Greg Medlock

Greg Medlock

@gregmedlock.bsky.social

VP Technology @ Vedanta Biosciences. Interested in repairing+controlling the human microbiome.

1.2K followers803 following183 posts

Greg Medlock
@gregmedlock.bsky.social

Fascinating story on the effects of C. difficile colonization in infants.

Joe Zackular@joeyzacks.bsky.social

Excited to share new work from my lab showing that early-life colonization with C. difficile remodels the developing infant gut, published today in @science.org! This study was co-led by two truly amazing scientists: @haidermanzer.bsky.social and Alexa Semon. www.science.org/doi/10.1126/...

science.orgEarly-life colonization with Clostridioides difficile remodels the developing gutClostridioides difficile causes severe disease in adults but commonly colonizes infants asymptomatically. The consequences of early-life colonization on host development remain unknown. In a neonatal ...

Greg Medlock reposted

Citizen Platano 🇵🇷
@daniloc.xyz

couple months ago, I was riding shotgun on a project that went sideways overall premise was good, it was aggressively spec'd, then it was fed to an agent, which completely mangled the intention in subtle ways this got me thinking about the missing spine for agent dev github.com/daniloc/cohe...

github.comGitHub - daniloc/coherence: The missing spine for agent-driven coding. Create the structure you need to reduce the cost of changes, verification and fixes.The missing spine for agent-driven coding. Create the structure you need to reduce the cost of changes, verification and fixes. - daniloc/coherence
Greg Medlock
@gregmedlock.bsky.social

AI shouldn't be doing review *for you*, but 1) if you've submitted a manuscript and it's not also preprinted and in the public domain already, that's careless, 2) current generation AI is better than the best humans at some aspects of peer review--it would be a disservice NOT to use it

Itai Yanai@itaiyanai.bsky.social

If you’re letting AI do a review of a manuscript for you, just know that (A) it’s super obvious to anyone reading it, (B) it’s dishonest - as you’re explicitly instructed not to do so, and (C) it’s careless - because you’re uploading someone’s confidential material to an AI app.

Greg Medlock
@gregmedlock.bsky.social

ICME abstracts are due this Wednesday, Aug 5! Please consider submitting your work.

Greg Medlock@gregmedlock.bsky.social

I'm excited to help organize #ICME2026 - join us to explore the latest advances in Microbiome Engineering! Our call for abstract is open and we are seeking sponsors. Please share, and reach out to me to learn more!

Greg Medlock reposted

Vice Mayor Burhan Azeem
@burhanazeem.bsky.social

In May, Vijeta and I had our wedding in Cambridge Commons with hundreds of you all. In June, her grandfather suddenly passed away. In July, her papa was diagnosed with stage IV cancer and a brain tumor. He is 58. He was at our wedding, already symptomatic, and none of us knew.

Greg Medlock
@gregmedlock.bsky.social

I'm excited to help organize #ICME2026 - join us to explore the latest advances in Microbiome Engineering! Our call for abstract is open and we are seeking sponsors. Please share, and reach out to me to learn more!

Greg Medlock reposted

Stephen Turner
@stephenturner.us

github.com/cyberpapiii/...

github.comGitHub - cyberpapiii/chipotlai-max: The AI coding agent that runs on stolen Chipotle compute 🌯 Fork of OpenCode with Pepper AI as default model. Community project to add providers from Home Depot, Low...The AI coding agent that runs on stolen Chipotle compute 🌯 Fork of OpenCode with Pepper AI as default model. Community project to add providers from Home Depot, Lowes, Target, Starbucks & more....
Greg Medlock
@gregmedlock.bsky.social

“entire 2026 budget” doing some heavy journalistic lifting here. As a large public co, 2026 budgets were probably more or less final pre-Opus 4.5 (maybe even pre-4.1). Very curious what the actual $$ was!

