Martin Kampmann

Very excited to share our new preprint: Synaptic activity controls local exposure of an 'eat-me' signal via ANO3-ITPR1 signaling Great team effort and collaboration, led by MD/PhD student @kunalshroff.bsky.social in my lab - read more details in his post below:

Our paper is (finally) out in Cell today! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis www.cell.com/cell/fulltex... Great collaborative effort - read more from first author @asamelson.bsky.social below:

Congratulations on passing your qualifying exam, Reet Mishra! 🍾 #kampmannlabproud

Kampmann lab Halloween costume this year: Revenge of the lab rats (Including several KO mice) Happy 👻🎃

Thank you Alzforum for featuring our new preprint identifying regulators of disease states of #microglia. Project led by Amanda McQuade, computation by Reet Mishra, collaboration with the Nunez and De Jager labs. Alzforum www.alzforum.org/news/researc... Preprint www.biorxiv.org/content/10.1...

Apply by Oct 15 - please spread the word!

Find the CrAAVe-seq plasmid pAP215 here: www.addgene.org/217635/ Exciting work, thanks for sharing!

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes @kampmann.bsky.social @ivlrose.bsky.social www.nature.com/articles/s41...

Excited that the paper presenting our mouse brain in vivo CRISPR screening platform is out today in @natneuro.nature.com! Great team effort, led by Biswa Ramani and @ivlrose.bsky.social in the Kampmann lab. www.nature.com/articles/s41...

Tenure-track faculty search of the UCSF Biochemistry & Biophysics Department is open for applications! We are looking for creative, innovative scientists asking fundamental questions in any area of biology. Join our vibrant, collaborative, and supportive community! aprecruit.ucsf.edu/JPF05702

Very honored to receive this year's Byers Award in Basic Science! Huge thanks to my lab and our funders for enabling our research on Alzheimer's disease and related dementias. www.ucsf.edu/news/2025/07...

Farewell party for 4 great lab members, excited for their next adventures: Biswa Ramani (starting the Ramani Lab ‪@ucsanfrancisco.bsky.social‬), @venushagan.bsky.social (PhD @ucsanfrancisco.bsky.social‬), Cristian Chavira (PhD ‪@uwmadison.bsky.social‬), Kean Ehsani (Ramani lab). Thanks & best wishes

Stand up for science - stand up for the NIH! I just signed the support letter for the #BethesdaDeclaration. Please consider signing as well: www.standupforscience.net/bethesda-dec...

Farewell to Emily Marzette. Thank you so much for your many contributions to the lab! We will miss you lots but are excited for you to start grad school at UCLA! 🎉

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

www.alz.org/news/2025/ke...

Congratulations Rudra Bose, on passing your qualifying exam with flying colors! 🎉🎉🎉 #kampmannlabproud

Silencing of transgenes during iPSC differentiation is a frequent problem. 🧬🫢 Check out the piggyBac system below, which has resisted silencing in many protocols across many labs. 💪 Excited that our lab could contribute to this team effort led by @tuenaka.bsky.social & Marius Wernig!

As Trump & Musk tear down our federal science agencies & jeopardize U.S. global science leadership, CA needs to step up. I introduced legislation (SB 829) to create the California Institute for Scientific Research & solidify CA’s global science leadership in the absence of federal leadership.🧵

Congratulations Dr. @parkergrosjean.bsky.social! 🎓🎉🎉🎉 Thank you for your contributions to the Kampmann lab & UCSF - combining AI/ML with functional genomics to uncover regulators of neuronal activity. We are missing you already - but excited for your next adventures at @insitro.bsky.social!

Excited for our iAssembloid work, led by @emmyli.bsky.social to be featured on the cover of today's issue of @cp-neuron.bsky.social

Honored and grateful to receive the 2025 Bowes Biomedical Investigator Award - along with my friend, colleague and collaborator @annamolofskylab.bsky.social 😊🎉🎉🎉 www.ucsf.edu/news/2025/02...

In this time of chaos - something good! We are excited to share our final (or near final) speaker list for the 3rd UCSF Full Circle Symposium 4/3-4/4 to highlight Native biologists! Please share the word and register to attend the webinar in person! More info: qbi.ucsf.edu/full-circle-...

Congratulations Dr. Olivia Teter! 🎓🎉🎉🎉 Thank you for your many contributions to the Kampmann lab - scientifically and socially. We will miss you lots. All the best for your next adventure at Calico!

Welcome to the Bluesky account for Stand Up for Science 2025! Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide! #scienceforall #sciencenotsilence

Check out our new preprint: Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics Project led by @parkergrosjean.bsky.social - see his "blue-torial" below!

Thank you Alzforum for featuring our work! CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions - project led by @emmyli.bsky.social www.alzforum.org/news/researc...

www.cell.com/cell/fulltex...

Interested in using functional genomics to understand the brain in health and disease? Check out our Gordon research conference below! Slots for posters and short talks are still available! Deadline March 9th www.grc.org/functional-g...

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

Happy holidays from the Kampmann lab (incl alumni)!🎄✨

The @samelsonlab.bsky.social will uncover mechanisms of protein aggregation using an innovative combination of biophysics, genetics and cell biology. And @asamelson.bsky.social is a fantastic mentor and colleague. Highly recommended!

Farewell party for Kampmann lab postdocs @asamelson.bsky.social and Steven Boggess. Thank you for all your contributions - we will miss you both a lot! But excited for your next adventures: @samelsonlab.bsky.social (Avi) and @arcinstitute.org (Steven). Congratulations! 🎉🎉🎉 #kampmannlabproud

Implementation and validation of single-cell genomics experiments in neuroscience - a consensus paper. Excited to contribute perturbation-based approaches. www.nature.com/articles/s41...

Seems that @biorxivpreprint.bsky.social ought to consider adding links to @bsky.app posts given the mass transfer of scientists from Twitter to @bsky.app that is taking place.

Proud of new work tinyurl.com/yhz4c6ry from the lab by Zhicheng (Chen) Cui using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ G. Napolitano,A. Esposito, and A. Ballabio.

The Lawrence Lab website (lawrence-lab.org) is live and we are hiring for our launch in Jan 2025! We combine high resolution structure 🔬 and cell biology 🧪🧫 approaches to define mechanisms of stress response signaling in health and disease. Live postings below--Please RT and send to recent grads!

Checkout our updated preprint! Now live on BioRxiv. www.biorxiv.org/content/10.1... @kampmann.bsky.social We present our new and improved technique to do large-scale (5000+ genes) CRISPR screens directly in a mouse brain, all with cell type-specific resolution using a Cre-responsive sgRNA. Enjoy!

Our updated preprint is live! www.biorxiv.org/content/10.1... @kampmann.bsky.social We add new data: 1. A new CRL5 complex that targets tau for degradation 2. CUL5 as a marker of vulnerability in Alzheimer's Disease 3. Oxidative stress-derived tau fragments change in vitro tau aggregation

Excited to share this review on one of my favorite biological problems: Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms. Out in @NatRevNeurosci today! www.nature.com/articles/s41...

New pooled library fom @johndoench.bsky.social! The human, genome-wide, CRISPR knockout enAsCas12a gRNA library targets single genes and paralog pairs, triples, and quads with arrays of four gRNAs. www.addgene.org/pooled-libra...