Waggoner Lab

@biorxivpreprint.bsky.social CAR T cells reinforce their own suppressive niche in AML through atypical memory B cell polarization www.biorxiv.org/content/10.6... @lmu.de

CAR-NK cells delay HIV rebound and reshape HIV reservoir composition @natcomms.nature.com www.nature.com/articles/s41...

@biorxivpreprint.bsky.social Lysosomal adaptation to extracellular acidity compromises CD8+ T cell cytotoxicity www.biorxiv.org/content/10.6... @univlille.bsky.social @inserm.fr

@biorxivpreprint.bsky.social Weaning imprints a hybrid cytotoxic-regulatory identity on intestinal CD4+ T lymphocytes www.biorxiv.org/content/10.6... @danmucida.bsky.social @rockefeller.edu @ambilate.bsky.social

@biorxivpreprint.bsky.social Disease-associated NK-cell state remodeling reveals transcriptional profiles predictive of clinical phenotypes www.biorxiv.org/content/10.6...

Compartmentalized immune dynamics in amyotrophic lateral sclerosis @natmed.nature.com ⬆️Long-lived intrathecal T cell clones -> slower disease progression ⬆️circulating T cells, CMV-specific T cells & antibodiesin CSF -> faster progression www.nature.com/articles/s41... @ki.se

Inflammatory exposure (IFN-γ) & cell plasticity imprint a lasting transcriptional & epigenetic memory on intestinal stem cells & their progeny, priming them for enhanced repair after subsequent injuries www.nature.com/articles/s41... @natcomms.nature.com @idibell.bsky.social @guiulab.bsky.social

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution in mice @natcomms.nature.com @columbiamed.bsky.social www.nature.com/articles/s41...

Review: Macrophage biology and immunoregulation in health and disease www.nature.com/articles/s41...

STAT3 with a patient-derived substitution causes immune dysfunction by sequestering wild-type STAT3 www.science.org/doi/10.1126/... @garvaninstitute.bsky.social

Congratulations to Simon Grassmann @simongrassmann.bsky.social on his latest paper describing how Stat3 can act as a rheostat of inflammation, integrating distinct cytokine signals to qualitatively tune NK cell responses depending on viral burden @mskcc.bsky.social www.science.org/doi/10.1126/...

A CD4-lineage erythro–myeloid progenitor within the adult bone marrow defines an alternative pathway for macrophage generation www.nature.com/articles/s41... @natimmunol.nature.com @shwetatikoo29.bsky.social @meduniwien.ac.at @centenaryinstitute.bsky.social @drrohitjain.bsky.social

The maternal–fetal interface is an early hematopoietic niche enriched in distinct erythro-myeloid progenitors www.nature.com/articles/s41... @natimmunol.nature.com @shwetatikoo29.bsky.social @meduniwien.ac.at @centenaryinstitute.bsky.social @drrohitjain.bsky.social

Colorectal cancers with distinct metastatic potential trigger divergent early T cell responses @jem.org @danmucida.bsky.social @rockefeller.edu rupress.org/jem/article-...

A microbiome-reactive TMIGD2hi Th17 subset is spatially enriched at the intestinal epithelium and expanded in inflammatory bowel disease @cp-immunity.bsky.social @thexavierlab.bsky.social @broadinstitute.org www.cell.com/immunity/ful...

Review @cp-immunity.bsky.social Human brain cellular xenografts in neuroimmunology and beyond www.cell.com/immunity/ful...

Review @cp-molcell.bsky.social Small genomes, big lessons: What viruses teach us about structure-based riboregulation www.cell.com/molecular-ce...

Review @cp-cellreports.bsky.social Oral vaccine delivery systems: Gastrointestinal barriers, gut microbiota, and emerging engineering strategies www.cell.com/cell-reports...

Single-cell multi-omics reveals archetypal regulatory programs shared across T cell subsets @cp-cellreports.bsky.social www.cell.com/cell-reports... @yuripritykin.bsky.social @princeton.edu

In vivo genome-editing therapy for Duchenne muscular dystrophy: Preclinical studies and first-in-human trial @cp-cell.bsky.social www.cell.com/cell/fulltex...

Cincinnati Children's researchers uncover how sensory nerves help regulate allergic inflammation and pain in eosinophilic esophagitis. Published in Nature. Learn more: #EoE #Neuroimmunology

Gut epithelial aryl hydrocarbon receptor deficiency aggravates fungal dysbiosis-mediated neutrophilic allergic airway disease in mice @natcomms.nature.com www.nature.com/articles/s41...

Opposing cell-type preferences for binding and replication shape influenza A virus infection in human airways www.science.org/doi/10.1126/...

In situ CAR-M engineered by liposomal mRNA nanomedicine remodels fibrotic microenvironment for ameliorating liver fibrosis www.science.org/doi/10.1126/...

