Lisa Buchauer

Lisa Buchauer

@libuchauer.bsky.social

Computational Biologist. Mathematical models, omics methods and data analysis for immunology and infection research at Charité Berlin. https://buchauer-lab.eu

794 followers926 following45 posts

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Lisa Buchauer reposted

We care a lot about time. Now one of my best science friends, Melania Barile, et al. introduce TemporalVAE, a deep generative model that maps scRNA-seq data onto developmental time! It works with zero-shot & identifies time-sensitive genes @natcellbio.nature.com 🧪

doi.orgTemporalVAE: atlas-assisted temporal mapping of time-series single-cell transcriptomes during embryogenesisNature Cell Biology - Liu et al. present TemporalVAE, a method for integrating single-cell time course data. The model proposes a workflow to determine the biological timing of samples and its...

Lisa Buchauer reposted

Few dates left to apply for this tenure-track professorship on Single-Cell Systems Biology in my department at @uni-wuerzburg.de. Competitive package and highly attractive research environment at the Institute of Systems Immunology.

Dominic Grün@dominicgrun.bsky.social

We have an attractive opening for a tenure-track professorship in Single-Cell Systems Biology. Excellent package and infrastructure at @uni-wuerzburg.de Institute of Systems Immunology. Great place to live and work in the heart of the franconian wine region! jobs.sciencecareers.org/job/673667/j...

Lisa Buchauer reposted

Lisa Buchauer reposted

We are currently recruiting a bioinformatics/computational biology postdoc to join the infrastructure project of a newly funded large research consortium (SFB-TRR) on Circadian Medicine between Charité - Universitätsmedizin Berlin and Universität zu Lübeck ⌚ ⏰ ⏱️ 🕰️ !

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We are currently recruiting a bioinformatics/computational biology postdoc to join the infrastructure project of a newly funded large research consortium (SFB-TRR) on Circadian Medicine between Charité - Universitätsmedizin Berlin and Universität zu Lübeck ⌚ ⏰ ⏱️ 🕰️ !

We are looking for independent, detail-oriented individuals that want to make a difference for the entire consortium by constructing high-quality data assets and innovative computational omics methods with a circadian twist.

Lisa Buchauer reposted

decoupler has been very useful for us & helps you dive into meaningful sc analysis quickly! small suggestion to increase uptake: consider changing the logo, at least two python users here initially immediately closed the tab as they thought is was an R package🙃

Saez-Rodriguez Group@saezlab.bsky.social

🔧 decoupler 2.0.6 is out thanks to @paubadiam.bsky.social‬, now as a core @scverse.bsky.social package scverse.org This release includes a streamlined API aligned with scverse standards, updated vignettes, and a new one on pseudotime enrichment analysis 👇 decoupler.readthedocs.io/en/latest/

Lisa Buchauer reposted

Honored that our lab made the shortlist for Best Research Environment. Awesome initiative by Junge Akademie and proud of the incredible Gaebler Lab team and the entire Infectious Disease Department at Charité/BIH that makes this place what it is! 👏 @libuchauer.bsky.social @sanderlab.bsky.social

Die Junge Akademie@jungeakademie.bsky.social

🦠 Das Department Translationale #Immunologie viraler #Infektionen an der Charité Berlin und am @bihatcharite.bsky.social ist mit 23 weiteren Teams im Lostopf für das „Beste Forschungsumfeld". Mehr zum Preis und den Teams hier lesen: 👉 www.diejungeakademie.de/de/projekte/...

Welcome Roberta, excited to have you with us & wishing you good luck!

Roberta Colapietro@robertacolapie.bsky.social

Been silently lurking here for a while 😶‍🌫️ so I figured it’s time to say something. And what better moment than the start of a new adventure in Berlin? And what better way to start an adventure than with the ISCO conference? Excited for everything scRNA-seq ahead with @libuchauer.bsky.social and team!

Lisa Buchauer reposted

🚨 Preprint Alert! New work from the group! 🟤 We set out to explore how brown adipose tissue (BAT) adapts to cold. 🧬🖥️ Using single-nucleus mRNA-sequencing, we dissected murine BAT and uncovered distinct adipocyte subtypes. 🫓 One in particular stood out... 🧵 1/7

Lisa Buchauer reposted

Come and join our seminar series!

CompCancer PhD programme@compcancer.bsky.social

Exciting line-up for our CompCancer colloquium for spring/summer 2025: - March 26th: Helen Byrne, Oxford - April 30th: Altuna Akalin, Berlin - May 14th: Florian Markowetz, Cambridge - June 16th: Sohrab Shah, New York 4pm, Maud Menten room, 3rd floor, House 18, Philippstr. 13, 10115 Berlin

Lisa Buchauer reposted

This! Also well put in this editorial in PLOS Comp Biol: Putting benchmarks in their rightful place: The heart of computational biology doi.org/10.1371/jour...

Joe Greener@jgreener64.bsky.social

I have a lot of time for benchmarking studies that don't try to sell a new method as well, it increases the credibility of the results. The thought of installing 55 pieces of bioinformatics software fills me with dread. (3/4)

Lisa Buchauer reposted

Lisa Buchauer reposted

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3) doi.org/10.1038/s415...

doi.orgAnalysis of multi-condition single-cell data with latent embedding multivariate regression - Nature GeneticsLatent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

Lisa Buchauer reposted

Nach den neusten RKI-Zahlen sinken die Impfquoten gegen verschiedene ansteckende Krankheiten wie Polio (Kinderlähmung). Gerade in Kreisen mit ohnehin niedrigeren Polio-Impfquoten (Beispiele Main-Tauber und Deggendorf in der Grafik) ging es drastisch nach unten; deutlich weniger Veränderungen wo…

Lisa Buchauer reposted

A few days left to apply if you would like to work on spatial multi-omics modeling in an interdisciplinary team!

Dominic Grün@dominicgrun.bsky.social

Hiring! I'm looking for a postdoc in machine learning of spatial single-cell data. Exciting project to develop methods for modelling cellular circuits in disease and regeneration of heart, liver and bone marrow using Xenium data from our lab. tinyurl.com/ymkvk7vn

Lisa Buchauer reposted

HIV - Heilung in Sicht? Sehr informativer und differenzierter Artikel in der @taz.de über die Fortschritte und Herausforderungen in der HIV-Forschung & Therapie und der Lange Weg zur Heilung. @cgaebler.bsky.social gibt spannende Einblicke in seine Forschung an der Klinik f. Infektiologie #Charité

taz.deHIV-Forschung: Kurz vor der Heilung?Einst bedeutete Aids den Tod, heute ist es eine gut behandelbare Erkrankung. Aber heilen lässt sie sich noch nicht. In Berlin will man das ändern.

Lisa Buchauer reposted