Cincinnati Children’s Research

Cincinnati Children’s Research

@cincyresearch.bsky.social

As one of the largest pediatric research teams in the United States, our @cincychildrens.bsky.social discoveries and innovations have changed modern medicine.

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Cincinnati Children’s Research
@cincyresearch.bsky.social

Cincinnati Children's research leader Tina Cheng and colleagues forecast dramatic improvements ahead for children of all ages, identifying 10 areas poised for major advances, from gene therapy and precision medicine to artificial intelligence, mental health, and cancer care. Learn more:

scienceblog.cincinnatichildrens.org10 Great Opportunities to Advance Child Health - Research HorizonsTina Cheng and colleagues at Cincinnati Children's outline 10 great opportunities for child health research.
Cincinnati Children’s Research
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Cincinnati Children's Dr. John Pestian presented an update on his research to develop an early risk detection tool for suicide at the AI4Peace conference sponsored by the Vatican. #AI #AI4Peace #MentalHealth

scienceblog.cincinnatichildrens.orgAI, Mental Health and the Common Good  - Research HorizonsDr. John Pestian presented an update on his research to develop an early risk detection tool for suicide at the AI4Peace conference sponsored by the Vatican.
Cincinnati Children’s Research
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A Cincinnati Children's led study, recently published in The Lancet Haematology, found that long-term data from the REACH trial show hydroxyurea safely treats children with #sicklecell anemia in Africa without increasing the risk of serious infections, expanding access to care.

scienceblog.cincinnatichildrens.orgChildren Living With Sickle Cell Can Be Treated Safely Using Hydroxyurea - Research HorizonsLong-term REACH trial data show hydroxyurea safely treats children with sickle cell anemia in Africa without increasing serious infections.
Cincinnati Children’s Research
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Researchers at Cincinnati Children's discovered that beneficial gut bacteria trigger production of calprotectin, an antimicrobial protein that helps newborns activate antimicrobial defenses, offering new insight into early-life immunity.

nam02.safelinks.protection.outlook.comHow Newborns’ First Microbes Help Build Protection Against Infection - Research HorizonsBeneficial gut bacteria help newborns activate antimicrobial defenses, offering new insight into early-life immunity.
Cincinnati Children’s Research
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National security does not begin at the Pentagon. It begins in childhood. In a new STAT editorial, Tina Cheng, our chief medical officer, chair of Pediatrics, and Research Foundation director, and others warn declining child health threatens our future and military readiness.

ow.lyNational Security Begins in Childhood - Research HorizonsCincinnati Children's research leader Tina Cheng co-authors child health policy editorial published in STAT.
Cincinnati Children’s Research
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New research led by Cincinnati Children's found that moderate-to-severe chorioamnionitis and cerebellar abnormalities were independently associated with higher autism risk in infants born before 32 weeks' gestation. Learn more:

scienceblog.cincinnatichildrens.orgTwo Early Risk Factors Point to Higher Autism Risk in Very Preterm Infants  - Research HorizonsModerate-to-severe chorioamnionitis and cerebellar abnormalities were independently associated with higher autism risk in infants born before 32 weeks' gestation, according to new research led by experts at Cincinnati Children's.
Cincinnati Children’s Research
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Earlier stem cell transplants may improve survival for youth with Shwachman-Diamond syndrome when high-risk features emerge, according to a study led by an expert at Cincinnati Children's and published in @nejm.org.

scienceblog.cincinnatichildrens.orgEarlier HCT Improves Survival for Youth with Shwachman-Diamond Syndrome - Research HorizonsEarlier stem cell transplants may improve survival for youth with Shwachman-Diamond syndrome when high-risk features emerge, according to a study led by an expert at Cincinnati Children's and publishe...
Cincinnati Children’s Research
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Join us in congratulating Cincinnati Children's chief medical officer, chair of Pediatrics and Research Foundation director, Tina L. Cheng on receiving The American Academy of Pediatrics' (AAP) highest honor, the 2026 Clifford G. Grulee Award! Learn more about Dr. Cheng’s career and impact:

