Parker Singleton

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out now in Nature Mental Health. Here's what we found and the open science infrastructure we built to support it 🧵 Open-Access Link: rdcu.be/fbU5V

#TWiNPP A living systematic review and meta-analysis supports MDMA-assisted therapy as a promising treatment for PTSD / @parkersingleton.bsky.social @bsevchik.bsky.social @jcobbscott.bsky.social @ted-satterthwaite.bsky.social www.nature.com/articles/s41...

Excited that this paper, "Highly replicable multisite patterns of adolescent white matter maturation", has now been published in Neuron! It may be found at cell.com/neuron/fullt.... To freely access the paper for the next 50 days, please use this link: authors.elsevier.com/c/1nxdd3BtfH...

Very excited to announce that this living systematic review and meta-analysis is now published in Neuropsychopharmacology! doi.org/10.1038/s413...

So excited that our work is now published in PLOS Biology!! 🎉 Check out the final version here: doi.org/10.1371/jour... And for a bit more context and what we found, here’s our earlier thread: bsky.app/profile/goli...

Very excited to announce that this work is now published in Scientific Data! doi.org/10.1038/s415...

Awesome new work by @tsalo.bsky.social and @parkersingleton.bsky.social — a small but valuable test-retest dataset comparing single & multi-echo fMRI. Completely open + fully processed!!!!

New dataset out in Data in Brief 🧠 We're releasing an open, test-retest neuroimaging dataset built for directly comparing single-echo vs. multi-echo fMRI, head-to-head, in the same people. 1/

Here's bonus slides on cross-validation tests, separate from our preprint. Covering: 1. paired (sign-flip) permutation test 2. label-swap permutation test 3. sample-level vs fold-averaged stats 4. a common misapplication of the corrected t-test 5. three bootstrap variants 1/N

Nice article on our recent Nature Mental Health paper: www.medscape.com/viewarticle/...

Thrilled to share our latest paper, out recently in Nature Mental Health. "Optimizing functional connectivity scanning conditions for predicting autistic traits" www.nature.com/articles/s44... 1/n

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development. 🔗 www.biorxiv.org/content/10.6...

Incredible work by the absolutely stellar @bsevchik.bsky.social and @parkersingleton.bsky.social — the second installment of our open-science living meta-analysis of psychedelics for mental health.

And here's our second installment of sypres.io, co-led by the brilliant @bsevchik.bsky.social !!

This paper has been a long time coming. Instead of reanalyzing the same old resting-state fMRI datasets, we combined nearly all datasets around the world. Note that we didn't exactly find indisputable evidence for "default mode network disintegration." www.nature.com/articles/s41...

Beyond delighted to see this paper -- our first from the SYPRES initiative -- now out at @natmentalhealth.nature.com. Check out Parker's awesome thread below, w/ links to dashboard + all code + data.

hello

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What makes brains (un)conscious? We provide new answers—and a universal mammalian blueprint for information processing—in a cross-species study of humans, macaques, marmosets & mice. Exploring convergent breakdown of integration in: www.nature.com/articles/s41... Led by @loopyluppi.bsky.social

Happy to have been a part of yet another tour de force led by the one and only @loopyluppi.bsky.social !

The 6x US memory champion – Nelson Dellis – can memorize a deck of cards in 40 seconds and knows the first 10K digits of pi. To figure out how, he let us peak inside his brain. Here is what we learned in our precision brain mapping study www.biorxiv.org/content/10.6... youtube.com/shorts/MryMq...

Very happy that this paper from our lab is now out in @pnas.org! What happens when the *same* person experiences the *same* information with a *different* interpretation? Nearly the whole 🧠—well, at least nearly all association cortex—changes how it represents that information! tinyurl.com/p8chj2j7

🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization. But is it actually the best way to estimate functional architecture? We tested this directly. 🧵1/8

We think of white matter as the highways of the brain. But when we followed development along those highways, we were surprised. The journey is more complex than we thought. My final PhD paper, “Two Axes of White Matter Development”, is now out in @natcomms.nature.com! 🛣️🧠✨ 🔗 bit.ly/wm2axes

Every participant had a MEQ-30 score of 150: youtu.be/-c9-poC5HGw?...

My first preprint is out! Thank you to my brilliant collaborators & mentors for making this possible @vmarchman.bsky.social @arokem.org @jyeatman.bsky.social, as well as everyone behind the awesome open source software that we use @pennlinc.bsky.social @cieslakmatt.bsky.social (& many not on bsky)

Another important one for psychedelics fMRI ppl: www.biorxiv.org/content/10.6...

Come join an amazing team where you're guaranteed to set yourself up for future success!

💊 🍸 Risk for substance use disorder (SUD) rises in adolescence. Family history and biological sex play major roles in a person's level of SUD risk. New evidence suggests neural markers of SUD may exist before substance use starts - yet how these markers differ across sexes is not understood.

🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550 www.biorxiv.org/content/10.1...

After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:

Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA 10.1093/brain/awaf391

Hot off the press!

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.

I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.

Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.

New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇 www.biorxiv.org/cgi/content/...

I'm near certain sLFOs are big for psychedelics.

Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊

"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" www.researchsquare.com/article/rs-7...