Juan Pierella Karlusich

Juan Pierella Karlusich

@jjpk.bsky.social

Marine microbiologist & bioinformatician. Ramón y Cajal group leader at IBVF (U Sevilla-CSIC, Spain). Former postdoc in Sergey Ovchinnikov’s lab at MIT/Harvard & Chris Bowler's lab at ENS-Paris. PhD in UNR-Argentina.

579 followers1.1K following14 posts

Juan Pierella Karlusich reposted

Milot Mirdita
@milot.bsky.social

ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim 🐍pip install colabfold[alphafold] CF2 Sneak Peak with AF3/Boltz/Protenix/ESMFold2… 🐍pip install "colabfold[alphafold3]@git+https://github.com/sokrypton/ColabFold@af3-preview"

Juan Pierella Karlusich
@jjpk.bsky.social

The deep ocean is one of Earth’s largest and least-explored biomes. This dark, high-pressure realm harbors extraordinary microbial diversity. Our latest Preview highlights two fascinating studies of its microbiomes. Free access for a limited time: lnkd.in/eeKmuj32

Juan Pierella Karlusich reposted

Yo Akiyama
@yoakiyama.bsky.social

Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!

cell.comExpanding the scope of protein language modeling to protein-protein interactions with MSA PairformerProtein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...

Juan Pierella Karlusich reposted

Simon Kozlov
@sim0nsays.bsky.social

Yours truly is a proper scientist now! TL;DR: we used AI to redesign parts of essential cell machinery with only 19 canonical amino acids instead of 20. Why? Great thread by @harriswang.bsky.social provides more context and details. Let me talk a bit about the AI design part of this. 1/

Harris Wang@harriswang.bsky.social

1/ Excited to share our new paper in Science @science.org: “Toward life with a 19-amino acid alphabet through generative artificial intelligence design.” A great collab w/ Sergey's group @sokrypton.org at MIT @columbiasysbio.bsky.social science.org/doi/10.1126/... 🦠🧬🛠️🖥️💥

science.orgToward life with a 19–amino acid alphabet through generative artificial intelligence designBecause all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

Juan Pierella Karlusich reposted

Tara Oceans Science
@taraoceans-science.bsky.social

Hot off the press, the most comprehensive survey ever performed of diatom distributions, abundances, and diversity in the global ocean. All enabled by the famous schooner@fondationtaraocean.bsky.social and lots of hard work from the Tara Oceans team! www.nature.com/articles/s41...

nature.comPatterns and drivers of diatom diversity and abundance in the global ocean - Nature CommunicationsUsing the Tara Oceans dataset, this study describes global patterns of diatom diversity, abundance and adaptation. The authors identify 25 distinct communities, with the Arctic as a hotspot, and highl...

Juan Pierella Karlusich reposted

Tim Baxter
@timinclimate.naruresearch.com.au

Bluesky tip for newbies: Bluesky has no real algorithm. Likes here do nothing but show the poster that you enjoyed their content. That kindness is always going to be appreciated by creators, but if you want to help to boost something here, you have to repost it so others see it. 🙂

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