scienceblog.cincinnatichildrens.orgTina Cheng Receives American Academy of Pediatrics’ Highest Honor - Research HorizonsThe AAP honor recognizes Cheng’s decades of service to pediatrics and work to improve health outcomes for children and families.
Cincinnati Children’s Research
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Cradle Cincinnati’s community-led collaboration helped Hamilton County cut infant deaths and move below the national infant mortality average. Published in The American Academy of Pediatrics. #InfantMortality #CommunityHealth #ChildHealth #PublicHealth

scienceblog.cincinnatichildrens.orgHow Cradle Cincinnati Helped Reduce Infant Mortality in Hamilton County - Research HorizonsCradle Cincinnati’s community-led collaboration helped Hamilton County cut infant deaths and move below the national infant mortality average.
Cincinnati Children’s Research
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We’re proud to be recognized once again in the U.S. News & World Report pediatric hospital rankings. Inspired by kids, guided by science.

Cincinnati Children's@cincychildrens.bsky.social

Every breakthrough starts with a child. Every answer starts with a team that never stops searching. For 20 consecutive years, Cincinnati Children’s has been recognized among the nation's best children's hospitals by U.S. News & World Report. 🔗 - www.cincinnatichildrens.org/about/us-news

Cincinnati Children’s Research
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Why do some disease-associated genetic variants remain so common? Cincinnati Children's researchers found that a lupus-associated IRF7 variant may boost antiviral immune responses while increasing autoimmunity risk, revealing an important biological tradeoff. Waggoner Lab #HumanGenetics #Immunology

scienceblog.cincinnatichildrens.orgWhen Antiviral Defense and Autoimmunity Collide: New Insights into Lupus Genetics - Research HorizonsResearchers discovered how a common lupus risk variant may boost antiviral defenses while increasing autoimmunity risk.
Cincinnati Children’s Research
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Anatool, a new clinical support tool developed by FARE in collaboration with Cincinnati Children's emergency medicine expert Tim Dribin, MD, helps healthcare professionals recognize and treat anaphylaxis using international consensus guidance. #AllergyResearch #EmergencyMedicine #AllergyAwareness

scienceblog.cincinnatichildrens.orgAnatool Launches to Improve Recognition and Treatment of Anaphylaxis - Research HorizonsAnatool, a new clinical support tool developed by FARE in collaboration with Cincinnati Children’s emergency medicine expert Tim Dribin, MD, helps healthcare professionals recognize and treat anaphylaxis using international consensus guidance.
Cincinnati Children’s Research
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September is #ChildhoodCancerAwarenessMonth. 🎗️ At Cincinnati Children's, cancer research spans the full continuum of discovery, from basic science to clinical trials evaluating new treatments. Explore recent advances in the fight against childhood cancer: #PediatricCancer #CancerResearch

scienceblog.cincinnatichildrens.orgResearch at Cincinnati Children’s Makes Impact in the Quest to Defeat Childhood Cancer - Research HorizonsIn recognition of Childhood Cancer Awareness Month, Cincinnati Children’s highlights several research advances led by cancer experts here, including work to develop FLASH proton therapy, evaluate safer CAR T-cell therapy, and investments to expand gene and cell therapies.
Cincinnati Children’s Research
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Cincinnati Children's researcher Avani Modi, PhD was recently interviewed by Healio about a pilot study evaluating a mobile intervention designed to help children with type 1 diabetes manage stress, burnout and the everyday challenges of self-care. Learn more on our blog: https://ow.ly/IQf450ZKZP9

ow.lyNovel intervention may reduce stress, burnout in adolescents with type 1 diabetesAn intervention designed to enhance executive functioning skills and self-management care for adolescents with type 1 diabetes reduced stress and burnout while increasing quality of life, according to a study in The Journal of Pediatrics. Avani C. Modi, PhD, pediatric psychologist at Cincinnati Children’s Hospital, and colleagues conducted a pilot randomized controlled trial to evaluate
Cincinnati Children’s Research
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Cincinnati Children's researchers report that KRAS inhibitors may offer a promising new strategy for shrinking NF1-related nerve tumors, based on preclinical mouse-model findings. Published in Science Magazine. #NF1Research #KRASInhibitors #PediatricOncology #CancerResearch

