dfachinetti.bsky.social

dfachinetti.bsky.social

@dfachinetti.bsky.social

817 followers321 following61 posts

dfachinetti.bsky.social
@dfachinetti.bsky.social

Still some time to register to this great meeting! Great science and great location for a very affordable registration cost!

dfachinetti.bsky.social@dfachinetti.bsky.social

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

fbs.osaka-u.ac.jpInternational Symposium on Chromosome Dynamics from Structure to Cellular Function
dfachinetti.bsky.social
@dfachinetti.bsky.social

Registrations are now open!!

dfachinetti.bsky.social@dfachinetti.bsky.social

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

fbs.osaka-u.ac.jpInternational Symposium on Chromosome Dynamics from Structure to Cellular Function
dfachinetti.bsky.social
@dfachinetti.bsky.social

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47

minilien.curie.frEpigenetics - 21st Course on Epigenetics 2026: Towards a quantitative understanding of nuclear dynamics during development and diseases | Institut Curie Advanced TrainingThe aim of this course is to provide an overview of epigenetic mechanisms and their links to gene expression and chromatin dynamics, in different systems. The diverse functions of the nucleus involvin...
dfachinetti.bsky.social
@dfachinetti.bsky.social

Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!

curie.frNouvelle moisson d’ERC Synergy Grants pour l’Institut Curie - Institut CurieRetrouvez Nouvelle moisson d’ERC Synergy Grants pour l’Institut Curie. L'Institut Curie est le 1er centre de recherche et de lutte contre le cancer en France.
European Research Council (ERC)@erc.europa.eu

The newly announced ERC Synergy Grant includes research on: ✴️ genetic drug design ✴️ the Big Bang's first microseconds ✴️ crowd movement ✴️ nature-society interactions 👉 buff.ly/ZQhLp4h Congrats to the 66 awarded research teams! #FrontierResearch

buff.lybuff.ly
dfachinetti.bsky.social
@dfachinetti.bsky.social

My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression. info and application here institut-curie.org/job/study-en....

institut-curie.orgStudy Engineer (F/M) - Institut CurieThe Curie Institute Research CenterThe Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a str...
dfachinetti.bsky.social
@dfachinetti.bsky.social

Thanks to @erhardtlab.bsky.social for the news and views on our paper on DNA methylation&centromere www.nature.com/articles/s41....

nature.comDipping into the function of DNA methylation at centromeres - Nature GeneticsHuman centromeres contain a small chromatin region with low levels of DNA cytosine methylation that resides with CENP-A. Salinas-Luypaert et al. find a role of DNA methylation in maintaining the size and function of centromeres by controlling the binding affinity of key centromere components.

dfachinetti.bsky.social reposted

Nature Genetics
@natgenet.nature.com

📢ONLINE @natgenet.nature.com 📰DNA methylation influences human centromere positioning and function. By Catalina Salinas-Luypaert, @dfachinetti.bsky.social, @naltemose.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...

nature.comDNA methylation influences human centromere positioning and function - Nature GeneticsGenome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.

dfachinetti.bsky.social reposted

Institut Curie
@institutcurie.bsky.social

Replying to @institutcurie.bsky.social

▶️ Pour en savoir plus ⏩ Lire l'actu : curie.fr/actualite/di... ⏩ Lire la publication : www.nature.com/articles/s41...

nature.comDNA methylation influences human centromere positioning and function - Nature GeneticsGenome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
dfachinetti.bsky.social
@dfachinetti.bsky.social

#4 We show that loss of DNAme leads to disruption of the centromere’s bipartite structure and also controls the presence of another centromere-associated protein, CENP-B. Excessive CENP-B makes centromeric DNA more fragile and prone to breakage.

dfachinetti.bsky.social
@dfachinetti.bsky.social

#2 During her PhD, Catalina Salinas-Luypaert developed human cell models that allowed us to directly alter DNA methylation at centromeres and observe the consequences. We show that DNA methylation is critical to keep CENP-A correctly positioned and centromeres functioning.

dfachinetti.bsky.social
@dfachinetti.bsky.social

#3 Using DiMeLo-seq, Rosa Lee and Danilo Dubocanin from the Altemose team mapped CENP-A binding with high precision. They found that when DNA methylation is lost, CENP-A spreads to inappropriate regions, causing centromere alterations and chromosomal imbalances.

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dfachinetti.bsky.social
@dfachinetti.bsky.social

Congrats to the team! Happy that we could help!

Nicolas Manel Lab@manellab.bsky.social

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

cell.comCentromeric DNA amplification triggered by viral proteins activates nuclear cGASHerpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...
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bendavidlab.bsky.social
@bendavidlab.bsky.social

Excited to get the #EMBOChromoploidy meeting started! 3 days of fantastic science and fun in beautiful Stresa are beginning now! meetings.embo.org/event/25-ane...

meetings.embo.orgChromosome Segregation and AneuploidyAneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …
dfachinetti.bsky.social
@dfachinetti.bsky.social

The Fachinetti team was there! #UneJonquilleContreleCancer

Institut Curie@institutcurie.bsky.social

🌼 Faites fleurir l'espoir contre le #cancer avec l'Institut Curie ! Tout au long du mois de mars, participez à la campagne #UneJonquilleContreleCancer et devenez acteurs de la lutte contre le #cancer aux côtés de nos équipes 🤝 👉 unejonquillecontrelecancer.fr

dfachinetti.bsky.social
@dfachinetti.bsky.social

Last week to register (March 2nd) to the next Genome Instability and Human Disease international course at @institut_curie! Gain knowledge of mechanisms ensuring genome stability, from fundamental molecular pathways up to large scale approaches.

training.institut-curie.orgGenome Instability and Human Disease | Institut Curie Advanced TrainingGenome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human d...
dfachinetti.bsky.social
@dfachinetti.bsky.social

Thanks to @cnrsbiologie.bsky.social for covering our work from @sol-herve.bsky.social and Andrea Scelfo with @katemiro.bsky.social

CNRS Biologie@cnrsbiologie.bsky.social

#RésultatScientifique🔎 Une étude publiée dans @naturecellbiology.bsky.social révèle comment sont détectés des anomalies chromosomiques. Des résultats qui mettent en lumière un rôle inédit de la mécanique du noyau. 🤝 @dfachinetti.bsky.social @institutcurie.bsky.social

buff.lyQuand le nombre de chromosomes déraille : un mécanisme inédit pour protéger l’intégrité du génomeLa mauvaise ségrégation des chromosomes lors de la division cellulaire entraîne des anomalies qui perturbent le bon fonctionnement de la cellule. L

dfachinetti.bsky.social reposted

Kate Miroshnikova
@katemiro.bsky.social

Excited to share the first paper from my lab 🤩 - a great collaboration with Dani Fachinetti lab - we discover a #mechanosensitive nuclear envelope #checkpoint that arrests cells directly post chromosome mis-segregation rdcu.be/d5AC9 👇🧵 #cancer #mechanics #p53 #chromatin