Nature Cell Biology

🎃Our October issue's out! Cover: Modeling #pancreatitis 👉Viewpoint on #senescence 🔬: #CellMigration #Lipids #Endocytosis #microtubules #DNADamage #Xchromosome #LiverCancer #Organoids #cholesterol #HumanAtlas #meningioma #omics & more! www.nature.com/ncb/volumes/...

nature.comThe rise of reducing reagent-resistant TfR1 dimer marks ferroptosis - Nature Cell BiologyHe et al. report the upregulation of a reducing reagent-resistant form of the transferrin receptor 1 dimer during lipid peroxidation and demonstrate its utility in detecting ferroptosis in tissue lysa...

☕ @ztslab.bsky.social & co report the upregulation of a reducing reagent-resistant form of the TfR1 dimer during lipid peroxidation and show its utility in detecting #ferroptosis in tissue lysates and extracellular vesicles from mice and humans. @notredame.bsky.social www.nature.com/articles/s41...

nature.comSpatial multi-omic atlas profiles early organogenesis of a Carnegie stage 12 human embryo - Nature Cell BiologyWang et al. map a Carnegie stage 12 human embryo with spatial transcriptomics and metabolomics.

☕ Wang et al. map a Carnegie stage 12 human #embryo with spatial #transcriptomics and #metabolomics. www.nature.com/articles/s41...

nature.comMonocyte surface Y RNAs potentiate innate immunity - Nature Cell BiologyJiang, He, Xu, Zheng et al. report a functional role for cell-surface Y RNAs in modulating extracellular histone-induced inflammatory signalling and cytokine secretion, which may contribute to the pat...

☕Jiang, He, Xu, Zheng et al. report a functional role for cell-surface Y RNAs in modulating extracellular histone-induced inflammatory signaling and cytokine secretion, which may contribute to inflammatory bowel disease pathogenesis. 👉https://rdcu.be/7aADBxa9Lnna www.nature.com/articles/s41...

nature.comIn vivo DNA damage protection during cell migration across confining embryonic tissue environments - Nature Cell BiologyHäkkinen et al. show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating neural crest cells experience neither nu...

@squeezycellslab.bsky.social @hannamariahakkinen.bsky.social & co show that zebrafish neural crest cells encounter increased tissue-scale confinement along the body axis. Despite nuclear deformation, migrating cells experience neither nuclear envelope rupture nor increased DNA damage. bit.ly/47S0v7z

Nature Cell Biology reposted

Elena Scarpa & The Squeezable Cells Lab

@squeezycellslab.bsky.social

Have you ever wondered how cells in developing embryos manage to squeeze through tiny spaces? And how do they cope with mechanical stresses imposed by surrounding tissues? Check out our paper, now out @natcellbio.nature.com : www.nature.com/articles/s41...

nature.comPower-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding - Nature Cell BiologyGudlin, Vukušić, Novak and colleagues propose spindle scaling in response to chromosome crowding consistent across eukaryotes. They show that metaphase plate width scales with genome size following a ...

☕ @lgudlin.bsky.social, @krunovuk.bsky.social, Novak et al propose spindle scaling in response to chromosome crowding consistent across eukaryotes; metaphase plate width scales with genome size following a power law with an exponent of ~1/3. @ivatolic.bsky.social www.nature.com/articles/s41...

nature.comChromosome crowding shapes spindle geometry - Nature Cell BiologyAccurate chromosome segregation requires precise spindle organization, but how spindle architecture adapts to genome size remains unclear. A study now highlights a general scaling law based on chromos...

🍰Read also the News & Views article written by Jing Xie & Daniele Fachinetti: 👉https://rdcu.be/Apw9ET8Y3gxa www.nature.com/articles/s41...

nature.comGlobal and specific mechanisms stimulate mistranslation in cancer - Nature Cell BiologyWernaart, Fumagalli et al. report ADAR1 and FTSJ1 as regulators of tryptophan-to-phenylalanine substitution in cancer. ADAR1 sustains mistranslation via ribosome quality control. FTSJ1 methylates tRNA...

☕Wernaart, Fumagalli et al. report ADAR1 and FTSJ1 as regulators of tryptophan-to-phenylalanine substitution in cancer. ADAR1 sustains mistranslation via ribosome quality control. FTSJ1 methylates tRNATrp and allows tRNATrp mischarging by phenylalanine. www.nature.com/articles/s41...

nature.comQuantification of lipid sorting during clathrin-mediated endocytosis - Nature Cell BiologyLennartz et al. evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma ...

