Cleanthis Michael

Cleanthis Michael

@clmich.bsky.social

Clinical Science PhD Candidate at UMich Clinical Intern at WPH/UPMC brain development | plasticity | adversity | mental health

185 followers187 following25 posts

Cleanthis Michael reposted

Thrilled to have matched at Western Psychiatric Hospital for my clinical psychology internship 🎉 I am so grateful for all the support I have had throughout this journey! #APPIC

Cleanthis Michael reposted

My lab at UW Madison is hiring a new lab manager! I’m looking for a motivated and detail-oriented person to help run the lab’s day-to-day, including our ongoing neuroimaging and behavioral studies. This is especially well suited for graduating undergrads thinking about grad school. Link below

Cleanthis Michael reposted

Check out our new paper evaluating the performance of five brain age algorithms in two population-based cohorts of youth 🧠 @ohbmofficial.bsky.social

Jamie Hanson@jamielarsh.bsky.social

🧠 Not all brain age algorithms are equal! In our new study, one algorithm (Pyment) outperformed other models in youth. Algorithms fail when your sample's age range is narrow or mismatched with training data. So, choose wisely... onlinelibrary.wiley.com/doi/10.1002/... #BrainAge #Neuroimaging

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We highlight several avenues to further delineate how experience interacts with the plasticity of the developing human brain – longitudinal designs, multimodal in vivo indices of neuroplasticity, heterogeneity of adversity exposure, and consideration of nurturing and promotive experiences

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Second, neuroplasticity is itself malleable and sensitive to experience (i.e., plasticity as an outcome). Consistent with prior theory, we propose that adversity may accelerate or delay brain maturation, thereby shifting the developmental timing of neuroplasticity

Third, drawing from in vivo proxies of neuroplasticity (e.g., myelination, intrinsic activity, metabolite concentrations), we argue that adversity may dampen or amplify the magnitude of neuroplasticity

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For example, the neurobiological effects of adversity exposure may be more widespread, and localized to early-maturing limbic regions, earlier in life – but more localized to later-maturing prefrontal regions later in development

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Synthesizing across developmental periods, we describe how neuroplasticity may be globally heightened during early childhood and localized later on, progressing along a sensorimotor-association axis across childhood and adolescence

We next propose three ways in which experience, focusing on adversity, may interact with neurodevelopmental plasticity. Understanding these dynamics can help elucidate how experience shapes development, risk, and resilience, and may ultimately inform the type and timing of interventions

Neuroplasticity has been difficult to define and assess – from process or capacity to change, to experience-dependent or expectant mechanisms, to separating experience-driven remodeling from development and genetic programming. We focus on plasticity as the brain’s capacity to adapt to experience

Cleanthis Michael reposted

#PenNLINC is recruiting a clinical coordinator / lab manager!!! Looking for someone who is good with both people + code, wants to learn to acquire + analyze imaging data. Alumni in this role have written 1st author papers + gone to top grad programs. Website: www.pennlinc.io Job: bit.ly/4ojvCir

pennlinc.ioneuroimaging | Satterthwaite Lab | UPennwww.satterthwaitelab.com Homepage for Satterthwaite lab neuroimaging | neurodevelopment | adolescence | psychiatry | machine learning | network science

Cleanthis Michael reposted

🚨 Excited to share the latest preprint form the lab ➡️https://tinyurl.com/32d3be9f Here we tackle a long-standing chicken-or-egg 🐣🥚question in #autism and developmental neuroscience ➡️ Is excitation–inhibition (E:I) imbalance a "cause" or a "consequence" of #autism? Check out what we found! 🧵1/n

Cleanthis Michael reposted

Cleanthis Michael reposted

thrilled to share this project over a decade in the making out now in @pnas.org! We show that precocious GABA boosting in neonates by early sevoflurane/propofol anesthetic exposure accelerates visual cortical maturation in human infants www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Cleanthis Michael reposted

🧠⚖️📉 How does the cortical excitation-inhibition ratio mature during adolescence? We asked this in our new paper just out in #ScienceAdvances ✨ “Adolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modeling” 📄 www.science.org/doi/full/10.... 🧵⤵️

science.orgAdolescent maturation of cortical excitation-inhibition ratio based on individualized biophysical network modelingIndividualized simulations reveal a decrease in excitation-inhibition ratio in association areas throughout adolescence.

Cleanthis Michael reposted

Cleanthis Michael reposted

Cleanthis Michael reposted

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