Thomas Elbenhardt Jensen

Thomas Elbenhardt Jensen

@elbenhardt.bsky.social

Professor in Molecular Exercise Physiology at NEXS, UCPH, DK. Main interest is striated muscle growth and metabolism.

196 followers387 following5 posts

Thomas Elbenhardt Jensen
@elbenhardt.bsky.social

Our latest work showing that GLUT4 exofacial antibodies can measure translocation in humans and rodent skeletal muscle fibers and is impaired in TBC1D4 KO rats despite rescued GLUT4 expression. Congrats Kaspar and co-authors. DM me for open access version: diabetesjournals.org/diabetes/art...

diabetesjournals.orgExofacial Epitope–Specific Antibodies Detect GLUT4 Translocation in Adult Human, Rat, and Mouse Skeletal MuscleSkeletal muscle glucose transporter 4 (GLUT4) translocation to the plasma membrane determines glucose uptake in response to insulin and exercise and is dis
Thomas Elbenhardt Jensen
@elbenhardt.bsky.social

PhD position available in my group at UCPH. Focus on delineating novel mechanisms of muscle hypertrophy using cutting edge models and analyses💪. Deadline Jan 29, 2026. Apply: candidate.hr-manager.net/ApplicationI...

candidate.hr-manager.netPhD fellowship in Molecular Exercise PhysiologyProject on Skeletal Muscle Hypertrophy Mechanisms in Mice The project: The Section for Human and Molecular Physiology invites applicants for a three-year PhD fe
Thomas Elbenhardt Jensen
@elbenhardt.bsky.social

In our latest paper, we show that inducible sk. muscle AXIN1 /2 double KO have normal AMPK, mTOR and glucose uptake regulation, questioning previously proposed dependencies on this scaffold protein. Thanks to all co-authors for their contributions physoc.onlinelibrary.wiley.com/doi/10.1113/...

physoc.onlinelibrary.wiley.comMuscle‐specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolismAbstract figure legend This study investigated the role of AXIN1 and AXIN2 in regulating skeletal muscle AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) sig....

Thomas Elbenhardt Jensen reposted

Juleen R. Zierath
@juleenrzierath.bsky.social

Latest from Jonas Treebak and team @cbmr.science NAD depletion in skeletal muscle does not compromise muscle function o... www.sciencedirect.com/science/arti...

sciencedirect.comNAD depletion in skeletal muscle does not compromise muscle function or accelerate agingNicotinamide adenine dinucleotide (NAD) is a ubiquitous electron carrier essential for energy metabolism and post-translational modification of numero…

Thomas Elbenhardt Jensen reposted

Carlos Henriquez-Olguin
@musclebiology.bsky.social

Check out our latest paper challenging the long-standing belief that insulin elicits a transient H₂O₂ production. New insights into skeletal muscle redox signaling and insulin action 🤩

Thomas Elbenhardt Jensen@elbenhardt.bsky.social

Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy www.sciencedirect.com/science/arti...

sciencedirect.comRevisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal MuscleThe intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…
Thomas Elbenhardt Jensen
@elbenhardt.bsky.social

Our new paper in Redox Biol showing that insulin stimulation of skeletal muscle surprisingly does not detectably increase the ROS H2O2 using state-of-art methods in different models including humans, but in fact causes a selective reductive shift - enjoy www.sciencedirect.com/science/arti...

sciencedirect.comRevisiting Insulin-Stimulated Hydrogen Peroxide Dynamics Reveals a Cytosolic Reductive Shift in Skeletal MuscleThe intracellular redox state is crucial for insulin responses in peripheral tissues. Despite the longstanding belief that insulin signaling increases…

Thomas Elbenhardt Jensen reposted

Christoph Handschin
@c-handschin.bsky.social

Replying to @c-handschin.bsky.social

“Exploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparison” by @robertoandresmv.bsky.social, @musclebiology.bsky.social, @elbenhardt.bsky.social et al. (sorry if I do not find all of the #bluesky handles). www.sciencedirect.com/science/arti... 3/17

sciencedirect.comExploring NADPH oxidases 2 and 4 in cardiac and skeletal muscle adaptations – A cross-tissue comparisonStriated muscle cells, encompassing cardiac myocytes and skeletal muscle fibers, are fundamental to athletic performance, facilitating blood circulati…

Thomas Elbenhardt Jensen reposted

Deutsches Zentrum für Diabetesforschung (DZD)
@diabresearch-dzd.bsky.social

🚨Paper Alert 🚨: PanK4 Identified as Regulator of Glucose and Lipid #Metabolism. A new study led by mkleinert.bsky.social‬ at our DZD-Partner #DIfE has identified PanK4 as a key regulator of energy metabolism in skeletal muscle. ⬇️ ⬇️ ⬇️ ⬇️

Maximilian Kleinert@mkleinert.bsky.social

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

nature.comPantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature CommunicationsHere, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...
Thomas Elbenhardt Jensen
@elbenhardt.bsky.social

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

faseb.onlinelibrary.wiley.commTOR Ser1261 is an AMPK‐dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activitymTOR Ser1261 is an AMPK-dependent phosphosite in human and mouse skeletal muscle that responds to exercise but not insulin, plays an unclear role in mTORC1 regulation, and is not required for mTORC2 ....

Thomas Elbenhardt Jensen reposted

Maximilian Kleinert
@mkleinert.bsky.social

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

nature.comPantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature CommunicationsHere, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Thomas Elbenhardt Jensen reposted

Plant Energy Biology Lab
@schwarzlanderlab.bsky.social

A new biosensor is born 👼 The NAPstar family of genetically-encoded sensors for live NADP redox monitoring🔋🪫 Jointly with the Morgan lab & @riemerlab.bsky.social we looked in vitro, in yeast, plants & mammalian cells 🧪🦠🧫🌱 Where to go next? @naturecomms.bsky.social doi.org/10.1038/s414...

doi.orgA family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes - Nature CommunicationsThis article presents NAPstars, a family of genetically-encoded biosensors that enable real-time monitoring of NADP redox dynamics across species. The sensors reveal robust NADP redox regulation, cell...

Thomas Elbenhardt Jensen reposted

Altmetric
@altmetric.com

🌟 ICYMI: Altmetric now tracks Bluesky mentions! ✔️ Comprehensive social media coverage 📊 Mentions reflected in your Altmetric score 🌐 Stay ahead in tracking research discussions Your research is moving to new spaces—don’t miss a thing! Read more here: www.altmetric.com/bl... #AcademicSky

altmetric.comTapping into data from BlueskyAltmetric has expanded its tracking capabilities by integrating data from Bluesky, the rapidly growing social media platform with over 24 million users.

Thomas Elbenhardt Jensen reposted

Juleen R. Zierath
@juleenrzierath.bsky.social

New from Anna Krook and team. Biological sex differences in skeletal muscle metabolism and exercise adaptation in People with type 2 diabetes #myoblue #exercise #metabolism www.nature.com/articles/s41...

nature.comSex differences in skeletal muscle metabolism in exercise and type 2 diabetes mellitus - Nature Reviews EndocrinologyThis Review focuses on currently available literature describing sex differences in skeletal muscle metabolism in humans, as well as highlighting current research gaps within the field. These discussi...

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