☕ @nadlerlab.bsky.social @mathilda95.bsky.social & co evaluate lipid enrichment in clathrin-coated pits and observe that the differential lipid partitioning into clathrin-coated pits is largely driven by the lipid asymmetry of the plasma membrane. www.nature.com/articles/s41...

nature.comCell atlas of the developing human meninges reveals a dura-like nature of meningiomas - Nature Cell BiologyVinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human meninges and perform comparative studies with meningioma data.

☕Vinsland et al. provide a single-cell and spatial transcriptomics atlas of postconceptional week 5–13 human #meninges and perform comparative studies with #meningioma data. www.nature.com/articles/s41...

nature.comSpatially resolved multiomics of human meningeal development reveal lineage and disease dynamics - Nature Cell BiologyTo, Pett, Dufva et al. perform single-nucleus RNA and ATAC sequencing, as well as spatial transcriptomics, to study human meninges at 6–21 weeks post conception.

☕ @teichlab.bsky.social , To, Pett, Dufva & co perform single-nucleus RNA and ATAC sequencing, as well as spatial transcriptomics, to study human meninges at 6–21 weeks post conception. www.nature.com/articles/s41...

nature.comTaxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling - Nature Cell BiologyMeiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation.

☕Meiring, Mahapatra et al. show that expanded microtubule lattice conformations, such as those induced by small-molecule taxanes, can lead to the release of GEF-H1 and thus induce RhoA activation. www.nature.com/articles/s41...

nature.comThe dual-enhanced graph learning framework DePass allows paired data integration in single-cell and spatial multiomics - Nature Cell BiologyLi, Jiang and colleagues present DePass, a graph-based deep learning framework for integrating paired multi-omics data in spatial and single-cell contexts. A dual-enhancement approach is used to remov...

☕Li, Jiang et al present DePass, a graph-based #DeepLearning framework for integrating paired #multiomics data in spatial and single-cell contexts. A dual-enhancement approach is used to remove noise from raw omics data. 👉https://rdcu.be/kxnPQVtLvtba www.nature.com/articles/s41...

Nature Cell Biology reposted

Springer Nature

@springernature.com

Every published paper has a story, conversations, & people behind it. Meet Sabrya, Senior Editor, as she shares insights into her work and what makes her experience at Springer Nature meaningful. Explore careers: group.springernature.com/gp/group/car... #LifeAtSpringerNature @natcellbio.nature.com

nature.comScientific culture in the age of AI - Nature Cell BiologyRecent changes in Genentech’s scientific organization, occurring as the company makes artificial intelligence (AI) increasingly central to its research strategy, highlight a broader question facing bi...

☕Changes in Genentech’s scientific organization, as artificial intelligence (AI) is being made increasingly central to its research strategy, highlight a broader question: how will the use of AI reshape the scientific discovery process? 👉https://rdcu.be/LPKhMQp2Vs8a www.nature.com/articles/s41...

nature.comBatten disease protein CLN8 enables a non-canonical phospholipid synthesis pathway - Nature Cell BiologyTwo studies show that the ER-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converted into BMP. These r...

☕Two studies show that the ER-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converted into BMP. These results provide insight into CLN8 Batten disease. www.nature.com/articles/s41...

www.nature.com/articles/s41...

nature.comThe Batten disease protein CLN8 is a stereospecific acyltransferase in bis(monoacylglycero)phosphate biosynthesis - Nature Cell BiologyTwo studies show that the endoplasmic reticulum-associated protein CLN8 catalyses the acyl CoA-dependent acylation of glycerophosphoglycerol, producing lysophosphatidylglycerol, which is then converte...

nature.comCLN8 recycles glycerol backbones for BMP - Nature Cell BiologyTwo studies identify CLN8 as a glycerophosphoglycerol acyltransferase that generates the lysophosphatidylglycerol precursor for CLN5-mediated bis(monoacylglycero)phosphate (BMP) biosynthesis. These fi...

🍰Read also the News & Views article written by Zhengyue Cao & Cunqi Ye on both studies: 👉https://rdcu.be/TeRExRneF4ka www.nature.com/articles/s41...

nature.comDFCP1-containing ER microdomains mediate lysosomal membrane repair - Nature Cell BiologyRadulovic et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit...

