Job opportunity at Columbia U., in "any combination of field, experimental, computational, or theoretical approaches to study fundamental questions in evolutionary biology".
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department.
Application deadline is October 15.
Come be our colleague.
Please RT!
apply.interfolio.com/193016
We have a (dry lab) Postdoc Position in Viral Genomics & Pathogen Surveillance here in wonderful and sunny San Diego 🏄♂️☀️!
We're looking to continue to build our AI and broader infectious disease surveillance efforts, with a focus on our outbreak.info platform.
Read more: andersen-lab.com/about/
Excited to be presenting my poster on Lorax at #PEQG26!
Lorax is a GPU-accelerated, web-native tool for real-time interactive visualization of Ancestral Recombination Graphs.
If you're at Asilomar this week, come check it out. Would love to chat about scalable ARG exploration and get your feedback
Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes.
www.biorxiv.org/content/10.6...
eDNA is possibly the coolest application! Below: read-level placement across a pan-vertebrate mitochondrial pangenome (left) where a clear cluster of read assignments supports the presence of many mammoth reads (right). Processing ~9 billion reads took just 8 minutes!
Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes.
www.biorxiv.org/content/10.6...
Because we score placements dynamically during a single tree traversal, it is very fast. Panmap takes less than one second to place a SARS-CoV-2 sample onto a 20,000 sample phylogeny, align the read, and call genotypes.
Panmap can also evaluate sample mixtures (e.g., what you get from wastewater or eDNA), by scoring the reads separately against every node and then estimating the abundances of lineages via EM.
Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes.
www.biorxiv.org/content/10.6...
There is a ton of cool stuff you can do using the index. In the first application, Panmap place a single sample onto the tree *without assembly* using the raw reads and then can align and genotype based on this closest known relative.
Alex Kramer, Alan Zhang and friends posted our preprint today. In it, we introduce Panmap, a tool for phylogenetic placement, assembly, lineage abundance estimation, and eDNA assignment using phylogenetic pangenomes.
www.biorxiv.org/content/10.6...
This is the result of our incredibly rewarding collaboration with Yatish Turakhia and members of his lab. In particular, and foundational to our work, we previously developed the underlying phylogenetic Pangenome data structure, PanMAN.
www.nature.com/articles/s41...
The central innovation of Panmap is indexing PanMANs by producing a “syncmer annotated tree”, where seed edits are stored only where sequences on the phylogeny change (including inferred ancestors). The index therefore exploits a type of “phylogenetic compression” and is very compact.
Open question for anyone that develops/maintains of bioinformatics tools, especially those used for public health - what do you think is the right way to fund this long term?
Grants are great for new research directions, but aren't really appropriate for most tool dev/maintenance.
I’m already getting community feedback on the core-pivotal index. I truly appreciate it. But in the spirit of core-pivoteering, I will only implement suggestions from whoever has the highest core-pivotal index.
@russcd.bsky.social ushers in a new era of academic metrics with the core-pivotal author index, which assigns all credit to authors that occupy the exact center of the author list, while non-central peripheral authors receive no credit whatsoever.
🔗 doi.org/10.1093/molbev/msag026#evobio#molbio
@pratikkatte.bsky.social and I just released Lorax 🌲, a tool for interactive exploration of biobank-scale ancestral recombination graphs (ARGs).
If you’ve ever wanted to scroll across the ancestries of thousands of genomes… this is for you.
Why this matters:
As biobanks + population sequencing projects scale into the hundreds of thousands (and millions), the bottleneck isn’t just inference. It’s exploration.
Feedback welcome 🌲
@pratikkatte.bsky.social and I just released Lorax 🌲, a tool for interactive exploration of biobank-scale ancestral recombination graphs (ARGs).
If you’ve ever wanted to scroll across the ancestries of thousands of genomes… this is for you.
Under the hood, Lorax runs on the incredibly powerful data model + API from tskit, developed by Jerome Kelleher and collaborators.
Tree sequences make it possible to store and traverse genome-wide genealogies efficiently, and Lorax uses that structure directly in the backend.
On the visuals inspiration side: a huge thanks to @theo.io and Taxonium.
Taxonium showed the community that we can interactively explore enormous phylogenetic trees in the browser at pandemic scale.
Lorax brings a similar philosophy to ARGs.
@pratikkatte.bsky.social and I just released Lorax 🌲, a tool for interactive exploration of biobank-scale ancestral recombination graphs (ARGs).
If you’ve ever wanted to scroll across the ancestries of thousands of genomes… this is for you.
What does Lorax do?
It lets you dynamically explore tree sequences at massive scales - zooming through local trees, inspecting mutations, querying ancestry.
Built for *huge* datasets with up to millions of samples.
We have posted data providing real-time measurement of human neutralizing antibody landscape to seasonal influenza.
Data explain spread of subclades K (H3N2) & D.3.1.1 (H1N1), identify subclade K subvariants w reduced neutralization, & can inform choice of strains for next vaccine.
A long time ago in a galaxy far away, there was a SARS-CoV-2 pandemic. Our paper, led by @martibartfast.bsky.social
a) correcting errors in 4.5 million genomes & their phylogeny
b) improving representation of the Global South in public data
www.nature.com/articles/s41...
(thread 1/n)
Genetti & @russcd.bsky.social investigated Puerto Rico honeybees, suggesting that local pressures on bee behavior may have induced changes in alleles linked to different ancestries at loci involved in neuronal development, behavior, and mating.
