Earlham Institute

Earlham Institute

@earlhaminst.bsky.social

Combining world-class technology and interdisciplinary expertise across genomics, engineering biology and data science to accelerate solutions for health, biodiversity, and food security.  📍 Norwich, UK 🔗 earlham.ac.uk

2.1K followers755 following981 posts

Earlham Institute
@earlhaminst.bsky.social

#ResearchJob: (Senior) Postdoctoral Research Scientist Developing novel computational and mathematical methods to study the soil microbiome.  🗓️ Apply by: 13 November 2026 ➡️ https://okt.to/MhAq6N #sciencejobs #postdocjobs

okt.to(Senior) Postdoctoral Research ScientistApplications are invited for a three-year position, with a possibility of extension, as a Postdoctoral Research Scientist to join the laboratory of Dr Quince in the High-Resolution Microbiomics group at the Earlham Institute, based in Norwich, UK. Background We are seeking to recruit an individual with a high-level of quantitative skills to develop novel computational and mathematical methods to study the soil microbiome.
Earlham Institute
@earlhaminst.bsky.social

We're recruiting a Programme Manager to join our Decoding Biodiversity research programme at Earlham Institute. This diverse role offers an excellent opportunity for someone to transition into project management within a research environment. #scijob

okt.toResearch Programme ManagerApplications are invited for a highly motivated Research Programme Manager to join the Research Faculty Office at the Earlham Institute, based in Norwich, UK. About the Earlham Institute The Earlham Institute is a world-leading research institute focused on understanding the scale and complexity of living systems. We bring together expertise across life sciences, engineering, computational science, and biotechnology to decode biological systems and help protect life on Earth.
Earlham Institute
@earlhaminst.bsky.social

Fully-funded 4-year #PhD project with @Conrad Nieduszynski at Earlham Institute, using genome language models and high-throughput testing to decode #DNAreplication regulation. 📅 Applications close: 30 November 2026

okt.toDecoding and designing DNA replication origins using genome language modelsHow does a cell know where and when to copy its DNA? And can we use artificial intelligence to design entirely new genetic elements that control this process? This exciting interdisciplinary PhD project will tackle a fundamental question in biology: how DNA replication origins are encoded and regulated within genomes.
Earlham Institute
@earlhaminst.bsky.social

This PhD aims to engineer gene expression to improve disease resistance in crops, applying automation and #engbio skills from the Earlham Biofoundry (@Carolina G) alongside collaborators at @2blades.bsky.social 📅 Applications close: 30 November 2026 #phd #synbio #plantscience

okt.toEngineering crop disease resistance to overcome the growth-defence trade-offDeveloping crops that are both productive and resillient is one of the major challenges facing agriculture. While disease-resistance genes can protect plants from devastating pathogens, they often come with a hidden cost: reduced growth and lower yields. This PhD will investigate whether engineering biology can overcome this trade-off by precisely controlling when and where resistance genes are expressed.
Earlham Institute
@earlhaminst.bsky.social

📣 Funded PHDs: Applications are now open for our 2027 #PhD programme, as part of the NRPDTP Doctoral Training Partnership, and ARIES programme. We have projects across computational biology, genomics, AI and engineering biology. 💻🧬🌱🦠 ➡️ https://okt.to/vgsRNA

Earlham Institute
@earlhaminst.bsky.social

💬 "The community is the best thing about the Norwich Research Park. The staff, students and the research culture are amazing. It’s a very supportive environment, and everyone is very helpful." https://okt.to/0JeaXM #PhD #Genomics

okt.toA Fine City for study: Life in Norwich as a PhD researcherIt's known for its literary merit, historic architecture, and a flourishing creative sector. But Norwich is also home to a thriving community of innovative, curious, and skilled scientists.

Earlham Institute reposted

Association of Applied Biologists
@aabiologists.bsky.social

This week we hosted our ECPro (Early Career Professionals) Network in Nottingham for Early Career Essentials for Applied Biologists 🌱 Here's some of our highlights from a fantastic 2 days of science, networking & careers advice from across sectors! #earlycareer #biology #plantscience

Earlham Institute reposted

Quadram Institute
@quadraminstitute.bsky.social

🆕 Vacancy! We’re looking for a Postdoctoral Research Scientist to investigate relationships between diet, the human gut microbiome and mental health across more than 20 European cohorts within the NUTRIMIND consortium 💷 £39,000 to £46,500 🗓️ Apply by 17 November 2026 ➡️ buff.ly/lh4ZBr0

