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The mission of the Center for Physical Genomics and Engineering at Northwestern University’s McCormick School of Engineering is to create new strategies for the treatment of disease and the reversible manipulation of living systems

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Friday Oct. 30 @ 12pm CT Asifa Akhtar, PhD presents the Monthly Seminar on Physical Genomics: "Gene Dosage Control And Histone Acetylation: Epigenetic Mechanisms In Health And Disease", live on Zoom. Join us! Register at: tinyurl.com/pr5nbkf3 #chromatin #epigenetics #genomics #histones #dna #cpge

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Tomorrow! The Physical Genomics Trainee Program Research Showcase featuring talks by PhD students Evelynn Chen and Eric Tong, live on Zoom. Join us! Registration is free at tinyurl.com/pr5nbkf3 #genomics #northwestern #cpge #biophysics #research #chromatin #biology #womenshealth #transcription

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Coming up at 12pm CT today! Michael Shelley, PhD presents the Monthly Seminar on Physical Genomics: "Modeling Chromatin as an Active Polymer Melt" live on Zoom. Join us! #northwestern #chromatin #genomics #polymer #modeling #biology #biophysics #dna Registration is free at: tinyurl.com/33daxm9u

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Tomorrow, Sept. 18 @ 12pm CT Michael Shelley, PhD presents the Monthly Seminar on Physical Genomics: "Modeling Chromatin as an Active Polymer Melt" live on Zoom. Join us! #northwestern #chromatin #genomics #polymer #modeling #biology #biophysics #dna Registration is free at: tinyurl.com/33daxm9u

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Join us Friday Sept. 18 @ 12pm CT as Michael Shelley, PhD presents the Monthly Seminar on Physical Genomics: "Modeling Chromatin as an Active Polymer Melt" live on Zoom. #northwestern #chromatin #genomics #polymer #modeling #biology #biophysics #dna Registration is free at: tinyurl.com/33daxm9u

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Governor JB Pritzker
@govpritzker.illinois.gov

A win for our state. NSF’s recognition of Northwestern’s Center for Genome Intelligence Engineering is a validation of the innovation we’re doing here to understand how cells function to prevent decline. We’re fostering the research and science needed to lead in Illinois.

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🏆Led by Northwestern University, the Center for Genome Intelligence Engineering was awarded $30M from the National Science Foundation.    Learn more

nsf.govNSF launches three new Science and Technology Centers with $90M investment in transformative researchThe U.S. National Science Foundation is investing $90 million over five years to support three new NSF Science and Technology Centers (NSF STC). These centers will advance American leadership in…
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The NSF has awarded Northwestern $30 million to launch the Center for Genome Intelligence Engineering (GENIE). By treating the genome as a physical and a computational system, GENIE will harness cellular memory to combat injury, disease, aging and more www.mccormick.northwestern.edu/news/article...

mccormick.northwestern.eduNorthwestern to Launch $30 Million Center to Unlock Genome’s Hidden CodeLed by Northwestern Engineering’s Vadim Backman, the multi-institutional Science and Technology Center will integrate experts in physics, biology, engineering, AI, and medicine to understand how the g...
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Today at 12pm CT! Francisco Robles, PhD presents the Monthly Seminar on Physical Genomics: "Advances And Applications Of Quantitative Phase Imaging And Refractive Index Tomography Of Opaque Samples Via Quantitative Oblique Back Illumination Microscopy" Register here: tinyurl.com/3zhzu57j #imaging

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Tomorrow at 12pm CT! Francisco Robles, PhD presents the Monthly Seminar on Physical Genomics: "Advances And Applications Of Quantitative Phase Imaging And Refractive Index Tomography Of Opaque Samples Via Quantitative Oblique Back Illumination Microscopy" Register here: tinyurl.com/3zhzu57j

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Just published in Advanced Science: "Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States" "We may soon be able to engineer chromatin packing states to influence cell function” postdoctoral fellow Cody Dunton said. www.mccormick.northwestern.edu/news/article...

mccormick.northwestern.eduStudy Reveals New Way Cells Organize Their GenomesProfessor Vadim Backman’s group showed that changing the nucleus’s ionic environment can rapidly reshape chromatin and alter how cancer cells respond to chemotherapy.
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“Our findings demonstrate that the genome is regulated not only by its DNA sequence and molecular machinery, but also by its physical organization. More importantly, we reveal that this organization can be rapidly and reversibly controlled” PhD student Paola Carrillo Gonzalez said.

