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I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
Daan Speth
@daanspeth.bsky.social
Computational microbiologist. Senior scientist at @cemess.bsky.social, @univie.ac.at. Microbial ecology, mostly of nitrogen cycle microbes, and data driven physiology. Maintainer of the GlobDB genome database https://globdb.org
1.7K followers1.8K following264 posts
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I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
Daan Speth reposted
Daan Speth reposted
I wrote something (as did Mehul Malik) More importantly, @royalsociety.org has just launched a series: a practical guide to starting your PI career royalsociety.org/blog/2026/10...
Daan Speth reposted
What if any dataset, any size, any number of dimensions, opened in a browser tab from a link? 🔬🧪💻 Luxar is out today: write it in Python, share it as a link, explore it in any browser. Open source. 🧵 @biohub.org Preprint: doi.org/10.5281/zen... Code: github.com/royerlab/luxar
Daan Speth reposted
*PLEASE RE-POST* Applications for the trainee-focussed GRS immediately preceding this meeting are also now open! We will begin accepting applicants on *January 15th, 2027*. We will expedite our review for applicants requiring Visas, so please submit ASAP. www.grc.org/microbial-po...
1/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply ASAP! June 27–July 2 • Andover, NH www.grc.org/microbial-po...
Daan Speth reposted
1/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply ASAP! June 27–July 2 • Andover, NH www.grc.org/microbial-po...
Daan Speth reposted
Here it is! @basicsci.fredhutch.org is searching for an associate or senior faculty member!
Thanks to the generosity of the Bezos Family Foundation, @basicsci.fredhutch.org is excited to announce a new search to recruit a Bezos Family Distinguished Scholar : apply.interfolio.com/193655
Daan Speth reposted
Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/
Daan Speth reposted
Excited to share our preprint on Ignicoccus cell divison: only the inner membrane divides, progeny cells accumulate in cell clusters and pop-out! www.biorxiv.org/content/10.6... Great work with the labs: @buzzbaum.bsky.social @curiousdina.bsky.social @anja1.bsky.social @tbharat-lab.bsky.social
Daan Speth reposted
You can now update bioRxiv/medRxiv preprints with funding information after the fact. Authors often omit/don't have all funding info when submitting, but funders understandably want it there. This solves the problem without requiring you to submit a whole new paper. openrxiv.org/updating-fun...
Daan Speth reposted
A Global Catalog of Microbial Symbionts 🌍🦠🧬🫨 New resource from @jgi.doe.gov, led by @astrogenomics.bsky.social and @fmschu.bsky.social with contributions by @emileyeloe-fadrosh.bsky.social @miferg.bsky.social and many more 🔓 www.nature.com/articles/s41... @biosci.lbl.gov @berkeleylab.lbl.gov
New AI Tool Maps the Global Catalog of Microbial Symbionts 🖥️ 🧬 🦠 Today in @natbiotech.nature.com: The publicly available Symbiont Genomes catalog is one of the most comprehensive guides to bacteria and archaea living in partnership with other organisms. Learn more ⬇️
Daan Speth reposted
Structural biology postdoctoral position open in my lab--apply now! For more information about the lab, see www.umassmed.edu/munsonlab/. Interested candidates should apply through the University of Massachusetts Chan Medical School jobs portal (www.ummsjobs.com/job/11668/).
Daan Speth reposted
I'm recruiting a PhD student to work on an NSF-funded project developing new models of trait evolution for phylogenetic comparative methods! Info about the lab here: mhibbins.github.io Applications to our grad program are due December 1. Please share!
Daan Speth reposted
📣 We’re hiring a postdoc for @hot-mes-asu.bsky.social ! 🦠🔬 We’re looking for someone excited about microbial interactions, ecology & evolution, and using molecular genetics and microfluidics to understand microbial communities. Come do fun science with us! apply.interfolio.com/190859
Daan Speth reposted
Come join us at ETH!
My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...
Daan Speth reposted
I’m thrilled to share that our search for a tenure-track colleague in my *truly wonderful and collegial* Genetics, Genomics, Evolution and Development Division in the MCB Department at Berkeley @berkeleymcb.bsky.social is live! Please share this broad search widely: aprecruit.berkeley.edu/JPF05481
Daan Speth reposted
New postdoc opportunity in our team! Topic is computational analysis of (meta)genomic data to study evolution of plant-microbiome interactions. Part of the AEGIS consortium (aegisearth.bio/en). Apply here: www.wur.nl/en/vacancy/p... Please RT!
Daan Speth reposted
Come be our colleague. I have been in this Division for 27 years (4 as a postdoc and 23 as a PI). It is an amazing place to work, collaborate, and be inspired. If you are applying to be an Assistant or Associate Professor this Fall, don't miss this deadline.
