David Weiss

journals.plos.orgTranslocation of bacteria from the gut to the brain in miceRecent studies link gut dysbiosis to neurological disease, but the underlying mechanisms remain unclear. This study shows that a high-fat diet increases gut permeability and enables bacterial transloc...

19 Mar

Never thought our paper would be mentioned here... @grakoui.bsky.social @anuradhaiitb.bsky.social @jakechoby.bsky.social @plosbiology.org

David Weiss@dweisslab.bsky.social

Bacteria in our BRAINS??! We observed translocation of bacteria from the gut to the brain via the vagus nerve. This occurred after high fat diet, or without dietary changes in mouse models of Alzheimer’s, Parkinson’s, and autism. journals.plos.org/plosbiology/...

the-scientist.comA High-Fat Diet May Drive Gut Bacteria to the Brain in MiceResearchers discovered that gut bacteria could travel to the brain via the vagus nerve in mice, offering clues to the gut-brain axis’ involvement in some neurological disorders.

Big thank you to @liuswrites.bsky.social for this wonderful piece about our study revealing bacterial translocation from the gut to the brain in settings of high-fat diet or in models of Alzheimer's, Parkinson's, and autism. www.the-scientist.com/a-high-fat-d...

In all models tested, bacterial translocation to the brain correlated with gut dysbiosis and intestinal barrier permeability, and the bacteria reaching the brain were always found in the gut. We hope other researchers will investigate these findings and share their results.

science.orgEfflux pumps control intracellular drug-target kinetics by limiting rebinding in bacteriaEfflux pumps disrupt antibiotic rebinding inside bacterial cells, amplifying multidrug resistance.

This was an amazing collaboration with Arash Grakoui @grakoui.bsky.social and an exceptional team, especially Manoj Thapa, @anuradhaiitb.bsky.social. Chui-Yoke Chin, @jakechoby.bsky.social and many others. Big thank you to @plosbiology.org! @bwfpath.bsky.social, @alzassociation.bsky.social

David Weiss reposted

Nature Microbiology

@natmicrobiol.nature.com

7 Feb

#NatMicroPicks More than just pumps? 🦠💊 Bacterial efflux pumps not only block drug entry but also disrupt intracellular drug–target interactions by preventing repeated drug rebinding #MicroSky www.science.org/doi/10.1126/...

David Weiss reposted

Cris Moreira

@moreiralab.bsky.social

5 Feb

🚨 Postdoc Opportunity – Microbiota & Cancer Biology 🚨 (@LSU) Moreira Lab seeks for enthusiastic postdoc to study microbiota–host interactions in oncology, with focus on 16S rRNA analysis, in vivo. PhD in microbiology/molecular/cell bio/oncology. Competitive salary w/exc.benefits. DM, w/CV and 3refs.

David Weiss reposted

Feldman Lab@WashU

@feldmanlab.bsky.social

4 Feb

We are hiring postdocs :)

David Weiss reposted

Victor J. Torres

@torreslab.bsky.social

24 Jan

Excited to announce the upcoming 2026 Microbial Toxins and Pathogenicity GRC and GRS meeting taking place July 12 - 17, 2026 at Waterville Valley in New Hampshire. This meeting will be chaired by yours truly and co-chaired by @sunnyshinlab.bsky.social www.grc.org/microbial-to...

grc.org2026 Microbial Toxins and Pathogenicity Conference GRCThe 2026 Gordon Research Conference on Microbial Toxins and Pathogenicity will be held in Waterville Valley, New Hampshire. Apply today to reserve your spot.

rdcu.beCopy number flexibility facilitates heteroresistance to increasing antibiotic pressure and threatens the beta-lactam pipelineNature Communications - Choby et al. show that dynamic increases in the copy number of preexisting β-lactamase genes in heteroresistance enables resistance of continua of cellular...

2 July 2025

We show how bacteria can adapt to B-lactam stress by increasing the copy number of "wimpy" beta-lactamases to overcome new drugs/B-lactamase inhibitors, without de novo evolution. This threatens the beta-lactam dominated antibiotic pipeline. Congrats @jakechoby.bsky.social and team! rdcu.be/euijW

meetings.cshl.eduMicrobial Pathogenesis & Host ResponseCold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

2 July 2025

@jakechoby.bsky.social is a rockstar - I encourage students/postdocs looking for an amazing mentor and excited to investigate a new frontier in antibiotic resistance to join Jake at UNC to study heteroresistance and defeat superbugs! Congrats, Jake and team on this exciting paper.

Jake Choby@jakechoby.bsky.social

Excited to share the work with @dweisslab.bsky.social‬ and great collaborators on how gene amplification generates dynamic heteroresistance to new beta-lactams, like cefiderocol. We hope drug developers will consider heteroresistance during antibiotic development rdcu.be/euijW

David Weiss reposted

Victor J. Torres

@torreslab.bsky.social

23 June 2025

Alert! The abstract deadline for the Microbial Pathogenesis & Host Response meeting has been extended to July 7 meetings.cshl.edu/meetings.asp...