🔗 doi.org/10.1093/gbe/evaf217#genome#evolution
POSTDOCS: We're hosting our fourth-annual Next Wave of Faculty in Genomics symposium in beautiful Santa Cruz, CA, to showcase rising talent in genomics research. Travel expenses are covered for selected applicants ✈️😎🏖
APPLY BY JAN 15: genomics.wordpress.ucsc.edu/calendar_eve...
Our lab has an opening for a research technician to contribute to our efforts to understand RSV evolution & its impact on antibody countermeasures (see journals.asm.org/doi/full/10....). The tech will also help w lab management.
If interested, apply here: careers-fhcrc.icims.com/jobs/29940/job
Diverging Arabidopsis populations quickly accumulate pollen-acting genetic incompatibilities
doi.org/10.1093/evle...
Now in @evolletters.bsky.social by Christopher Condon et al.
Hey! That's me! Check out my latest where I develop a method for pinpointing where mutation spectra change along phylogenies. Striking, nodes with large changes are significantly enriched for protein changes in the RdRp (catalytic domain of the polymerase) suggesting a causal role.
Using ~8M SARS-CoV-2 genomes, a new phylogenetic algorithm by @russcd.bsky.social detects 10 shifts in mutation patterns, some of them linked to changes in viral polymerase. This provides new perspectives on the evolution of mutational processes.
🔗 doi.org/10.1093/molb...#molbio#evobio#covid
More generally, my approach is a part of a "functional surveillance" paradigm where we infer changes in the functional properties of pathogens using genome sequence data.
Excited to do a postdoc in beautiful Neuchatel / Switzerland🇨🇭?
We have several postdoc positions open at the moment!
Check our website for the full ads here: pathogen-genomics.org/jobs
Happy to answer any question and please spread the word to anyone who might be interested!
So glad this is finally out. The method has been instrumental in allowing us to compress the AllTheBacteria data - ~2 million bacterial genomes shrink from 3Terabytes (gzipped) to 100Gb using phylogenetic compression. Great work by @brinda.eu
Our latest paper, in which @brinda.eu (along with @zaminiqbal.bsky.social and others) introduces phylogenetic compression for storage and search of enormous microbial genome libraries, was published today in @naturemethods.bsky.social:
rdcu.be/eg4OA
1/
This is absolutely fascinating! Impressive analysis (3.2M TEs in 1.9K samples) and super interesting examples of locally adaptive TE insertions. Congrats to @tobybarilbio.bsky.social and all the authors.
Excited to share our latest preprint 🥳
Historic transposon mobilisation waves create distinct pools of adaptive variants in a major crop pathogen
@danielcroll.bsky.social#TESkywww.biorxiv.org/content/10.1...
Building on the UShER tree of millions of SARS-CoV-2 genomes maintained by Angie Hinrichs, Hugh Haddox and Georg Angehrn (and others in @matsen.bsky.social lab and @jbloomlab.bsky.social) have looked into how the neutral mutation rate varies along the genome:
[1/N]
www.biorxiv.org/content/10.1...
Delighted to organize the Next-Wave Symposium again this year! If you are an awesome postdoc in genomics---very broadly defined---come tell us about your amazing science!
Calling all postdocs! We're hosting a symposium in beautiful Santa Cruz, CA, to showcase rising talent in genomics research. Travel expenses are covered for selected applicants ✈️😎🏖 The event will be held on April 15. Applications due Feb 15: bit.ly/NextWave25
There's a lot of uncertainty about the future right now.
I'd like to do something constructive: if you teach students in #publichealth, #microbiology, #genomics, #bioinformatics, I'd be happy to talk about CDC AMD, #fellowships, gov sci and career paths. #microsky#blackinmicro 🧬🖥️
www.cdc.gov/amd
Got milk virus genomes? (or any H5N1?) Throw them at usher.bio and see where they land in per-segment trees of tens of thousands of public Influenza A H5N1 sequences!
Horizontal transmission of functionally diverse transposons is a major source of new introns https://www.biorxiv.org/content/10.1101/2024.06.04.597373v1
So glad our paper on lethal hybrid incompatibilities is out at Nature today: rdcu.be/dvFcM ! @ben-moran.bsky.social moved mountains for this project: we identified two new incompatibilities in swordtail hybrids , characterize mechanisms of lethality, and their evolutionary history.
The Ecology & Evolution department at UC Santa Barbara is searching for an Assistant Professor of Evolutionary Biology. Please apply and/or spread the word! recruit.ap.ucsb.edu/JPF02635
DEADLINE APPROACHING! We're hosting a postdoc symposium in beautiful beachside Santa Cruz, CA, to showcase rising talent in genomics research. Travel expenses are covered for selected applicants. The event will be held on March 12. Applications due Jan 12: genomics.ucsc.edu/calendar_eve...
UShER has been an amazing project, but we never really documented exactly how we maintain the 16M sample SARS-CoV-2 tree 😬... In a paper the came out over the break, we go back through our server logs to retrospectively walk through the major choices we made. Check it out here: rdcu.be/du5q5
I'm pleased to share our new article in MBE! We dug deep into the molecular details of the classic Ruff inversion that mediates different plumage and mating display phenotypes. w/ Jason Hill and Huijan Bi and others with Leif Andersson
Save the date: The Fall 2023 #BAPG (Bay Area Population Genomics Conference) will be hosted by the Petrov lab at Stanford on Dec 2, 2023. The details are to follow! As always registration is free and most speaking slots are reserved for graduate students and postdoctoral fellows.