Earlham Institute
@earlhaminst.bsky.social

Working with @whaerty.bsky.social and partners at @cefasgovuk.bsky.social applications are open for this #PhD working on #pangenomes for genetic diversity in UK wild fisheries species. 🧬🐟 📅 Apply by: 16 December 2026 @ARIES DTP

okt.toPangenomes and population genomics of wild fisheries speciesThe characterisation of genetic diversity and demographic structure of fish populations are essential in assessing and maintaining stocks sustainability. Population structure and genetic diversity of stocks have mainly been assessed using limited genetic markers. While useful for broad population estimates, these methods lack power to quantify gene flow and cannot detect structural variants.
Earlham Institute
@earlhaminst.bsky.social

Applications are open for a new 3-year Postdoctoral role developing novel computational and mathematical methods to resolve the #genomic diversity of the soil microbiome. 📅 Apply by: 13 November 2026 #soil #microbiome

okt.to(Senior) Postdoctoral Research ScientistApplications are invited for a three-year position, with a possibility of extension, as a Postdoctoral Research Scientist to join the laboratory of Dr Quince in the High-Resolution Microbiomics group at the Earlham Institute, based in Norwich, UK. Background We are seeking to recruit an individual with a high-level of quantitative skills to develop novel computational and mathematical methods to study the soil microbiome.
Earlham Institute
@earlhaminst.bsky.social

Projects include: - #engineeringbiology for future crops - developing trustworthy #AI for predictive models - understanding origins of #DNAreplication - #singlecell genomics of #protists Visit our website to find out more!

Earlham Institute
@earlhaminst.bsky.social

🩸 Could blood reveal what is happening inside tissue, and tell us when the answer is trustworthy? Apply for this #PhD project at Earlham Institute developing trustworthy AI for tissue #geneexpression. 📅 Applications close: 30 November 2026

okt.toCan blood reveal the body? Trustworthy AI for tissue gene expressionA blood sample can be collected repeatedly, but a biopsy from the brain, liver or intestine cannot. Could blood reveal what is happening inside these tissues, and tell us when the answer is trustworthy? This PhD will develop Blood2Tissue, a probabilistic model that predicts tissue-specific gene activity from whole-blood or immune-cell measurements.
Earlham Institute
@earlhaminst.bsky.social

We're recruiting a #postdoc researcher with a background in bioinformatics, mathematics or statistics, to develop computational and mathematical methods to study the #soil #microbiome. #sciencejobs 🗓️ Apply by: 13 November 2026

okt.to(Senior) Postdoctoral Research ScientistApplications are invited for a three-year position, with a possibility of extension, as a Postdoctoral Research Scientist to join the laboratory of Dr Quince in the High-Resolution Microbiomics group at the Earlham Institute, based in Norwich, UK. Background We are seeking to recruit an individual with a high-level of quantitative skills to develop novel computational and mathematical methods to study the soil microbiome.
Earlham Institute
@earlhaminst.bsky.social

Congratulations to Earlham Institute alum Dr Hannah Rees (@hannahcr6.bsky.social) on her Dorothy Hodgkin Fellowship for her work on biological clocks!

IBERS - Institute of Biological, Environmental and Rural Science@ibers.bsky.social

🌟 Congratulations to Dr Hannah Rees on being awarded a prestigious 2026 Dorothy Hodgkin Fellowship from the Royal Society, recognising outstanding early career scientists and supporting the next generation of research excellence. 🖱️ https://ow.ly/1U4y50ZXWs5 #research #seagrass

Earlham Institute
@earlhaminst.bsky.social

It’s known for its literary merit, historic architecture, and a flourishing creative sector. But Norwich is also home to a thriving community of innovative, curious, and skilled scientists. We're proud to be a part of this science community and call Norwich our home. 1/2

Earlham Institute
@earlhaminst.bsky.social

As are a growing community of PhD students, drawn here not just for world-class facilities and expert training, but for a city that makes it easy to build a life alongside a career in research. We spoke to 3 recent PhD students on what life is like as a #PhDstudent in Norwich 👇 2/2 #PhDlife

okt.toA Fine City for study: Life in Norwich as a PhD researcherIt's known for its literary merit, historic architecture, and a flourishing creative sector. But Norwich is also home to a thriving community of innovative, curious, and skilled scientists.
Earlham Institute
@earlhaminst.bsky.social

Are you a motivated #undergrad with a passion for #engbio and #plantscience?  Apply for this @NRPDTP PhD programme with @Sarah Guiziou, engineering lateral root initiation. 🌱🧬 📅 Applications close: 30 November 2026

okt.toEngineering biology to decode gene regulatory networks in lateral root initiationWe're offering an exciting PhD opportunity with the Guiziou Group at the Earlham Institute using engineering biology and single-cell genomic technology to drive forward our understanding of lateral root initiation. The aim of this PhD project is to use DNA-based recorders to reconstruct the gene expression programme during lateral root founder cell specification.
Earlham Institute
@earlhaminst.bsky.social

