Nilsson lab

Nilsson lab

@nilssonlab.bsky.social

413 followers100 following27 posts

Nilsson lab reposted

The Menachery Lab
@themenacherylab.bsky.social

Replying to @themenacherylab.bsky.social

Here, we build on our prior works with @nilssonlab.bsky.social for SARS2 NSP3 & with J. Paul Taylor's group for Nucleocapsid (N) showing each viral protein disrupt different elements of SG formation. In this manuscript, we generated a NSP3/N mutant that disrupted key motifs in both (YF/F17A)(2/6).

Nilsson lab
@nilssonlab.bsky.social

Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...

nature.comA proteome-wide dependency map of protein interaction motifs - Nature Structural & Molecular BiologyAmbjørn and Meeusen et al. functionally characterize all reported and a comprehensive set of predicted short linear motifs (SLiMs) using base-editing screens, identifying 450 reported and 264 predicte...
Nilsson lab
@nilssonlab.bsky.social

I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...

candidate.hr-manager.netPhD student position in the Cell Signaling and Cell Cycle group at the Danish Cancer Institute.The Cell Signaling and Cell Cycle group, headed by Prof. Jakob Nilsson, is looking for a highly motivated and enthusiastic PhD student to establish novel CRISPR

Nilsson lab reposted

Carlos Conde
@carlos-conde.bsky.social

Our latest research in collaboration with @nilssonlab.bsky.social, @andrea-musacchio.bsky.social and Mathieu Bollen reveals a new regulatory strategy employed by cells to control PP1 in mitosis. Check it out in @currentbiology.bsky.social www.sciencedirect.com/science/arti...

sciencedirect.comPolo kinase inhibits protein phosphatase 1 to promote the spindle assembly checkpoint and prevent aneuploidyProtein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains i…
Nilsson lab
@nilssonlab.bsky.social

We uncover CYB5R4 as an activator of PP4 and PP6 but not the closely related PP2A. CYB5R4 is a dedicated reductase for the catalytic metal ions and we show that this pathway is conserved from yeast to man. Thus PP4 and PP6 activity is regulated by oxidation and reduction of the metal ions.

Nilsson lab reposted

Prasad Jallepalli, MD, PhD
@prasad.bsky.social

www.nytimes.com/2025/02/14/o... An eloquent defense of American science by Harold Varmus, a Nobel Prize winning scientist during his days at UCSF, former director of the NIH and NCI, and former President of Memorial Sloan Kettering Cancer Center (full disclosure — it’s where I work)

nytimes.comOpinion | American Science is Under Attack (Gift Article)The Trump administration hobbles research and endangers the public health.

Nilsson lab reposted

The Groth lab
@grothlab.bsky.social

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

tinyurl.com6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

Nilsson lab reposted

Ellenberg Lab
@ellenberglab.bsky.social

Congratulations to @andibrunner.bsky.social and the team, and many thanks to the lab of Jan-Michael Peters for support! We found that the interphase and mitotic chromatin loop organization have more in common than previously thought: In both stages big loops are built first, small ones second

Journal of Cell Biology@jcb.org

@andibrunner.bsky.social et al. @ellenberglab.bsky.social show that interphase organization into Cohesin-driven loops occurs in a sequential and hierarchical manner - just like the mitotic organization by Condensins. https://buff.ly/426gIEu @wanluzhang.bsky.social

Nilsson lab reposted

Carlos Conde
@carlos-conde.bsky.social

Just in time for Christmas. Latest from the lab www.biorxiv.org/content/10.1... great collaborative effort with @nilssonlab.bsky.social @andrea-musacchio.bsky.social and Mathieu Bollen.

biorxiv.orgPOLO kinase inhibits Protein Phosphatase 1 to promote the Spindle Assembly Checkpoint and prevent aneuploidyProtein phosphatase 1 (PP1) is essential for spindle assembly checkpoint (SAC) silencing and mitotic exit, but its regulation during mitosis remains ill-defined. Here, we demonstrate in vitro and in D...
Nilsson lab
@nilssonlab.bsky.social

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community: candidate.hr-manager.net/ApplicationI...

candidate.hr-manager.netComputational scientist for new optical pooled screening infrastructure at the Danish Cancer InstituteComputational scientist for new optical pooled screening infrastructure at the Danish Cancer Institute Do you want to be part of a state-of-the-art core facilit

You are up to date.