Pietro Berico

New preprint from the Hernando lab! www.biorxiv.org/content/10.6... Combining 3D genome profiling and high resolution imaging we demonstrate how chromatin architecture cooperate with mechanical confinement in conferring melanoma mesenchymal cells high migratory capacities.

gentlemansride.comPietro Berico | The Distinguished Gentleman's RideSupport Pietro Berico's fundraising campaign. They've raised $52 so far!

4 Apr

Support my DGR fundraising journey! I will be riding my Indian Chieftain with hundreds of others bikers to rise awarness on men's mental health and prostate cancer! gentlemansride.com/fundraiser/P...

Last but not least, thanks to our fundings from NIH/NCI, @melanomaresearch.bsky.social , Melanoma Research Foundation and National Cancer Center!

Thanks to our neighbors collaborators at @nyulangone.bsky.social , @nyumedpostdocs.bsky.social, particularly the Skok and Aifantis Labs.

Thanks to the Backman Lab, our main collaborator from the @physgencenter.bsky.social at Northwestern University in Chicago!

aacrjournals.orgA targetable developmental program co-regulates angiogenesis and immune evasion in melanomaAbstract. Ultraviolet (UV)-induced DNA mutations generate genetic drivers of cutaneous melanoma and numerous neoantigens that can trigger anti-tumor immunity. Melanoma cells must therefore rapidly eva...

4 Feb

Sharing our latest work from the Hernando lab in @aacrjournals.bsky.social Cancer Discovery. Thanks to the collaborative effort between #nyulangone and internation institutions we show how melanoma cells can evade the immune system by activating the transcription factor HOXD13.

@whitefishlab.bsky.social

6 Feb

Thanks to @melanomaresearch.bsky.social, MRF and NCC for funding my postdoc and this work!

Pietro Berico reposted

Richard White

28 Aug 2025

Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new Nature (@nature.com)‬ paper, Miranda Hunter (@mrndhntr.bsky.social‬) found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2

biorxiv.orgThe carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasisBrain metastatic cells undergo metabolic adaptations, such as increased reliance on oxidative phosphorylation. Integrating proteomic and transcriptomic profiling of patient samples revealed a consiste...

5 Apr 2025

Another great preprint out from the Hernando lab, lead by Maria Gomez and Allie Kartz. Did you know that melanoma brain metastasis upregulate the carnosine dipeptidase CNDP1 through MITF to prevent intracellular copper accumulation? www.biorxiv.org/content/10.1...

nature.comPan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity - Nature CommunicationsSuper-enhancers (SEs) drive specific gene expression programmes underlying different cancer cell states offering opportunities for therapeutic targeting. Here, the authors suggest targeting SE-depende...

9 Jan 2025

Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to the only one Frédéric Coin and collaborators! www.nature.com/articles/s41...

Pietro Berico reposted

Dan Landau

@landau.bsky.social

2 Jan 2025

Excited to share a major breakthrough from the lab! D&D-seq is a new technology that bridges a key gap in single-cell multi-omics/genomics : the ability to map DNA:Protein interactions (e.g., TFs or chromatin remodellers). Led by Ivan Raimondi, Wei-Yu Chi and Sang-Ho Yoon

ivanraimondi.bsky.social@ivanraimondi.bsky.social

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting. Check it out here: biorxiv.org/content/10.1... #Genomics #Epigenetics

biorxiv.orgSingle-cell mapping of regulatory DNA:Protein interactionsGene expression is coordinated by a multitude of transcription factors (TFs), whose binding to the genome is directed through multiple interconnected epigenetic signals, including chromatin accessibil...