Excited to share work by @yemilywang.bsky.social & Zhouyu Zhang, in a collab with PKU: Martini 3 CG sims overestimate lipid scrambling, predict it in proteins that don't scramble, and give anomalous binding, from low headgroup polarity. But small parameter refinements fix it. tinyurl.com/m3scramble
corrylab.bsky.social
corrylab.bsky.social
@corrylab.bsky.social
Computational protein research group of Prof Ben Corry. We love molecular dynamics and all kinds of membrane proteins including ion channels, transporters and immune receptors ~Posts by group members
1.1K followers839 following32 posts
Great new preprint by our @ciarawallis.bsky.social and Abi Partridge!
β¨ So excited to share our latest preprint from the @corrylab.bsky.social & Lehane lab investigating resistance-conferring mutations in the malaria parasite lactate/H+ symporter, PfFNT π π¦ Here we show two new mutations, one of which is found outside the transport pathway π tiny.cc/PfFNTresista...
Kudos to @ciarawallis.bsky.social & @yiechanglin.bsky.social for their elegant publication testing #AlphaFold for predicting protein oligomeric states including advice on when it is likely to do well and when it can fail. ππππ#StructuralBiology #AI #Biophysics tiny.cc/oligos
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Some very cool simulations, look at those little guys climb that ladder! #MolecularNodes
Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. π₯π #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...
Excited to share this paper from @yiechanglin.bsky.social showing how lipids can move between bacterial membranes along the bridge like protein TamB. Also happy to be able to post the cool movie. π₯π #MDsimulations #StructuralBiology doi.org/10.1016/j.bp...
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Join us on campus & online on Thursday, 23 April 2026 at 1pm for a seminar by Dr Caroline Puente-Lelievre, Research Fellow from the School of Biological Sciences and Centre for Computational Evolution, University of Auckland. @corrylab.bsky.social Details: rb.gy/ik3ep3
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πThe @corrylab.bsky.social are so excited to be at #BPS2026! π See Emily TODAY 4:45 PM, Room 207 talking about a simulation PIPeline to predict PIP binding sites π₯οΈ + me tomorrow 8:45 AM, Room 201 for when AlphaFold can predict homo-oligomeric states π€ + both of us @ posters B218 & B11 on Tues! π
How does your immune system tell pathogenic RNA from your own, even though theyβre made of the same stuff? Our latest paper with @gantierlab.bsky.social shows some self RNA act as an off switch preventing autoimmunity in the absence of pathogens. π§¬π¬β www.nature.com/articles/s41590-026-02429-2
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π₯³So excited to announce our latest preprint on PfFNT!! The lactate/H+ exporter from the malaria parasite that challenges the standard definitions of transporters vs channels πͺβ¨ 1/6 tiny.cc/pffnt
Beginning 2026 with a flipping good paperπ OSCA/TMEM63 proteins do double duty: theyβre ion channels and mechanically activated lipid scramblases helping reshape membranes and survive mechanical stress. π @yiechanglin.bsky.social @charlesdcox.bsky.social doi.org/10.1038/s414...
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Join us on campus & online on Monday, 16 Feb 2026 at 1pm for a seminar by Ciara Wallis, PhD Candidate @corrylab.bsky.social! Details: biology.anu.edu.au/news-events/....
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You cant focus on new priorities if you don't have people and funding to do the work. Let's keep the scientists we do have.
Save the CSIRO Our national science & research agency is now facing more job cuts than under Tony Abbott Call on the Albanese Govt to fund the scientists & research we need to tackle big issues we face from climate to food security and everything in between www.davidpocock.com.au/save_our_csiro
Great to see this paper with @elainetao.bsky.social out in print at the Biophysical Journal. Using Alphafold to study conformational transitions in 32 voltage-gated channel superfamily members #ionchannel #AI #StructuralBiology www.sciencedirect.com/science/arti...
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π£ Save the date for the 51st Lorne Conference on Protein Structure and Function! β¨ Lorne, Victoria, Australia. We have a packed program and we'll be sharing all the details here - Like, Follow and Share - because friends don't let friends miss the epic Lorne Proteins π www.lorneproteins.org
2 yrs ago @yiechanglin.bsky.social sent me this movie of lipid scrambling by OSCA1.2. Now we show itβs common to WT OSCA/TMEM63 proteins, mechanically activated, cholesterol dependent, and protects cells from damaging forces. Awesome collab with @charlesdcox.bsky.social &Zhang lab. tiny.cc/tmem63
Applications for this position are closing tomorrow! Get yours in quickly π
π We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids π Join us at #scienceanu with amazing collaborators and great working conditions! Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
π We are hiring! Seeking a postdoc to use molecular dynamics and AI to understand how ion channels are regulated by membrane lipids π Join us at #scienceanu with amazing collaborators and great working conditions! Email me (karri.anu.edu.au) or apply here (tiny.cc/corry). Please share & repost!
