Stephanie Kath-Schorr

Stephanie Kath-Schorr

@kathlab.bsky.social

Professor at University of Cologne, Germany. Organic Chemistry, Chemical Biology, Nucleic Acids

1.3K followers353 following13 posts

Stephanie Kath-Schorr reposted

Universität zu Köln
@unicologne.bsky.social

⚗️🧪 Universität zu Köln legt Grundstein der neuen Chemie Heute, am 1. Juni, wurde der Grundstein für die Neubauten der Chemischen Institute für die Bereiche Chemie und Biochemie und der Didaktiken in einem feierlichen Akt gelegt. Mehr dazu ▶️ uni.koeln/EX7YJ #uniköln #unicologne #unibaut #chemie

Stephanie Kath-Schorr reposted

Universität zu Köln
@unicologne.bsky.social

🔬📈 Bringing research to the market Patents are more than just legal protection: they transform laboratory discoveries into marketable innovations. The #UniCologne supports its researchers every step of the way, from the initial idea to the granting of a #patent. Read more ▶️ uni.koeln/WGUMB

Stephanie Kath-Schorr reposted

Universität zu Köln
@unicologne.bsky.social

📰 Das neue #Unimagazin ist da🎉 Diesmal mit einer Allianz fürs Leben, Verschwörungstheorien am Küchentisch und wie Forschung auf den Markt oder auch ans Krankenbett kommt. 🤝📈🏥 Alle Artikel sind auch online und als PDF verfügbar 🔗 uni.koeln/MHWK8 📲 #uniköln #unicologne #unimagazin #liebedeineuni

Stephanie Kath-Schorr reposted

Universität zu Köln
@unicologne.bsky.social

🧬🔬 A research team led by @kathlab.bsky.social has developed an artificial DNA base pair that works according to a new chemical principle. In contrast to natural bases, the novel artificial base pairs use halogen bonds that are enzymatically incorporated into DNA. Read more: ➡️ uni.koeln/AP4XF

uni.koelnArtificial DNA base pair developed based on halogen bondsA research team at the University of Cologne has developed an artificial DNA base pair that works according to a new chemical principle. In contrast to natural bases, the novel artificial base pairs u...
Stephanie Kath-Schorr
@kathlab.bsky.social

New paper in @jacs.acspublications.org 🎉: A de novo designed unnatural base pair that exploits halogen bonding as pairing force in DNA for genetic alphabet expansion. 🧬 ⚗️ @unicologne.bsky.social @chemunicologne.bsky.social @breugstlab.bsky.social pubs.acs.org/doi/abs/10.1...

pubs.acs.orgInvestigating Halogen Bonds as Pairing Force in an Artificial DNA Base PairThe past decades have seen significant expansion of the nucleic acid space with the development of modified artificial base pairs based on natural nucleic acid analogues and even entirely new designed base pairs. This expansion has led to tremendous potential for applications such as site-specific labeling and structural investigations. However, natural nucleic acids rely strongly on hydrogen bonding as the attraction force, which has driven the development of artificial base pairs that adapt this mechanism. To achieve orthogonality with natural bases, unnatural base pairs with alternative attraction forces, such as hydrophobic interactions, have been developed which however can perturb duplex structures. Our work introduces a completely newly designed artificial base pair that leverages halogen bonding (R–Hal···) as a directional hydrogen bonding-like interaction. We report computational studies that led to the development of this novel unnatural base pair and its synthesis. Our results demonstrate the successful acceptance of a bulky iodinated nucleoside triphosphate by KlenTaq DNA polymerase, enabling the selective enzymatic synthesis of a DNA strand containing the dIIPO–doIPP base pair. Our work presents the first demonstration of a novel base pair with halogen bonding potential that is enzymatically incorporated into DNA.
Stephanie Kath-Schorr
@kathlab.bsky.social

Honored to share some big news: I’m now tenured as a W3 Professor of Organic Chemistry @UniCologne! Immensely grateful to all the group members who contributed to this journey🙏 — this milestone is ours to share. @ChemUniCologne #OrganicChemistry #Tenure 🍾🎉🧪🧬

