PathoGenOmics Lab

PathoGenOmics Lab

@pathogenomics.bsky.social

PathoGenOmics research group at I2SysBio. Having fun learning how pathogens evolve.

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1/6 Our new paper is out in Emerging Infectious Diseases.We introduce Pathotypr, a free, alignment-free tool for lineage identification, drug resistance detection and mixed infection screening in the Mycobacterium tuberculosis complex (MTBC).A short thread on what it does.

1/6 Our new paper is out in Emerging Infectious Diseases.We introduce Pathotypr, a free, alignment-free tool for lineage identification, drug resistance detection and mixed infection screening in the Mycobacterium tuberculosis complex (MTBC).A short thread on what it does.

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4/6 Beyond lineage assignment, Pathotypr detects drug-resistance mutations included in the WHO catalogue and flags potential mixed infections. These analyses are integrated into a single workflow.

5/6 We evaluated Pathotypr on 88,071 samples. It showed complete major-lineage concordance with TB-Profiler in directly comparable samples, while identifying rare L10, A1 and A2 isolates not resolved by its lineage classification scheme.

1/6 Our new paper is out in Emerging Infectious Diseases.We introduce Pathotypr, a free, alignment-free tool for lineage identification, drug resistance detection and mixed infection screening in the Mycobacterium tuberculosis complex (MTBC).A short thread on what it does.

3/6 The method uses 2,145 phylogeny-derived markers identified from 26,813 genomes. It works directly with genome assemblies (FASTA) or raw sequencing reads (FASTQ), without requiring conventional read mapping.

Aun estáis a tiempo de ver el espectáculo de danza contemporánea y circo que ha puesto en marcha Álvaro Chiner. Nos cuenta lo sucedido durante una gran epidemia de forma exquisita y sugerente. Vale mucho la pena.

PathoGenOmics Lab reposted

Want to analyse bacterial genomes yourself? ONE-BAG 2026 at @i2sysbio.es takes you from raw reads to interpretable phylogenies, with hands-on training in QC, SNPs, assembly, annotation, pangenomes, outbreaks, AMR and typing. Learn more: onebag.uv.es

onebag.uv.esONE-BAG 2026 | Bacterial Genomics for One HealthFrom raw reads to a tree you can defend. Four days in Valencia, free for EOHA full members and 300 euro for everyone else. Applications close 1 October 2026.

PathoGenOmics Lab reposted

🏅 Congratulations to Margo Diricks, winner of the Gertrud Meissner Award at #ESM2026! We're delighted to celebrate Margot's outstanding contribution to mycobacteriology, recognising the excellence and dedication she brings to our field. So well deserved 👏 #ESM2026 #ESMyco

Bouke's innovative thinking, rigorous pursuit of knowledge and colaborative way of conducting research make this recognition incredibly well-deserved. Thank you for your outstanding contributions to the field and your unique ability to inspire the mycobacterial community.

Troels Lillebaek@tlillebaek.bsky.social

Congratulations to Bouke de Jong, winner of the Gardner Middlebrook Award at #ESM2026!

PathoGenOmics Lab reposted

🔬 El #CSIC e #ISGLOBAL firman un acuerdo de colaboración para reforzar la investigación en salud ➡️ Ambas entidades promoverán proyectos de investigación y asesoramiento, así como seminarios y jornadas especializadas 👉 http://tiny.cc/2ll1101

The toolkit integrates multiple modules in one workflow: Train / Predict for lineage classification, Split FASTQ / Classify for genotyping from reads or assemblies, and Match Ref to identify the closest reference genome for each sample.

In benchmarking, Pathotypr showed very high concordance with phylogenetic lineage assignment and achieved very fast analysis speeds, making near real-time TB genomic surveillance feasible even on standard desktop hardware. It is available as both a command-line tool and an easy desktop GUI.

Pathotypr supports all 14 currently recognised MTBC lineages, including human-adapted lineages L1-L10 and animal-adapted clades A1-A4. It also incorporates recently described diversity such as L10, helping standardise TB genomic surveillance across settings.

PathoGenOmics Lab reposted

The “curse of interdisciplinarity”: Fields like bioinformatics fall between the cracks in grant evaluation. 🧬 For bios: Too little mechanistic validation 🧮 For math: Not enough new theory 💻 For computing: “Just” applied computing Interdisciplinarity is essential, but evaluation hasn’t caught up.

🔬 World TB Day 2026 — Behind the mask, inside BSL-3. Our team works daily to understand M. tuberculosis evolution, resistance & transmission through genomics. TB still kills 1.25M people/year. Research matters. @i2sysbio.es #WorldTBDay #EndTB #Tuberculosis

Proud to celebrate 10th anniversary of @i2sysbio.es 🎉 Being part of a community dedicated to discovery, collaboration, and advancing science is truly inspiring. Grateful to contribute, learn, and grow alongside such passionate colleagues. Here’s to many more years of knwledge and impact! 🔬✨

PathoGenOmics Lab reposted

PathoGenOmics Lab reposted

From fàstic to fantastic population genetics with @pathogenomics.bsky.social :announcing Fstic a high-performance Rust CLI that computes N×N genetic distance matrices from VCFs or allele-frequency tables at scale. (fàstic=Valencian/Catalan for annoyance)Code: github.com/PathoGenOmic... @i2sysbio.es

github.comGitHub - PathoGenOmics-Lab/fstic: Calculates pairwise distances between samples using alelle frequenciesCalculates pairwise distances between samples using alelle frequencies - PathoGenOmics-Lab/fstic

PathoGenOmics Lab reposted

El #I2SysBio (@csic.es - @uv.es) ha lanzado una serie de vídeos sobre los diferentes grupos de investigación en este centro. El nuevo video es sobre el grupo Orquestación transcripcional del metabolismo vegetal de Tomas Matús @jtmatus.bsky.social 🎥🌐 youtu.be/43V4MOtAf4k?... 🧪🧬🖥️ 🌾🌱🍇 #plantscience

youtu.beInterview of Tomás Matus, PI of the Transcriptional Orchestration of plant metabolism groupYouTube video by Institute for Integrative Systems Biology I2SysBio

PathoGenOmics Lab reposted

VIPERA v1.2.1 is here!! 🐍🐍🐍 Our workflow for SARS-CoV-2 intra-patient evolution analysis now fully supports Snakemake 8/9 (with dedicated CI tests), BIONJ trees, richer reports, added config parameters, modular Snakefiles and more! 🧪👉 github.com/PathoGenOmics-Lab/VIPERA

github.comGitHub - PathoGenOmics-Lab/VIPERA: A Snakemake workflow for SARS-CoV-2 Viral Intra-Patient Evolution Reporting and AnalysisA Snakemake workflow for SARS-CoV-2 Viral Intra-Patient Evolution Reporting and Analysis - PathoGenOmics-Lab/VIPERA

PathoGenOmics Lab reposted

Today, I2SysBio researchers were busy with #scienceoutreach activities at #Expociencia. Here are photos of the Pathogenomics lab @pathogenomics.bsky.social explaning in a playful way how our immune system works 🧬🖥🦠🧫🧪

Paula@paururo.bsky.social

Nuestro 4to año superado con creces, #expociencia2025 @pathogenomics.bsky.social @i2sysbio.bsky.social

🦠 ¿Amigos o enemigos? La infección por tuberculosis depende de la compatibilidad patógeno-hospedador. Si encajan bien, la bacteria prospera; si no, fracasa. ¡Cuestión de genética! #EndTB #DíaMundialTuberculosis