Jelle van den Ameele

Absolutely thrilled 💣 to share our preprint 🖨️: "Mapping active cis-regulatory elements from transcription initiation events”. www.biorxiv.org/content/10.6... We introduce nucCAGE and PRIME to identify active cis-regulatory elements (CREs) and disease-associated, non-coding variants.

@lilyfoundation.bsky.social is advertising for a new #PPIE Manager. This person will strengthen the teams’ ability to embed PPIE within the @lifearc.bsky.social as well as across the #mito community. @londonmito.bsky.social @mitonewcastle.bsky.social www.thelilyfoundation.org.uk/charity/what...

Great to bring together 70+ researchers & partners at the LifeArc Centre for Rare Mitochondrial Diseases Annual Meeting in Cambridge last week! From scientific updates and flash talks to patient voice discussions it was a day full of insight and collaboration!

A Research Briefing on our MitoPerturb-Seq paper just came online @natsmb.nature.com too: www.nature.com/articles/s41.... Hopefully even more accessible than the manuscript! 😉

Really pleased to see this out @natsmb.nature.com: www.nature.com/articles/s41.... MitoPerturb-Seq combines #singlecell #CRISPR screening with whole-cell Multiome, to identify nuclear modifiers of mtDNA dynamics. @mitocamb.bsky.social @mrc-mbu.bsky.social @prudentlab.bsky.social and Stephen Burr

📢 We are inviting you to the second session of the 2026 @cambridgeflyclub.bsky.social talks.

Fantastic to join the #EdinburghScienceFestival with our lab’s Stitch and Fly workshop! We had a highly interactive, fully booked session discussing our research alongside fruit fly-inspired stitching! Huge thanks to the PhD students in our lab and SBS public engagement team. #Drosophila #Genetics

Wonderful and honoured to write a perspective with @prudentlab.bsky.social @mrc-mbu.bsky.social on such an intriguing and cool observation of beautiful mitochondrial biology! Amazing work on how pearling allows mitochondrial genome organisation by @jclandoni.bsky.social @sulianamanley.bsky.social!

@jellevda.bsky.social @ritahorvath.bsky.social @lilyfoundation.bsky.social @londonmito.bsky.social @mitonewcastle.bsky.social

We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7

Closes 12/01/2026. A great team and a great centre to be a part of! @camneurodept.bsky.social @taylorlabncl.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @robpitceathly.bsky.social

www.gimjournal.org/article/S109... I am very proud of this new paper! Congratulations to Thiloka and the team of young researchers! 👍

Excited to share our first bioinformatics contribution! 🎉 Led by Niek Wit in collaboration with the van den Ameele lab @jellevda.bsky.social , we developed DamMapper damid-seq.readthedocs.io/en/latest/, a workflow for DamID-seq analysis, to map SET1B and HIF-1 chromatin occupancy. rdcu.be/eK2TS

Delighted that Ziqi Dong's PhD paper is out for all to read! Hypoxia is fundamental to normal development, and fascinating! Thanks to all of our co-authors including @jamesnathanlab.bsky.social @jellevda.bsky.social authors.elsevier.com/sd/article/S...

Bluesky, I am pleased to present to you the main product of postdoc work, published in @science.org ☝️ As it turns out, the very quality control mechanism that can remove mutant mtDNA copies is the one that maintains high mutant burden, or heteroplasmy levels

This is amazing news!! @camneurodept.bsky.social @mrc-mbu.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @mito-news.bsky.social

📢 We are hiring a Senior Research Associate in Bioinformatics & Statistical genetics @cam.ac.uk @mrc-mbu.bsky.social @camneurodept.bsky.social @jellevda.bsky.social It's a great time to join this dynamic and world leading team working on #mitochondria Closes 28/8/25 www.cam.ac.uk/jobs/senior-...

Welcome to the new serie of Cambridge Fly Club meetings. We organise several events every year to foster collaboration and maintain a positive dynamic between Drosophila groups in Cambridge.

