Andres Hidalgo

ahidalgolab.comHidalgo Lab | Mapping Innate ImmunityResearch on neutrophil biology, innate immunity, and cardiovascular disease at Yale School of Medicine. Led by Dr. Andrés Hidalgo.

I am excited to present our long-overdue lab website. Please visit us to learn who we are, our past work, and our current lines of research! ahidalgolab.com Thank you to Gerardo Barcia for his beautiful design and constant support in building it

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

Kudos to @Aleejandra__ and the amazing #Sandra_Martin that performed tons of MI work including a full circadian experiment! This would have not been possible with the generous support of @casanova-acebes.bsky.social and @mariangelesmoro.bsky.social

Also our thanks to #Gerry_Nicholaes #Hector_Bueno and many others who were important collaborators Support always from #CNIC #Yale_VBT @yaleschoolofmed.bsky.social And very special to @caixaresearch.bsky.social for funding this work

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

We then use a skin model to visualize the mechanism of this protection. The excitement came from finding that blocking the circadian clock repositions neutrophils right into the injury zone - thereby sparing the healthy tissue from the cytotoxicity of neutrophils

rupress.orgA circadian checkpoint relocates neutrophils to minimize injury | Journal of Experimental Medicine | Rockefeller University PressAroca-Crevillén et al. identify a circadian checkpoint in neutrophils, mediated by the CXCL12–CXCR4 axis, that limits tissue injury by inhibiting their int

Find out more here rupress.org/jem/article/...

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

We uncover a circadian “checkpoint” in neutrophils that naturally reduces inflammation by targeting their intrinsic circadian clock! Activating CXCR4 represses circadian-related activation of neutrophils, critically reducing inflammatory injury to the infarcted heart

Journal of Experimental Medicine

With #Lidiane_Torres we show this also protects the vasculature in sickle cell disease by blunting aggressive behaviors

Andres Hidalgo reposted

@jem.org

📰 Press Release: Researchers at @yaleschoolofmed.bsky.social have identified a way to suppress the daily fluctuations in the activity of key immune cells known as neutrophils. www.eurekalert.org/news-release... See original paper from the @drusqui.bsky.social group: rupress.org/jem/article/...

authors.elsevier.comauthors.elsevier.com

What are #Neutrophils? why are there so many? how are they shaped by disease? how is it that they maintain memory despite their short lifespan? Our views on this and much more written with #Ivan_Ballesteros for @cp-cell.bsky.social 👇 authors.elsevier.com/a/1mFj9L7PXu...

For a better understanding of where these ideas came from, check out our recent paper modeling the entire neutrophil compartment with @dcerezowallis.bsky.social #AndreaRubio and #Laiguan_Ng www.nature.com/articles/s41...

nature.comArchitecture of the neutrophil compartment - NatureMapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and ...

Our gratitude to those who helped us polish our ideas into a more decent text @snarasimhan.bsky.social and the anonymous reviewers at @cp-cell.bsky.social @casanova-acebes.bsky.social #Daniela_Quail @dcerezowallis.bsky.social #Laiguan_Ng

authors.elsevier.comauthors.elsevier.com

go.nature.comArchitecture of the neutrophil compartment - NatureMapping of the neutrophil compartment using single-cell transcriptional data from multiple physiological and patological states reveals its organizational architecture and how cell state dynamics and trajectories vary during health, inflammation and cancer.

Spoiler: We model the power of neutrophils as a reflection of their Collective behavior. Yes, just like insects… they become powerful. Here’s an idea of how this works

Andres Hidalgo reposted

Nature

@nature.com

5 Dec 2025

Nature research paper: Architecture of the neutrophil compartment go.nature.com/4oD2Nh5

Andres Hidalgo reposted

Journal of Experimental Medicine

@jem.org

3 Dec 2025

Fetal liver #macrophages support red blood cell production and pyrenocyte clearance in the developing embryo. Stifter, Greter et al. demonstrate that XPR1, a phosphate exporter and regulator, is required for the development and function of fetal liver macrophages. rupress.org/jem/article/...

3 Dec 2025

Today, we see the fruit of 5+ years of teamwork. We have built a map of the neutrophil compartment (mostly in mice - but also humans). It provides a biological structure that focuses on a single immune cell lineage to discover the many ways in which neutrophils "interpret" physiology.

Daniela Cerezo-Wallis@dcerezowallis.bsky.social

I’m thrilled to introduce you to the NeuMap! our latest work in@nature.com. A global, comprehensive, single-cell transcriptional atlas of neutrophils across 47 biological conditions in human and mice. A real tour de force www.nature.com/articles/s41...

3 Dec 2025

Kudos to the wonderful people in our labs who made this possible @dcerezowallis.bsky.social #andrea_rubio #ivanbamartin #LaiguanNg and to the many collaborators who helped us along the way and many many others. Science is a team sport.

Andres Hidalgo reposted

Alaz Ozcan

@alazozcan.bsky.social

nature.comStructural immunity: immune cells as architects of tissue barriers - Nature Reviews ImmunologyThis Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in antimicrobial defence, we posit that immune cells co...

Thrilled to share our Perspective on structural immunity, where we discuss how immune cells double as architects, weaving and reshaping the fabric of our tissues. Grateful to @drusqui.bsky.social, all co-authors, and the wonderful @natrevimmunol.nature.com team for making it such a joy to write!

