Patryk Poliński

Patryk Poliński

@ppolinski.bsky.social

Postdoc at @EMBLBarcelona. Working on unusual forms of splicing.

76 followers80 following19 posts

Patryk Poliński reposted

EMBL
@embl.org

Congratulations to Vikas Trivedi & collaborators for being awarded the HFSP grant! An international team coordinated by EMBL Barcelona researchers has been awarded $1.5M to study how developing organisms stay on track despite climate-driven temperature instability. www.embl.org/news/awards-...

embl.orgNew funding to explore how embryos survive temperature stress in the era of climate change | EMBLAn international team coordinated by Vikas Trivedi at EMBL Barcelona has been awarded an HFSP grant worth $1.5 million (€1.3 M) to study how developing organisms stay on track despite climate-driven t...
Patryk Poliński
@ppolinski.bsky.social

Thrilled to see the El·lipse article live! Proud that my push to rename the rooms after Maria Skłodowska-Curie and Rita Levi-Montalcini is sparking conversations about history, identity, and respect in science. Grateful to PRBB for amplifying this—names matter.

Parc de Recerca Biomèdica de Barcelona@prbb.org

✨ Small changes, big impact!  🤝 At PRBB, we promote a more inclusive scientific culture with the EDI group. 🔬Patryk Polinski from @embl.org  shares his research and discusses how shared values improve research life. 👉Read more: https: //tuit.cat/WsoWq

Patryk Poliński
@ppolinski.bsky.social

Very happy to be the parto of this great initiative that involves young investigators in the peer review. A very promising start for this initiative at @embopress.org and @reviewcommons.org. Thanks to all the postdocs for brainstorming and the trainers for the encouragement! @embl.org @embo.org

EMBO@embo.org

Yesterday, EMBO Press hosted a #webinar "Peer review in practice: Insights from EMBO Press editors" part of a pilot project in collaboration with EMBL, aimed at encouraging the engagement of postdocs in the #PeerReview process. 🧪 #LifeSciences #research

Patryk Poliński reposted

Maria Bernabeu
@mariabernabeu.bsky.social

Come to Biomalpar xxii!!! We have an outstanding line up of speakers!!! It is a true honor to be an organizer of Biomalpar. It was the first conference I ever attended during my 2nd PhD year so it feels special. And don't miss the beautiful poster image from Hannah Fleckenstein!

EMBL Events@events.embl.org

Do you want to join a community working to reduce the devastating toll of #malaria by pushing forward new ideas, innovations, and strategies? 🦟 🧬 Registration is now open for #EMBLMalaria: https://s.embl.org/bmp26-01-bl ✍️ Submit your abstract by 18 Feb 🗓️ 27 – 29 May 2026 #BioMalPar

Patryk Poliński reposted

Maria Bernabeu
@mariabernabeu.bsky.social

Pre-print alert 🚨 We answer a longstanding question in the field. Do immune cells cause cerebral malaria? The answer is YES!!!! And independently of P. falciparum accumulation in the brain. www.biorxiv.org/cgi/content/...

biorxiv.orgInnate immune responses to Plasmodium falciparum disrupt the blood-brain barrierPlasmodium falciparum accumulation at the blood-brain barrier (BBB) is a hallmark of cerebral malaria, a life-threatening complication. Conversely, the contribution of the immune response to vascular ...

Patryk Poliński reposted

Mireya Plass
@mireyaplass.bsky.social

🚨New preprint from the lab! This work led by @akshayjg.bsky.social & @smfernandezmoya.bsky.social shows how the RNA binding protein STAU2 regulates the timing of neurogenesis in iPSC-derived human cells www.biorxiv.org/content/10.1...

biorxiv.orgStaufen2 modulates the temporal dynamics of human neurogenesis in vitroRNA-binding proteins (RBPs) play a central role in post-transcriptional regulation during brain development, yet their specific functions in coordinating human neural lineage decisions remain poorly u...

