Maxim Greenberg

🚨Preprint Drop🚨 We are very pleased to release our study on DNA methylation dynamics at enhancers during ESC differentiation! This work was led by Marlet Morales-Franco and Priscillia Lhoumaud 🧵(1/13) www.biorxiv.org/content/10.6...

When I was a student moving from engineering to biology, I often heard that I was moving to a ‘soft science.’ Whereas physics and chemistry and mathematics had ground truth rules that were true no matter what, biology seemed like anarchy by comparison.

🚨Preprint from our lab🚨 How and when did TADs emerge during evolution? 🐁🐟🪰 HINT: the diversification of CTCF regulation and functions enabled new mechanisms of 3D chromatin folding 🧬 With Liene Astica & @rdacemel.bsky.social Link: www.biorxiv.org/content/10.6... Bluetorial 1/15👇

Today would have been my daughter's 21st birthday. It's a tough one. I miss her like crazy and would give anything to have her chaos back in our lives. What I can do today is ask for your help. We created the Sophie Burdine-Schwartz Impact Fund through the @angelmanfoundation.bsky.social /1

Join us to explore whether transposable elements can be harnessed to uncover new immunotherapy targets for childhood AML. A fully funded PhD combining cancer genomics, epigenetics and immunology, with access to unique paediatric AML patient datasets and samples. Join us at Barts Cancer Institute! 👇

www.nature.com/articles/s41... We are delighted to share our new study published in Nature Communications today.

I voted today by mail. Please, please, please vote!

Our Dept. of Genetics and Developmental Biology at the Institut Curie in the heart of Paris is hiring a new junior PI. It has a nice start up package and excellent I. Curie facilities. Please spread the word: Deadline Dec. 18th! jpi-recruitment-curie-umr3215-u934.curie.fr

Cripes. The ERC StG success rate is expected at around 5% this year: 373 grants for 7710 applications. Research strategies across the EU are shaped around securing ERC grants. But with such low odds, aligning national or institutional priorities with ERC objectives becomes a deeply flawed strategy.

📢 We are excited to announce our latest work on oocyte meiotic checkpoint signalling @crick.ac.uk Led by George Sioutas, the work allowed us to delineate the early steps of the checkpoint signalling program of pre- and postnatal oocytes 🐭🧬https://www.biorxiv.org/content/10.64898/2026.10.13.758765v2

IMO the paper of the year in the gene regulation field - such a clean and clear study, showing how promoter-enhancer contacts mediate transcriptional activation. www.cell.com/cell/abstrac...

(1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @andersshansen.bsky.social! We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions: www.biorxiv.org/content/10.6...

Artificial intelligence is rapidly transforming molecular biology. In this issue of Molecular Cell, we highlight recent advances at the intersection of AI and molecular biology, spanning structure prediction, design, genome engineering, and functional genomics. www.cell.com/molecular-ce...

The GRC Epigenetics conference is back to US next summer, in Holderness. Pleasure to have arranged a fantastic speaker line-up with @hitenmadhani.bsky.social. Apply before June 4. The sooner the better. The venue is very popular, we will select abstracts on the fly ! www.grc.org/epigenetics-...

I'm reviewing a grant right now that is so cool, it would be such a shame to waste this experience on a robot

Just come across this - completely gobsmacked, an absolutely scandalous tragedy

Bloop 🫧 bloop 🫧 bloop 🫧 Fluid-filled lumens are everywhere in our body How do they get soooo big? We find that osmotic pressure vastly dominates mechanical forces in controlling lumen swelling in mouse embryos biorxiv.org/content/10.6... @louise-dagher.bsky.social @matteo-bassanini.bsky.social

How do DNA sequence features tune the timing, level or duration of gene expression? Join us for a 4 year PhD @mrc-lms.bsky.social with @perez-carrasco.bsky.social @jamesware.bsky.social to build models and help us better predict the impact of non-coding sequence variation #devbio #quantitativebio👇

Happy to share that our previous preprint showing that KMT2B controls the enhancer-like activity of LINE-1 elements is now published in @natcomms.nature.com 🎉 Thanks to all co-authors and to @ibbtec.bsky.social @csic.es @univcantabria.bsky.social www.nature.com/articles/s41...

Excited to share PostChicago, our lab's new R/Bioconductor package for the analysis of Capture-(Hi)C data downstream of loop calling. We present two of its applications: Meta-profiling of interactions and detection of crosslinking artefacts: www.biorxiv.org/content/10.6...

Most animal species pack sperm DNA with protamines instead of histones. Protamines are essential for male fertility. They are among the fastest-evolving genes in animals. That makes little sense. We think we know why, in a new paper led by @ching-hochang.bsky.social. www.science.org/doi/10.1126/...