☕ @majarad.bsky.social et al. show that phosphatidylinositol 3-phosphate (PI3P), produced by the phosphatidylinositol 3-kinase PIK3C3, is formed on ER domains after lysosome damage. ER domain PI3P helps to recruit the ATPase DFCP1, which promotes lysosome repair. www.nature.com/articles/s41...

nature.com4D nucleome landscape reveals dissolution of bipartite active X chromosome in liver cancer development - Nature Cell BiologyXie, Tan, Mo and colleagues show that a liver-specific bipartite structure of the active X chromosome is lost early in hepatocarcinogenesis in mice and humans, driving X-linked gene activation and pre...

18 Sept

☕Xie, Tan, Mo et al. show that a liver-specific bipartite structure of the active X chromosome is lost early in hepatocarcinogenesis in mice & humans, driving X-linked gene activation and premalignant transformation, particularly in males. 👉https://rdcu.be/mqgkumVG1YFa www.nature.com/articles/s41...

nature.comGain-of-function suppressors restore microtubule dynamics and rescue dominant-negative tubulinopathies - Nature Cell BiologyXu, Guo et al. report suppressor screens in Caenorhabditis elegans to counteract tubulin mutants. They report several missense variants in tubulin genes that may restore microtubule architecture and d...

16 Sept

☕Xu, Guo et al. report suppressor screens in C. elegans to counteract tubulin mutants. They report several missense variants in tubulin genes that may restore microtubule architecture and dynamics. 👉https://rdcu.be/PFSRCSoPDyoa www.nature.com/articles/s41...

bit.lyThe periphery of nuclear speckles defines a spatially and temporally regulated compartment of long-lived intron-retained RNAs that resolves during mitosis - Nature Cell BiologyBiayna, Baranovskii and colleagues report that intron-retained RNAs derived from cell cycle- and genome maintenance-related genes are pooled at the periphery of nuclear speckles and undergo synchronou...

16 Sept

☕ @gabrijelad.bsky.social & co report that intron-retained RNAs derived from cell cycle- and genome maintenance-related genes are pooled at the nuclear speckle periphery and undergo synchronous splicing at mitosis, thus contributing to their temporal regulation. bit.ly/4xpanzZ

14 Sept

👋Our September issue's out! Cover: #embryo implantation mechanics 👉Perspective on #ferroptosis 🔬: #mechanobiology #CellDeath #autophagy #chromatin #RNA #mitosis #circadian control #ribosome #brain #ExtracellularVesicles #transcription #MassSpectrometry & more! www.nature.com/ncb/volumes/...

nature.comTissue flow acts as a guidance cue for immune cell polarization and directional migration - Nature Cell BiologyLe et al. show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell interactions.

7 Sept

☕ @anhhle2702.bsky.social @mayorlab.bsky.social & co show that in Xenopus embryos, local ectodermal tissue flows provide a directional cue that polarizes and guides embryonic myeloid cells migration via cell-on-cell interactions. www.nature.com/articles/s41...

nature.comProteomics-based insights into mammalian oocyte and early embryo development - Nature Cell BiologyThis Perspective highlights the use of current proteomics technologies in defining stage-specific reprogramming events to understand reproductive ageing, improve oocyte quality, and refine the outcome...

4 Sept

☕Have you read this? This Perspective highlights the use of current #proteomics technologies to understand reproductive #aging, improve #oocyte quality, and refine the outcomes of assisted reproductive technology (ART). 👉Read here: rdcu.be/BgbMZ6KYkesa www.nature.com/articles/s41...

nature.comDynamic control of nucleotide metabolism in physiology and disease - Nature Cell BiologyThis Review discusses the spatial organization of nucleotide metabolism and its integration with cellular signalling pathways, emphasizing its importance as a dynamic regulatory axis in both physiolog...

4 Sept

☕Have you read this? This Review discusses the spatial organization of #nucleotide #metabolism and its integration with cellular signaling, emphasizing its importance as a dynamic regulatory axis in physiological contexts and disease. 👉Read here: rdcu.be/MFmEW6tWF7Ga www.nature.com/articles/s41...

2 Sept

☕Have you read this? This Review presents lysosomal dysfunction as a hallmark of #aging and highlights emerging therapeutic strategies that enhance lysosomal activity to promote healthy aging or ameliorate aging-related diseases. #lysosome 👉https://rdcu.be/BSLiWf16FiMa www.nature.com/articles/s41...

nature.comnature.com

nature.comMulti-stromal organoid co-culture modelling reveals epithelial–fibroblast heterogeneity in pancreatic cancer and pancreatitis - Nature Cell BiologyLi, Jihad and colleagues develop an organoid co-culture system, alongside patient tissue and mouse model analyses, to model, characterize and compare cellular interactions between epithelia and stroma...

