Tim

Tim

@timisstuck.bsky.social

Executive Editor at Life Science Alliance. I help decide how biology thinks 🤔 Views are my own and do not reflect editorial policy. www.timfessenden.com

930 followers248 following430 posts

Pinned

Out now, a deep meditation on how we get from data collection to a richer understanding of biology: "The aim is only this: to protect the seam between doing and thinking, so that neither experimental rigor nor theoretical depth is euthanized to the pressure for rapid output."

Life Science Alliance@lsajournal.org

More data ≠ more understanding. Commentary in LSA maps where biomedical research breaks down along the data-information-knowledge-wisdom hierarchy and why scientists and AI alike must stay open to being wrong. #DIKW #AI @dokhlab @MedicineUVA www.life-science-alliance.org/content/10/1...

A very huge/syncitial congratulations to the authors. Reviewers really appreciated this work!

Our recent work on #Cellularization of the #ichthyosporean S. arctica is finally out in its final form @lsajournal.org www.life-science-alliance.org/content/10/1... Congrats to @margaridaaraujo.bsky.social @hiralshah.bsky.social @gautamdey.bsky.social & the rest of the team

Tim reposted

Comments to this are a shitshow. Essentially xkcd.com/927/. Honestly why did ORCID not succeed the way ror.org and to a great extent Crossref did? I'm sure there are many reasons but I do think they made a fundamental strategic error by refusing to own the researcher profile.

xkcd.comStandards

Tim reposted

We have published 3 papers through @reviewcommons.org The most notable difference was always how the manuscripts were evaluated for what they were rather than for the journal in which they were eventually published. That's simply how peer review should be!

EMBO@embo.org

We spoke with four researchers who have repeatedly chosen Review Commons as a preprint #PeerReview platform for their own work. 🧪 Learn why they decided on Review Commons here: https://www.embo.org/features/why-i-chose-review-commons/ #LifeSciences #research #publishing #preprint

Tim reposted

Thanks to Russ Vought for exposing this woke research

Geoff Brumfiel@gbrumfiel.bsky.social

The IceCube neutrino detector has won the 2026 Nobel Prize in physics. The Trump administration has proposed slashing its budget in half in 2027.

Most researchers treat impact factor like an objective measure of some natural law that just flows directly from journal performance. Approximately zero researchers know that IF is "owned" by a single company, and that many other measures of journal performance might be used instead.

Richard Sever@richardsever.bsky.social

Any sane academic evaluation policy would forbid mention of Impact Factor

Today's seminar speaker at Rockefeller was Svante Pääbo, who was introduced with the appropriate list of accolades/prizes. Including the Time Magazine top 100 people in 2007, shared with Barack Obama and Oprah. He began his talk by telling us he also shared the Times list with Osama Bin Laden 😂

Tim reposted

In 2022 we published an open-source hardware, software, and protocols ecosystem for repurposing sequencers as automated fluidics coupled imaging instruments. On Oct 13 @yougotkunal.bsky.social & @nygenome.org will host a workshop on current applications. Register here: regenseq.github.io/meeting/

regenseq.github.ioRegenSeq Community Meeting 2026Bringing together the RegenSeq community across multiplexed imaging, spatial transcriptomics, and optical pooled screening.

Immunology journal editor (in a webinar) "reviewers spend 1-2 hours to write a quality review" Seems kind of low to me? Is that true, immunologists?

It's Peer Review Week!! The one week a year when I actually read the peer reviews at LSA 😌 (this was a joke) But seriously this week I worked with a 1st time peer reviewer to significantly improve their comments which were initially not really appropriate. A win for us all!

We are all watching this experiment! Whatever the outcome, Biology Open deserves credit for testing this out. In the meantime, I am confident that every researcher who is shouting "pay peer reviewers!!" is of course sending all of their own manuscripts to this journal 😉

Biology Open@biologyopen.bsky.social

For this year's #PeerReviewWeek, we want to thank all the reviewers that have participated in BiO's Fast & Fair - an initiative that aims to provide authors with faster peer review decisions without compromising quality.

Do you think a seminar talk should be citable the way a paper is? Do you think oral presentations should be tracked and ranked the way clicks and citations on papers are? In this case I really worry about attention deficit disorder 😅

Altmetric@altmetric.com

NEW ATTENTION SOURCE From today Altmetric is tracking when research is cited within @cassyni.bsky.social recorded video seminars. Altmetric tracks both mentions of research in seminars, AND the seminars themselves as they are shared and cited.

I need to hear from the people about italicizing "in vitro" and "in vivo" in manuscripts: Should @lsajournal.org stick to the Council of Science Editors and various others' conventions and force authors to remove italics for these? I have heard that this request makes some authors unhappy...

QED Science correctly celebrates high-scoring preprints that were later published in lower impact journals. This is a helpful time to remind everyone that impact factor is a journal-level metric, was not, and still is not, any kind of metric for a single paper. But also...

