Nature Biotechnology

Expanding global access to synthetic biology - @sudarshangc.bsky.social @iitalk.bsky.social www.nature.com/articles/s41...

Giving AI a seat at the peer review table - @kdrosatos.bsky.social www.nature.com/articles/s41...

@regeneron.com's newly approved antibody stops abnormal bone growth in patients with the devastating disease fibrodysplasia ossificans www.nature.com/articles/s41...

Ever wondered what a cell has experienced in the past? This is in general hard to measure. Here we introduce the recordanelle, to equip cells with a tool that lets them record their own history. www.nature.com/articles/s41... @natbiotech.nature.com @ethz.ch @bsse.ethz.ch

Our final version of human AGO2 led editing of RNA is out today in @natbiotech.nature.com! Led by @rflusi.bsky.social, we got excited by the reduced immunogenic risk and efficacy advantages of using a human-derived protein for non-downregulatory RNA manipulation. www.nature.com/articles/s41...

My major postdoctoral work is out today in Nature Biotechnology! Grateful to my co-authors Salvi and Corey, and to my advisor @stevenbanik.bsky.social

btw, @natbiotech.nature.com has a fantastic podcast series on the company and its founder, Stan Crooke: www.nature.com/immersive/d4...

Huge congratulations to @vivzhong.bsky.social, @michaelajonesphd.bsky.social and team on the publication of their work in Nature Biotechnology today! They engineered plants to produce a non-canonical amino acid that regulates gene expression in engineered microbes! 🌱 doi.org/10.1038/s415...

Epithelial organoids are grown without Matrigel using a single-chain antibody go.nature.com/3Le6j3i rdcu.be/8aRvgWzbvuRa

An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13 go.nature.com/4oglebG rdcu.be/ZaS8Y5zE3WVa

Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells - @darkobar.bsky.social @weillcornell.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

Regeneron approval brings relief for ‘second skeleton’ bone disorder www.nature.com/articles/s41...

Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints go.nature.com/4aRDpk8 rdcu.be/ZqESYB6vavSa

Genetic code expansion enables plant-directed control of bacterial activity - @kunjapur.bsky.social @jennbrophy.bsky.social www.nature.com/articles/s41...

Engineered human Argonaute 2 for targeted C-to-U RNA base editing - @stevenbanik.bsky.social @stanfordchemistry.bsky.social @stanford-chemh.bsky.social www.nature.com/articles/s41...

In Brief: @fda.gov greenlights $IONS's #Zanvastro, the first disease-modifying drug for a rare, progressive and often fatal neurological condition known as Alexander disease www.nature.com/articles/s41... rdcu.be/ufenZXWBDYda

Five questions with Bowen Li www.nature.com/articles/s41...

Each year, we highlight companies that received sizeable early-stage funding in the previous year. Bioptimus is developing multimodal and multiscale AI pathology models for biomarker and drug treatment prediction www.nature.com/articles/s41...

FDA approves breast cancer drug that nips resistance in the bud. My latest story for @natbiotech.nature.com Camizestrant is one of a wave of new drugs developed for estrogen receptor-positive breast cancer www.nature.com/articles/s41... readcube: rdcu.be/R76RPfTXWvsa

Fabulous to see this editorial from @natbiotech.nature.com highlighting HCA achievements and technologies over the past 10 years, and the ambitious plans for the future. Watch this space! #HumanCellAtlas #Genomics

While mammalian delivery technologies are advancing to translation at an exceptional rate, delivery to plant tissues faces challenges, limiting their practical applications www.nature.com/articles/s41...

In Brief: @fda.gov approves $RVMD’s #Rasonque, a first-in-class RAS inhibitor targeting the most common form of pancreatic cancer. An early-stage trial shows that the drug also has promise in lung cancer www.nature.com/articles/s41... rdcu.be/hJwr1gqQSW3a

SaprotHub is a community repository for protein language models go.nature.com/47lrRSX rdcu.be/haoUoENZakxa

Research Highlight: Engrafting human cortical organoids www.nature.com/articles/s41... rdcu.be/1Rumz1MRUdEa

The global patent landscape of CRISPR–Cas applications in medicine www.nature.com/articles/s41...

Ten years, tens of millions of cells www.nature.com/articles/s41...

The October issue is live www.nature.com/nbt/volumes/... On the cover, engineered inhalable exosomes display a bispecific T cell activator targeting a cancer cell along with a T cell go.nature.com/496Ins7 rdcu.be/avnjBsFZKzFa

Excited to share Shotgun Genetic Engineering, developed by @julietrolle.bsky.social out now @natbiotech.nature.com! Read on to learn how Julie enabled mammalian cells to grow without 2 essential amino acids for the first time in >500 million years using highly multiplexed metabolic engineering!

🚨 NEW PUBLICATION 🚨 "Detectrons convert transient RNA sequences into stable DNA barcodes for high-throughput analysis of RNA-dependent processes" @seth-shipman.bsky.social @jihoon-han.bsky.social @natbiotech.nature.com