Screening a library of ~400 transcription factors meant months of manual Agrobacterium transformation for Davide Annese, until he found the Earlham Biofoundry. 🤖🧬 Now, as an automation scientist, he's on the other side of the robot, building the workflows to help others save time. #plantscience

okt.toWhere biology meets automation: Inside the Earlham BiofoundryIntegrating automation with synthetic biology expertise, Davide Annese in the Earlham Biofoundry. is helping the bioscience community reduce manual labour, speed up process, and increase precision.
Earlham Institute
@earlhaminst.bsky.social

💬 "If you only have an engineer, they might not be able to recognise whether an issue is down to a technical problem with the robot or a fundamental biological process.”  📖 Read: 'Where biology meets automation: Inside the Earlham Biofoundry' with Davide Annese 👇 #automation #synbio

okt.toWhere biology meets automation: Inside the Earlham BiofoundryIntegrating automation with synthetic biology expertise, Davide Annese in the Earlham Biofoundry. is helping the bioscience community reduce manual labour, speed up process, and increase precision.
Earlham Institute
@earlhaminst.bsky.social

Are you looking to develop your skills in plant, microbial, and data science? 🌱🧫🧬 Applications are now open for the John Innes Foundation Rotation PhD Programme in Plant and Microbial Sciences at the @John Innes Centre, @The Sainsbury Laboratory and The Earlham Institute 👇

okt.toJohn Innes Foundation Rotation PhD ProgrammeA four-year Rotation PhD Programme at the Earlham Institute, John Innes Centre, and The Sainsbury Laboratory - three internationally recognised centres of excellence in plant, microbial and data sciences, based in Norwich, UK.

Earlham Institute reposted

Hall Lab
@halllab.bsky.social

Huge congratulations to @hannahtriv.bsky.social and the team on this fantastic work! 👏 Brilliant to see long-read metagenomics revealing new insights into the gut microbiome and antimicrobial resistance in advanced liver disease. Highlights the potential role of MDR Enterococcus in cirrhosis! 🧬🦠

Hannah Trivett@hannahtriv.bsky.social

Delighted to share our new paper in Genome Medicine! We used long-read #metagenomics to uncover striking changes in the gut #microbiome with advanced #LiverDisease, including E. faecium dominance and #AMR @halllab.bsky.social #Genomics #ECR #Resistome #Cirrhosis link.springer.com/article/10.1...

link.springer.comDecoding the microbiome and resistome of advanced chronic liver disease through long-read metagenomics - Genome MedicineBackground Patients with advanced chronic liver disease (ACLD) and underlying cirrhosis frequently require repeated courses of antimicrobial therapy, with both the frequency and spectrum of antimicrob...

Earlham Institute reposted

Hannah Trivett
@hannahtriv.bsky.social

Delighted to share our new paper in Genome Medicine! We used long-read #metagenomics to uncover striking changes in the gut #microbiome with advanced #LiverDisease, including E. faecium dominance and #AMR @halllab.bsky.social #Genomics #ECR #Resistome #Cirrhosis link.springer.com/article/10.1...

link.springer.comDecoding the microbiome and resistome of advanced chronic liver disease through long-read metagenomics - Genome MedicineBackground Patients with advanced chronic liver disease (ACLD) and underlying cirrhosis frequently require repeated courses of antimicrobial therapy, with both the frequency and spectrum of antimicrob...
Earlham Institute
@earlhaminst.bsky.social

Inspired by the potential of #automation to accelerate synthetic and #engineeringbiology, Davide Annese develops automated workflows helping scientists navigate hurdles of speed, scale, and precision. 👇 https://okt.to/FLQqnh

okt.toWhere biology meets automation: Inside the Earlham BiofoundryIntegrating automation with synthetic biology expertise, Davide Annese in the Earlham Biofoundry. is helping the bioscience community reduce manual labour, speed up process, and increase precision.
Earlham Institute
@earlhaminst.bsky.social

🆕 Applications are open for a new 3-year Postdoctoral role developing novel computational and mathematical methods to resolve the #genomic diversity of the soil microbiome. 📅 Apply by: 13 November 2026 #soil #microbiome

okt.to(Senior) Postdoctoral Research ScientistApplications are invited for a three-year position, with a possibility of extension, as a Postdoctoral Research Scientist to join the laboratory of Dr Quince in the High-Resolution Microbiomics group at the Earlham Institute, based in Norwich, UK. Background We are seeking to recruit an individual with a high-level of quantitative skills to develop novel computational and mathematical methods to study the soil microbiome.
Earlham Institute
@earlhaminst.bsky.social

📣 Save the date! The Norwich #SingleCell and #Spatial Symposium returns in 2027. Join a supportive forum for researchers working on similar challenges across diverse systems to discuss, network, and share knowledge. 📝 Register your interest to hear more! 🗓️ 22-23 June 2027

okt.toNorwich Single-Cell and Spatial Symposium 2027Bringing together the international single-cell and spatial community for a two-day discussion across model and non-model systems.
Earlham Institute
@earlhaminst.bsky.social

