Green Lab JHMI

Green Lab JHMI

@greenlab.bsky.social

Ribosome is life. Posts by grads/postdocs, approved (sometimes) by Rachel Green. @Johns Hopkins Medical Institute https://greenlabjhmi.org

150 followers6 following5 posts

Green Lab JHMI reposted

Molecular Cell
@cp-molcell.bsky.social

Online Now: Oligo(uridine) tailing and exonucleolytic decay drive 40S ribosome degradation in response to stress Online now:

dlvr.itOligo(uridine) tailing and exonucleolytic decay drive 40S ribosome degradation in response to stress40S ribosomes are degraded in diverse stress conditions. Diehl et al. find that in response to stress, TUT7 is recruited to ubiquitylated 40S ribosomes and adds 3′ oligo(U) tails to the 18S rRNA. Iterative uridylation and 3′-5′ decay by the exonuclease DIS3L2 drive 18S rRNA and ultimately 40S ribosome degradation.
Green Lab JHMI
@greenlab.bsky.social

Pre-print alert! SERBP1 regulates the interactions between ribosomes and different proteins. We find that it prevents interactions between ribosomes and RNF10/RIOK3 to protect ribosomes from selective 40S degradation. Congrats! @nicollearosa.bsky.social www.biorxiv.org/content/10.6...

biorxiv.orgSERBP1 is a master regulator of ribosome interactionsRibosome function depends on interactions with diverse proteins whose activities determine translational efficiency, impose quality control and activate signaling pathways. These many competing activi...
Green Lab JHMI
@greenlab.bsky.social

Wait, what?! This isn’t about ribosomes? Check out our new work where we find that a #Legionella effector thought to target host translation instead targets metabolism by modifying a host glycolytic metabolite. Led by @drjoshblack.bsky.social www.cell.com/molecular-ce...

cell.comThe Legionella pneumophila effector SidL is an adenylyltransferase that modifies the glycolytic intermediate 3-phosphoglycerateBlack et al. identify the L. pneumophila effector SidL as an adenylyltransferase that targets host glycolysis. SidL covalently modifies the glycolytic intermediate 3-phosphoglycerate (3PG) with AMP, g...

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