Geming Lu

Geming Lu

@brian98er.bsky.social

Immunologist and islets biologist, dedicated to the autoimmune and Metabolism research of T1D, T2D, colitis, and multiple sclerosis.

119 followers137 following34 posts

Geming Lu
@brian98er.bsky.social

Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes. www.nature.com/articles/s42...

nature.comCell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes - Nature MetabolismMapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age- and type 2 diabetes-dependent adaptations, and CRISPR-based epigenetic editing strategies validate k...
Geming Lu
@brian98er.bsky.social

Taming Autoimmunity: Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Promote Regulatory T Cell Crosstalk to Reverse Diabetes: Molecular Therapy www.cell.com/molecular-th...

cell.comTaming Autoimmunity: Alpha-1 Antitrypsin Overexpressing Mesenchymal Stem/Stromal Cells Promote Regulatory T Cell Crosstalk to Reverse DiabetesAAT-overexpressing MSCs reverse new-onset diabetes in NOD mice by enhancing Treg expansion, suppressing pathogenic CD4+ and CD8+ T cells, and improving immune communication in pancreatic tissues. This...
Geming Lu
@brian98er.bsky.social

Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes. www.nature.com/articles/s41...

nature.comFrustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes - Nature CommunicationsPROTACs induce degradation by bridging a target protein and E3 ubiquitin ligase. Here, authors show that protein interface frustration correlates with cooperativity, offering a structural metric to prioritize PROTAC candidates prior to synthesis.
Geming Lu
@brian98er.bsky.social

Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene. www.nature.com/articles/s41...

nature.comHuman pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene - Nature Communicationsβ-cell dysfunction and dedifferentiation towards an α-cell-like phenotype are hallmarks of type 2 diabetes. Her,e the authors detect five α-cell subpopulations, find differences between healthy and diabetic donors, and identify SMOC1 as an inducer of human β-cell dysfunction and dedifferentiation.
Geming Lu
@brian98er.bsky.social

Pregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stresses: Trends in Endocrinology & Metabolism www.cell.com/trends/endoc...

cell.comPregnancy-induced metabolic reprogramming and regenerative responses to pro-aging stressesPregnancy is associated with physiological adaptations that affect virtually all organs, enabling the mother to support the growing fetus and placenta while withstanding the demands of pregnancy. As a...
Geming Lu
@brian98er.bsky.social

Inhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation. www.nature.com/articles/s41...

nature.comInhibition of polymorphonuclear cells averts cytotoxicity against hypoimmune cells in xenotransplantation - Nature CommunicationsXenotransplantation is a promising option when allogeneic donors are unavailable but hampered by a more stringent immunological barrier. Here authors show that hypoimmune cells engineered to overcome ...
Geming Lu
@brian98er.bsky.social

Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms. www.cell.com/cell-genomic...

cell.comEffects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphismsLeveraging Finnish nationwide multi-generational registers and the biobanks of FinnGen, Wang, Liu, et al. investigated the effect of parental autoimmune diseases on offspring T1D. Their creative and r...

Geming Lu reposted

Liora Katz
@likatz.bsky.social

Excited to share our work in @naturecomms.bsky.social We shows that molecular glues of the ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. This could lead to new treatments for Diabetes by preserving beta cell function. www.nature.com/articles/s41... #DiabetesResearch #BetaCells

nature.comMolecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity - Nature CommunicationsTargeting transcription factors with small molecules remains a significant challenge in drug discovery. Here, the authors present a structure-based approach to stabilize ChREBPα/14-3-3 interactions, s...
Geming Lu
@brian98er.bsky.social

Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes. www.nature.com/articles/s41...

nature.comSingle-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes - Nature CommunicationsThe pancreatic vasculature displays significant heterogeneity, with the islets perfused by a specialized microcirculation with greater density than the surrounding acinar tissue. Using single-cell RNA...

Geming Lu reposted

Diabetologia
@diabetologiajnl.bsky.social

High glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of #diabetic #kidney disease by inhibiting the Th1 response tinyurl.com/nhhj48sx 🔓

tinyurl.comHigh glucose/ChREBP-induced Hif-1α transcriptional activation in CD4+ T cells reduces the risk of diabetic kidney disease by inhibiting the Th1 response - DiabetologiaAims/hypothesis Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular respo...

Geming Lu reposted

Klaus Kaestner
@kkaestner.bsky.social

Dear Friends, Happy to share our new preprint which describes the discovery of a new alpha to beta cell transitional cell type in the human pancreas using singe cell multiomic and genetic lineage tracing. www.biorxiv.org/content/10.1...

biorxiv.orgSingle-cell multiome analysis supports α-to-β transdifferentiation in human pancreasSpontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin secreting beta cells has been observed in mouse but not in human islets1. Here, we analyzed the largest single cell d...
Geming Lu
@brian98er.bsky.social

Sex-specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors. faseb.onlinelibrary.wiley.com/doi/full/10....

faseb.onlinelibrary.wiley.comSex‐specific cytokine, chemokine, and growth factor signatures in T1D patients and progressorsOur study underscores the critical role of sex as a significant variable in T1D patients and T1D progressors, with discernible differences in cytokine levels observed only when stratified by sex. Det...

Geming Lu reposted

Hao Yin
@haoyin.bsky.social

Apology for the non-working link to this intriguing Spatial Skin paper. Spatiotemporal single-cell roadmap of human skin wound healing Here is the correct link www.cell.com/cell-stem-ce...

cell.comSpatiotemporal single-cell roadmap of human skin wound healingXu Landén and colleagues conducted a unique study on human skin wound healing by inducing wounds in healthy donors and collecting wound-edge tissues at three healing stages. Transcriptome profiling from this study deepens our understanding of tissue repair mechanisms, paving the way for novel therapeutic targets to treat chronic wounds.
Hao Yin@haoyin.bsky.social

#SpatialTranscriptomics #Visium Human Healthy Skin Wound Healing (This is a Human Trial!🥸 N=7) D0/1/7/30 Angiogenic niche comprising #EndothelialCell Fibroblast Mφ Mφ secretome D1 (inflam) IL1A/B CCL7 D7 (prolif) TGFB C1QB D30 (remodeling) IGF1 C1QB #CellStemCell 2024 www.cell.com/cell-stem-ce...

Geming Lu
@brian98er.bsky.social

A famsin-glucagon axis mediates glucose homeostasis. www.cell.com/cell-metabol...

cell.comA famsin-glucagon axis mediates glucose homeostasisGlucagon is essential for glucose homeostasis during fasting and in diabetes, yet the mechanisms regulating its secretion are not fully understood. Long et al. demonstrate that famsin, a gut-secreted hormone, stimulates glucagon secretion through calcium mobilization, thereby promoting hepatic glucose production to maintain glucose homeostasis during fasting and in diabetes.
Geming Lu
@brian98er.bsky.social

Long-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineages. www.cell.com/cell/fulltex...

cell.comLong-term in vitro expansion of a human fetal pancreas stem cell that generates all three pancreatic cell lineagesIdentification of an LGR5 as a marker for a tripotent stem/progenitor cell of the human fetal pancreas. Organoids derived from single LGR5+ cells are capable of long-term expansion in vitro and genera...

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