Markus Elsner

LLMs are a curse for rebuttal letters. If I ask a simple question, I don’t need to be reminded of the whole history of the project, its potential applications to everything in biomedicine, and (a new, annoying LLM tic) a long list of things you can't conclude.

A more than 40% risk reduction “would send many researchers over the Moon”. This personalised mRNA vaccine reduced the risk of skin cancer returning or the recipient dying by 42% go.nature.com/4ik3TNr

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We report a new RNA imaging platform based on 𝗥𝗵𝗼𝗕𝗔𝗦𝗧 and fluorescence life time microscopy; 𝗥𝗵𝗼𝗕𝗔𝗦𝗧-𝗙𝗟𝗜𝗠. It is more sensitive than intensity based imaging and enables higher resolution in 𝗦𝗧𝗘𝗗. It was very fun to work with amazing @xiaoxiao94.bsky.social and Berkan in this project. Congrats!

Want to try out the recordanelle? All key plasmids are now available at @addgene.bsky.social ➡️ addgene.org/browse/artic... Paper: nature.com/articles/s41... @natbiotech.nature.com #OpenScience #SynBio #scRNAseq

Just published! Recordanelles for transcriptome-wide single-cell RNA recording in human cells 📝 Find the plasmids here: www.addgene.org/browse/artic...

The transition to setting up one's own lab is a steep learning curve. From 21–23 October, EMBO is hosting a workshop for group leaders in #Singapore to help them navigate this transition: https://meetings.embo.org/event/starting-your-own-lab-2 🧪 Leadership Sculptor GmbH #career #SoftSkills #training

As someone who thinks about the Roman Empire more than he should, this is a Cell paper to my taste (and totally unrelated to what I do in my day job): www.cell.com/cell/fulltex...

This sounds cool!

Deep dynamical models of single-cell multiomic velocities predict loss-of-function and rescue perturbations in B cells - @darkobar.bsky.social @weillcornell.bsky.social @mskcancercenter.bsky.social www.nature.com/articles/s41...

Can't wait to test this

1/n Crossover episode! We just released RFD4-Proteina, our latest protein design model - and the result of a year-long collaboration between the Baker Lab and NVIDIA GenAIR (the name says it all…). I hope you’ll agree - the results are astonishing. 🌐 Website: rfd4-proteina.org

What if we could control where drugs are delivered in the body? Our lab developed tiny particles that can carry mRNA to specific parts of the body, and with 3D imaging, we can visualize where they go 🤩 This technology can help with so many chronic diseases... Paper: www.biorxiv.org/content/10.1...

This Review in the October issue discusses insights from clinical studies on mRNA-based therapeutics, including enzyme replacement therapies, cancer immunotherapies, genome-modifying therapies and immune cell reprogramming therapies www.nature.com/articles/s41... rdcu.be/7oahN7b3b3Ha

This is a project very dear to my heart. Very proud to be able to contribute to this a bit.

Our multi-immersion oblique plane microscope manuscript is online now. A light-sheet system that can be adapted to different imaging tasks, including a volumetric correction for imaging in media of any refractive index. @amsikking.bsky.social www.nature.com/articles/s41...

BindCraft2 v1.0.4 has been released: with significantly improved VHH, scFv, ARP, and induced fit targeting. WE also improved speed and code stability. Try your difficult campaigns again. Great work by @erikmaeots.bsky.social , Leonardo Tredese and @liza-ch.bsky.social

🇧🇷 **Brasil soberano!** **BRAZIL BELONGS TO BRAZILIANS. NOT TO TRUMP.** **OUR COUNTRY IS NOT FOR SALE!** Bolsonaro nunca mais. #BrasilVerdeAmarelo #Lula13

🎉 Our paper is out today in @science.org! How does the intestine maintain the right balance of cell types? We find that signalling rhythms matter! So proud of our three shared first authors, Sonja Weterings, @hiromuneeto.bsky.social & @jddeleede.bsky.social! 🔗 www.science.org/doi/10.1126/...

LoL-align is out in @natmethods.nature.com! It aligns protein structures without superposition. More sensitive than TM-align and DALI, producing better alignments 5–20× faster. Now available in Foldseek! 📄 www.nature.com/articles/s41... 💾 github.com/steineggerlab/foldseek 🌐 search.foldseek.com

Arggg, I wish German trains were on time once in a while. Another missed late night connection that buys us an hour at beautiful Frankfurt Main station

We have an incredible October issue on in vitro systems, which was spearheaded by my amazing colleague Valeria Caprettini on my team. I'm just so proud of her and the issue for how beautifully it all came together.