Join @FredHutch.org's Basic Sciences Division as an Assistant or Associate Professor and help shape the future of fundamental biology. We welcome applicants whose work will complement, extend, or bring new directions to the division.
Daan Speth reposted
Join us at Institute of Biology Leiden (IBL) as an Assistant/Associate/Full Professor in Mechanisms of Disease Apply before 31st August, 2026: careers.universiteitleiden.nl/job/Assistan...
Daan Speth reposted
Our paper on how better amino acid substitution matrices trained on cleaned alignments improve gene tree inference, and on best practice for cleaning MSAs more broadly, is now out academic.oup.com/mbe/advance-.... New options in both IQTree and Muscle5. @phylowheeler.bsky.social
Sequence alignments are notoriously prone to error. Our latest preprint offers a new tool for filtering errors out, assesses it and other filtering tools, and recommends new best practice. www.biorxiv.org/content/10.6... @phylowheeler.bsky.social 1/10
Daan Speth reposted
It's out! Excited to present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), a comprehensive DB of 1000s of high-quality prokaryote, virus, plasmid, and chromosome-level eukaryote MAGs using Nanopore long reads. Subthreads incoming. Please share widely. 🙂 www.nature.com/articles/s41...
Daan Speth reposted
Starting with the DNA sequence of a #phage genome, #PholdAPhage will create a 3D reconstruction of the complete phage, almost like you did cryoEM on it! Check out Renee's awesome software github.com/reneegreen81... to assemble unknown phage particles one protein at a time
Daan Speth reposted
🚨 We're hiring! My new lab at EMBL Hamburg is looking for a Research Technician. I'm looking for someone excited by phages, metabolism, enzymes, structural biology and bacterial immunity—if you know the right person, please share this post!🧵⬇️ Apply here: embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Daan Speth reposted
Daan Speth reposted
Postdocs and early career folks - this is a truly wonderful opportunity to spend time in Berlin, gain time to think, and expand your network! call.wiko-berlin.de/procedure/65...
Daan Speth reposted
@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...
Daan Speth reposted
My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...
Daan Speth reposted
New study by Alexander Henoch (@ahenoch.bsky.social), a PhD student in our group @hifmb.de and @awi.de, shows what it takes to bring gene synteny into microbial pangenomes, and what we learn about the variability landscape of genomes when we do that. See the pre-print here: doi.org/10.64898/202...
Daan Speth reposted
Synteny-aware microbial pangenome graphs reveal blueprints of genomic variation https://www.biorxiv.org/content/10.64898/2026.07.03.736256v1
Daan Speth reposted
Ancestral genome reconstructions get noisier the deeper in time you go. The usual response: distrust them and joke about reading entrails. Ours is to train on the noise! The result is calibrated phenotype prediction back to the LBCA deep in the Archaean. New preprint www.biorxiv.org/content/10.6...
Daan Speth reposted
Membrane protein solubilization and structure determination using de novo–designed proteins | Science www.science.org/doi/10.1126/...
Daan Speth reposted
Have ideas for your own, independent research program in Theoretical Biology? Then come and join us as a Group Leader at the @mpi-evolbio.bsky.social in Plön, Germany!
Daan Speth reposted
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
1) Dereplication of the datasets is now done using Galah (github.com/wwood/galah), which takes into account checkM2 quality scores. This means a lot of species representative genomes have changed relative to release 226.
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
@aroneys.bsky.social and @benjwoodcroft.bsky.social generated the full 7-level taxonomy, and a singleM metapackage and two sylph databases are available for profiling metagenome datasets using the GlobDB.
I'm happy to announce the release of GlobDB r232! This version contains 346,233 bacterial and archaeal genomes, based on 26 datasets. More info globdb.org 🦠🖥️🧬
Daan Speth reposted
Daan Speth reposted
New paper alert!! We just discovered a new filament system that is widespread exclusively within CPR bacteria! www.biorxiv.org/content/10.6.... Short thread below. 🦠🔬🚀
Daan Speth reposted
I'm happy to share the first pre-print of out Lab! 🎉 Introducing ArchaeaHQ www.biorxiv.org/content/10.6... We curated 21,644 genomes across all 4 archaeal kingdoms to bridge the gap in public datasets for computational biology What is inside ArchaeaHQ... (1/2)
Daan Speth reposted
I'm looking for an enthusiastic student to join my team as a PhD candidate on archaeal genome evolution 🦠💻 Work in beautiful Utrecht, at @binfutrecht.bsky.social, an international group full of caring, amazing scientists, and with frequent cake breaks! www.uu.nl/en/organisat... Please share! 🙏
Daan Speth reposted
Sulfoquinovose degradation by cow rumen microbiota #microbiology #microbiota #rumen #MicroSky @isme-microbes.bsky.social doi.org/10.1093/isme...