David Enard

This looks very interesting to clean up alignments: academic.oup.com/mbe/article/...

Our paper on detecting (or not) balancing selection is now out, in all its typeset beauty, in the October issue of @molbioevol.bsky.social: academic.oup.com/mbe/article/...

📣Our department is hiring a new group leader!📣 Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question. Apply by December 18th: jpi-recruitment-curie-umr3215-u934.curie.fr

🧬🔬 Why are enhancers transcribed and how does that impact gene regulation? I’m really excited to share our new paper in @science.org showing that noncoding RNAs control the timing of gene activation in embryos. With Mike Levine #ScienceResearch @columbiamed.bsky.social A few highlights below... 🧵👇

Where did bats come from?🦇🌍 After decades of debate, the biggest bat genome + fossil study ever done has an answer - and it’s not where anyone expected! 🤩OUR PHASE 1 FLAGSHIP is out today in nature! doi.org/10.1038/s415... A thread 🧵

I am hiring a postdoc! Are you interested to work on population genetics/ drug resistance/ data? Want to work in Montpellier, France? Fastq files don't scare you? PhD required, start date hopefully Nov 1! (end date Sep 30 2028) Please share! abetterscientist.wordpress.com/2026/09/29/p...

We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...

Does someone know what game Paraguay was playing yesterday? Asking because it was not soccer. Clearly the referee was also confused. Sad to see teams who forgot that it is also about entertaining the public with beautiful technical fits.

Some deep work by my former student Matthew Aguirre on what the properties of cis- and trans eQTLs can teach us about the structure of gene regulatory networks!

Deeply interesting comment on a paper on compensatory evolution following "host" adaptation to a selfish genetic element. Reminescent of our finding of compensatory protein stability evolution after ancient viral epidemics. #evolution www.nature.com/articles/s41...

It is unfortunate that this has to be reminded so much to reviewers at all steps: doing this things right or at least as well as possible IS in itself a strong innovation.

You know you have great collaborators when they bring your own enthusiasm back at times when it has been vacillating. You know who you are :).

A bad case of using a non official gene/protein name that makes it even worse by introducing ambiguity with another gene name. This makes curation efforts far more difficult: pmc.ncbi.nlm.nih.gov/articles/PMC...

I have now heard repeatedly from non-US PIs they stopped to go to American confs because the PIs there being socially exclusive and not including much anyone else in social interactions. I have also seen it, I find it disconcerting to this day.

@pratikkatte.bsky.social and I just released Lorax 🌲, a tool for interactive exploration of biobank-scale ancestral recombination graphs (ARGs). If you’ve ever wanted to scroll across the ancestries of thousands of genomes… this is for you.

Recently we're working with SNPs from whole genome assemblies to estimate ARGs. It's a pain to go from alignment files to vcf, keeping track of masked and invariant sites. So we wrote a snakemake/SLURM pipeline. Hope it's useful to others, and don't hesitate to post issues if there are problems!

The Goldberg lab at UCLA is hiring one or more postdocs. Flexible start date. We develop methods to study population genetics of humans, our primate relatives, and our pathogens. www.goldberglab.org/join

Have you ever wondered how many archaic populations contributed DNA to modern humans? We know about Neanderthals and Denisovans, but the fossil and genetic evidence suggests a much more complex history! www.biorxiv.org/content/10.6...

Excited to share our new preprint! 🍇🧬 We analyzed 639 genomes across 48 grape species to understand how hybridization drives adaptation. • ~14% of average Vitis genome is introgressed • Most parallel adaptations are shared via gene flow • Two "hybrid species" are actually hybrid swarms

For those interested, a new version (v3.1.0) of poolfstat is now on CRAN, including new functions and updates, new stats (Fh, Fd, FdM) implemented in sliding.windows.fstat; and a revised vignette. [https://cran.r-project.org/web/packages/poolfstat/index.html](cran.r-project.org/web/packages...)

To add one thing: if you have the data to run both classic dN/dS tests and MK tests, choose the latter. dN/dS tests are blind to positive selection in the important, constrained proteome, while MK test will work regardless of constraint, if DFE well estimated. #evolution #adaptation #popgen

Always a great feeling when the new labs in the EEB Department @uofa-eeb.bsky.social each attract multiple fantastic new grad students. Very happy to see younger colleagues succeed.

Great news for anyone using ARGs in non-model species: www.biorxiv.org/content/10.1...

Happy to share our last study on how age, biological sex and genetics affect not only the extent of antibody responses against viruses but also the specific viral epitopes recognised. Thanks to Axel Olin @EtiennePatin @LabExMI @institutpasteur @cdf1530 @CNRS www.nature.com/articles/s41...

I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.

Are you interested in human DNA from ancient sediments? Do you want to do a PhD in Vienna? We have two open positions in our group! You can learn more and apply here (scroll down to the very bottom, ours are the last two listings): careers.univie.ac.at/en/praedoc/s...

Counting publications is such a poor proxy for scientific productivity. Counting discoveries, with a bonus for discoveries that were not anticipated, and important insights is a much better proxy. I am wondering if there are standardized, systematic ways of quantifying this.

That looks great! To avoid errors due to starting with spotty gene annotations (gene loss vs. not annotated), I would suggest re-annotating every genome used with TOGA2 from the Hiller lab: github.com/hillerlab/TO... Many annotations out there are not optimal and TOGA2 has great power and accuracy.

Calling all OrthoFinder users! We’ve just released GLADE, a tool to infer gene gains, losses, duplications, and ancestral genomes across a phylogeny. GLADE runs directly on OrthoFinder results. www.biorxiv.org/content/10.6... github.com/lauriebelch/... (1/10)

📣 *Abstract submission by January 31st* "Host adaptations to viral infections” International Meeting May 10th-13th 2026 @cnrs.fr Station Biologique Roscoff, Brittany, France Register & Join us +amazing international speakers! #CNRS @cnrsbiologie.bsky.social #IRP www.insb.cnrs.fr/fr/evenement...

PEQG! My favorite conference ever*. Single session, fantastic talks, great discussions. Only once every 2 years. And in the best conference location too! Abstract deadline coming up Feb 5! *Disclosure: I am required to say it's the best conference because it is and I told my mom I wouldn't lie.

This is shaping up to be a great workshop. There is still time to register before the deadline! Please RT! #evolution #viruses #pathogens

I forgot using tags again: #evolution #genomics #machinelearning #CNNs