons with @lambrechtslab.bsky.social lab at @pasteur.fr. Great science in a great place. Congrats to the new @sorbonne-universite.fr Doctor Alexander Bergman!

The Lambrechts Lab
@lambrechtslab.bsky.social

WOW! Systematic testing of 2 #Wolbachia strains for their ability to block transmission of 60 genetically diverse #DENV isolates in #mosquitoes shows substantial heterogeneity and suggests potential long-term selection risks in Wolbachia-based control interventions.

Chantal Vogels@chantalvogels.bsky.social

📢New preprint on the impact of dengue virus genetic diversity on inhibition by Wolbachia 🦟🦠🧬 Project led by Afeez Sodeinde, @emiliefinch.bsky.social, and @keli5734.bsky.social! ✨ Key findings in thread below 👇 www.biorxiv.org/content/10.1...

biorxiv.orgHeterogeneity in inhibition of genetically diverse dengue virus strains by WolbachiaThe release of Aedes aegypti mosquitoes transinfected with the virus-inhibiting Wolbachia bacterium has the potential to reduce the burden caused by dengue virus (DENV). However, the robustness of thi...

The Lambrechts Lab reposted

Erica McAlister
@flygirlnhm.bsky.social

www.nhm.ac.uk/discover/new... Mosquitoes that have been in the collection for nearly a hundred years are helping us in dealing with an even older but also current problem - malaria @sangerinstitute.bsky.social @nhm-london.bsky.social

nhm.ac.ukGenetic study of malaria-carrying mosquitoes tracks evolution of insecticide resistance | Natural History MuseumIt crucially also reveals promising genetic targets for potential control.

The Lambrechts Lab reposted

Vasilakis Lab
@vasilakislab.bsky.social

1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue risk | Science www.science.org/doi/10.1126/.... A seminal paper of great interest to all. Great work and congratulations to the team!

science.org1206 genomes reveal origin and movement of Aedes aegypti driving increased dengue riskThe emergence and global expansion of Aedes aegypti puts more than half of all humans at risk of arbovirus infection, but the origin of this mosquito and the impact of contemporary gene flow on arbovi...

The Lambrechts Lab reposted

Didier Mazel
@amazeld.bsky.social

Striking and frightening 😒 "They found multiple instances of insecticide-resistance variants in this malaria vector, although most of these weren’t shared with museum specimens collected as recently as 1967, suggesting rapid emergence" www.science.org/doi/10.1126/...

science.orgGenomic diversity of the African malaria vector Anopheles funestusAnopheles funestus s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and ...

The Lambrechts Lab reposted

Le Monde
@lemonde.fr

Chikungunya : forte hausse des cas autochtones en métropole, Santé publique France appelle à la vigilance face aux moustiques tigres

lemonde.frChikungunya : forte hausse des cas autochtones en métropole, Santé publique France appelle à la vigilance face aux moustiques tigresL’implantation du moustique tigre dans 81 départements métropolitains inquiète les autorités, qui redoutent une propagation accrue du chikungunya et d’autres maladies vectorielles cet automne.

The Lambrechts Lab reposted

Sarah Merkling
@merklinglab.bsky.social

@elodiecouderc.bsky.social is on 🔥 this month ! Our review (which the literature really missed, imho) giving an historical perspective on the methods used to study of mosquito-virus interactions in now online at @cp-trendsmicrobiol.bsky.social. Check it ou here: www.cell.com/trends/micro...

cell.comcell.com
Elodie Couderc@elodiecouderc.bsky.social

New #review out 🚨 for mosquito enthusiasts 🦟 ! Have you ever questioned the approach you routinely use to investigate #mosquito-virus #interactions? ⬇️ www.sciencedirect.com/science/arti...

The Lambrechts Lab reposted

Sarah Merkling
@merklinglab.bsky.social

Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...

microbe.tvTWiV 100: TWiV catches a big fish | This Week in VirologyVincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
Matthew Cobb@matthewcobb.bsky.social

Co-discoverer of reverse transcriptase at 32, Nobel Prize at 37, played a key role at the 1975 Asilomar comference.

nytimes.comDavid Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

The Lambrechts Lab reposted

Elodie Couderc
@elodiecouderc.bsky.social

🚀 Excited to share (with a little delay) my first first-author publication on #Vago genes in #mosquitoes! 🦟 🦠 Have a look to see how we questioned a mosquito immunity dogma and challenged the existing understanding of Vago-like genes as antiviral factors ⬇️ bmcbiol.biomedcentral.com/articles/10....

bmcbiol.biomedcentral.comAedes aegypti VLG-1 challenges the assumed antiviral nature of Vago genes - BMC BiologyBackground Arthropod-borne viruses (arboviruses) such as dengue virus (DENV) and Zika virus (ZIKV) pose a significant threat to global health. Novel approaches to control the spread of arboviruses foc...