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The July Seminar on Physical Genomics with Prof. Janet Sorrells is now accessible on the CPGE YouTube Channel: "Biochemical, Metabolic, And Structural Profiling Of The Tissue Microenvironment With Computationally Accelerated Multimodal Nonlinear Optical Microscopy" www.youtube.com/watch?v=TsYH...

youtube.comJanet Sorrells- Biochemical, Metabolic, Structural Profiling Of Tissue MicroenvironmentYouTube video by Center for Physical Genomics and Engineering
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Today at 12pm CT! Janet Sorrells, PhD presents the Monthly Seminar on Physical Genomics: Biochemical, Metabolic, And Structural Profiling Of The Tissue Microenvironment With Computationally Accelerated Multimodal Nonlinear Optical Microscopy" live on Zoom. Register here: tinyurl.com/3zhzu57j

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Tomorrow! The Monthly Seminar on Physical Genomics features Dr. Vasundhara Agrawal, CPGE alumnus and Applications Manager for Spatial Biology Image Analysis at Leica Microsystems, discussing her path from academia to industry. #northwestern #leica Registration is free at: tinyurl.com/2rw8n7bt

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This Friday! The Monthly Seminar on Physical Genomics features Dr. Vasundhara Agrawal, CPGE alumnus and Applications Manager for Spatial Biology Image Analysis at Leica Microsystems, discussing her path from academia to industry. #northwestern #leica Registration is free at: tinyurl.com/2rw8n7bt

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The June Seminar on Physical Genomics will feature Dr. Vasundhara Agrawal, CPGE alumnus and Applications Manager for Spatial Biology Image Analysis at Leica Microsystems Boston Innovation Hub, discussing her career path from academia to industry. Registration is free at: tinyurl.com/2rw8n7bt

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Today's Seminar on Physical Genomics with Michael Shelley, PhD will be rescheduled due to illness. Notifications have been sent to all registrants - we will have a new date as soon as possible. Thank you!

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Join us at 12pm CT tomorrow, May 29, as Michael Shelley PhD presents the Monthly Seminar on Physical Genomics: "Modeling Chromatin as an Active Polymer Melt". Registration is free but required at tinyurl.com/2rw8n7bt #chromatin #genomics #northwestern #polymer #physics #nyu #cpge #nih #nsf

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CPGE in Biophysical Journal: "One Chromatin, Many Structures: From Ensemble Contact Maps to Single-Cell 3D Organization" SR-EV clarifies the probabilistic nature of genome architecture and provides a reference framework for interpreting multimodal genomic/imaging data www.cell.com/biophysj/ful...

cell.comOne Chromatin, Many Structures: From Ensemble Contact Maps to Single-Cell 3D OrganizationUnderstanding how chromatin folds in three dimensions remains challenging because most experimental assays capture low-dimensional projections of an underlying, highly heterogeneous polymer. Here we p...
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Join us on Zoom Friday May 29 @ 12pm CT as Michael Shelley, PhD presents the Monthly Seminar on Physical Genomics: "Modeling Chromatin as an Active Polymer Melt". Registration is free, but required at tinyurl.com/2rw8n7bt #chromatin #genomics #northwestern #polymer #physics #modeling #nyu

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Last week's fantastic seminar by Prof. Harmit Malik, "Genetic Conflicts Drive The Unexpected Rapid Evolution Of Essential Chromatin Proteins", can now be viewed on CPGE's YouTube channel! youtu.be/VxSppXrqGfI #chromatin #genomics #evolution #northwestern #genomics #proteins #dna #fredhutch

youtu.beHarmit Malik- Genetic Conflicts Drive The Unexpected Rapid Evolution Of Essential Chromatin ProteinsYouTube video by Center for Physical Genomics and Engineering
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Next Friday April 24 @ 12pm CT, Dr. Harmit Malik presents the Monthly Seminar on Physical Genomics: "Genetic Conflicts Drive The Unexpected Rapid Evolution Of Essential Chromatin Proteins", live on Zoom. Registration is free, but required at tinyurl.com/2rw8n7bt #chromatin #genomics #proteins #dna

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Prof. Javier Rodriguez-Casariego's fascinating seminar, "Epigenetic Mechanisms of Rapid Environmental Plasticity in Reef-Building Corals", is now available for viewing on the CPGE YouTube channel. Enjoy! #epigenetics #chromatin #genomics #corals #northwestern #reefs #science youtu.be/lcp9TyW8UTs

youtu.beJavier Rodriguez-Casariego- Epigenetic Mechanism of Rapid Environment Plasticity Reef-Building CoralYouTube video by Center for Physical Genomics and Engineering
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Today @ 12pm CT! Dr. Javier Rodriguez-Casariego presents the Monthly Seminar on Physical Genomics: "Epigenetic Mechanisms Of Rapid Environmental Plasticity In Reef-Building Corals", live on Zoom. Join us! Registration is free, but required at tinyurl.com/2rw8n7bt #epigenetics #corals #genome