2 Sept

☕Li, Jihad et al. develop an #organoid co-culture system, alongside patient tissue and mouse model analyses, to model, characterize and compare cellular interactions between epithelia and stroma in pancreatitis versus pancreatic ductal #adenocarcinoma. www.nature.com/articles/s41...

nature.comMechanisms underlying propagation of ferroptotic cell death - Nature Cell BiologyThis Perspective discusses emerging evidence for non-cell-autonomous propagation of ferroptotic cell death and highlights the mechanisms that underlie its restriction in tissues, as well as ferroptosi...

31 Aug

☕This Perspective discusses evidence for non-cell-autonomous propagation of ferroptotic #CellDeath and highlights the mechanisms that underlie its restriction in tissues, as well as #ferroptosis surveillance beyond the cellular level. 👉https://rdcu.be/5U4865D9thEa www.nature.com/articles/s41...

nature.comAdvanced imaging of membrane contact sites - Nature Cell BiologyThe detailed study of membrane contact sites is challenging owing to their small size and highly dynamic nature. This Review highlights advanced imaging methods and available biosensors that can be us...

31 Aug

☕This Review highlights advanced imaging methods and available biosensors that can be used to elucidate the composition and dynamics of membrane contact sites. 👉https://rdcu.be/4uDgJ3upkD1a www.nature.com/articles/s41...

nature.comThe proportional scaling of mRNA and ribosome concentrations controls eukaryotic cell growth - Nature Cell BiologyGao et al. show that yeast grow faster by proportionally increasing mRNA and ribosome concentrations to increase actively translating ribosomes, while elongation remains constant. A mass-action model ...

☕Gao et al. show that yeast grow faster by proportionally increasing mRNA and ribosome concentrations to increase actively translating ribosomes, while elongation remains constant. A mass-action model explains growth-rate changes. 👉https://rdcu.be/fCD18 www.nature.com/articles/s41...

nature.comElevated contractility drives implantation failure in mouse embryos from aged females - Nature Cell BiologyCavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

☕Embryos from aged mice have increased contractility & tissue viscosity on E4.5, causing poor spreading and attachment. Similar age-associated mechanical changes in human embryos correlate with implantation potential. @katecavanaugh.bsky.social 👉https://rdcu.be/fCDVb www.nature.com/articles/s41...

nature.comA mechanical origin for pregnancy loss related to maternal age - Nature Cell BiologySuccessful pregnancy rates decline with maternal age, even when embryos appear genetically normal. We show that maternal ageing changes the physical properties of the embryo, which reduces implantatio...

🍰Read also the Research Briefing: 👉https://rdcu.be/fCD0t www.nature.com/articles/s41...

nature.comCircadian control of circulating tumour-derived extracellular vesicle secretion affects targeted therapy efficacy - Nature Cell BiologyChen, Zhang and colleagues report ctEV-CLOCK as a tool to characterize circulating tumour-derived extracellular vesicles and demonstrate a pattern of circadian oscillation, which may be leveraged to d...

☕Chen, Zhang et al report ctEV-CLOCK as a tool to characterize circulating tumor-derived #ExtracellularVesicles and demonstrate a pattern of #circadian oscillation, which may be leveraged to design time-synchronized targeted #cancer therapy. 👉https://rdcu.be/fCDTU www.nature.com/articles/s41...

nature.comDREAMS illuminates spatial DNA and RNA modification landscapes - Nature Cell BiologyPeng, Xue et al. develop a nucleic acid metabolites detection method, DNA RNA Elements Areal Mass Spectrometry (DREAMS) which enables the identification of DNA and RNA modifications, as well as spatia...

☕ @epigenome.bsky.social & co develop a nucleic acid metabolites detection method, DNA RNA Elements Areal Mass Spectrometry (DREAMS) which enables the identification of DNA and RNA modifications, as well as spatial mapping of these modifications within tissues. www.nature.com/articles/s41...

nature.comA versatile cGAMP reporter reveals principles of cGAS activation by DNA damage and chromosome instability - Nature Cell BiologyLebrec et al. present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chroma...

☕Lebrec, @zierlab.bsky.social & co present a FRET-based cGAS reporter and show that cGAS activation by genotoxic stress is rare and uncoupled from micronuclei. The study implicates R-loop structures and subtypes of chromatin bridges as potential cGAS activators. www.nature.com/articles/s41...

nature.comBiosensor reveals unexpected variability in the cGAS response to DNA damage - Nature Cell BiologyWe present an updated reporter as the most sensitive readout for cGAS activation. Using this biosensor, we show that cGAS activation during genotoxic stress is rare, and that it is not driven by micro...