Dare Obasanjo@carnage4life.bsky.social

Uber's COO recently voiced an uncomfortable truth that many in the tech industry are yet to admit. He said while Uber's engineers are consuming massive amounts of AI tokens, it is incredibly difficult to prove that this spending actually benefits the end user or improves the product proportionally

fortune.comUber burned through its entire 2026 AI budget in four months. Now its COO is questioning whether it's worth it | FortuneThe rideshare giant's COO says “it’s very hard to draw a line” between rising AI costs and useful features for customers.
Greg Medlock
@gregmedlock.bsky.social

Just released an update of Medusa, a Python package for managing ensembles of genome-scale metabolic models (github.com/opencobra/Me...) This release incorporates improvements by Jeroen Gilis from Chalmers University, including speeding up ensemble generation from a set of SBML files >10X

github.comGitHub - opencobra/Medusa: Analysis of ensembles of metabolic network reconstructionsAnalysis of ensembles of metabolic network reconstructions - opencobra/Medusa
Greg Medlock
@gregmedlock.bsky.social

Michael, this reads as downright conspiratorial. Have you interacted in any way with NSF staff working on this? There’s extensive oversight. No/minimal human subject work is even likely to be funded. There is independent merit-based review. Where are you getting your info?

This post is unavailable.

Greg Medlock reposted

Ákos T Kovács
@evolvedbiofilm.bsky.social

Managing microbial interactions in environmental biotechnology: can we scale interaction principles? @cp-trendsmicrobiol.bsky.social Review by @wenyugu.bsky.social (EPFL), Xiang-Yi Li Richter, and Dave Johnson at @eawag.bsky.social www.cell.com/trends/micro...

cell.comManaging microbial interactions in environmental biotechnology: can we scale interaction principles?Microbial interactions hold vast potential for improving sustainability, including waste upcycling, greenhouse gas mitigation, contaminant bioremediation, and host performance. However, attempts to ma...
Greg Medlock
@gregmedlock.bsky.social

Save the date - join the 9th International Conference on Microbiome Engineering! 📍Durham, NC 🗓️ Dec 1-3, 2026 Are you obsessed with controlling microbiomes? Want to learn all the ways accomplishing this goal benefits society? This is the meeting for you! www.aiche.org/sbe/conferen...

aiche.org9th International Conference on Microbiome EngineeringThis conference brings together scientists across the quickly growing field of microbiome engineering. The conference integrates synthetic biology, systems biology, microbial ecology, and bioinformati...
Greg Medlock
@gregmedlock.bsky.social

The Anthropic team does lots of helpful posting to X, but unfortunately has not prioritized bluesky cross-posting (makes sense, X algo loves everything AI) @j4ck.xyz made this tool to mirror those accounts, and takes community requests. Boris @bcherny-x.bsky.social Thariq @trq212-x.bsky.social

jack@j4ck.xyz

I’m glad it’s useful, I’ve been trying to bridge useful Twitter accounts here for this very reason! There’s a list I made of all bots here → bluesky-mirrors.vercel.app

bluesky-mirrors.vercel.appBluesky Mirror DirectoryExplore mirrored accounts from Twitter/X to Bluesky with search and sorting.
Greg Medlock
@gregmedlock.bsky.social

Bonus: with these mirrors, your feed doesn't get populated by anthropic's gracious replies to "tHeY NErFeD dA MoDEl" or "what do you mean I can't deploy Claude as a service in my app using my $100/month subscription?" engagement bait.

Greg Medlock
@gregmedlock.bsky.social

Trying to reduce my use of social media with algorithmic feeds, and found this very nice bot today. So much of Anthropic’s dev and media teams just post to X as a sole outlet. 2nd best is subscribing to new release notes for Claude code on github.

Anthropic {bot}@anthropicai.xmirror.bot

Introducing Claude Opus 4.7, our most capable Opus model yet. It handles long-running tasks with more rigor, follows instructions more precisely, and verifies its own outputs before reporting back. You can hand off your hardest work with less supervision.

