Journal of General Physiology

📣 Call for Papers 📣 You are invited to submit papers on the topic of the @sgpweb.bsky.social 2026 meeting, “Membrane Excitability and Reproductive Biology,” to be published throughout the year and highlighted in a special issue! Learn more and submit here 👉 rupress.org/JGP/pages/ca...

Commentary: A new study by Hariharan, @talongden.bsky.social et al. (rupress.org/jgp/article/...), reveals reduced function of brain capillary pericyte KATP channels in a mouse model of #Alzheimers disease. William F. Jackson discusses the questions raised by the study: rupress.org/jgp/article/...

Dissecting diastolic stiffness. New study by Shahid et al. (rupress.org/jgp/article/...) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from heart failure with preserved ejection fraction model mice. In Research News: rupress.org/jgp/article/... #HFpEF

📣 #CallForPapers on #Myofilaments is now open! JGP welcomes submissions that focus on #myofilament structure, elasticity, and regulatory networks in muscle function and disease. Learn more and submit your work here 👉 rupress.org/JGP/pages/ca...

Great study! Congratulations to @talongden.bsky.social and team!

Early disruptions in brain capillary blood flow control in a mouse model of #Alzheimers disease. New study from Ashwini Hariharan, Thomas A. Longden and colleagues @medschool.umaryland.edu: rupress.org/jgp/article/... #IonChannels #Pathophysiology #SystemsPhysiology

Research News: JGP study by Arooj Shahid, Mei Methawasin et al. (rupress.org/jgp/article/...) reveals sex-based differences in the contributors to diastolic stress in #cardiomyocytes from #HFpEF model mice. rupress.org/jgp/article/... #CardiacMuscle

Hariharan, Longden et al. @medschool.umaryland.edu show that in a mouse model of #Alzheimers disease, capillary blood flow control fails early: endothelial Kir2.1 currents decline at 2–4 mo, followed by pericyte KATP channel impairment by 6–8 mo. rupress.org/jgp/article/... #IonChannels

Chamber-specific regulation of #myofilament Ca²⁺ sensitivity by nNOSβ via #Troponin I phosphorylation: Predominance in the right ventricle. New study from Jae Won Kwon, Sung Joon Kim, Young Keul Jeon and colleagues (Seoul National University): rupress.org/jgp/article/... #CardiacMuscle

📣 #CallForPapers on the topic “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease.” Submissions of all article types are welcome, incl. Research Articles, Communications, Hypotheses, Methods and Approaches, & Reviews 👉 rupress.org/JGP/pages/ca...

Jae Won Kwon, Sung Joon Kim, Young Keul Jeon et al. show that myofilament-associated nNOS preferentially restrains right ventricular contraction by regulating Ca²⁺-binding affinity through #troponin I phosphorylation. rupress.org/jgp/article/... #CardiacMuscle #CellularPhysiology

State-dependent inhibition of LRRC8 volume-regulated anion channels by DCPIB. New study from Toshiki Yamada, Erkan Karakas, and Jerod S. Denton @vanderbilt.edu: rupress.org/jgp/article/... #MolecularPharmacology #MembraneTransport #IonChannels

A fluorescent non-hydrolyzable probe for the nucleotide binding sites of KATP. New study from Priscilla Rubio, Michael C. Puljung and coleagues @trinitycollege.bsky.social: rupress.org/jgp/article/... #Biochemistry #Biophysics #MolecularPhysiology #CellularPhysiology #IonChannels

📣 2026 #CallForPapers on #Myofilaments is now open! The review process will be overseen by JGP Editor Henk Granzier, with Guest Editors and subject experts Brett Colson, Jonathan Kirk @jonathankirk.bsky.social, Julian Stelzer, and Jennifer Van Eyk. 👉 rupress.org/JGP/pages/ca...

Yamada, Karakas, & Denton @vanderbilt.edu show that the prototypical LRRC8/VRAC inhibitor DCPIB stabilizes an inactivated channel state through coordinated interactions spanning extracellular, transmembrane, & N-terminal channel domains rupress.org/jgp/article/... #IonChannels #MolecularPharmacology

KATP channels link a cell’s metabolic state to its electrical excitability through the binding of ADP/ATP to three classes of nucleotide-binding site. Rubio, Puljung et al. synthesize and characterize a fluorescent ATP derivative to probe the activity of these sites. rupress.org/jgp/article/...

The proximal N terminus of IRAG is required for potentiation of HCN4 channels. New study from Lucas M. Blecker, John R. Bankston and colleagues @cuanschutz.bsky.social: rupress.org/jgp/article/... #MolecularPhysiology #MembraneTransport #Biophysics #IonChannels

🔬 From our September issue (rupress.org/jgp/issue/15...): Compiled image of HEK cells showing both dark-field imaging and TMRM fluorescent signal. Colomer-Molera et al. show that structural determinants at KCNE4 position 145 govern Kv1.3 channel function. doi.org/10.1085/jgp....

