Paul Sample

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Today would be a great day for the AI research community to leave X for good. In your own self interest and for the public perception of AI, take a stand. Unless you agree with using it as a misinformation and propaganda machine, I guess.

Introducing SciArena, a platform for benchmarking models across scientific literature tasks. Inspired by Chatbot Arena, SciArena applies a crowdsourced LLM evaluation approach to the scientific domain. 🧵

Anthropic's Claude Code Python SDK just released? Currently sitting at 1 star! github.com/anthropics/c...

These are wonderfully weird.

Robin: A multi-agent system for automating scientific discovery [new] Automating scientific discovery via a multi-agent system that integrates literature search and data analysis to propose/validate hypotheses.

Power-Hungry Data Centers Are Warming Homes in the Nordics https://bloom.bg/4jYABDI #AI #DataCenters #climate

WhyTF would people use Grok when they do things like this? Not to mention the pollution they’re producing in Memphis.

There is no bigger turn off to reading a paper than seeing the words “is all you need” in the title.

Finally, the Twitter/X killer. Nothing quite as satisfying as operating in purely in a terminal. www.itter.sh

I always look forward to FutureHouse releases. I had to do a little digging for API information so here it is for those who are interested. futurehouse.gitbook.io/futurehouse-...

I knew he would do this. I wrote a whole article about how he would do this. I am not surprised he’s undermining vaccination. I know he’s an anti-vaxxer & a predatory crank. And yet…you have got to be fucking kidding me. He’s promoting infant mortality.

Tahoe-100M: A Giga-Scale Single-Cell Perturbation Atlas for Context-Dependent Gene Function and Cellular Modeling [new] Atlas maps 50 cancer lines' trancriptomic response to 1.1k mols, aiding AI modeling.

Genome modeling and design across all domains of life with Evo 2 [new] Evo 2: Learns genomic features across life's domains from DNA alone and generates coherent, controllable genome sequences at scale.

"Most baffling to many were the firings of hundreds whose jobs were not funded by taxpayers. Their positions were financed through congressionally approved agreements that routed fees from the drug, medical device and tobacco industries to the agency." 🤡 www.nytimes.com/live/2025/02...

For decades, the US government has painstakingly kept American science #1 globally—and every facet of American life has improved because of it. The internet? Flu shot? Ozempic? All grew out of federally-funded research. Now all that's being dismantled. 1/ www.technologyreview.com/2025/02/21/1...

Has anyone tried this? Struggling to find an information retrieval system I like. www.perplexity.ai/help-center/...

Severance obsessives like myself may be interested to hear that the first 8 chapters of The You You Are by Dr. Ricken Lazlo Hale, PhD are now available for free as both text and an audiobook read by Ricken himself: books.apple.com/us/book/the-...

Avoidance is better for mental health but not for decision making in an increasingly complex and unpredictable world.

Aider reports that R1+Sonnet (R1 Thinking + Sonnet) set a new SOTA on the aider polyglot benchmark at 14X less cost compared to o1. 64% R1+Sonnet 62% o1 57% R1 52% Sonnet 48% DeepSeek V3 aider.chat/2025/01/24/r...

I tried a few biology-related queries and was impressed with the results. Researchers should check this out.

How have I been coding with Python for 10 years and just learned today that you can update the same line in a terminal using '\r' and end=''? print(f"\rDownload progress: {percent}%", end='') Thanks Claude.

98% of microplastic particles (MP) in bottled water are smaller than 20 μm, which are much more likely to get thru the GI tract to blood and organ tissue. Municipal tap water was higher in MP than 8 of 10 bottled water brands journals.plos.org/water/articl...

Not to brag but apparently I'm "on a roll!" over at LinkedIn. Blessed 🙏.

I'll get straight to the point. We trained 2 new models. Like BERT, but modern. ModernBERT. Not some hypey GenAI thing, but a proper workhorse model, for retrieval, classification, etc. Real practical stuff. It's much faster, more accurate, longer context, and more useful. 🧵

Excited to share that we have just released genomenotebook 1.0 together with @trichomedoctor.bsky.social ! If you like to analyze genomics data in Jupyter notebooks this is for you. You can get beautiful genome browsers directly in your notebooks: dbikard.github.io/genomenotebo...

I made this free and open source dev tool: gitingest.com Replace "hub" with "ingest" in any github URL to get a text digest that you can feed into any LLM

Once again reminded of the amazing storytelling through data visualization that W.E.B Du Bois was doing in 1899!

New ESM models! Unlike ESM3 these seem to be classic sequence-only PLMs. The 300M and 600M param models are open source and available for commercial use, while the 6B param model is academic use only www.evolutionaryscale.ai/blog/esm-cam...

InterPLM: Discovering Interpretable Features in Protein Language Models via Sparse Autoencoders InterPLM uses sparse autoencoders (SAEs) to extract interpretable features from ESM-2 embeddings, revealing thousands of features linked to biological concepts, surpassing individual neuron ... (1/8)

www.anthropic.com/news/model-c...

Interested in open datasets for ML and AI? I've just created this feed with posts about @huggingface.bsky.social datasets! Don't miss the latest news and conversations about the secret sauce behind every AI model. bsky.app/profile/dvil...

Does anyone know of a good tool or model for extracting figures from academic papers? I'm hoping to pass in a PDF, get the bounding boxes for each figure, and then save them as images.

Excited to see our T-cell exhaustion preprint published! This work is led by Tristan Tay and collaborators at AstraZeneca. See the sub-thread (reformatted for bluesky) originally composed and posted by the newly minted Dr. Tay www.cell.com/cell-reports...

So will it all turn out OK once thermostatic public opinion turns around? Unfortunately, we have now put anti-democracy authoritarians in power, and there's a real possibility that this may have been our last more or less free election 4/

I will not reinstall WoW, I will not reinstall WoW…

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with Jeremy, Saro, and an amazing team at MIT and Genesis Therapeutics. A thread!

It feels like we’re watching a hurricane, looming in the Gulf. Uncertain of the magnitude of the chaos that it will bring when it makes landfall on January 20th.

In a gratuitous attempt to acquire more followers myself 😁, I've made a start on a "starter pack". Hopefully as more people from 🐦 make it over to 🦋, we can extend this a bit. Suggestions welcome! I've noticed not all accounts seem to be eligible to be added, anyone know what's up with that? 🤔

I tried to make a bioml starter pack. DM if you want me to add or remove you? go.bsky.app/2VWBcCd

This looks like a great resource for studying enhancers. www.biorxiv.org/content/10.1...

3rd(?) ‘foundation model’ in the past 2 weeks predicting RNA biology from DNA sequence. www.biorxiv.org/content/10.1...