🍰Read also the Research Briefing: 👉https://rdcu.be/fCakD www.nature.com/articles/s41...

nature.comAn EZH2–SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis - Nature Cell BiologyKim et al. demonstrate a non-canonical function for EZH2 in modulating cholesterol metabolism and tumour development by interacting with SREBP2, which may be targeted by PROTACs to disrupt its oncogen...

☕Kim et al. demonstrate a non-canonical function for EZH2 in modulating #cholesterol metabolism and #tumor development by interacting with SREBP2, which may be targeted by PROTACs to disrupt its oncogenic activity. 👉https://rdcu.be/fCahY www.nature.com/articles/s41...

go.nature.com4th Frontiers in Electron and Scanning Probe Microscopy for the Physical and Life SciencesAdvances in electron microscopy instrumentation and methods continue to drive progress in the physical and life sciences. The 4th edition of this conference will bring together researchers from physic...

25 Aug

Join at Princeton University this October to hear the latest electron microscopy instrumentation and methods driving progress in the physical and life sciences. go.nature.com/4h0zAME

nature.comMega-enhancers compartmentalize transcriptionally active long genes in the brain - Nature Cell BiologyZhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on the transcription factor...

☕Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on Etv1 and is dynamic during neuronal maturation. 👉https://rdcu.be/fBGcW www.nature.com/articles/s41...

nature.comTargeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia - Nature Cell BiologyLi et al. report that FLT3 inhibition impairs selenoprotein translation and induces ferroptosis to suppress FLT3-mutant leukaemia. This can be counteracted by dietary vitamin E, which may disrupt the ...

☕Li et al. report that FLT3 inhibition impairs selenoprotein translation and induces #ferroptosis to suppress FLT3-mutant #leukemia. This can be counteracted by dietary vitamin E, which may disrupt the efficacy of tyrosine kinase inhibitors in AML treatment. www.nature.com/articles/s41...

nature.comThe mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation - Nature Cell BiologyChen, Xu, Zhou, Wu et al. report that a citric acid cycle enzyme OGDH regulates METTL3 succinylation and its activation as an m6A reader, thereby modulating NRF2 translation, disulfidptosis evasion an...

☕Chen, Xu, Zhou, Wu et al. report that a citric acid cycle enzyme OGDH regulates METTL3 succinylation and its activation as an m6A reader, thereby modulating NRF2 translation, #disulfidptosis evasion and #tumor growth. #CellDeath www.nature.com/articles/s41...

nature.comEvading disulfidptosis via NRF2 translation - Nature Cell BiologyMetabolic adaptation functions as an important selective bottleneck during tumour development. A study reveals that in response to glucose starvation, a metabolite from the TCA cycle is leveraged to e...

🍰Read also the News & Views article written by Liam Baird & Masayuki Yamamoto: 👉https://rdcu.be/fBF6X www.nature.com/articles/s41...

🏖️Our August issue's out! Cover: profiling #atherosclerosis 👉Reviews: #imaging membrane contact sites; #lysosomes in #aging; #nucleotide #metabolism 🔬: #ClonalHematopoiesis #PRC2 #embryogenesis #ferroptosis #cancer #neurobiology #intestine #vesicles & more! www.nature.com/ncb/volumes/...

nature.comCLOCK/BMAL1 interactome uncovers homeodomain factors as tissue regulators - Nature Cell BiologyAygenli et al. map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to ...

☕ @robles-lab.bsky.social & co map chromatin-bound CLOCK/BMAL1 protein complexes across three mouse tissues and uncover PROX1, HNF1B and HOXA5 as homeodomain cofactors that directly bind and co-occupy BMAL1 sites to establish tissue-specific circadian transcription. www.nature.com/articles/s41...

nature.comStromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis - Nature Cell BiologyMistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.

☕ @trowbridgelab.bsky.social & co propose that Dnmt3a-mutant hematopoietic cells induce mesenchymal stromal cell #senescence. Removal of senescent non-hematopoietic cells reduces Dnmt3a-mutant #hematopoiesis. #ClonalHematopoiesis www.nature.com/articles/s41...

nature.comPre-cancerous blood cells prematurely age the bone marrow to fuel cancer risk - Nature Cell BiologyIn clonal haematopoiesis, pre-cancerous mutant blood cells induce premature senescence in bone marrow stromal cells, creating an environment that allows mutant blood cells to outcompete healthy ones. ...

🍰Read also the Research Briefing: 👉https://rdcu.be/fyYSI www.nature.com/articles/s41...