scienceblog.cincinnatichildrens.orgNew class of KRAS Inhibitors Shows Promise at Shrinking NF1 Nerve Tumors - Research HorizonsCincinnati Children’s researchers report that KRAS inhibitors may offer a promising new strategy for shrinking NF1-related nerve tumors, based on preclinical mouse-model findings.
Cincinnati Children’s Research
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Researchers at Cincinnati Children’s identified naïve CD8 T cell subsets with different abilities to generate protective immune responses and discovered these states can change over time . #Immunology #TCells #Vaccines #InfectiousDiseases #ResearchDiscovery

scienceblog.cincinnatichildrens.orgWhat Makes Some Naïve T Cells Better Responders? - Research HorizonsScientists have learned a great deal about the specialized T cells that emerge after activation, including effector, memory and exhausted populations. Yet a fundamental question has remained: how much of a T cell’s future success is determined before it ever encounters a virus, tumor or vaccine?
Cincinnati Children’s Research
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AI is expanding the potential of the pediatric ECG. David Leone, MD, MS, shared how AI-enhanced ECGs may support earlier detection and risk assessment for pediatric heart disease. Learn more about his findings: #ArtificialIntelligence #Cardiology #PediatricResearch #HeartHealth #DigitalHealth

Cincinnati Children’s Research
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A recent PECARN - Pediatric Emergency Care Applied Research Network study involving 7 U.S. pediatric EDs, including Cincinnati Children's, found that clinicians often disagree on common examination findings used to diagnose pneumonia. Published in JAMA Network Open.

scienceblog.cincinnatichildrens.orgStudy finds common physical exam findings unreliable for diagnosing pneumonia in children - Research HorizonsStudy finds clinicians often disagree on common physical exam findings used to diagnose pneumonia in children, underscoring the need for more reliable diagnostic tools.
Cincinnati Children’s Research
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How does diet shape immunity? New research from Cincinnati Children's reveals a previously unknown pathway linking vitamin A signaling to intestinal tuft cells, key regulators of immune responses in the gut. Read more: #Immunology #GutHealth #CellReports

scienceblog.cincinnatichildrens.orgNew Clues to How Diet Regulates Intestinal Immunity - Research HorizonsResearchers uncovered a pathway linking vitamin A signaling to tuft cell development and type 2 immune responses.
Cincinnati Children’s Research
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In the latest “Road to Researcher” feature, pulmonary pathologist Kathryn Wikenheiser-Brokamp, MD, PhD, reflects on the mentors, experiences and scientific questions that shaped her path to Cincinnati Children's—and her work advancing pediatric research. Read her story: #WeAreCincyKids

scienceblog.cincinnatichildrens.orgRoad to Researcher: Kathryn Wikenheiser-Brokamp, MD, PhD - Research HorizonsLearn why Cincinnati Children’s has remained the ideal place to pursue both research and medicine for this pulmonary pathologist.
Cincinnati Children’s Research
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By studying near-sightedness in tree shrews, experts at Cincinnati Children's and UAB Department of Pediatrics report a potential method for protecting the vision of hundreds of millions of children: bringing a slice of sunshine indoors. Published in Cell Reports Methods: https://ow.ly/jXQ450ZBrl9

scienceblog.cincinnatichildrens.orgRestoring a Missing Slice of Sunshine to Indoor Light May Help Prevent Myopia - Research HorizonsIndigo-enriched indoor lighting may help prevent childhood myopia by restoring wavelengths missing from standard lighting.
Cincinnati Children’s Research
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Cincinnati Children’s study finds cardiac immune cells can both protect and harm the heart, depending on timing and disease context. Learn more on our Science Blog: scienceblog.cincinnatichildrens.org/study-challe...

Journal of Clinical Investigation@jci.org

Selective expansion of cardiac macrophage subtypes reveals nuanced roles doi.org/10.1172/JCI2... Jeffery D. Molkentin & team's findings highlight the different contributions of tissue-resident versus monocyte-derived macrophages to cardiac health and disease.