Excited to share John's new work in Nat Coms! We demonstrate how PfCRT, a polyspecific peptide transporter, turns into a drug transporter for antimalarials like chloroquine and why this causes a fitness cost for the malaria parasite (1/2) tiny.cc/PfCRT
Also bittersweet to announce the final work of @elainetao.bsky.social in our lab, using AF2 to study conformational transitions in 32 voltage-gated channel superfamily members π€© we're so excited to watch you Nav-igate the next steps of your career, Dr. Tao & are so proud of you π© tiny.cc/VSD-AF2
Bittersweet to announce the wonderful YC's final work in our lab. We are so proud of everything she's accomplished (incl. this beautiful study showing how the TAM complex facilitates lipid flow between the bacterial inner & outer membranes). We can't wait to see what you do next, Dr. Lin π€©
1/ In my final project as part of the @corrylab.bsky.social, we show the bacterial TAM complex facilitates the spontaneous flow of phospholipids from the IM to the OM in MD simulations.. www.biorxiv.org/content/10.1101/2025.03.12.642747v1
Thrilled to share our latest preprint from @yiechanglin.bsky.social & @ciarawallis.bsky.social showing that AF2-Multimer and AF3 can quickly & accurately predict the oligomeric states & structures of proteins (& maybe can identify multiple biologically relevant oligomeric states π) tiny.cc/oligomers
Big congratulations to the very sharp @elainetao.bsky.social who submitted her PhD last week! Our greatest Nav channel expert is rumoured to be joining the dark side of Kv. #drtao #phdone @scienceanu.bsky.social πͺππ©βπ¬π©βπ
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Big congratulations to @riottowow.bsky.social .bsky.social for winning an Anders Early Career Award at @lorneproteins.bsky.social ! Presenting his work on the lipid lined pore of the OSCA mechanosensitive channel. #lorneproteins2025
Proud of our latest work w/ the Zhang lab showing from structure & simulation how XPR1, the only known human Pi exporter, is regulated by InsP8 & KIDINS220 + Pi selection & permeation through a channel-like βknock-kiss-kickβ mechanism πͺπ𦡠π» by @ciarawallis.bsky.social & @riottowow.bsky.social
Read more about XPR1 here! www.biorxiv.org/content/10.1...
Excited to be going to #bps2025 in LA!
The Channels, Receptors & Transporters Subgroup of the @biophysicalsoc.bsky.social is excited to announce the final program for our 2025 Symposium. Please join us on Feb 15 to hear from @willowcoyote.bsky.social @drcontrexin.bsky.social @corrylab.bsky.social and others πThanks to our sponsors!
I should have included one of the nice figures from the paper! rupress.org/jgp/article-...
Excited to start the year with this paper with @elainetao.bsky.social. Using simulations we show sodium channel blocking drugs bind at many sites within the pore and fenestrastions rather than at a single distinct pose. @jgenphysiol.bsky.social @scienceanu.bsky.social #ionchannels hubs.la/Q031spy70
Season's Greetings from our (lab) family to yours! P.s. can you guess which lab member is which?? ππ πͺ Baking by @yiechanglin.bsky.social, Elaine Tao, ZhouYi Wang, @ciarawallis.bsky.social, + honorary member @caloflaherty.bsky.social β₯οΈ
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Delighted to publish my new molecular animation: DNA Break Repair by Homologous Recombination youtu.be/Xe-83tBcxhs
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Weβve had nearly 3 years of review, review, review. We need reviews, but itβs blindingly obvious that Australian research needs much greater Government investment while those reviews are done. This was true 3 years ago. Still true now. By @drjr.bsky.social
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Excited to share our preprint about volume regulated ion channels here! We solved structures of heteromeric LRRC8A:D channels and show how they are gated closed by pore-blocking lipids. Led by @antonylurie.bsky.social + David Kern #IonChannel #cryoem www.biorxiv.org/content/10.1...
I'm following the Friday trend to make my own word scramble. Mine is a bit of a historical mess, but lots of fun to try scholargoggler.com
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Ok, trying to bring my community back together... I created a starter pack for lipids and membrane protein aficionados! Feel free to share, add and distribute, so we can come together again! π go.bsky.app/AEeXh86
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May be a bit premature, but here is the Starter Pack I am trying to populate for #IonChannel research. Ping me and Iβll add you obviously! (Or to be removed) go.bsky.app/6taxHfx @jgenphysiol.bsky.social @auditorynerves.bsky.social @plesslab.bsky.social @rainbowlabuol.bsky.social
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I made a MD starter pack! Dm or reply to be added βΊοΈβΊοΈ go.bsky.app/QQjPjbL
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