Dan Bose

Really pleased to share the *final* version of @katiegelder.bsky.social's super work, profiling the functional roles of #IDRs in CBP. Published today 🎉 🔗https://doi.org/10.1016/j.celrep.2026.117109 #IDRs #condensates #transcription #CBP #generegulation #enhancers (1/7)

Really enjoyed this. Used to looking at changing enhancer/CRE use across tissues, but it's very cool to see it during evolution as well

LoL-align is out in @natmethods.nature.com! It aligns protein structures without superposition. More sensitive than TM-align and DALI, producing better alignments 5–20× faster. Now available in Foldseek! 📄 www.nature.com/articles/s41... 💾 github.com/steineggerlab/foldseek 🌐 search.foldseek.com

Calling cell biology ECRs - the British Society for Cell Biology are looking for new student and postdoc committee reps. Apply now! I guarantee you will learn a lot, meet interesting people AND you get to attend the annual BSCB meeting for free!

November's UK Biomolecular Condensates on-line seminar is on the way (6th Nov 2026, 1 pm GMT). Melanie Bailey and Simon Cook are presenting! @drsimoncook.bsky.social @physicsoflifeuk.bsky.social #condensates

This is awesome! So many possible applications (and loads of fun experiments I can't want to try in the lab!)

Thrilled to share my freshly "baked" Baker lab paper. We took a bottom-up approach to designing transcriptional regulators. Instead of relying on natural activation domains, we designed compact proteins that recruit specific cofactors. Activators for now, repressors to come!

IMO the paper of the year in the gene regulation field - such a clean and clear study, showing how promoter-enhancer contacts mediate transcriptional activation. www.cell.com/cell/abstrac...

Really enjoyed this commentary, which creates a super framework for current thoughts and future studies on enhancer function.

It's so exciting how quickly #IDR targeting is moving. So much potential for new therapeutics, by to also for unlocking problems for us in the lab...

Have you ever looked at a gene in IGV or a genome browser and wondered “What are all those (ATAC-seq/H3K27ac/CTCF ChIP-seq/…) peaks doing?” 🤔 I’m thrilled to share that we developed a new technology called Swap-seq to answer that exact question. Swap-seq: www.biorxiv.org/content/10.6...

We got our first orange 🔥 on @addgene.bsky.social 🎉🎉How exciting!! Glad that @katiegelder.bsky.social's herculean cloning efforts are as useful for the community as they have been for us 🧬😅

De novo design of flexible protein interactions with GuideFlip https://www.biorxiv.org/content/10.64898/2026.09.27.754145v1

I'm excited to share our new preprint: Generation of a transgenic cephalopod tinyurl.com/pc86jxz8 Cephalopods (cuttlefish, octopus & squid) are crazy critters that dynamically camouflage to their surroundings by changing the color, pattern, & texture of their skin, which they control w their brain.

FRET-guided integrative modeling resolves Mg2+-dependent RNA tertiary-contact formation https://www.biorxiv.org/content/10.64898/2026.09.17.752353v1

Enhancer Tuning by Sequence-Specific Repressors https://www.biorxiv.org/content/10.64898/2026.09.11.751074v1

One of my favourite meetings! Great science and fantastic community- you should register before it's too late!

Fantastic #postdoc opportunity with @a-radzisheuskaya.bsky.social !

Nice 🧵 describing super study on #eRNA regulation of gene expression- really nice work and highlights the complexity of enhancer activity

Online today @science.org Noncoding transcription controls the developmental dynamics of long-range gene regulation | Science www.science.org/doi/10.1126/...

Permanent academic position as a Lecturer in cryo-ET open at York. We are looking for someone to lead a research program making the most of the stunning advances occurring in cryo-ET. It's a research and teaching post but with a focus on research in the early years. jobs.york.ac.uk/vacancy/lect...

Fantastic to finally see this out. It's already been incredibly useful for us and I'm sure will continue to be in the future!

The Diamond Light Source is one of the UK's most productive scientific faclities. Just signed an open letter urging the STFC to ensure decisions about its future are "transparent, evidence-led, and made in meaningful consultation with its […] user communities." openletter.earth/open-letter-...

Very cool story, and potentially more nice evidence for link between #RNA transcript length and #condensate-depend #transcription regulation from CREs

Super work from @dozenoaks.bsky.social lab to help standardise #smFRET studies between in vitro and in cell models. 📏🔬🎇

We built a free tool to check your bibliography before you submit your manuscript for publication. Along the way, we ran experiments to understand what actually causes AI to hallucinate citations, and which references are most at risk.

