Russ Corbett-Detig

Russ Corbett-Detig

@russcd.bsky.social

I like my data small. corbett.ucsc.edu

319 followers177 following35 posts

Russ Corbett-Detig reposted

Job opportunity at Columbia U., in "any combination of field, experimental, computational, or theoretical approaches to study fundamental questions in evolutionary biology".

Andres Bendesky@bendeskylab.com

We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016

Russ Corbett-Detig reposted

We have a (dry lab) Postdoc Position in Viral Genomics & Pathogen Surveillance here in wonderful and sunny San Diego 🏄‍♂️☀️! We're looking to continue to build our AI and broader infectious disease surveillance efforts, with a focus on our outbreak.info platform. Read more: andersen-lab.com/about/

andersen-lab.comAbout | Andersen LabLearn more about the Andersen Lab, as well as jobs and career opportunities.

Russ Corbett-Detig reposted

Excited to be presenting my poster on Lorax at #PEQG26! Lorax is a GPU-accelerated, web-native tool for real-time interactive visualization of Ancestral Recombination Graphs. If you're at Asilomar this week, come check it out. Would love to chat about scalable ARG exploration and get your feedback

lorax.ucsc.eduLorax
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eDNA is possibly the coolest application! Below: read-level placement across a pan-vertebrate mitochondrial pangenome (left) where a clear cluster of read assignments supports the presence of many mammoth reads (right). Processing ~9 billion reads took just 8 minutes!

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Because we score placements dynamically during a single tree traversal, it is very fast. Panmap takes less than one second to place a SARS-CoV-2 sample onto a 20,000 sample phylogeny, align the read, and call genotypes.

Panmap can also evaluate sample mixtures (e.g., what you get from wastewater or eDNA), by scoring the reads separately against every node and then estimating the abundances of lineages via EM.

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There is a ton of cool stuff you can do using the index. In the first application, Panmap place a single sample onto the tree *without assembly* using the raw reads and then can align and genotype based on this closest known relative.

The central innovation of Panmap is indexing PanMANs by producing a “syncmer annotated tree”, where seed edits are stored only where sequences on the phylogeny change (including inferred ancestors). The index therefore exploits a type of “phylogenetic compression” and is very compact.

Russ Corbett-Detig reposted

Open question for anyone that develops/maintains of bioinformatics tools, especially those used for public health - what do you think is the right way to fund this long term? Grants are great for new research directions, but aren't really appropriate for most tool dev/maintenance.

I’m already getting community feedback on the core-pivotal index. I truly appreciate it. But in the spirit of core-pivoteering, I will only implement suggestions from whoever has the highest core-pivotal index.

Molecular Biology and Evolution@molbioevol.bsky.social

@russcd.bsky.social ushers in a new era of academic metrics with the core-pivotal author index, which assigns all credit to authors that occupy the exact center of the author list, while non-central peripheral authors receive no credit whatsoever. 🔗 doi.org/10.1093/molbev/msag026 #evobio #molbio

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Why this matters: As biobanks + population sequencing projects scale into the hundreds of thousands (and millions), the bottleneck isn’t just inference. It’s exploration. Feedback welcome 🌲

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Under the hood, Lorax runs on the incredibly powerful data model + API from tskit, developed by Jerome Kelleher and collaborators. Tree sequences make it possible to store and traverse genome-wide genealogies efficiently, and Lorax uses that structure directly in the backend.

On the visuals inspiration side: a huge thanks to @theo.io and Taxonium. Taxonium showed the community that we can interactively explore enormous phylogenetic trees in the browser at pandemic scale. Lorax brings a similar philosophy to ARGs.

What does Lorax do? It lets you dynamically explore tree sequences at massive scales - zooming through local trees, inspecting mutations, querying ancestry. Built for *huge* datasets with up to millions of samples.

Russ Corbett-Detig reposted

We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza. Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.

Russ Corbett-Detig reposted

Russ Corbett-Detig reposted

Russ Corbett-Detig reposted

Genetti & @russcd.bsky.social investigated Puerto Rico honeybees, suggesting that local pressures on bee behavior may have induced changes in alleles linked to different ancestries at loci involved in neuronal development, behavior, and mating. 🔗 doi.org/10.1093/gbe/evaf217 #genome #evolution

doi.orgSignals of Ancestry-Specific Selection in Gentle Africanized Honey BeesAbstract. Understanding the genetic basis of adaptive responses to environmental and human mediated pressures is a central concern in evolutionary biology.

I am 100% stoked to lead this effort again this year! Come on out to beautiful Santa Cruz and show off your awesome-est science.

UC Santa Cruz Genomics Institute@ucscgenomics.bsky.social

POSTDOCS: We're hosting our fourth-annual Next Wave of Faculty in Genomics symposium in beautiful Santa Cruz, CA, to showcase rising talent in genomics research. Travel expenses are covered for selected applicants ✈️😎🏖 APPLY BY JAN 15: genomics.wordpress.ucsc.edu/calendar_eve...

