Pauli Group (posts by Andi Pauli)

New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat

Finally out! Our work uncovers evolutionary links between bacterial and archaeal ribosome hibernation and eukaryotic energy sensing, through the archaeal hibernation factor AHA link.springer.com/article/10.1...

Is it a virus, or a retrotransposon? Amazing story how an endogenous retrotransposon uses a small, FAST-like protein to cause soma-to-oocyte transfer in Drosophila. Kudos to @mayavoichek.bsky.social, Kirsten Senti, @juliusbrennecke.bsky.social plus the entire team for this exciting discovery!

We are so excited to have @dorie00.bsky.social Doris Kaltenecker join the @impvienna.bsky.social soon. Doris is using cutting edge technologies to study cancer cachexia. I can highly recommend joining a junior lab and can't wait to have her around!

Seven stories of 'Frontier Science', including our own led by @vdeneke.bsky.social & Andreas Blaha, on the discovery of a trimeric complex bridging sperm and eggs in vertebrates. Thank you @hfspo.bsky.social for supporting out-of-the-box science & allowing us to push the boundaries of what is known!

Do you want to label the nuclear envelope? Do you work on a non-model species? Try Concanavalin A! We tested ConA on various species across the eukaryotic tree and find it is a very useful ExM-compatible marker for the NE and ER. Read all about it in our preprint: www.biorxiv.org/content/10.6...

We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016

Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22

🔔 Doctoral Insights Symposium is THIS Thursday. PhD programs across Europe. Live panels. Q&A with real students and coordinators. Free. Online. Undergrad thinking about a PhD? This is for you. Register → doctoralinsights.at #DocInsights #Symposium

The #ViennaBiocenter Summer School 2026 has wrapped up! 🎊 19 early-career researchers from across the globe spent the summer at VBC institutes and presented at the Fellows' Symposium on 28 Aug. Want to join us in 2027? Check our website from mid-October 👉 https://ow.ly/S6v850ZIGNX #ViennaBiocenter

Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳 www.sciencedirect.com/science/arti... 1/8

Happy to share a new protocol for ex vivo #zebrafish #ovary culture from Amal Shawahny and Yoel Bogoch! Protocol for culture of zebrafish developing ovaries as an ex vivo system for investigating early oogenesis and ovarian development: STAR Protocols www.cell.com/star-protoco...

How do you visualize highly complex data without losing important information? Prof. Erik van Nimwegen’s team developed a new tool, Bonsai, that provides a faithful picture of the structure in the data. @erikvannimwegen.bsky.social @unibas.ch @dhdegroot.bsky.social @imbavienna.bsky.social

Wonderful to see so many @mblscience.bsky.social Woods Hole Zebrafish Course friends here in Vienna for #EZM2026 - from student alumni, current & former faculty to TAs. As @cohouart.bsky.social put it, a truly cross-generational 'historical' picture (and a few were even missing in the pic....).

Thanks for visiting us Claudia @kellervalsecchi.bsky.social and sharing your creative and out-of-the-box science with us!

Looking for a research technician job? Come join our lab! We are hiring a part-time Research Technician to work in our lab at @devneuro.bsky.social @kingsioppn.bsky.social on Guy's Campus. A perfect opportunity for a recent graduate to get wet lab experience. www.kcl.ac.uk/jobs/151245-...

Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)

Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]

New preprint by my former colleagues in the Pauli lab 🫶 When I first joined the lab, I naively thought Bouncer’s interacting partner was a single protein. Years later, it turns out that at least 7 components on the sperm side may mediate fertilization - meet the SPARK complex! ✨

Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.

Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...

Join us at our special anniversary Symposium on RNA biology at the @vbcscitraining.bsky.social campus! We promise 3 days of interesting science, discussions and hopefully new ideas and learnings for everyone - plus a symposium dinner at the Vienna city hall!

Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...

Want to find out how a zebrafish develops from a small ball of cells into a functioning organism? 🐠 Then join us at the microscopes this Friday at @viennabiocenter.bsky.social for the Long Night of Research 🔬👩‍🔬 langenachtderforschung.at/station/592 📍Vienna BioCenter, 1030 Wien ⏰ 17:00-23:00

Big congratulations to our former postdoc @lorenzoorts.bsky.social, now leading her own at the @imbmainz.bsky.social, for receiving the Biochemical Society Early Career Research Award! Amazing news and so well deserved - super proud of you, Laura!

👇👇👇 If are you excited about helping us recruit and train the next generation of scientists, don't hesitate to apply! The @viennabiocenter.bsky.social is a great place to work. 🙂

A big shout-out for @lorenzoorts.bsky.social and @hohmannulrich.bsky.social - super happy for both of you that it worked out! If I was a student starting my career and interested in mechanistic work at the interphase of biochemistry/structural biology/development, I would immediately apply!

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).

Learn more about the collaboration possibilities offered at Vienna BioCenter as Victoria Deneke shares her insights as a Postdoc at the Research Institute of Molecular Pathology. The VIP³ PostDoc Program call is open – apply now! training.vbc.ac.at/post-docs/vi... #VBCPostDoc

What an opportunity! Don’t miss it!!

Excited for the years to come working with this great crowd @juliusbrennecke.bsky.social @pauligroup.bsky.social @haselbachlab.bsky.social & Andela Saric! 🥳

I could not agree more with @trayon.bsky.social: We were all supported by amazing scientists, mentors & colleagues that allowed us to achieve our dreams. I want to be such a supportive mentor myself & give back by supporting others - from my own @pauligroup.bsky.social members to other scientists!

the deadline is coming soon👇 don't miss it, we are looking forward to welcoming all teleost (not just zebrafish 😉) afficionados in Vienna! 🙂🐟🐠🤓

Welcome Danny to our campus! Looking forward to interacting more and having you around!