David B. Sauer

Wonderful 2026 group picnic with the amazing membrane protein scientists at the @cmd.ox.ac.uk!

The new PNAS Early-Career Researcher Portal includes resources to help emerging researchers better understand publishing, peer review, submission requirements, and opportunities to engage with PNAS and PNAS Nexus. Explore the portal: https://ow.ly/NwqU5100mHR

We're delighted to announce our new website is live today. We're holding an online open day on 18th November from 14:00-16:30. To find out more about the ILESLA programme, and to register for the event, please visit www.ilesla.ox.ac.uk/home

The joy isn’t in knowing — it’s in figuring out.

Well deserved 🏅 congratulations

Researchers @oxfordchemistry.bsky.social and @kavlioxford.bsky.social how that phospholipid transfer proteins are not redundant: each prefers different acyl chains, while tissue-specific expression and phosphorylation help fine-tune membrane composition

Treat biological databases as infrastructure, not projects www.nature.com/articles/d41...

Try for your protein at py2dmol.solab.org (Style → Cartoon)

UT Southwestern Medical Center is hiring: Instructor – Structural Biology – Rosenbaum Lab #structuralbiology #biochemistry

Learn the foundations of Python and discover how coding can unlock new approaches to biochemical data analysis and research, launching on 5 October 2026! https://ow.ly/t0KG50ZypQA 🧪

Happy to see our NHE6 story published today in @natcomms.nature.com! Led by @lukasfeilen.bsky.social we reveal the #cryoEM structure, ion selectivity and regulation of the endosomal Na+/H+ exchanger NHE6, providing a framework for understanding Christianson syndrome. www.nature.com/articles/s41...

1/ The toolkit behind the discovery is out. In @natcomms.nature.com, we report the selective NUDT5 degrader toolkit that helped uncover NUDT5’s hidden biology - and show antagonistic roles for NUDT5 and NUDT15 in 6-TG response. doi.org/10.1038/s414...

Curious about how drugs are designed? Check out this seminar for non-scientists by Chris Tate, Group Leader in the LMB’s Structural Studies Division. He covers how drugs work and how researchers are working to design drugs better, faster and with fewer side effects. youtu.be/fOzwbmiKNKI

@wheelerlab.org is talking about his effort to build a resource for protein dynamics (PDB for MD). MDRepo is a repository to store simulation data. This is really needed to push the needle in design, function and more. Please help make it successful by sharing your MD data. #ismb2026 🌐 mdrepo.org

A water molecule is crucial to maintaining the structure and transport activity of VcINDY! academic.oup.com/pnasnexus/ad... Fantastic collaboration by the groups of @danengw.bsky.social (NYUSoM) and @chrismulligan.bsky.social (Univ. of Kent)

Thank you to @wehi-research.bsky.social for squeezing me in for a quick visit! Fascinating chats about targeting membrane proteins and structural biology for drug development!

Thank you @rosemaryjcater.bsky.social for a fantastic visit to UQ’s Institute for Molecular Bioscience!! Wonderful day chatting about the spectacular science in Brisbane, and squeezing in some time to visit the local fauna.

Kicking Arsenic to the Curb: a paper from the labs of Douglas Reese & Bill Clemons of @caltech.edu that describe cryo-EM structure of a bacterial metalloid pump & the mechanisms that could offer more insight into ridding environments of toxic metalloids. Read more here: buff.ly/dnyw7U1 #SBGrid

Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria. The deadline is 31st July. Informal enquires are welcome. Please share!

Take a look at the fantastic lineup of speakers we have assembled for the 2026 Kuo Symposium in Beijing! The workshop is already FULL, but symposium registration is still open, and early-bird rates are still available. See you in Beijing! www.bsc.org.cn/KuoSymposium...

Little one is obsessed with "Random Walks in Biology" (deceptively small as most biophysicists know) We should start with something easier, like partial differential equations?!

Structural basis of substrate recognition and allosteric inhibition in human B0AT2 www.biorxiv.org/content/10.64898/2026.06.16.732524v1 #cryoEM

How did animal senses evolve? Max Coyle et al. used choanoflagellates to uncover TRPW, ancient ion channels predating animal somatosensory receptors. TRPW links microbial prey ecology to evolution of receptor structure, sensory organelles, & multicellular processing. www.biorxiv.org/content/10.6...

