Kirsty Wan

Kirsty Wan

@micromotility.bsky.social

Cilia and cell motility enthusiast, basal cognition, weird organisms esp protists and larvae, how do living systems compute? Professor of Cellular & Biophysical Dynamics, Living Systems Institute, Exeter (past: DAMTP, Cambridge) www.micromotility.com

2.7K followers593 following307 posts

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Do #tintinnids dream of electric sheep? 🤯 Here is a single cell capable of building a lorica and living inside it for protection... it also swims, feeds, hunts Can even detect and habituate to mechanical cues! #celllearning #protistsonsky #cilia Read more in our preprint doi.org/10.64898/202...

Kirsty Wan reposted

An old friend asked if I had any videos of cilia laying around for her class to see. I dug up this one from about 10 years ago and it could maybe win a prize for 'most similar to a wacky waving inflatable tube man'.

The future of biology is not just about collecting more data, but also about uncovering new principles and deriving new understanding. Theory and expts go hand in hand! See www.asimov.press/p/theory-bio... Excited that Theory & Concepts is back for the 3rd edition: come join us at EMBL next July!!

asimov.pressOn the Role of Theory in BiologyBiology is often seen as an experimental science, with theory serving to generalize patterns from empirical data. But history reveals that theory plays a more generative role in discovery itself.
EMBL Events@events.embl.org

Are you curious about theoretical and quantitative approaches to understanding living systems? Then you should not miss out on #EESTCBio! 🧬 Submit your abstract by 13 Apr to explore how biology can be understood, not just measured: s.embl.org/ees27-06-bl

in which we will explore which new theories and concepts (not just AI!) are needed to help us understand and explain living systems, uncover universal principles, and formulate 'Hilbert problems' for biology... We already have a fantastic list of speakers lined up, see you there! 😜

Kirsty Wan reposted

Lise Meitner was the 2nd woman to earn a physics PhD at the Univ of Vienna and Germany’s first female physics professor. She fled Nazi Germany, helped explain nuclear fission, and has an element named for her. 49 Nobel nominations, she never won. Her male colleague did. #SheShed #VivaHerAlliance

Love this little article about all the beautiful appendages found in the microscopic world! #flagella #archaella #cilia The best part: no AI in sight! (next time I will need to put some scalebars on! 😉)

STCmicrobeblog@stcmicrobeblog.bsky.social

Watching Flagella (or Cilia) in Motion by Christoph — Still images do not tell whether cells rotate their flagella like a propeller or flap them like a whip. To find out, one has to film living cells...

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the study suggests that protistan predators can perceive and adapt to environmental changes (such as prey abundance) by modulating their behaviour -- a basic form of cellular cognition. Could such ancient traits have been present in LECA?? studying these #excavates could provide new insights!

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...over successive days of typical culture cycles. The same basic morphology leads to surprisingly different adaptive behaviours! While some species dramatically increase proportion of swimmers and the effective diffusivity of foraging as food becomes increasingly scarce...

Cells have a characteristic morphology: two flagella and a feeding groove, the posterior flagellum beats inside the groove to facilitate feeding. We performed expansion microscopy to compare their morphologies, and extensive live-imaging and tracking to compare their behaviours...

Kirsty Wan reposted

From bioRxiv to PNAS! 🎉 Very happy to see our paper “Diversity and spatial segregation of TRP channels in the closest relatives of animals” now published in @pnas.org. Another piece in the puzzle of how animal cell signalling evolved. www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
Pawel Burkhardt@pawelburkhardt.bsky.social

How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...

yes so happy for him!!! this is exactly why we do curiosity-driven science... #chlamydomonas #protistsonsky Funders and universities are you watching...???

Nobel Prize@nobelprize.org

Peter Hegemann and Georg Nagel – awarded the 2026 medicine prize – discovered a remarkable protein, channelrhodopsin, in a single-celled alga. Hegemann wondered how Chlamydomonas, a single-celled alga, is able to swim towards a light source.

