ericgreerlab.bsky.social

ericgreerlab.bsky.social

@ericgreerlab.bsky.social

We are a lab studying the molecular mechanisms of epigenetics and how epigenetics impacts a variety of biological processes and diseases. https://thegreerlab.com/

903 followers631 following47 posts

ericgreerlab.bsky.social reposted

NYCLU
@nyclu.org

"We are living with the legacy of the McCarthy era, and what Donald Trump is doing is really resurrecting the worst."⁠ ⁠ After a performance of "Are You Now Or Have You Ever Been," @dlnyclu.bsky.social spoke at a talkback on the attacks we're enduring on free speech and the fight for our democracy.⁠

ericgreerlab.bsky.social reposted

Brice Letcher
@bricoletc.bsky.social

Absolutely beautiful paper by a core team at the RIKEN in which the telomerase RNA component has (finally) been identified, in the nematode *C. elegans*. Surprisingly, it does not have its own promoter, but is located inside the intron of a germline-expressed gene (nmy-2)! 🤩 doi.org/10.1126/scie...

doi.orgNematode telomerase RNA hitchhikes on introns of germline–up-regulated genesTelomerase is a ribonucleoprotein complex that elongates telomeric DNA, ensuring germline immortality. In this study, we identified the Caenorhabditis elegans telomerase RNA component 1 (terc-1), as t...

ericgreerlab.bsky.social reposted

The Allard lab
@allard-lab-ucla.bsky.social

Really cool paper from Marie-Anne Felix's lab. Genetic variation in set-24 controls the duration of epigenetic inheritance. www.cell.com/current-biol...

cell.comIntraspecific variation in the duration of epigenetic inheritance in wild isolates of C. elegansFrejacques, Saglio, et al. demonstrate variation among C. elegans wild isolates in the multigenerational memory of an initial RNA interference trigger. Genetic polymorphisms and environmental variable...
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ericgreerlab.bsky.social
@ericgreerlab.bsky.social

We also performed a directed screen and identified that depletion of the argonautes CSR-1 and HRDE-1 accelerated the transgenerational adaptation (2 generations instead of 4 for no fertility phenotype) and depletion of the H3K27 trimethylase PRC2 complex eliminated the worms ability to adapt 7/9

ericgreerlab.bsky.social
@ericgreerlab.bsky.social

Really excited for the next steps of this project to further study whether transgenerational adaptation is universal to different environmental stresses, how conserved this is in other species, and what the precise molecular mechanism is for the transgenerational adaptation. 8/9

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ericgreerlab.bsky.social
@ericgreerlab.bsky.social

We also tested elevated glucose which increases neutral lipids and decreases fertility in exposed worms and unexposed descendants. After two successive exposures to elevated glucose neutral lipid levels and fertility were the same as unexposed controls.Therefore transgenerational adaptation..5/9

ericgreerlab.bsky.social
@ericgreerlab.bsky.social

..is not unique to hypoxia and might be a general phenomena. We performed RNAseq to examine which genes were adapting their expression to repeated generational hypoxia exposure. We found that most genes still respond to hypoxia treatment but a small subset adapt to repeated generational hypoxia 6/9

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ericgreerlab.bsky.social
@ericgreerlab.bsky.social

We found that after 2 successive generational exposures to hypoxia, worms were no longer long lived. After 4 successive generational exposures to hypoxia, worms no longer displayed a reduction in fertility. The worms adapted on a transgenerational scale to the repeated environmental stress! 4/9

ericgreerlab.bsky.social
@ericgreerlab.bsky.social

Recent work has demonstrated that a single exposure to a dramatic stress induces transgenerational phenotypes of altered color, obesity, glucose tolerance, behavior and longevity. But we are exposed to different environmental stresses each generation (changes in pesticides and fungicides etc) 2/9

ericgreerlab.bsky.social reposted

Aaron Rupar
@atrupar.com

MADELEINE DEAN: The president is unhinged. He's unwell JOHNSON: A lot of folks on your side are too D: Oh my god, please. That performance in front of the generals? J: I didn't see it D: It's so dangerous! Our allies are looking elsewhere. Our enemies are laughing. You have a POTUS who's unwell.

ericgreerlab.bsky.social reposted

NPR
@npr.org

A federal judge in Boston said she found it "difficult to conclude anything other than that [the Trump administration] used antisemitism as a smokescreen for a targeted, ideologically-motivated assault on this country's premier universities, and did so in a way that runs afoul of [federal law]."

n.prTrump administration illegally froze billions in Harvard funds, judge rulesThe ruling is a legal victory for Harvard but the White House says it will appeal the decision.