A new lab has launched at our Janelia Research Campus! The Lincoln Lab — led by Group Leader Richard Lincoln — combines photochemistry, computational modeling, & physical chemistry to engineer next-gen fluorescence microscopy tools for Tools@HHMI: bit.ly/3Vq0mFI. 📸 Richard Lincoln & Matthew Benton

Where does the Spike protein end up in the body? 🔬 Using DISCO-seq, researchers like me can now explore this in 3D by mapping SARS-CoV-2 Spike S1 across the bodies of mice. Could this help us better understand #LongCOVID? Lead by @harsharanbhatia.bsky.social at: www.biorxiv.org/content/10.6...

See first, profile second- in case you missed our DISCO-seq paper!

We recently introduced DISCO-seq 🤩: scRNA-seq after tissue clearing 🧬 www.biorxiv.org/content/10.6... Image whole organs or bodies in 3D at cellular resolution. Select regions for unbiased scRNA-seq. From glioblastoma to whole-body SARS-CoV-2 S1 mapping 👇🏻 #DISCOseq

Last week @science.org A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis | Science www.science.org/doi/10.1126/...

The October issue is live www.nature.com/nbt/volumes/... On the cover, engineered inhalable exosomes display a bispecific T cell activator targeting a cancer cell along with a T cell go.nature.com/496Ins7 rdcu.be/avnjBsFZKzFa

New preprint! Antibodies activate an immune response… so why do immune cells have an inhibitory receptor FcγRIIB that binds antibodies? We found that FcγRIIB sets a time-limit for signaling. This makes macrophages eventually quit phagocytosis and prevents inflammation. doi.org/10.64898/202...

Postdoc opening: My lab at NYU Langone Health is looking for a new postdoctoral fellow with wet-lab experience for an exciting project.

Glycosylation is among the most important modifications in biology. We know relatively little about glycobiology, because it is hard to study. This Nat Rev Methods primer describes our best tools for analyzing glycosylation 🔽

Online Now: The AdipoCode: an information-fidelity framework for adipose–brain communication #trends #endocrinology #metabolism

Your skull isn't just protecting your brain. It's also an immune hub! 🧠 Watch this cool 3D visualization of a mouse after stroke. 🩷 Neutrophils and monocytes 🩵 Bones and internal organs 🔬 vDISCO imaging study from our lab published in Cell doi.org/10.1016/j.ce... Happy #FluorescenceFriday!

Phenomenal #glycotime by Meg Lunn-Halbert, Joel Allen and colleagues demonstrates through de novo protein design how steric hindrance controls N-glycan maturation ⬇️ doi.org/10.64898/202... Protein design with RFdiffusionAA coupled with glycosylation with GlycoShape 🧪

mCranberry: A rationally engineered monomeric red fluorescent protein with 85% quantum yield by Premashis Manna and team: www.biorxiv.org/content/10.6...

So honored to announce our latest @cancergrand.bsky.social publication on Mapping the functional #DarkProteome in Cancer! It is out today in Nature Reviews Cancer @natureportfolio.nature.com. Thanks to @annaedart.bsky.social for her awesome efforts as editor! www.nature.com/articles/s41...

Still no Nobel Prize for next-gen sequencing? Taking nothing away from the recent Nobel Prizes for methods, but IMO there is really nothing that has changed biology more than next-generation sequencing in the last decades.

Need to find time to read it in detail but this sounds pretty amazing: www.biorxiv.org/content/10.6...

🏁 That's a wrap! The @biohub.org Cell Tracking machine learning challenge on @kaggle.com is over: 4,478 participants, 3,947 teams, 120 countries, 95,438 submissions, tracking every cell of zebrafish embryos. 🧪🔬🧵 kaggle.com/competition... #microscopy

Thank you to everyone sharing in this moment! I’m so grateful to all my trainees & collaborators… dlab.stanford.edu/group-members (pic: Peter and I together in 2017) Reading for all those asking: for technical details: dlab.stanford.edu for everyone: deisseroth.org/projections

Was real fun doing this during Covid!

Congratulations to Karl Deisseroth, Peter Hegemann and Georg Nagel on the 2026 Nobel Prize in Physiology or Medicine

I would love this, too!

We’re excited to launch the Bluesky account for DFG-funded Research Training Group 3142: Biological Making of Materials Follow us to learn more about our research, people and activities. Learn more: www.digs-ils.phd/rtg-bmm #RTG3142 #Biomaterials #Science #Research #DFG

Me, too, actually

A reminder that the abundance of 'house keeping' proteins varies significantly across cells and tissues. GAPDH (glyceraldehyde-3-phosphate dehydrogenase) is often slandered a 'house keeping' protein, and its abundance varies significantly across human tissues.

Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases ->Nature | More on "CAR-T cell therapy autoimmune diseases" at BigEarthData.ai | #Health #Disease

October A&R Clinical Connections (2 of 2) Dual-Targeting BCMA–CD19 CAR-T Cell Therapy in SLE Key Points • Dual-targeting CAR-T therapy was associated with deeper depletion of plasma-lineage compartments compared to single-targeting therapy. ...