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...We all know and recognize papers whose quality and significance seems discordant with the journal's impact factor. I think everyone feels really good pointing to unsung heroes, super important papers that were totally missed by editors and/or reviewers of competitive journals.

But I'm constantly told by potential authors that @lsajournal.org impact factor is not high enough for tenure/funding requirements. These "hidden gems" we all applaud were complete failures, according to institutional/grant review/prestige metrics!! Link: www.nature.com/articles/d41...

nature.comThis AI tool claims to pick the top 1% of preprints. Should researchers trust it?QED Science says that its metrics reduce bias by assessing papers solely on the basis of their originality and validity.

QED Science correctly celebrates high-scoring preprints that were later published in lower impact journals. This is a helpful time to remind everyone that impact factor is a journal-level metric, was not, and still is not, any kind of metric for a single paper. But also...

By pointing to a discordance between their article-level QED score and (perceived) journal prestige, they are reinforcing this toxic and flawed connection. (reminder journal impact factor was conceived as a tool solely for librarians to make subscription decisions) But this raises a paradox...

Tim reposted

🚨🚨🚨 #Editor Job alert! I’m not an editor, but if I decided to pursue career in scientific #publishing, then Company of Biologists is the organisation I’d most want to work for, & @jcellsci.bsky.social is the journal I’d want to work at 🤩 Details + link to job description in the link 👇

Journal of Cell Science@jcellsci.bsky.social

We’re looking for a Reviews Editor to join the team. Joining an experienced & successful journal team, this is an exciting opportunity for a talented scientific editor to make a significant contribution to an important journal in the field of cell biology. www.biologists.com/about-us/wor...

Weekend reading: this back and forth about a p16 reporter mouse for senescence and aging research. Read here in @emboreports.org and many more comments PubPeer. It seems to me that many journals are quite reluctant to publish these correspondences, to their great detriment.

This reflects a pathological conservatism of the glam journals, terrified of any potential blemish on reputation/prestige. But if we have journals for anything, surely it is as a venue to air these discussions. Anyway here's the link: doi.org/10.1038/s443...

doi.orgLimitations of the p16-3MR mouse model for detecting and eliminating senescent cells - EMBO ReportsThe p16-3MR mouse model, designed to express Renilla luciferase, mRFP, and herpes simplex virus 1 thymidine kinase (HSV-TK) under the p16INK4a promoter, has been widely used to visualize and ablate senescent cells in vivo, but our analyses revealed critical limitations. Bioluminescence signals in p16-3MR mice were extremely weak and virtually indistinguishable from those of wild-type mice injected with coelenterazine-h, indicating that previously reported signals largely reflected substrate background rather than authentic reporter expression. Signal intensity remained unchanged with aging, doxorubicin treatment, or cutaneous wound healing, failing to replicate earlier observations. Furthermore, RFP signals were undetectable in senescent fibroblasts from p16-3MR mice, and senescent cells were not eliminated by ganciclovir treatment, suggesting poor expression and lack of functional activity of the mRFP and HSV-TK transgenes. These results demonstrate functional deficiencies in all three transgenes, highlighting the importance of using wild-type controls and calling for careful reevaluation of studies employing this system.

They've been playing us for absolute fools. 8 basic sounds?? Completely derivative, no creativity whatsoever.

Quentin Bacquelé@quentinbacquele.bsky.social

1/ The world's songbirds sing in just 8 basic sounds. And where a bird lives decides which ones it uses. My first PhD paper is out now in @science.org (www.science.org/doi/10.1126/science.aee6239) Here is what we found:

Nice benchmarking resource for publication integrity guardrails with AI They prompted agents to generate false data or other forms of misconduct. Prompts were overt or covert attempts at misconduct, compared against a benign request. Strong showing for Claude, quite poor for DeepSeek

Tim reposted

People say scientists are serious but marine biologists will spend hours quietly sitting around tables drawing on styrofoam cups and then tying said cups to deep sea submarines Because ocean pressure will squeeze the air from the cups And we are but human & we want tiny cup

Congrats on this important babysitting adventure!

Peiwei Chen@peiwei-chen.bsky.social

How do transposons jump when they’re released from host control? I babysat two chromosomes for 2 years, making sure they are ok without most piRNAs. Here’s what we found & excited to share my 1st postdoc paper: “piRNA loss unleashes episodic transposition bursts” www.biorxiv.org/content/10.6...

Tim reposted

This collection explores emergent phenomena in #CellBiology incl. how cellular events are rapidly coordinated by waves of chemical & electrical signals, how tissue patterning is governed at the cellular level & how cellular interfaces guide cellular migration & morphology rupress.org/jcb/collecti...

As absolutely bat shit, crazy as this sounds, we should ask ourselves why an author might make this assumption. If you are an editor, could an author make this assumption about your journal? If you are an author, does the editor give any signal that they read the reviews?

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