Nature Reviews Immunology@natrevimmunol.nature.com

NEW Perspective by @alazozcan.bsky.social, Tommaso Vicanolo, Veronique Angeli, Yuval Rinkevich & @drusqui.bsky.social presents a model of immune cells as architects of tissue barriers, by depositing matrix components or by interactions with structural cells and the ECM #structuralimmunity #immunosky

rdcu.beStructural immunity: immune cells as architects of tissue barriersNature Reviews Immunology - This Perspective presents a framework of ‘structural immunity’ that positions immune cells as architects of tissue structure. Beyond their roles in...

Here is a full-text access to a view-only version of the paper: rdcu.be/eM7xA

Nature Reviews Immunology@natrevimmunol.nature.com

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Nature Reviews Immunology@natrevimmunol.nature.com

Kudos to @alazozcan.bsky.social, Tommaso, Yuval and Veronique for their insights and work for this review.

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Nature Reviews Immunology@natrevimmunol.nature.com

rupress.orgHeart of the matter: Neutrophils, cancer, and cardiovascular disease | Journal of Experimental Medicine | Rockefeller University PressCancer and cardiovascular disease are the leading causes of death worldwide. Cancer patients display an abnormally elevated burden of cardiovascular diseas

Immune cells are more than aggressors; they are also diplomats that prevent conflict by improving the barrier capacity, the ECM, and the mechanical properties of tissues. We are just beginning to scratch the true impact of immune cells on tissues and overall organismal physiology.

Andres Hidalgo reposted

Jose M. Adrover

@adrover.bsky.social

12 Aug 2025

Here's our take on how neutrophils can be a critical link between cancer and cardiovascular disease! "Heart of the matter: Neutrophils, cancer, and cardiovascular disease", just published @jem.org with Saira Ambreen, Afshan McCarthy and @drusqui.bsky.social rupress.org/jem/article/...

Andres Hidalgo reposted

Carolina Lucas

@carolilucas.bsky.social

28 Apr 2025

🚨 Our new study is live in The Lancet Microbe! “The impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational study” Led by @jaycrandell.bsky.social , Valter Monteiro and Lauren Pischel www.sciencedirect.com/science/arti... A thread 🧵!

sciencedirect.comThe impact of orthopoxvirus vaccination and Mpox infection on cross-protective immunity: a multicohort observational studyCross-reactive immune memory responses to orthopoxviruses in humans remain poorly characterised despite their relevance for vaccine design and outbrea…

Andres Hidalgo reposted

Open Box Science

@openboxscience.bsky.social

3 Apr 2025

OBS #Immunology Seminar Neutrophils and regulation of skin physiology 📆 Thu, 10th April, 12 pm EDT/5 pm CET 🎙️ Speaker @alazozcan.bsky.social @yalesph.bsky.social @drusqui.bsky.social @cnic @nature.com 📣 Moderator @eugecc.bsky.social us02web.zoom.us/meeting/regi...

Andres Hidalgo reposted

Nature

@nature.com

21 Mar 2025

Nature research paper: Matrix-producing neutrophils populate and shield the skin https://go.nature.com/4iJSgy5

go.nature.comMatrix-producing neutrophils populate and shield the skin - NatureA population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

rdcu.beMatrix-producing neutrophils populate and shield the skinNature - A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of...

Excited to post for the first time to present our exciting new paper @Nature. The fruit of massive work by Tommaso Vicanolo, @alazozcan.bsky.social and Jackson Li, and our superb collaborators Laiguan and Stefan Uderhardt. True teamwork! Free link: rdcu.be/eeeA2 www.nature.com/articles/s41...

Big thank you to everyone @CNIC and @VBT_Yale that contributed to this paper with funding, ideas, reagents or just moral support. We owe you.

t.cohttps://www.nature.com/articles/d41586-025-00796-8

Thank you Miryam Naddaf for your beautiful News piece t.co/ccZDZdhAC5

You can find a lot more details, controls and ideas in the paper With @alazozcan.bsky.social can we are now exploring if this unconventional matrigenic capacity of immune cells matters in other physiological and pathological contexts… stay tuned for more surprises!

A final take-home message: In biology, cells are not what they look but what they do. Cell lineages are human divides, and the remarkable plasticity of myeloid cells teaches us that biology works by instructing functional programs at defined times and places.

We interpret that neutrophils complement fibroblasts with their unique migratory properties, and capacity to reach places other cells can’t.

When we created a small wound in the skin, matrix-producing neutrophils would rapidly accumulate around the lesion to build matrix "rings" that protected from small molecules or microbes… magical images from the hands of the master of microscopy Uderhardt and @alazozcan.bsky.social

To demonstrate this, we generated a reporter mouse in which collagens produced by neutrophils (or fibroblasts, for comparison) are labeled with mCherry. Amazing craft by @alazozcan.bsky.social to set this up...

We propose that what is unique to neutrophils is their capacity to dynamically reinforce the matrix: the skin becomes stiffer at night-time, when neutrophils enter the tissue! An experiment from the mind and hands of @TVicanolo !

An exciting finding was that neutropenic mice, or mice lacking TGF signaling in neutrophils, both have major alterations in the skin: matrix structure, composition and skin mechanics are dramatically altered, resulting in a more permeable skin