Friedrich Förster

Friedrich Förster

@fridof.bsky.social

Structural biologist, Cryo-EM aficionado, signal peptide nerd, teacher, mentor, dad, …

429 followers145 following9 posts

Friedrich Förster
@fridof.bsky.social

Very happy and honored to be elected as an EMBO member. Looking forward to contributing to this great European society. Thanks for being nominated and the trust of the members.

EMBO@embo.org

Welcome and congratulations to the 60 new members and 11 associate members who have been elected to the EMBO Membership! They join a community of more than 2,200 leading scientists. 🧪 https://www.embo.org/press-releases/seventy-one-leading-scientists-elected-to-the-embo-membership/ #EMBOMembers2026

Friedrich Förster
@fridof.bsky.social

The first cut is the deepest: Cleavable signal peptides direct thousands of different nascent proteins to the endoplasmic reticulum. Oddly, SPs are all different and nevertheless cleaved with exquisite specificity. Our new cryo-EM structures + MD solve this paradox: www.nature.com/articles/s41...

nature.comStructural basis of signal peptide recognition by the signal peptidase complex - Nature CommunicationsSignal peptides are highly variable, yet the signal peptidase complex processes them with remarkable specificity. Here, authors combine cryo-EM, molecular dynamics simulations and modeling to reveal a...
Friedrich Förster
@fridof.bsky.social

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

uu.nl33 million euro investment for national electron microscope facility EMPowerA major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...
Friedrich Förster
@fridof.bsky.social

Congratulations Marten! We hope this new version of pytom will be useful to many cryo-ET enthusiasts.

Marten Chaillet@martenchaillet.bsky.social

Final PhD paper now reviewed and published in JSB:X. I was happy with some great reviews that improved the paper! Thanks to Sander Roet for his help with the code base, and Remco Veltkamp and @fridof.bsky.social

Friedrich Förster reposted

PfefferCryoLab
@pfeffercryolab.bsky.social

Online today at @naturecomms.bsky.social and a great opportunity for our first post @bsky.app: in a major team effort, we reveal the structural mechanisms for centrosomal recruitment and organization of the human microtubule nucleator γ-TuRC: www.nature.com/articles/s41...

nature.comStructural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC - Nature CommunicationsThe γ-TuRC plays a central role for nucleation of microtubules at the centrosome. Here, the authors dissect structural mechanisms for centrosomal recruitment and regulation of the γ-TuRC and identify ...
Friedrich Förster
@fridof.bsky.social

And now to something completely different: the response of an anaerobic archaeon to oxidative stress. Tubular nanocompartments encapsulate virus-like particles! Great work by Wenfei Song and many colleagues from @bijvoet-centre.bsky.social and @mib-wur.bsky.social. www.biorxiv.org/content/10.1...

biorxiv.orgStructure of an oxygen-induced tubular nanocompartment in Pyrococcus furiosusReactive oxygen species (ROS) pose a significant threat to biological molecules, prompting organisms to develop systems that buffer oxidative stress and contain iron, which otherwise amplifies ROS pro...

Friedrich Förster reposted

Bijvoet Centre
@bijvoet-centre.bsky.social

In one of our first publications in 2025, with colleagues from St. Louis, Leiden and Boston, we shed light on the molecular mechanisms of motile cilia, structures used by cells to propel themselves through fluid or to move fluid across their surfaces. www.nature.com/articles/s41...

nature.comStructural diversity of axonemes across mammalian motile cilia - NatureCryoelectron microscopy, cryoelectron tomography and proteomics are used to resolve the 96-nm modular repeat of axonemal doublet microtubules from both sperm flagella and epithelial cilia of the ovidu...

Friedrich Förster reposted

Amrei Bahr
@amreibahr.bsky.social

Starkes Signal!! Über 60 dt. Hochschulen & Forschungsinstitutionen haben heute ihren Ausstieg bei X bekanntgegeben, s.u. #eXit X sei nicht mehr vereinbar mit ihren Grundwerten: „Weltoffenheit, wissenschaftliche Integrität, Transparenz und demokratischer Diskurs.“ Liste der Beteiligten hier:

nachrichten.idw-online.deHochschulen und Forschungsinstitutionen verlassen Plattform X - Gemeinsam für Vielfalt, Freiheit und Wissenschaft
Friedrich Förster
@fridof.bsky.social

My new life in blue starts with sharing a preprint of amazing Max Gemmer’s ex vivo analysis that sheds light on the machinery responsible for inserting many multispanning transmembrane proteins into the ER membrane #teamtomo: www.biorxiv.org/content/10.1...

biorxiv.orgExploring the molecular composition of the multipass translocon in its native membrane environmentbioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

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