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This Friday March 27 @ 12pm CT Dr. Javier Rodriguez-Casariego presents the Monthly Seminar on Physical Genomics: "Epigenetic Mechanisms Of Rapid Environmental Plasticity In Reef-Building Corals", live on Zoom. Registration is free, but required at tinyurl.com/2rw8n7bt #epigenetics #corals #genome

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Join us Friday March 27 @ 12pm CT for the Monthly Seminar on Physical Genomics as Dr. Javier Rodriguez-Casariego presents "Epigenetic Mechanisms Of Rapid Environmental Plasticity In Reef-Building Corals" live on Zoom. Registration is free, but required at tinyurl.com/2rw8n7bt #epigenetics #corals

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This Friday Feb. 27 at 12pm CT, Prof. Steve Henikoff presents the Monthly Seminar on Physical Genomics: "Histone Overexpression In Cancer" live on Zoom. Join us! Registration is free at tinyurl.com/2rw8n7bt #northwestern #cancer #genomics #research #chromatin #dna #epigenetics #science #fredhutch

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Friday Feb. 27 at 12pm CT, Prof. Steve Henikoff presents the Monthly Seminar on Physical Genomics: "Histone Overexpression In Cancer" live on Zoom! Registration is free at tinyurl.com/2rw8n7bt #northwestern #cancer #genomics #research #chromatin #dna #science #biology #cpge #fredhutch #research

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“We did not set out to directly kill cancer cells. We wanted to take away their superpower — their inherent ability to adapt, to change and to evade.” CPGE's latest cancer research featured in Northwestern Magazine #cancer #chromatin #genomics #cpge magazine.northwestern.edu/discovery/va...

magazine.northwestern.eduHacking Cancer’s Survival CodeNorthwestern professor Vadim Backman, who teaches in the McCormick School of Engineering and the Feinberg School of Medicine, is director of the University’s Center for Physical Genomics and Engineeri...
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Today at 12pm CT! The Monthly Seminar on Physical Genomics featuring Taekjip Ha, PhD of Harvard Medical School: "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions" Register for free at: tinyurl.com/3zhzu57j #genomics #chromatin #dna #biophysics #biology

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Tomorrow at 12pm CT! The Monthly Seminar on Physical Genomics featuring Taekjip Ha, PhD of Harvard Medical School: "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions" Register for free at: tinyurl.com/3zhzu57j #genomics #chromatin #dna #biophysics #biology

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Join us Friday, Jan. 30 at 12pm CT for the Monthly Seminar on Physical Genomics featuring Taekjip Ha, PhD of Harvard Medical School: "DNA Mechanics And Nucleosome Condensability As Biophysical Backdrop Of Genome Functions" Register for free at: tinyurl.com/3zhzu57j #genomics #chromatin #dna #gene

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Friday, Nov. 21 @ 12pm CT, Wendy Bickmore, PhD presents the Monthly Seminar on Physical Genomics live on Zoom: "Chromatin Folding And Gene Activation: From The Nucleosome To Transcription Hubs" Registration is free. Join us! tinyurl.com/f9njvnyu #chromatin #genomics #northwestern #biology #dna

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Kim Bellard
@kimbbellard.bsky.social

Think we've got DNA all figured out? Nope. Researchers at Northwestern University say our genome has a geometric code, and we may be "living, breathing computational systems." 😲 H/T @kylemacquarrie.bsky.social @physgencenter.bsky.social @nuintmed.bsky.social kimbellard.medium.com/life-is-geom...

kimbellard.medium.comLife Is GeometryIn 2025, we’ve got DNA all figured out, right? It’s been over fifty years since Crick and Watson (and Franklin) discovered the double helix…
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New CPGE research in Advanced Science describes a language hidden in the genome, beyond the DNA sequence. The geometric code may help cells “remember” how to create and preserve memories, functioning like a network of living computers. #chromatin #dna www.mccormick.northwestern.edu/news/article...

mccormick.northwestern.eduFrom Sequence to Shape: Scientists Discover the Possible Geometric Blueprint of Complex LifeNew research from Professors Vadim Backman and Igal Szleifer reveals the language that stores cell memory -- written in the shape of the genome itself.