Patryk Poliński reposted

Barcelona Collaboratorium
@barcelonacollaboratorium.com

Excited to welcome Eli Weinstein, DTU & ELLIS, to Collaboratorium Symposium Nov 10-11! His work on AI & causal biology is groundbreaking, advancing how we understand molecular systems and drug discovery. Join us! #Collaboratorium2025 #AI #Biology

Patryk Poliński reposted

EVOMG-Doctoral Network
@evomg-dn.bsky.social

At EvoMG-DN we believe that evolutionary history shapes both the human genome and its pathogens and ultimately disease susceptibility. We will tackle health challenges from an evolutionary perspective in the topic of: ageing, cancer and infectious diseases. #PhD #EvolutionaryBiology #MSCA

Patryk Poliński reposted

Barcelona Collaboratorium
@barcelonacollaboratorium.com

📢 Join us at the Barcelona Collaboratorium on October 2, 2025! Markus Deserno will present “On the thermodynamics of ternary asymmetric lipid membranes”. A deep dive into the physics behind lipid rafts and membrane complexity.🧬 #Biophysics #BarcelonaCollaboratorium

Patryk Poliński reposted

Maria Bernabeu
@mariabernabeu.bsky.social

Have you ever wondered what happens with your microvessels after exposure to high temperature in fever? In this preprint former postdoc (ans soon to be PI) Viola Introini found that high temperatures cleaves glycocalyx , having severe consequences in malaria www.biorxiv.org/cgi/content/...

biorxiv.orgFebrile temperature enhances Plasmodium falciparum cytoadhesion by disrupting the endothelial glycocalyxFever, a universal host defense in infection and inflammation, paradoxically contributes to neurological complications in malaria. While febrile temperatures enhance the expression of parasite virulen...

Patryk Poliński reposted

EMBL
@embl.org

Time to accelerate! ⏱️4 weeks left to apply for EMBL ARISE2 fellowship programme. Are you interested in developing or improving technologies for life science research? #ARISE2 trains you to become a future research infrastructure leader. 🧪 Apply now! www.embl.org/training/ari... #careers

Patryk Poliński reposted

Miki Ebisuya
@ebisuyamiki.bsky.social

Keystone symposia on stem-cell-based embryo models (SCBEMs). Join us in discussing the development, measurement, and manipulation of SCBEMs in California in Feb 2026! www.keystonesymposia.org/conferences/... Scholarship/ShortTalk Deadline: Oct 21 Early Registration Deadline: Dec 18 (Save $200!)

keystonesymposia.orgStem Cell Models in Embryology | Keystone SymposiaJoin us at the Keystone Symposia on Stem Cell Models in Embryology, February 2026, in Pacific Grove, with field leaders!

Patryk Poliński reposted

Sophie Bonnal
@sobonnal.bsky.social

Thanks to all co-authors and to everyone who supported this work - check it out!

Manuel Irimia@mirimiam.bsky.social

Very happy to share the peer-reviewed version of our work on the cis-regulatory determinants of #microexon #splicing regulation by SRRM3/4, published in @natsmb.nature.com! rdcu.be/ezGqT Work led by @sobonnal.bsky.social, with Simon Bajew & @rmartinezcorral.bsky.social. @crg.eu @upf.edu

rdcu.beCore splicing architecture and early spliceosomal recognition determine microexon sensitivity to SRRM3/4Nature Structural & Molecular Biology - Using massively parallel splicing assays and mathematical modeling, Bonnal et al. uncover that conserved splice site strength and exon length encode...
Patryk Poliński
@ppolinski.bsky.social

Summarizing, we discovered that a neural-specific microexon in DAAM1 is a novel regulatory mechanism of actin cytoskeleton dynamics, which is necessary for proper memory formation and learning in mammals. Thank you to everyone involved for putting this together!

Patryk Poliński
@ppolinski.bsky.social

Next, we investigated in detail the molecular mechanism of the observed phenotypes. One of the leads guided us to increased RHOA/ROCK signaling in KO neurons! RhoA is a direct interactor of Daam1, whose activity is commonly associated with the number of “learning spines”.

Patryk Poliński
@ppolinski.bsky.social

Yet, the most exciting part began when we generated genetically engineered DAAM1-MIC KO mice! We performed multiple assays to evaluate animal behavior. Strikingly, they showed clear learning impairments after microexon removal. What are the cellular and molecular bases for this?

Patryk Poliński
@ppolinski.bsky.social

I focused on formin proteins, the most versatile actin regulators. Bioinformatic analysis identified a neural-specific and evolutionarily conserved microexon in DAAM1 (DAAM1-MIC) that modifies its core enzymatic unit without major structural changes.

Patryk Poliński
@ppolinski.bsky.social

Microscopy-based 🔬 biochemical assays showed that microexon inclusion significantly affects actin polymerization, both quantitatively and qualitatively, likely due to differential actin binding.

Patryk Poliński
@ppolinski.bsky.social

The actin cytoskeleton and its turnover are crucial for proper brain development and function. Understanding its regulation is essential for neuroscience. In my PhD, I investigated how alternative splicing modulates these processes.

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