A Universal Protein Ladder for Standardization of Diverse FRET Assays - Smith - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...

Ah, what a great resource!

For all you #Neuro people out there, there's still time to sign up for #NeuroBioUK! One of the friendliest and best value meetings happening anywhere. It's a must for anyone interested in the fundamentals of how #neurons work. 🧠

Very interesting new preprint from @jengreitz.bsky.social lab arguing that rather than there being significant enhancer-promoter compatibility, promoters simply differ in their enhancer responsiveness. If promoters are responsive, they respond to all enhancers. www.biorxiv.org/content/10.6...

Really elegant work showing the importance of transient enhancer/promoter contacts. Also highlights why sometimes, building a tightly controlled model system in cells gives us the best way to get a clear answer to a complex question

(1/n) Very excited to share tri-lab collab (Mirny & Zechner) led by Harvey, Henrik & Jack: Q: How do enhancers & promoters interact in space (contact vs. action-at-a-distance) and time (stable vs. transient)? A: Transient E-P contact (~25-42 nm lasting ~10-20 sec): www.biorxiv.org/content/10.6...

Fun to see star grad student Owen Godwin present at today's single molecule SM@SH meeting!! Take homes: if you want to get nice streptavidin grids for enriching RNA on your grids, get your talc from Waitrose! @sheffielduni.bsky.social #cryoEM #eRNA

Here's a really exciting #phd opportunity to work with us on non-coding #RNAs in Bladder Cancer as part of a collaboration with Dr Jon Griffin and @iansudbery.bsky.social -check it out! tinyurl.com/4rp9abxr

Our latest review is out. We take a deep dive into the human mutations in microtubule motors that drive devastating neurodevelopmental and neurodegenerative diseases. Taking in motor protein biophysics, animal models of disease as well as patient phenotypes. onlinelibrary.wiley.com/doi/full/10....

Congrats! This is very cool!

Lots of coffee being drunk and vendor goodies being snapped up ahead of today's @mcb-sheffield.bsky.social research day- excited to hear about all our exciting projects! 🧫🧬🐁🔬

New preprint from our lab! We've been working out how the CMG replicative helicase gets built. 🧵 1/3

Guess what neurobiology fans?!? Registration is open!! More info on the website neurobiouk.sites.sheffield.ac.uk/registration #neurobiology #neurobiouk #neuronalcellbiology #molecularneurobiology #cellularneuroscience #neuroscience

Really enjoyed this review on co-translational folding

Really excited to meet @kellythd-nguyen.bsky.social in @sheffielduni.bsky.social today for the SM&SH #singlemolecules seminar.

Why can't we explain enhancer action despite 2 decades of chromosome conformation technologies? 😬 Our new study spearheaded by Leonid Mirny's group points to a flaw in our assumptions, and to a solution from physical principles By @timothyfoldes.bsky.social 💻& @karissalhansen.bsky.social 🧪 🧵👇

Nice structural work highlighting mechanisms of #RNA binding in the absence of sequence or structural conservation.

Super excited to launch POCAxOMAP with @dschweppe.bsky.social and @oligopain.bsky.social and led by Eli Biletch, Conor Herlihy and Lidan Li. If you’ve ever wanted to do proximity labeling on DNA, RNA, or protein without genetic engineering, look no further. www.biorxiv.org/content/10.6...

#IDRs play critical roles shaping how #CBP and #p300 regulate #transcription and #chromatin. Despite many years of study, new behaviours continue to emerge. In her new Review, grad student Grace Gilbert takes a look at where the field is 👀: tinyurl.com/cbpidrs @biochemsoc.bsky.social

Only few days left to submit an abstract for our second annual QMUL centre for epigenetics meeting in June in London! Deadline 3rd may! Details below

We've thought really hard about using #NMR to look at #RNA dynamics at our RNA-binding interfaces but always figured it was too hard for our system. Really exciting to see the possibility moving a step closer! Super work, congratulations!! #RBPs #IDRs #RNAstructure

Distribution and p300/CBP dependency of cis-regulatory elements are encoded by unique combinations of histone lactylation and acetylation https://www.biorxiv.org/content/10.64898/2026.04.14.718598v1

Run an MD simulation of any protein in the AlphaFold Protein Structure Database using AF-CALVADOS Thanks to @sobuelow.bsky.social AF-CALVADOS is now on Colab colab.research.google.com/github/KULL-...