Thanks to @lilyfoundation.bsky.social for taking these snaps of the centre leads and team members! Together we hope to do great things over the next 5 years of the LifeArc Centre! #mito @ucl-qs-cnmd.bsky.social @taylorlabncl.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social

We spent a great afternoon at the House of Lords for the launch of the @lifearc.bsky.social Centre for #Rare #Mitochondrial Diseases, supported by @mdukcharity.bsky.social The event centre hosted staff, dignitaries, patients, MPs & those involved in rare disease policy & research. We even unveiled…

It was a great day and a fantastic #PPIE workshop!! @lifearc.bsky.social @ritahorvath.bsky.social @jellevda.bsky.social @robpitceathly.bsky.social @taylorlabncl.bsky.social @dwong47.bsky.social @mitogene.bsky.social @mrc-mbu.bsky.social @mitonewcastle.bsky.social @uclqsion.bsky.social

🚨 Join us for the @faseborg.bsky.social Meeting on Mechanisms of Mitochondrial DNA Mutation and Repair, June 1 - 5, 2025 | Nashville, Tennessee. 📅 Abstract submission & Early Registration close on April 20, 2025! Don't miss out: events.faseb.org/event/mitoch... Please re-post!

2x CRA posts extended until end of April. So you have another chance to work with #mito disease patients as part of the @lifearc.bsky.social centre for #rare #mito diseases! See links below to apply! @eastgenomics.bsky.social @camneuro.bsky.social @cuhnhs.bsky.social

Our new preprint is out! We optimized our open-source platform, HyDrop (v2), for scATAC sequencing and generated new atlases for the mouse cortex and Drosophila embryo with 607k cells. Now, we can train sequence-to-function models on data generated with HyDrop v2! www.biorxiv.org/content/10.1...

We are hiring #bioinformaticians. One post to work on the new @lifearc.bsky.social centre for rare #mitochondrial diseases, and one is a joint project @mrc-mbu.bsky.social with Prof Patrick Chinnery & @mitogene.bsky.social Apply here: www.jobs.cam.ac.uk/job/50861/ www.jobs.cam.ac.uk/job/50860/

Exited to share our latest preprint! mRNA-LNPs are efficiently delivered to healthy livers, but what about liver tumours? Our postdoc @laura-leighton.bsky.social found liver tumours efficiently take up mRNA, enabling next generation mRNA-LNP cancer therapeutics. www.biorxiv.org/content/10.1...

All the jobs, all in one place!!

📢 We have not 1 but 3 clinical/patient-facing jobs working with #mitoCAMB on the #LifeArc #raredisease centre for #mito diseases. 1x pre/post-doctoral CRA; 1x post-doctoral CRA (with potential to become a 4 year ACL); 1x research coordinator Join us! Links below.

We are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD - lnkd.in/dtKz_gnA PostDoc - lnkd.in/dBgn6AcK

BBC news article about one of our patients with #neuroferritinopathy on the DefINe clinical trial, funded by #LifeArc. Spread the word about this disease, and also this trial - more participants needed! www.bbc.com/news/article... @ritahorvath.bsky.social @jellevda.bsky.social

Very excited to share this #LifeArc video about the 4 new #rare disease centres across the UK, with our centre for #mitochondrial diseases being one of them! @jellevda.bsky.social @ritahorvath.bsky.social @frisophagy.bsky.social @mrc-mbu.bsky.social www.linkedin.com/posts/lifear...

Congratulations Meghana, Marco and Eva! Great to have played a small part in this beautiful work!

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below

Final week to apply for this research coordinator position, working on all things #mito & the LifeArc centre for rare diseases. Join us! www.jobs.cam.ac.uk/job/48491/ @ritahorvath.bsky.social @jellevda.bsky.social

For any patients (or researchers) interested in #mito research, the Lily Foundation has launched its new 'research zone': www.thelilyfoundation.org.uk/affected-by-... @ritahorvath.bsky.social @jellevda.bsky.social

New year, new bluesky account, and new website: mitocamb.medschl.cam.ac.uk