A new preprint introduces two standardized, end-to-end pipelines for single-cell RNA-seq and imaging-based #spatialtranscriptomics analysis. EISCA supports droplet- and plate-based scRNA-seq, while EISTA is tailored for high-resolution spatial platforms. #SingleCell #RNAseq

okt.toPreprint: EISCA and EISTA: Full-Spectrum Pipelines for Single-Cell and Spatial Transcriptomics AnalysisScientists at Earlham Institute, John Innes Centre, University of Freiburgh, and University Medical Center Rotterdam present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial transcriptomics analysis.
Earlham Institute
@earlhaminst.bsky.social

With both pipelines and a Galaxy workflow available, the developers welcome the #scRNAseq and #spatial community to use and test the pipelines, and suggest features to help shape future developments.

Earlham Institute
@earlhaminst.bsky.social

Later this month, Group Leader Dr @Sarah Guiziou will be at @European Synthetic Biology Society presenting her group's research using recombinase and integrase genetic tools to record gene expression with single-cell resolution and engineer plant development. 🌱🧬 🗓️ Tuesday 20 October

okt.toBiocomputing and Logic Circuits for Sustainable Agriculture with Sarah Guiziou · LumaCan we program how plants grow? In this talk, Dr. Sarah Guiziou will explore how advanced recombinase and integrase genetic tools let researchers record gene...
Earlham Institute
@earlhaminst.bsky.social

💬 “Through COPO we have spent years developing meaningful standards and tooling which properly describe research data. This multiplies its usefulness, making it comparable, reusable and trainable for the community at large." #FAIRdata #ResearchDataManagement #biodiversity

earlham.ac.ukAccelerating UK biodiversity research with FAIR metadataThe University of Sheffield’s NERC Environmental Omics Facility (NEOF) and Data Science platforms at the Earlham Institute will serve as the backbone data infrastructure for the newly announced Advanc...
Earlham Institute
@earlhaminst.bsky.social

From scripting robots to troubleshooting experiments, Davide Annese brings together biology and automation expertise at the Earlham #Biofoundry. In a new article find out how automated workflows are helping researchers tackle high-throughput biology. 🧬🤖🔁 #synbio #automation

okt.toWhere biology meets automation: Inside the Earlham BiofoundryIntegrating automation with synthetic biology expertise, Davide Annese in the Earlham Biofoundry. is helping the bioscience community reduce manual labour, speed up process, and increase precision.
Earlham Institute
@earlhaminst.bsky.social

💬 "The role ARIA has given to data management across this priority area demonstrates how vital FAIR data management is in enabling discovery and innovation." https://okt.to/elVur2

okt.toAccelerating UK biodiversity research with FAIR metadataThe University of Sheffield's NERC Environmental Omics Facility (NEOF) and Data Science platforms at the Earlham Institute will serve as the backbone data infrastructure for the newly announced Advanced Research and Invention Agency (ARIA) Accelerated Adaptation programme.
Earlham Institute
@earlhaminst.bsky.social

📃 In a new preprint, scientists introduce two standardized, end-to-end pipelines for single-cell RNA-seq and imaging-based #spatialtranscriptomics analysis. EISCA supports droplet- and plate-based scRNA-seq, while EISTA is tailored for high-resolution spatial platforms. #SingleCell #RNAseq

Earlham Institute
@earlhaminst.bsky.social

💬 "We invite researchers to try these pipelines on their own single-cell and spatial transcriptomics datasets and encourage users to report issues and suggest feature requests to help shape future developments." - Huihai Wu, Senior Bioinformatician at Earlham Institute.

Earlham Institute
@earlhaminst.bsky.social

'Full-Spectrum Pipelines for Single-Cell and Spatial Transcriptomics Analysis' is now available on bioRxiv, with both pipelines available on GitHub. Read more below 👇 https://okt.to/Ho3Qac

okt.toPreprint: EISCA and EISTA: Full-Spectrum Pipelines for Single-Cell and Spatial Transcriptomics AnalysisScientists at Earlham Institute, John Innes Centre, University of Freiburgh, and University Medical Center Rotterdam present EISCA and EISTA, two standardized, end-to-end pipelines for single-cell RNA- seq and imaging-based spatial transcriptomics analysis.
Earlham Institute
@earlhaminst.bsky.social

The extraordinary diversity, biology and complexity of #protists pose significant challenges to the #genomics community. A new collaboration will address some of the major technical barriers for sequencing protists from bulk cultures and the environment. 🧬🦠🧪 Read more 👇

okt.toMajor investment to unlock the potential of protist researchA new collaboration will tackle major technical challenges currently limiting protist genomics, helping to unlock the potential of protist research for biomanufacturing, sustainable agriculture and environmental applications.