Kirsty Wan reposted

Having seen the news: www.bbc.co.uk/news/article... thought I'd share a cilia movie captured at UCL GOS ICH with Eriomina Shahaj & Vanesa Papastavrou using simple DIC on a Nikon Ti2 with DIC at 60x1.4. 500 fps here slowed down 20 times. Processed with Nikon's denoiseAI and an unsharp mask in Fiji.

Kirsty Wan reposted

#FluorescenceFriday: Given the recently grown interest in ciliary beating, here is a movie of beating cilia in a human airway model that I captured last week with lattice light-sheet microscopy. No AI „processing“, this is the raw data! Frame rate is ca. 170fps, displayed here at 25fps.

Kirsty Wan reposted

To add to all the lovely videos of non-AI processes multicilia beating: ctenophore multiciliated cells! They can reach up to 1mm long, causing a rainbow light refraction effect with the correct light positioning! Taken by myself at MBL in 2019 embryology. Realtime frame-rate!

The (another) weird thing about this is where the 'flow' comes from, they are beating quite randomly to start off with but then suddenly all bend to one side when the 'camera' sweeps across the field of view

Peter Carlton@carltonlab.org

Registered from the beginning, caveats about compression etc apply of course

Kirsty Wan reposted

I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky

FMI science@fmiscience.bsky.social

📢 We’re hiring! Join Caitlyn McCafferty’s (@computingcaitie.bsky.social) new group as Lab Manager and help shape lab operations, develop protocols and support research on the structure and dynamics of motile cilia. Apply by October 9: www.fmi.ch/education-ca...

Kirsty Wan reposted

Terence Tao says AI companies are harming mathematics by dropping new results without engaging with academia. “These companies are dumping carcasses of raw meat onto our table and saying ‘here you go, I solved your food problem’ and then they just leave." www.newscientist.com/article/2588...

newscientist.comTerence Tao: AI companies are harming mathematics | New ScientistAI companies are making new mathematical discoveries at a rapid pace but not sticking around to help unpick the new proofs. That is not the way to advance our understanding, says mathematician Terence...

Kirsty Wan reposted

Kirsty Wan reposted

I really like this work, from imaging to analysis. Here is my 5 cents on why it is cool. In short, to acquire a shape of a beating cilium without a smear, you need to record at ~1000 fps, i.e. have time resolution of ~ 1 ms. This is a current limit of modern "high-end" scientific cameras. (1/N)

Kirsty Wan@micromotility.bsky.social

Pterosperma is a beautiful flagellate w/ 4 extremely long cilia. These cilia are so long that they can produce an entire spectrum of beating modes... To resolve the these beating patterns, we analysed >200,000 waveforms, and reconstructed the underlying manifold - strikingly low dimensional!

Pterosperma is a beautiful flagellate w/ 4 extremely long cilia. These cilia are so long that they can produce an entire spectrum of beating modes... To resolve the these beating patterns, we analysed >200,000 waveforms, and reconstructed the underlying manifold - strikingly low dimensional!

The ciliary beat patterns obey a fascinating mathematical relationship known as a "dispersion relation" — which links how fast the cilia beat (temporal freq) to the shape of the waves (spatial freq) they produce. (such a relationship exists for any undulatory swimmer, from C. elegans to snakes!)

Kirsty Wan reposted

Thrilled to announce that together with Klaus Lehnertz and Timo Bröhl, Universitätsklinikum Bonn , Wolfram Barfuss, The University of Bonn and Mehrnaz Anvari, Fraunhofer SCAI we are organizing the XLVII Dynamic Days Europe 2027 in Bonn! #DynamicDaysEurope @mpinb.mpg.de

Kirsty Wan reposted

Cool new behavior caught on video! This is a special type of octopus known as a #papernautilus (aka #argonaut) and her shell is a little less than 5cm. Watch as she extends and retracts her fleshy mantle - at the end, she rapidly retracts it all! #blackwater #blackwaterdiving

Kirsty Wan reposted

While the Fields Medal celebrates the under-40s, the mathematician Joan Birman has, at the age of 99, solved a major open problem in representations of the Braid groups, a topic she has worked on for more than 60 years.