Australopithecus 3 million years ago:

Check out our latest paper! Big congrats to the first authors Valentin Hure and Maghnia Kawter Ellir and all co-authors for this great work! rdcu.be/PPScXQKpFzqa

It was such a thrill to have Haifeng Wang from Tsinghua University (one of the most sophisticated scientists working on CRISPR technologies) sit in on our lab meeting! We got such great input and ideas! #EpigenomeEditing ✏️🧬

Hello World ! Its pre-print time ! Awesome collaboration led by Michel Cohen-Tannoudji (not on Bsky) and the one and only @deborahbourchis.bsky.social. #BFF We solved the molecular mechanism underlying a mysterious hybrid incompatibility in mice: the DDK syndrome. 🧵🍿 www.biorxiv.org/content/10.6...

Je confirme. Très très fier de la GenZ. Leurs manifs sont juste géniales. Inclusives, joyeuses, engagées. Les vieux c..s ont du soucis à se faire.

This is one of the devious ways grant agencies reduce application numbers, im almost positive. People throw their computers out the window in frustration before they can press submit

It's live! The next @embo.org #EvoChromo meeting will take place next year October in St Feliu de Guíxols (Spain), check it out here: meetings.embo.org/event/27-chr.... It's been great to co-organise with @dodonova-sveta.bsky.social @kellervalsecchi.bsky.social @cedricfeschotte.bsky.social & Nick I.

📣Our department is hiring a new group leader!📣 Want to start your team in a vibrant scientific environment in the center of Paris? I was very lucky to do that 10 years ago, reach out if you have any question. Apply by December 18th: jpi-recruitment-curie-umr3215-u934.curie.fr

Why optogenetics deserves the hype www.wiringthebrain.com/2013/09/why-... (a piece I wrote in 2013 explaining how it works and why modulating specific cell types is so key to understanding how neural circuits and systems work)

Hello fly and chromosome people in Paris! I’m giving a seminar on Friday October 2nd, kindly hosted by Marie-Anne Felix at IBENS (salle Favard, IBENS 46 rue d'Ulm 75005 Paris) at noon. Come to hear the latest from the lab (although we’re evolutionary biologists so sometimes things move slowly) 🫠

Hanging out with the best people in a great restaurant in Paris. (One should be so lucky) @antoinemolaro.bsky.social Ines Drinnenberg

X and Y chromosomes as determinants of aging and disease www.science.org/doi/10.1126/...

Happy to see our latest work published in @jcb.org. Led by an excellent PhD student, Abir Elfarkouchi, and in collaboration with @francoizochsenbein.bsky.social and co-first author Arthur Vitard, we investigated the structural mechanism of CM1 domain autoinhibition rupress.org/jcb/article/...

Every time I return to Paris, I notice they've done more to reclaim streets from drivers and cars, including removing on-street parking, protecting cyclists from drivers, and prioritizing pedestrians and cyclists in shared spaces. Other cities can learn a lot from Paris.

FYI: New online! The mechanistic and evolutionary diversity of programmed DNA elimination

Using AI to help you write a competitive grant makes me think of this Simpsons bit www.youtube.com/watch?v=sRtl...

For those of you who, like me, missed the Vatican #EvoDevo: www.pas.va/en/events/20..., don't worry, there will be a more earthly local version next week (Friday) in Cambridge Dept of Zoology, program here: londonevodevo.co.uk. Can't promise cardinal vestments in the background though.

Must listen!

Delighted to share our first preprint of the lab! We introduce TEgment, a new RNA-seq pipeline that classifies TE expression into distinct structural modalities, distinguishing functional TE activity from transcriptional noise! www.biorxiv.org/content/10.6...

So proud of Angelique’s work, which culminated in a beautiful thesis, and a lively defense. Thanks so much to jury members @chribue.bsky.social @robklose.bsky.social @pablonavarrolab.bsky.social @danielholoch.bsky.social and Valerie Mezger for a scientifically enriching day!

Reposting this postdoc opening in our lab. We also now have an opening for a graduate research assistant for the same project. Deadline 23rd October 2026 and details here: elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Tim Bestor has left us. This obituary captures him well — you always had to be at your intellectual peak with him, while his trainees always spoke highly of their experiences. He made a massive contribution to epigenetics, a giant in our field. www.genetics.cuimc.columbia.edu/news/memoria...

A happy update to this preprint: our work is now published in Nature Communications! Fair and transparent peer review genuinely made the paper stronger – many thanks to the reviewers for pushing us to go deeper into the mechanics 🔩⚙️ www.nature.com/articles/s41...

ICYMI: New online! The shared evolutionary capacities of plasmids and extrachromosomal DNA

A weird thing about living in France is no one knows why some fall Monday mornings you show up to work acting like your pet died or something