obcbioimaging.bsky.social

obcbioimaging.bsky.social

@obcbioimaging.bsky.social

140 followers128 following114 posts

obcbioimaging.bsky.social reposted

1/3 The Euro-BioImaging UK Node has grown from 7 to 13 sites! 🔬 Open access to 60+ imaging techniques, image analysis & expert support across the UK. Welcome to Babraham, Birmingham, Leeds, Newcastle, Oxford & UK-BIAS 👋

obcbioimaging.bsky.social reposted

From bioRxiv to PNAS! 🎉 Very happy to see our paper “Diversity and spatial segregation of TRP channels in the closest relatives of animals” now published in @pnas.org. Another piece in the puzzle of how animal cell signalling evolved. www.pnas.org/doi/10.1073/...

pnas.orgPNASProceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
Pawel Burkhardt@pawelburkhardt.bsky.social

How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...

View full thread

This revealed that the basal body of these cells has a unique arrangement and is unusually short, and that microgametocytes have a deuterosome-like structure that may provide a nucleating platform for the intiial basal body formation, allowing for the very rapid assembly of flagella

Also the SBF-SEM imaging captured microgamete entry into the macrogamete, revealing new insights into Plasmodium fertilization. This information is important for the development of potential transmission blocking vaccines to prevent malaria!

obcbioimaging.bsky.social reposted

(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯

bioRxiv Biophysics@biorxiv-biophys.bsky.social

Structural cell biology by mega-expansion microscopy https://www.biorxiv.org/content/10.64898/2026.08.05.743040v1

Importantly, knocking out the KIAP4 protein reduces Leishmania haptomonad adhesion and colonization of the sandfly stomodeal valve. This makes it these proteins an important target for reducing parasite transmission and therefore infection!

This work identifies the KIAP4 protein, a new component of the Leishmania adhesion complex, which is involved in parasite transmission. KIAP4 is part of a larger gene family that is found in other kinetoplastid parasite species like Trypanosoma congolense

The Sunter and Wheeler groups used Centre for BioImaging equipment to study the function of the ESB1 gene in the life-cycle of the pathogen Leishmania. ESB1 is located in a specific nuclear body, and it helps control expression of δ-amastins (cell surface glycoproteins important for infection)

New review in the Journal of Microscopy: From EM to AI:Multiscale imaging of the secretory pathway with insights from plant cells Charlotte Pain and Emily Farley discuss the history of imaging the ER, from classical EM to fluorescent super-resolution LM, and future possibilities with AI analysis

On a personal note, this publication was a long struggle, so a *huge* thank you to colleagues and everyone who gave advice and experimental support, and also to the reviewers and editors that greatly improved the manuscript 🔬🍀🙏

It turns out that the apical notch has a substructure, that paracrine signalling appears to be important, and notches can reorientate in response to damage. Outside of the notches there is no clear predictability where meristems regenerate- apart from the oldest (stalk scar) cells not regenerating

There is also longer-range signalling between apical notches and regenerating regions. It appears that the central tissues can transmit this signal, but peripheral regions cannot. The phytohormone auxin is involved, with a balance between sources and sinks being important

The liverwort Marchantia makes clonal propagules called gemmae that are very accessible for experimentation and microscopy. This work explores the two (pre-)meristematic "apical notches" of the gemma and how meristem regeneration proceeds if these apical notches are removed or perturbated

obcbioimaging.bsky.social reposted

How ancient are the building blocks of animal sensory systems? Key components of animal sensory systems evolved before animals. We find that choanoflagellates possess diverse & spatially segregated TRP channels, pointing to ancient origins of sensory specialization. doi.org/10.64898/202...

obcbioimaging.bsky.social reposted

obcbioimaging.bsky.social reposted

🔬 UK researchers - funding is available to access world-class bioimaging facilities! The UK Bioimaging User Access Fund offers up to £5K for bioimaging or £2K for image analysis at 6 UK sites Open to PhD students, postdocs, technicians & PIs 📅 Next deadline: 31 Jul '26 👉https://shorturl.at/M2ckv

obcbioimaging.bsky.social reposted

PhD Opportunity Alert! The Marie Skłodowska-Curie Actions PhD programme AGILE (Advanced microscopy and image analysis around the plant nucleus) has 15 PhD positions in 6 different countries. This includes one here at Oxford Brookes University with the Kriechbaumer group.