IFN-λ signaling to maternal dendritic cells protects against congenital Zika virus infection www.science.org/doi/10.1126/... @lazearlab.bsky.social

NAD+ metabolic restoration resolves the inflammation-immunocompetence trade-off in lung graft-versus-host disease www.science.org/doi/10.1126/...

Histone methyltransferase NSD2 shapes CD8+ T cell fates through the H3K36me2-Zbtb20 axis www.science.org/doi/10.1126/...

Death receptor–driven assembly of RIPK1/FADD/Caspase-8 complexes in senescent cells orchestrates addiction to IAPs www.science.org/doi/10.1126/... @tcddublin.bsky.social

An innovative colon inflammation-targeting platform for ulcerative colitis treatment www.science.org/doi/10.1126/... @hopkinsmedicine.bsky.social

An in situ forming immunomodulatory hydrogel reinvigorates exhausted CD8+ T cells via preserving their mitochondrial fitness doi.org/10.1126/scia...

ATF3-dependent IL-9 production by GITR-stimulated ILC2s promotes eosinophil accumulation and cytotoxic tumor control @sciimmunology.bsky.social www.science.org/doi/10.1126/...

Tissue-resident macrophages sense colonic stiffening via Piezo1, releasing NGF to sensitize TRPV1+ nociceptors for visceral pain @sciimmunology.bsky.social www.science.org/doi/10.1126/... 🇨🇳

Antigen-independent IgM BCR signaling intrinsically limits human IgM plasma cell differentiation, survival, and in vivo persistence by elevating basal calcium flux and restraining IRF4 and BLIMP1 induction rupress.org/jem/article-... @jem.org @seattlechildrens.org

Multi-omics profiling of primary human B cells activated via distinct stimuli www.nature.com/articles/s41... @natcomms.nature.com @bostonchildrens.bsky.social

Review @natimmunol.nature.com Cytokine circuits in CNS homeostasis and disease www.nature.com/articles/s41...

Hydrogel for sustained and localized delivery of a regulatory T cell-inducing agent promotes bone regeneration @natbiomedeng.nature.com @harvard.edu www.nature.com/articles/s41...

Microparticles released from ultraviolet-irradiated erythrocytes enhance anti-tumoural T cell immunity via TH1 cell adjuvant activity @natbiomedeng.nature.com www.nature.com/articles/s41... www.nature.com/articles/s41...

Determinants of response to CAR T cell therapy in a multicenter, multi-trial cohort analysis of patients with lymphoma @natmed.nature.com www.nature.com/articles/s41...

Serine protease inhibitor A3 is a soluble SIRPα ligand that suppresses inflammation and antitumor immunity @natimmunol.nature.com www.nature.com/articles/s41...

NF-κB responses are functionally partitioned by enhancer architecture: phos-sensitive sites define a NF-κB-dominated latent enhancer compartment, whereas primed sites are embedded in broader networks of lineage-determining factors @cp-immunity.bsky.social www.cell.com/immunity/ful...

Taurine lowers inflammaging by regulating the NLRP3 inflammasome in macrophages @cp-cell.bsky.social www.cell.com/cell/fulltex...

A granzyme-independent function of perforin as a direct executioner of cancer cell death through ferroptosis @cp-cell.bsky.social www.cell.com/cell/fulltex... @umichmedicalschool.bsky.social @harvardmed.bsky.social @barroso8.bsky.social #Zou #Lieberman

Could GLP-1s change how the immune system responds to disease? LJI Prof. Alessandro Sette (@settelab.bsky.social) is investigating whether GLP-1 medications change immune cell responses to antigens associated with common infections and neurodegenerative diseases. bit.ly/4zSQoeZ #GLP1 #health

Lung neuroendocrine cancer induces immunosuppressive macrophages via serotonin to drive resistance to the T cell engager tarlatamab @cp-cancercell.bsky.social www.cell.com/cancer-cell/...

Lifestyle-induced regulatory T cell fragility primes adverse events after immune checkpoint blockade @cp-cell.bsky.social @overacrelab.bsky.social @upmchillmancc.bsky.social www.cell.com/cell/fulltex...

Intron retention regulates STAT2 function and associates with immunotherapy response in lung cancer @science.org www.science.org/doi/10.1126/...

Two proteins that permeabilize mitochondria promote cell death through distinct mechanisms @science.org @mskcancercenter.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...

The TCF-1-E-protein axis preserves stem-like Th17 identity and prevents autoimmune pathology @cp-cellreports.bsky.social www.cell.com/cell-reports...

Review @cp-cellrepmed.bsky.social CNS targeted AAV gene therapies: Recent advances and clinical insights www.cell.com/cell-reports...

Deletion of Ctps1 in T cells prevents GVHD and reduces skin rejection @cp-cellrepmed.bsky.social @inserm.fr www.cell.com/cell-reports...