Cincinnati Children’s Research
@cincyresearch.bsky.social

What causes barrier dysfunction in eosinophilic esophagitis (EoE)? Researchers at Cincinnati Children's identified a pathway linking IL-13 inflammation to reduced SPINK7 expression, offering new insight into disease mechanisms and potential treatment targets.

ow.lyStudy Links Inflammation to Barrier Failure in EoE - Research HorizonsResearchers identified a pathway linking inflammation to barrier dysfunction in EoE, supporting current and future therapies.
Cincinnati Children’s Research
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Congrats to @labwaggoner.bsky.social at Cincinnati Children's on these findings. Learn more about the study on our Science Blog: scienceblog.cincinnatichildrens.org/new-approach...

scienceblog.cincinnatichildrens.orgNew Approach Opens Rare Immune Cells to Genetic Risk Research - Research HorizonsNew genomic approach reveals how genetic risk influences genes in rare immune cells through long‑distance DNA interactions.
Science X / Phys.org@sciencex.bsky.social

3D genome mapping in rare ILC3 immune cells linked Crohn’s risk variants to more than 100 genes they may affect. About half had not previously been connected to the disease. doi.org/hcdmrr

medicalxpress.com3D genome mapping in rare immune cells reveals new Crohn's disease genesA new study co-led by professor Valeriya Malysheva, group leader at the VIB-UAntwerp Center for Molecular Neurology, published in Nature Genetics, uncovers how the three-dimensional organization of DNA in rare immune cells can help explain genetic risk for Crohn's disease and other autoimmune conditions.
Cincinnati Children’s Research
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A new vaccine could vanquish a major cause of deadly diarrheal disease. Thank you Dr. Frenck and colleagues! Thank you study participants! #shigella #vaccines #infectiousdisease Study in The Lancet Infectious Diseases: www.sciencedirect.com/science/arti... Story in NPR www.npr.org/2026/08/07/g...

npr.orgA new vaccine could vanquish a major cause of deadly diarrheal diseaseOver 1 million people a year die from diarrheal disease. Nearly half are kids under age 5. A new vaccine in trials offers great hope.
Cincinnati Children’s Research
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Infants face the highest risk of severe illness from common respiratory viruses, according to new research from Cincinnati Children's, though most infections never result in a healthcare visit. Published in The American Academy of Pediatrics. Learn more: #ChildHealth #RSV #InfectiousDiseases

scienceblog.cincinnatichildrens.orgHow Respiratory Virus Symptoms Vary in Children - Research HorizonsAnalysis of nearly 16,000 infections reveals distinct symptom patterns and outcomes across common respiratory viruses.
Cincinnati Children’s Research
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Cincinnati Children's has received a six-year, $38.4M NIH grant renewal to lead the next phase of the Bench to Bassinet Program. The new initiative, B2B CHANGE, will connect genomic discoveries to long-term health outcomes and future care needs. Congratulations to the team behind this work!

scienceblog.cincinnatichildrens.org$38.4 Million NIH Grant Renewal to Expand Landmark Congenital Heart Disease Genomics Program - Research HorizonsCincinnati Children’s receives a $38.4 million NIH grant renewal to expand Bench to Bassinet, a national congenital heart disease genomics program.
Cincinnati Children’s Research
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New Approach Opens Rare Immune Cells to Genetic Risk Research. Congratulations to the team! Learn more: scienceblog.cincinnatichildrens.org/new-approach...

Waggoner Lab@labwaggoner.bsky.social

Excited this multi-year collaboration is in print @NatureGenet with @mspivakov.bsky.social @MalyValerie @HelenR_J Low-input Capture Hi-C reveals promoter-anchored chromosomal interactions in human ILC3 prioritzing CLN3 & other genes as potential ILC3-specific mediators of genetic risk for #IBD

Cincinnati Children’s Research
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Cincinnati Children's researchers developed an address-level model that links housing, crime, eviction, birth and neighborhood data to pediatric hospitalization risk, offering a more precise framework for place-based child health interventions. Learn more:

scienceblog.cincinnatichildrens.orgNew Research Tool Maps Child Hospitalization Risk at the Address Level - Research HorizonsCincinnati Children’s researchers developed an address-level model that links housing, crime, eviction, birth, and neighborhood data to pediatric hospitalization risk, offering a more precise framework for place-based child health interventions.
Cincinnati Children’s Research
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New @gohealio.bsky.social article featuring @cincychildrens.bsky.social researcher Timothy Dribin, MD. A model can predict which children who received an #epinephrine dose for #anaphylaxis before ED arrival are at risk for receiving it again after arrival using prehospital data.