Greg Medlock
@gregmedlock.bsky.social

Vedanta Biosciences Announces the Phase 3 RESTORATiVE303 Study of VE303 for the Prevention of Recurrent C. difficile Infection Will Continue as Planned Following Protocol-Specified Interim Analysis

Greg Medlock
@gregmedlock.bsky.social

This is wild, we eat so much yeast

Manuel Kleiner@manuelkleiner.bsky.social

I thought it was quite mind boggling to see that around 10% of the protein in a standard yeast based bread is actually yeast protein! Here our #metaproteomics analysis of microbial protein in fermented foods pubs.rsc.org/en/Content/A... Congratulations to first authors Laura Winkler and Ayesha Awan

pubs.rsc.orgAssessing the diversity and functional profile of the “microbial proteome” in fermented foodsFermented foods are staples in diets worldwide and are known for their health benefits. Microorganisms are the key to fermented food production as they convert raw substrates into digestible, nutritio...

Greg Medlock reposted

Tami Lieberman
@contaminatedsci.bsky.social

If you're a senior PhD student or recent graduate interested in doing work at the intersection of AI and microbial genomics and/or microbiomes, please feel free to reach out to discuss the possibility of applying together for an MIT Novo Nordisk Fellowship engineering.mit.edu/novo-nordisk

engineering.mit.eduNovo Nordisk FellowshipPotential areas of focus for postdoctoral fellows participating in the MIT-Novo Nordisk Postdoc Program include, but are not limited to, the following: Your complete application should include: In the...
Greg Medlock
@gregmedlock.bsky.social

CARB-X is opening a new funding round soon—sign up for their newsletter (link in replies) to get the announcement. CARB-X is one of few organizations making meaningful progress ensuring access to new antimicrobial drugs and supporting preventatives/diagnostics.

Greg Medlock
@gregmedlock.bsky.social

Tried Edison Analysis (not Kosmos) on two tasks and was blown away: 1. Uploaded 96 high-res NMR spectra of bacterial supernatants and asked for metabolite ID and quantification 2. Uploaded a bacterial genome and asked it to identify mobile genetic elements (more complex, but this is the gist)

Sam Rodriques@sgrodriques.bsky.social

Give it a try here: platform.edisonscientific.com And read our paper: edisonscientific.com/kosmos-report We have built this to accelerate science, and we think it's pretty neat. We are super excited to see what people think.

platform.edisonscientific.comEdison PlatformAI Agents for Scientific Discovery
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Greg Medlock
@gregmedlock.bsky.social

For the genomic analysis, Edison performed similarly, but "connected the dots" within the analysis in a way it is hard to imagine a PhD student doing on their own 5 years ago.

Greg Medlock
@gregmedlock.bsky.social

Really encourage folks who had bad impressions of earlier LLMs & hallucinations to take a look at domain-specific, agentic systems like Edison, Claude Code, etc. Semantics aside--these things are just very useful now.

Greg Medlock
@gregmedlock.bsky.social

Tried Edison Analysis (not Kosmos) on two tasks and was blown away: 1. Uploaded 96 high-res NMR spectra of bacterial supernatants and asked for metabolite ID and quantification 2. Uploaded a bacterial genome and asked it to identify mobile genetic elements (more complex, but this is the gist)

Sam Rodriques@sgrodriques.bsky.social

Give it a try here: platform.edisonscientific.com And read our paper: edisonscientific.com/kosmos-report We have built this to accelerate science, and we think it's pretty neat. We are super excited to see what people think.

platform.edisonscientific.comEdison PlatformAI Agents for Scientific Discovery
Greg Medlock
@gregmedlock.bsky.social

I knew what reasonable results should be and how long it would take a human. For the NMR task, Edison performed similarly to a senior PhD student that manually reviewed the entire spectra, and correctly identified things like negative controls without instruction.

Greg Medlock reposted

LifeArc
@lifearc.bsky.social

Antimicrobial resistance (AMR) is one of the greatest threats to public health, with the potential to undo decades of medical progress. This #WAAW2025, head to our LinkedIn to hear from world-leading experts on how we can tackle AMR and protect the future of medicine: t.ly/3Oxk1

t.ly#worldamrawarenessweek #waaw2025 | LifeArcAntimicrobial resistance (AMR) is one of the greatest threats to public health, with the potential to reverse decades of medical progress. Despite the severity of the problem, the pipeline for new dr...