Ready to start coding? Practical Python for Beginners begins 5 Oct 2026 and will help biochemists develop core Python skills for analysing and visualising complex biochemical data. https://ow.ly/FwKT50ZbyAM

🔬 We’ll be at the 6th NY Area #CryoEM Meeting on May 27, presenting recent developments in #CryoSPARC for Homogeneous Ab Initio Refinement and workflows for small proteins. bit.ly/4dYMUze We’re also proud to support the meeting as a sponsor — stop by our poster to learn more!

The OpenBind consortium’s first release of experimental data marks a milestone in efforts to improve how artificial intelligence (AI) is used in drug discovery. Find out more ⬇️ https://www.ox.ac.uk/news/2026-05-12-openbind-releases-first-open-dataset-and-ai-model-for-drug-discovery

Proton-coupled alternating access in a versatile Spns drug efflux pump from Mycobacterium smegmatis https://www.biorxiv.org/content/10.64898/2026.05.09.724020v1

It's great to see this important paper by Alexander Shtyrov out. If you hadn't read it yet on @biorxivpreprint.bsky.social, you can now do so in @pnas.org. 😀

Structural basis for the transport mechanism and cholesterol modulation of the human proline transporter pubmed.ncbi.nlm.nih.gov/42091899/ #cryoEM

New publication for SLC13A5 targeting compounds! Discovery of the BI chemical probe is out now in J. Med. Chem. Great work by Andrew Quigley, Liz Carpenter, and colleagues from Oxford's @cmd.ox.ac.uk, @boehringerglobal.bsky.social, and @thesgc.bsky.social pubs.acs.org/doi/10.1021/...

In another case of transporters doing more than you expect: SPNS2 is a glucose importer, in addition to its S1P export activity! Wonderful collaboration with Sarah Spiegel and colleagues at VCU School of Medicine, and the team at @cmd.ox.ac.uk www.nature.com/articles/s41...

Save the date: NYC-ISB26 Integrative Structural Biology symposium - Oct 8-9, 2026 Registration coming soon. Integrative structural biology is a powerful approach toward understanding biological macromolecular systems by bridging structural biology and biophysical methods. nysbc.org/nyc-isb26/

Starting 27 April 2026, our online Introduction to Statistics for the Life Sciences course helps you build confidence in data analysis and strengthen your research skills. Enrol today and study at your own pace: ow.ly/xuxT50YAvtN

Starting 27 April 2026, our online Introduction to Statistics for the Life Sciences course helps you build confidence in data analysis and strengthen your research skills. Enrol today and study at your own pace: https://ow.ly/xuxT50YAvtN

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join and pursue unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-spr...

Are you excited by virology? Would you like to do a PhD? Three fantastic opportunities are available to do joint PhDs between @cvrinfo.bsky.social and @pirbrightinst.bsky.social Details in the thread below - please share! Deadline 8th May 2026, fully funded for UK Home students (1/4)

Register for the April 30 CodeBMB Webinar for - Scientists in the biosciences starting to code - Post-docs and graduate students who want to bring coding into their learning - Instructors involved in Biochemistry and Molecular Biology Education

I’m recruiting! I'm excited to share a new 4-year fully funded Leverhulme Trust PhD studentship to define the rules governing membrane protein folding. www.findaphd.com/phds/project... Advert closes 1st June for a 1st October start. Please reach out for more info! PDRA ad (4 years) to follow!

Step-by-step protocol to make stable cell lines for large-scale expression of muscle-type nAChR (and other multi-subunit targets)! By the inexhaustible and tenacious @annaliiiiiiii.bsky.social in collab with Dong group in #MRCWIMM and @cmd.ox.ac.uk www.cell.com/star-protoco...

Limited places remaining! Join the 7th UK Workshop on Membrane Proteins for lectures, workshops & hands-on lab training in purification and biophysical techniques. Secure your place now! Register here: https://ow.ly/zkVT50YrcNC

Come work with Ben Berks FRS in Oxford 2 x PDRA posts: Molecular Analysis of Bacterial Outer Membrane Protein Biogenesis 2 complementary projects investigating bacterial outer membrane protein biogenesis. Building on our recent work (Nature (2015) 647: 479-487) my.corehr.com/pls/uoxrecru...