Christopher Frøhlich

🚨PREPRINT🚨 Enzyme function does not rely only on static structure 🧩, but also on the rate at which functional sub-states interconvert ⏱️, making this interconversion subject to natural selection 🧬. #OXA-48 #ceftazidime #enzymeevolution www.biorxiv.org/content/10.6...

Crazy

Huge congratulations to our PhD student Daniel Salamonsen, who defended his thesis last week! 🎓 Thanks to Daniel Rozen, Clarissa Czekster and Edda Marie Rainer for serving as opponents and travelling all the way to the Arctic. Very inspiring having you here ❄️

very cool. old questions, new methods = nuanced view of evolutionary landscape of selection, chance, and contingency elifesciences.org/articles/103...

🧬 I'm looking for a Researcher (2 years) in Molecular Biology and Antimicrobial Resistance at UiT The ❄️Arctic University of Norway (Tromsø). 🔬 If you have experience building and screening enzyme libraries and characterising the variants that come out, get in touch.

🦠 #Collateralsensitivity, when resistance to one antibiotic creates vulnerability to another, offers a route to fight #AMR. We followed the evolution of #β-lactamase OXA-48 and show mutations can both create AND mitigate these trade-offs. 💊 doi.org/10.1016/j.jm...

We studied the causes of #collateralsensitivity from a single enzyme perspective using and how stable such #tradeoffs are during #coselection. In short, resistance evolution can cause strong but migigatable trade-offs. Preproof is now available on @JMB: www.sciencedirect.com/science/arti...

Looking for a PostDoc in molecular biology and structural biology ? Check out the position in my group: www.jobbnorge.no/en/available...

doi.org/10.1093/nar/...

Sometimes, adaptation to one #antibiotics can make bacteria more vulnerable to other drugs. #CollateralSensitivity. 💡 By following the evolution of a β-lactamase, we uncovered how mutations can both create and mitigate such collateral sensitivity networks. www.biorxiv.org/content/10.6...

Living in the Arctic 🥶 means Christmas comes early 🎁🥳 10 MNOK (≈1 MUSD) Early Career Investigator grant from the Research Council of Norway to work with the fabulous @bunzela.bsky.social (Max Planck Institute) on uncovering the molecular mechanisms of antibiotic resistance. #AMR #beta-lactamases

Interested in #β-lactamase inhibitors? 🧪 Our new #mSphere paper shows how a covalent boronic-acid + chelator fusion ⚗️ can restore β-lactam susceptibility in metallo-β-lactamase producers, even in variants that are difficult to inhibit with #taniborbactam. journals.asm.org/doi/full/10....

Is it too early for a year review? 🤔 Research stays at ETH Zürich with Adrian Bunzel and at UBC Vancouver with Nobu 🤓. Now I’m moving labs to start as Associate Professor at UiT, which means organising freezer contents 📦. Two β-lactamase evolution preprints coming soon 🧬. Stay tuned!

🔄 #Enzymes can adopt multiple #conformations. ⚡ Some of these act as functional sub-states. 📚 We summarised recent studies, the methods used to uncover these hidden states, and the challenges ahead in linking them to #proteinevolution. www.sciencedirect.com/science/arti...

I highly recommend this conference, i thoroughly enjoyed the 2022 meeting 👇🏻

#JournalClub 🚨 Out Now! A short read describing a xanthone-derived antibiotic which has multifaceted mode of action. #MicroSky #AMR www.nature.com/articles/s41...

🔬 Join us! We are hiring three PhD students to advance enzyme design and develop photoenzymes for carbon capture and nitrogen fixation. If you are passionate about protein engineering, computational modeling, or synthetic biology, check out the job openings! 📌 www.mpg.de/24336572/phd...

🔬 PhD in Antibiotic Resistance Evolution – Join Us in the Arctic! ❄️ Passionate about enzymes and tackling antibiotic resistance?🧬✨ 🔍 We’re looking for candidates with experience in: ✅ Genetic manipulation ✅ Protein expression & purification ✅ Enzyme biochemistry 🔗 Apply now: lnkd.in/eZRrgJKF

📣 Preprint Alert: How can evolution recruit existing enzymes during bacterial lifestyle changes? Discover how mutations in a bifunctional enzyme 🔄 alter bacterial c-di-GMP metabolism, decoupling it from external polyamine signaling, and steering cells from a planktonic to a biofilm lifestyle 🦠

🌟 Enzyme Evolution: Marie Curie Fellowship in Tromsø! 🌟 Are you a late-stage PhD student or postdoctoral scholar specializing in biochemistry, molecular biology, or a related discipline? Connect with us to explore the potential for a MSCA collaboration. euraxess.ec.europa.eu/jobs/309710

Are you interested in biofilms and how evolution regulates them? Follow @oeyvindml.bsky.social PhD defence online. 1045 Central European time! Here is the link to the live stream: uit.cloud.panopto.eu/Panopto/Page...

Are you interested in how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis Full read: rdcu.be/dzqjk

Are you interested in how #epistasis shapes the AMR evolution? We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis Full read: rdcu.be/dzqjk

Postdoc Opportunity UiTNorgesarktis! 🇳🇴 🧪Join our Arctic MSCA-PF program in Enzyme & AMR evolution. 24-months MSCA in Tromsø's stunning landscape. ⏱️Apply by Feb 16: 3-page CV & 2-page proposal to cfr016@uit.no. #sciencejobs #postdocposition euraxess.ec.europa.eu/jobs/189491

🌟Exciting News! Our AMR & Biofilms research just received an 8M kroner grant from #HelseNord. Big thanks for supporting young researchers and fueling scientific innovation. Grateful to all who've contributed to this success. Looking forward to what comes next.