Heart rate is controlled, in part, by the opening and closing of the ion channel HCN4. Blecker, Bankston and colleagues describe the functionally relevant domains of both the channel and its ER-resident potentiator, IRAG. rupress.org/jgp/article/... #Biophysics #IonChannels #MolecularPhysiology

#CallForPapers 📣 You are invited to submit papers on the topic “What’s Hot in #Myofilament Structure, Elasticity, and Regulatory Networks in Muscle Function and Disease.” Learn more & submit here 👉 rupress.org/JGP/pages/ca...

The many faces of #Orai1 dysfunction: Molecular mechanisms and clinical manifestations. New review from Magdalena Prantl, Lara Atzgerstorfer, Isabella Derler and colleagues @jku.at: rupress.org/jgp/article/... #IonChannels #Biophysics #ProteinDynamics #MembraneTransport #Pathophysiology

On our September cover (rupress.org/jgp/issue/15...): Gaitán‑Peñas et al. (doi.org/10.1085/jgp....) show how the VRAC inhibitor DCPIB binds the extracellular selectivity filter through adaptable interactions, providing new insights into the molecular basis of channel inhibition.

A hERG blocker facilitates K⁺ channel current by promoting pore opening while blocking. New study from Steffen Docken, Matthew Marquis, Kazuharu Furutani, Timothy Lewis, Jon Sack @ucd-physiology.bsky.social et al.: rupress.org/jgp/article/... #MolecularPharmacology #Biophysics #IonChannels

Here in lovely Woods Hole for the annual meeting @sgpweb.bsky.social, where I am delighted to chat about both @lsajournal.org and @jgp.org A great theme this year on excitability in human reproduction!! (My congrats to Sue on her impressive puddle)

Tunable AMPA receptor function via recurrent #evolution of heterotetramers. New study from Yuhong Wang, Alexander Edwards, Jelena Baranovic, and Timothy Lynagh @msarscentre.bsky.social: rupress.org/jgp/article/... #MolecularPharmacology #MembraneTransport #Biochemistry #Biophysics #IonChannels

Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated #ionchannel, ELIC. New study from Mark J. Arcario, Wayland W. L. Cheng and colleagues @washumedicine.bsky.social: rupress.org/jgp/article/... #Biophysics #MembraneTransport

📣 Call for Papers ⏰ DEADLINE APPROACHING: SEPTEMBER 30 📣 JGP welcomes submissions that focus on increasing our understanding of the role of voltage-gated sodium channels in the broad physiological and pathophysiological context. 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers #WSCC26

Diastolic contributors in cardiomyocytes of a cardiometabolic HFpEF-like mouse model. New study from Arooj Shahid, Mei Methawasin (University of Missouri) and colleagues: rupress.org/jgp/article/... #CardiacMuscle

#PMB researchers explore drug interactions with hERG channels in this paper from @jgp.org

New review: Prantl, Atzgerstorfer, Derler et al. @jku.at catalog known disease-associated #Orai1 mutations, explain how they disrupt the activation sequence, and link them to their clinical impact. rupress.org/jgp/article/... #IonChannels #Biophysics #ProteinStructure #MembraneTransport

Docken, Marquis, Furutani, Lewis, Sack @ucd-physiology.bsky.social et al. test the hypothesis that the antiarrhythmic drug nifekalant opens hERG gates while blocking, revealing a mechanism that may reduce #arrhythmia risk. rupress.org/jgp/article/... #IonChannels #MolecuarPharmacology #Biophysics

Wang, Lynagh et al. investigated the biophysical function, pharmacology, and kinetics of AMPA receptors from diverse bilaterians, uncovering convergent #evolution on functional hallmarks, such as heteromerization & channel properties, throughout the AMPA receptor family. rupress.org/jgp/article/...

Using #MolecularDynamics, computational #electrophysiology, and single-channel recordings, Arcario, Cheng et al. identify a cryptic extracellular lateral fenestration in the pentameric ligand-gated #ionchannel, ELIC, that becomes the dominant cation conduction pathway. rupress.org/jgp/article/...

📣 #CallForPapers on #Myofilaments is now open! JGP welcomes submissions that focus on #myofilament structure, elasticity, and regulatory networks in muscle function and disease. Learn more and submit your work here 👉 rupress.org/JGP/pages/ca...

A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions. New approach developed by Ryan J. Farrell, Timothy A. Ryan @weillcornell.bsky.social and colleagues: rupress.org/jgp/article/... #Biophysics #MolecularPhysiology #CellularPhysiology

Shahid, Methawasin et al. show that, in the #cardiomyocytes of male two-hit HFpEF-like model mice, both increased passive sarcomere stiffness and diastolic crossbridge activity represent potential therapeutic targets for reducing cardiomyocyte diastolic stiffness. rupress.org/jgp/article/...

📣 Call for Papers ⏰ DEADLINE APPROACHING: SEPTEMBER 30, 2026 📣 We welcome papers on Voltage-Gated Sodium Channels for a special issue, initiated in the context of the second Worldwide Sodium Channel Conference #WSCC26. Submit here 👉 rupress.org/jgp/pages/ca... #IonChannels #CallForPapers