Daan Speth

Daan Speth

@daanspeth.bsky.social

Computational microbiologist. Senior scientist at @cemess.bsky.social, @univie.ac.at. Microbial ecology, mostly of nitrogen cycle microbes, and data driven physiology. Maintainer of the GlobDB genome database https://globdb.org

1.7K followers1.8K following264 posts

Daan Speth reposted

Three years ago, my dad said that all fish are the same shape. Out of spite, I decided to draw all 478 families of bony fish listed in Nelson 2016. There's still some stuff I need to edit and some fish I want to redraw but, after 985 days, I finished my big dumb fish project last night.

Daan Speth reposted

*PLEASE RE-POST* Applications for the trainee-focussed GRS immediately preceding this meeting are also now open! We will begin accepting applicants on *January 15th, 2027*. We will expedite our review for applicants requiring Visas, so please submit ASAP. www.grc.org/microbial-po...

grc.org2027 Microbial Population Biology (GRS) Seminar GRCThe 2027 Gordon Research Seminar on Microbial Population Biology (GRS) will be held in Andover, New Hampshire. Apply today to reserve your spot.
Will Ratcliff@wcratcliff.bsky.social

1/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply ASAP! June 27–July 2 • Andover, NH www.grc.org/microbial-po...

Daan Speth reposted

Jan-Willem Veening@veeninglab.com

Clonal does not mean uniform. #MicroSky Our new review explores how genetically identical bacteria adopt different cell states, and how that diversity shapes survival, cooperation, antibiotic responses and gene transfer. 🧵 doi.org/10.1146/annu...

Daan Speth reposted

You can now update bioRxiv/medRxiv preprints with funding information after the fact. Authors often omit/don't have all funding info when submitting, but funders understandably want it there. This solves the problem without requiring you to submit a whole new paper. openrxiv.org/updating-fun...

openrxiv.orgUpdating funder information on preprints - openRxivFor the past year, bioRxiv and medRxiv authors have been able to include funder information with their preprints. This can be entered in a dedicated field during the submission process, using Research...

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Daan Speth reposted

Come join us at ETH!

Pedro Beltrao@pedrobeltrao.bsky.social

My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...

Daan Speth reposted

I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481

aprecruit.berkeley.eduAssistant Professor -Genetics, Genomics, Evolution, and Development - Molecular and Cell BiologyUniversity of California, Berkeley is hiring. Apply now!

Daan Speth reposted

Daan Speth reposted

Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.

Fred Hutch Basic Sciences Division@basicsci.fredhutch.org

Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.

Daan Speth reposted

Our paper on how better amino acid substitution matrices trained on cleaned alignments improve gene tree inference, and on best practice for cleaning MSAs more broadly, is now out academic.oup.com/mbe/advance-.... New options in both IQTree and Muscle5. @phylowheeler.bsky.social

academic.oup.comImproved gene tree inference from removing alignment errors both from focal genes and when training substitution modelsAbstract. Multiple Sequence Alignment (MSA) is a key step in phylogenetic analysis and is prone to error. Unfortunately, algorithms that remove likely alig
Joanna Masel@joannamasel.bsky.social

Sequence alignments are notoriously prone to error. Our latest preprint offers a new tool for filtering errors out, assesses it and other filtering tools, and recommends new best practice. www.biorxiv.org/content/10.6... @phylowheeler.bsky.social 1/10

Daan Speth reposted

It's out! Excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂 www.nature.com/articles/s41...

nature.comThe planktonic microbiome of the Great Barrier Reef - NatureThe Great Barrier Reef Microbial Genomes Database compiles prokaryotic, viral and eukaryotic genomes from seawater collected from the Great Barrier Reef, providing a rich resource for the study of mar...

Daan Speth reposted

Starting with the DNA sequence of a #phage genome, #PholdAPhage will create a 3D reconstruction of the complete phage, almost like you did cryoEM on it! Check out Renee's awesome software github.com/reneegreen81... to assemble unknown phage particles one protein at a time

Daan Speth reposted

🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

embl.wd103.myworkdayjobs.comResearch Technician (Osterman Group – Metabolism-driven immunity)EMBL Hamburg / CSSB The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organization, with more than 110 independent research groups across Heidelberg, Hamburg, Grenobl...

Daan Speth reposted

Excited to share that I've been awarded a 5-year NIH MIRA (R35) from the National Institute of General Medical Sciences! The lab is growing! We're recruiting postdocs and research techs interested in microbial ecology, quantitative microscopy, microfluidics, and molecular biology. Please share!

Daan Speth reposted

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Daan Speth reposted

Ancestral genome reconstructions get noisier the deeper in time you go. The usual response: distrust them and joke about reading entrails. Ours is to train on the noise! The result is calibrated phenotype prediction back to the LBCA deep in the Archaean. New preprint www.biorxiv.org/content/10.6...

biorxiv.orgModels trained with noisy genomes extend bacterial phenotype prediction into deep timePredicting phenotype from genotype in extant organisms is increasingly tractable through the accumulation of genome sequences and the development of machine-learning algorithms. Here we show that mach...

Daan Speth reposted

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2) The minimal quality thresholds have been upgraded to the same quality threshold that the GTDB uses (completeness - 5* contamination > 50), but using checkM2 quality scores. We opted for this change because the quality of the source datasets is less uniform as the number increases.

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As with previous versions, all genome IDs are standardized and anvio contigs databases, contig nucleotide fasta, protein fasta and basic annotations (KEGG/COG/PFam/CAZymes) are available.

Daan Speth reposted

The lab has several new papers out led by fantastic postdocs, with important contributions from other lab members and collaborators. Each paper focuses on different aspects of Wolbachia spread and effects on hosts. The first paper was led by Dylan Shropshire and is now in Genetics.

Daan Speth reposted