ericgreerlab.bsky.social reposted

Liz Krueger
@lizkrueger.bsky.social

Donna Lieberman of @nyclu.org is absolutely right. It's vital that @governor.ny.gov sign these critical bills to protect New Yorkers' reproductive freedom, including the NY Health Information Privacy Act that I carry w/@lindabrosenthal.bsky.social. www.timesunion.com/opinion/arti...

timesunion.comCommentary: Hochul must sign bills that protect access to reproductive careAs threats mount nationwide, New York must do all it can to ensure everyone can get the care they need.
ericgreerlab.bsky.social
@ericgreerlab.bsky.social

We found that dimt-1 deficiency requires the TOR signaling pathway and an intact germline to extend lifespan. Using auxin-inducible degron tagged dimt-1 and tissue specific RNAi we found DIMT-1 functions in the worms' germline after mid-life to regulate organismal lifespan 5/8

ericgreerlab.bsky.social
@ericgreerlab.bsky.social

We also found that DIMT-1 regulates selective translation of stress resistance and lifespan regulating transcripts in the worm's germline but not in the muscle. One transcript which we identified as displaying differential ribosome occupancy was the cytochrome P450 enzyme DAF-9. 6/8

ericgreerlab.bsky.social
@ericgreerlab.bsky.social

We found that DIMT-1 functions in the germline and works after mid-life to extend lifespan. This reveals a new layer of regulation of lifespan, which transcripts are selectively translated, and found that ribosome heterogeneity is critical later in life to promote healthy aging. 3/8

ericgreerlab.bsky.social
@ericgreerlab.bsky.social

An RNAi screen identified that dimt-1 KD caused lifespan extension. We had previously shown that DIMT-1 is an 18S rRNA m62A methylase and that methylated rRNAs are transmitted to subsequent generations to drive intergenerational response to starvation pubmed.ncbi.nlm.nih.gov/37689068/ 4/8

pubmed.ncbi.nlm.nih.gov18S rRNA methyltransferases DIMT1 and BUD23 drive intergenerational hormesis - PubMedHeritable non-genetic information can regulate a variety of complex phenotypes. However, what specific non-genetic cues are transmitted from parents to their descendants are poorly understood. Here, w...
ericgreerlab.bsky.social
@ericgreerlab.bsky.social

As we age there is a dysregulation of which proteins are degraded and which proteins are produced. We showed that DIMT-1 methylation of the ribosome selectively regulates the production of stress resistance and longevity regulating proteins and regulates aging. 2/8

ericgreerlab.bsky.social reposted

Donna Lieberman
@dlnyclu.bsky.social

I was born in the McCarthy era, but this is McCarthyism on steroids. Our democracy is under dire threat. But we have a government of laws, not men. And NO ONE is above the law.

NYCLU@nyclu.org

Across the country, the ACLU has already filed more than 50 lawsuits to defend free speech, due process, equal rights, and the rule of law. We’ve got the assignment. And we’re not slowing down. @dlnyclu.bsky.social 📍Foley Square

ericgreerlab.bsky.social reposted

Rosa DeLauro
@delauro.house.gov

Last week, House Democrats opposed giving Elon Musk and Trump a blank check funding bill that would allow them to gut programs and services families rely on. The Senate must pass a short-term spending bill so we can pass bipartisan bills that protect programs for our communities.

ericgreerlab.bsky.social reposted

Alexandria Ocasio-Cortez
@aoc.bsky.social

KEEP CALLING. PEEL OFF ALL DEM SENATORS YOU CAN. ☎️: (202) 224-3121 Tell them to vote NO on Cloture and NO on CR. Vote is pushed to after 1:15ish for now. Situation is fluid. The only public YES votes are Schumer and Fetterman. They need 7-8 total. KEEP CALLING. Call retiring Senators too!

ericgreerlab.bsky.social reposted

Alexandria Ocasio-Cortez
@aoc.bsky.social

CALLS ARE WORKING - it has bought us precious time, but we NEED to keep the pressure up. Tomorrow is the cloture vote. KEEP CALLING: (202) 224-3121 ☎️☎️☎️ Tell your Dem Senator to vote NO on Cloture and NO on the Republican spending bill. Do NOT assume your Senator will be good on this. Trust me.

Alexandria Ocasio-Cortez@aoc.bsky.social

🚨 Everyone needs to call their Dem Senator right now. They are starting to cave. Tell them: 1. Vote NO on Cloture AND 2. Vote NO on the Republican spending bill. Don’t let them pivot to reconciliation. GOP doesn’t need Dem votes on that and they know it. TODAY is the showdown. 🤳🏽: (202) 224-3121

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