healio.comModel identifies pediatric patients with anaphylaxis who may not need ED visitA model can predict which children/adolescents who received an epinephrine dose for anaphylaxis before ED arrival are at risk for receiving it again after ED arrival using prehospital data, according ...
Cincinnati Children’s Research
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Researchers at Cincinnati Children's developed the 5-item BRACHA-S tool to help identify youth most likely to become aggressive during emergency psychiatric visits. The tool may help staff prepare and address concerns before they escalate. Published The American Academy of Pediatrics.

scienceblog.cincinnatichildrens.orgRisky Agitation Can Be Predicted in Emergency Departments - Research HorizonsA new Cincinnati Children’s study shows BRACHA-S can help predict agitation risk in pediatric psychiatric emergency visits.
Cincinnati Children’s Research
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Congratulations to Daniel Starczynowski, PhD, who was appointed director of Cincinnati Children's Division of Experimental Hematology & Cancer Biology, scientific & innovation director of the Cancer & Blood Diseases Institute, and research director of University of Cincinnati's Cancer Center.

scienceblog.cincinnatichildrens.orgDaniel Starczynowski Appointed to Key Cancer Research Leadership Roles - Research HorizonsOne of the nation's top leukemia researchers will guide Cincinnati Children's cancer and blood disease research and scientific collaboration with UC Cancer Center.
Cincinnati Children’s Research
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New research from Cincinnati Children's found that hospital-based mental health interventions can reduce anxiety, stress and depression among NICU parents. The review included 160 studies and more than 16,000 parents. Published in JAMA Pediatrics.

scienceblog.cincinnatichildrens.orgParents Benefit from NICU Mental Health Support - Research HorizonsA Cincinnati Children’s-led study finds that NICU-based mental health support can reduce anxiety, stress and depression among parents, suggesting these services should become part of standard neonatal care.
Cincinnati Children’s Research
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A Cincinnati Children's led team and collaborators at Forge Biologics report that #genetherapy restored key #fragileX syndrome traits in mice. Study found improvements in seizure susceptibility, sensory hyperactivity and EEG biomarkers that could help bridge animal studies and future human trials.

scienceblog.cincinnatichildrens.orgGene Therapy Restores Key Fragile X Traits in Preclinical Study - Research HorizonsGene therapy restored key fragile X syndrome traits in mice, supporting future work on FMR1 replacement as a potential disease-modifying treatment.
Cincinnati Children’s Research
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A new multi-model study from Cincinnati Children's researchers found that targeted immune‑modulating therapies can outperform current anti-inflammatory treatment for TB meningitis. Published in Nature Communications. Read more: #Tuberculosis #InfectiousDiseases #GlobalHealth #Neurology

scienceblog.cincinnatichildrens.orgStudy Points to New Strategy for TB Meningitis Care - Research HorizonsMulti-model study shows host-directed therapies reduce inflammation and outperform anti-inflammatory care in TB meningitis.
Cincinnati Children’s Research
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It is with heartfelt sadness that we share the passing of Susan Thompson, PhD, an internationally recognized leader in the Division of Rheumatology at Cincinnati Children's. For more than 30 years, she advanced the understanding of autoimmune diseases. Learn more about her legacy:

scienceblog.cincinnatichildrens.orgIn Memoriam: Susan Thompson, PhD, 1958 – 2026 - Research HorizonsLearn about our Rheumatology division's first female faculty, whose research in juvenile arthritis helped shaped pediatric autoimmune research worldwide.
Cincinnati Children’s Research
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Maisam Abu-El-Haija, MD, MS, medical director, Pancreas Care Center, was named the recipient of the Caper: Collaborative Alliance for Pancreatic Education & Research Senior Mentor Award, the organization's highest distinction. Dr. Abu-El-Jaija delivers a featured lecture today at #PancreasFest26.