Peter Cook

Peter Cook

@drpetercook.bsky.social

Enthusiastically attempting to understand why fungi cause allergy. Still trying to dabble with running… https://experts.exeter.ac.uk/35000-peter-cook

456 followers316 following15 posts

Peter Cook
@drpetercook.bsky.social

Check out our latest preprint, tracking fungal spores we were able to make some fascinating insights on how dendritic cells cause #fungal allergy. #immunosky. Huge thanks to our awesome collaborators who helped with this study! www.biorxiv.org/content/10.1...

biorxiv.orgMgl2+ cDC2 triggering of fungal allergic inflammation depends on a spore induced glycolytic shift fuelled by local availability of glucoseFungal spores are a major cause of severe asthmatic disease. However, the precise events that cause individuals to become sensitised to spores are poorly understood. Mgl2+ type 2 conventional dendriti...

Peter Cook reposted

Iliev Lab
@ilievlab.bsky.social

The past several weeks have taken a toll on all of us. We wrote this before the thick fog fell over science, out now, highlighting the exciting collective progress in the area of #microbiota and #IBD. Hoping reason prevails—for the sake of all and the collective progress of #science

Nature Reviews Microbiology@natrevmicro.nature.com

New online! Microbiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunities

nature.comMicrobiota in inflammatory bowel disease: mechanisms of disease and therapeutic opportunitiesNature Reviews Microbiology, Published online: 10 March 2025; doi:10.1038/s41579-025-01163-0In this Review, Iliev, Ananthakrishnan and Guo explore the gut microbiota in inflammatory bowel disease, highlighting bacterial and fungal components, immune…

Peter Cook reposted

Yosuke Kumamoto
@ykumamoto.bsky.social

Excited to see this finally out!! We found IL-2 made by CD301b+ DCs critical for the Th2 fate decision of CD4T cells and skewing them away from the Tfh fate. They also seem to use their own CD25 to direct IL-2 to the cognate clone. www.nature.com/articles/s41...

nature.comCD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation - Nature CommunicationsA subset of migratory type 2 conventional dendritic cells marked by CD301b expression (CD301b+DC), are required specifically for the development of Th2 cells. Here authors show that at the mechanistic...

Peter Cook reposted

Timothy Hinks
@hinkslab.bsky.social

Out today - a new role for MAIT cells. We've shown MAIT cells are antibacterial; antiviral; and promote tissue repair. In this paper from our group we show MAIT cells are recruited and activated to protect tissues in sterile lung injury, and potentially in IPF - enjoy! doi.org/10.1016/j.ce...

Peter Cook
@drpetercook.bsky.social

*PhD project available funded by BBSRC WoH DLP,*. Are you interested in viral and fungal immunity? Keen to use learn the latest cutting edge technologies to address this working with partners at UKHSA? If yes then please reach out. Further details at: www.surrey.ac.uk/bbsrc-wessex...

surrey.ac.ukBBSRC Wessex One Health (WOH) Doctoral Landscape Award | University of Surrey17 PhD studentships for October 2025 start: Interdisciplinary approaches to Infection Biosciences to combat disease threats to human and animal health.
Peter Cook
@drpetercook.bsky.social

Completely agree @profandrewmac.bsky.social! A pleasure to work with wonderful colleagues at several institutions including @mrccmm.bsky.social, @lydiabeckeriii.bsky.social and @uoe-eid.bsky.social. Fungi are major causes of asthma but why our immune cells do this is poorly understood.

Andrew S. MacDonald @profandrewmac.bsky.social

Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪 rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social

rdcu.beMgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in miceNature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...
Peter Cook
@drpetercook.bsky.social

To tackle this, we found fungal spores lead to both type 2 / type 17 allergic responses and that DCs & CD4+ T cells were crucial. Several single cell technologies revealed DC subsets change drastically. We show that Mgl2+ cDC2 depletion is crucial for type 2 but not type 17 allergic responses.

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