Stephanie Kath-Schorr reposted

ChemComm
@chemcomm.rsc.org

New from our Pioneering Investigators collection 🎉 'Towards a hydrolysis stable artificial base pair with C-glycosides' by Stephanie Kath-Schorr (@kathlab.bsky.social) and colleagues. #OpenAccess 🔓

buff.lyTowards a hydrolysis stable artificial base pair with C-glycosidesArtificial base-pairs expand the genetic alphabet and allow for site-specific labeling, for example with fluorophores or spin labels, thereby enhancing the capabilities of biomolecular sensing. We…

Stephanie Kath-Schorr reposted

RSC Chemical Biology
@rscchembio.rsc.org

We’re pleased to announce our latest Emerging Investigators article collection, highlighting work from outstanding early career researchers selected from the chemical biology community. Discover this exciting work, all #openaccess and free to read, at rsc.li/CBEMI24.

Stephanie Kath-Schorr reposted

TheGatherLab
@thegatherlab.bsky.social

Many thanks to all for this great collaboration pushing further the limits of microlasers - this time for DNA sensing. In particular to former #HCNB postdoc @sorayacaixeiro.bsky.social now at UBath and our friends from @kathlab.bsky.social in organic chemistry @chemunicologne.bsky.social.

bsky.appbsky.app
Stephanie Kath-Schorr@kathlab.bsky.social

🧬🔬New paper online: Nucleic acid sensing using DNA-functionalized whispering gallery mode microlasers! Great collaboration with @thegatherlab.bsky.social @sorayacaixeiro @schubertlab.bsky.social @chemunicologne.bsky.social 🧪 #DNASensing #microlasers pubs.acs.org/doi/full/10....

pubs.acs.orgDNA Sensing with Whispering Gallery Mode MicrolasersNucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring, and molecular biology research by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on DNA-functionalized whispering gallery mode (WGM) microlasers. By correlating spectral shifts in laser emission to changes in the refractive index, we demonstrate real-time detection of DNA hybridization and structural changes. The addition of gold nanoparticles to the DNA strands significantly enhances sensitivity, and exclusively labeling the sensing strand or a hairpin strand eliminates the need for secondary labeling of the target strand. We further show that ionic strength influences DNA compactness, and we introduce a hairpin-based system as a dual-purpose sensor and controlled release mechanism for drug delivery. This versatile WGM-based platform offers promise for sequence-specific nucleic acid sensing, multiplexed detection, and in vivo applications in diagnostics and cellular research.
Stephanie Kath-Schorr
@kathlab.bsky.social

🧬🔬New paper online: Nucleic acid sensing using DNA-functionalized whispering gallery mode microlasers! Great collaboration with @thegatherlab.bsky.social @sorayacaixeiro @schubertlab.bsky.social @chemunicologne.bsky.social 🧪 #DNASensing #microlasers pubs.acs.org/doi/full/10....

pubs.acs.orgDNA Sensing with Whispering Gallery Mode MicrolasersNucleic acid sensing is crucial for advancing diagnostics, therapeutic monitoring, and molecular biology research by enabling the precise identification of DNA and RNA interactions. Here, we present an innovative sensing platform based on DNA-functionalized whispering gallery mode (WGM) microlasers. By correlating spectral shifts in laser emission to changes in the refractive index, we demonstrate real-time detection of DNA hybridization and structural changes. The addition of gold nanoparticles to the DNA strands significantly enhances sensitivity, and exclusively labeling the sensing strand or a hairpin strand eliminates the need for secondary labeling of the target strand. We further show that ionic strength influences DNA compactness, and we introduce a hairpin-based system as a dual-purpose sensor and controlled release mechanism for drug delivery. This versatile WGM-based platform offers promise for sequence-specific nucleic acid sensing, multiplexed detection, and in vivo applications in diagnostics and cellular research.

Stephanie Kath-Schorr reposted

TIDE (RTG 2591)
@tide-rtg.bsky.social

Hello Bluesky! We are the TIDE group, a research training group working on template-designed #organicelectronics at #UniCologne and #UniBonn, funded by @dfgpublic.bsky.social. Follow us for news about our #research, our graduation program and events! ⠀ #phd #phdsky #sciencesky #chemistry #physics

Stephanie Kath-Schorr reposted

Thorn-Seshold Lab
@thornsesholdlab.bsky.social

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

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