Russ Corbett-Detig reposted

Super glad to see this out ! Lovely collaboration with @russcd.bsky.social @crouxevo.bsky.social and the groups of @meauxjuliette.bsky.social @plantadaptation.bsky.social

Evolution Letters@evolletters.bsky.social

Diverging Arabidopsis populations quickly accumulate pollen-acting genetic incompatibilities doi.org/10.1093/evle... Now in @evolletters.bsky.social by Christopher Condon et al.

Hey! That's me! Check out my latest where I develop a method for pinpointing where mutation spectra change along phylogenies. Striking, nodes with large changes are significantly enriched for protein changes in the RdRp (catalytic domain of the polymerase) suggesting a causal role.

Molecular Biology and Evolution@molbioevol.bsky.social

Using ~8M SARS-CoV-2 genomes, a new phylogenetic algorithm by @russcd.bsky.social detects 10 shifts in mutation patterns, some of them linked to changes in viral polymerase. This provides new perspectives on the evolution of mutational processes. 🔗 doi.org/10.1093/molb... #molbio #evobio #covid

Would you consider applications from a slightly more senior postdoc? ... Asking for a friend, of course. :)

Daniel Croll@danielcroll.bsky.social

Excited to do a postdoc in beautiful Neuchatel / Switzerland🇨🇭? We have several postdoc positions open at the moment! Check our website for the full ads here: pathogen-genomics.org/jobs Happy to answer any question and please spread the word to anyone who might be interested!

Russ Corbett-Detig reposted

So glad this is finally out. The method has been instrumental in allowing us to compress the AllTheBacteria data - ~2 million bacterial genomes shrink from 3Terabytes (gzipped) to 100Gb using phylogenetic compression. Great work by @brinda.eu

Michael Baym@baym.lol

Our latest paper, in which @brinda.eu (along with @zaminiqbal.bsky.social and others) introduces phylogenetic compression for storage and search of enormous microbial genome libraries, was published today in @naturemethods.bsky.social: rdcu.be/eg4OA 1/

This is absolutely fascinating! Impressive analysis (3.2M TEs in 1.9K samples) and super interesting examples of locally adaptive TE insertions. Congrats to @tobybarilbio.bsky.social and all the authors.

Toby Baril@tobybarilbio.bsky.social

Excited to share our latest preprint 🥳 Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen @danielcroll.bsky.social #TESky www.biorxiv.org/content/10.1...

Russ Corbett-Detig reposted

Delighted to organize the Next-Wave Symposium again this year! If you are an awesome postdoc in genomics---very broadly defined---come tell us about your amazing science!

UC Santa Cruz Genomics Institute@ucscgenomics.bsky.social

Calling all postdocs! We're hosting a symposium in beautiful Santa Cruz, CA, to showcase rising talent in genomics research. Travel expenses are covered for selected applicants ✈️😎🏖 The event will be held on April 15. Applications due Feb 15: bit.ly/NextWave25

Russ Corbett-Detig reposted

There's a lot of uncertainty about the future right now. I'd like to do something constructive: if you teach students in #publichealth, #microbiology, #genomics, #bioinformatics, I'd be happy to talk about CDC AMD, #fellowships, gov sci and career paths. #microsky #blackinmicro 🧬🖥️ www.cdc.gov/amd

cdc.govAdvanced Molecular Detection (AMD)CDC’s Advanced Molecular Detection program leads national efforts to develop and expand the use of

Russ Corbett-Detig reposted

Excited to dig into this - very cool work from @russcd.bsky.social‘s lab! 🙌 #TEworldwide #TEsky

Are you a postdoc doing awesome research in genomics?! Apply to present at the NextWave of Faculty in Genomics symposium! Also, please repost!

UC Santa Cruz Genomics Institute@ucscgenomics.bsky.social

DEADLINE APPROACHING! We're hosting a postdoc symposium in beautiful beachside Santa Cruz, CA, to showcase rising talent in genomics research. Travel expenses are covered for selected applicants. The event will be held on March 12. Applications due Jan 12: genomics.ucsc.edu/calendar_eve...

Russ Corbett-Detig reposted

I'm pleased to share our new article in MBE! We dug deep into the molecular details of the classic Ruff inversion that mediates different plumage and mating display phenotypes. w/ Jason Hill and Huijan Bi and others with Leif Andersson

Russ Corbett-Detig reposted

Registration for BAPG at Stanford Dec. 2, 2023 is now open. The registration is free but required: docs.google.com/forms/d/14ne...

Dmitri Petrov@petrovadmitri.bsky.social

Save the date: The Fall 2023 #BAPG (Bay Area Population Genomics Conference) will be hosted by the Petrov lab at Stanford on Dec 2, 2023. The details are to follow! As always registration is free and most speaking slots are reserved for graduate students and postdoctoral fellows.

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