Prisca Liberali

lakeconferences.orgConference - Modelling Life from Tissues to Cells: Coordination and Robustness - Lake Conferences

8 Sept

What if we stop asking only how cells build tissues and ask how tissues shape cells? That’s what we’ll explore at Modelling Life from Tissues to Cells 🇨🇭 lakeconferences.org/conf/8334d9b...

8 Sept

How do tissue-level dynamics shape cell behaviour? And how does robust biological organization emerge across scales?

8 Sept

Biology × physics × modelling × AI 📍 Thun | 21–25 March 2027 🗓 Apply by 10 Dec

Prisca Liberali reposted

fmi.chHow the gut rebuilds order after injuryFMI researchers and their collaborators have shown how regenerating intestinal tissue turns small initial differences between cells into stable patterns. The findings reveal a general principle for ho...

13 July

Now out in Cell @cellpress.bsky.social: Researchers in the @priscaliberali.bsky.social lab & collaborators at @istaresearch.bsky.social show how regenerating gut tissue turns small cellular differences into stable patterns, revealing a broader principle of tissue repair. www.fmi.ch/news-events/...

cell.comMultiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterningDuring regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Using mouse intestinal regeneration + organoids, we find a critical intermediate tissue density acts as a regenerative timer: only in this window does heterogeneity in the mechanosensor YAP1 emerge, encoding lineage-biased competence at the chromatin level.

FOXA1 reads out the YAP1 state and couples it to Delta–Notch feedback, generating fate bistability. That bistability stores a memory of transient YAP1 activity — converting fleeting heterogeneity into stable, self-organized tissue architecture. 🧬

After injury, intestinal cells lose their identity and the tissue has to rebuild its pattern from scratch. Classic theory assumes a "blank slate" of identical cells — but real cells are heterogeneous from the start.

Prisca Liberali reposted

2 June

Our seminar room was almost overflowing for the third Friedrich Miescher Lecture, hosted by @priscaliberali.bsky.social and delivered by Ewa Paluch from @cam.ac.uk. Paluch gave a fascinating talk on cell shape and the cross-talk between cell shape and cell fate 🔬🧫

alleninstitute.org2026 Lake ConferenceJoin the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...

Emergence and Self-organisation across biological scales! I hope you are ready for next year conference! It will be an incredible event April 20-22 2026. The first of many #LakeConference organised by @ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org

allen institute@alleninstitute.org

#CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel! 📆 April 20-22, 2026 📍 Seattle, USA 🔬 All career stages welcomed. Apply to attend by 12/12: alleninstitute.org/events/aics-...

Jennifer A. Lewis, Harvard Jesse Veenvliet, MPI Jun Allard, UCI Karen Alim, MPI L. (Maha) Mahadevan, Harvard Matthias Lutolf, EPFL Michael Elowitz, Caltech Miguel L. Concha, Universidad de Chile

Miki Ebisuya, TU Dresden EMBL Mukund Thattai, NCBS Nicoletta Petridou, EMBL Paul François, McGill Rashmi Priya, Crick Sara Wickström, MPI Takashi Hiiragi, Hubrecht Institute Wendell Lim, UCSF Yanlan Mao, MRC

alleninstitute.org2026 Lake ConferenceJoin the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...

allen institute@alleninstitute.org

alleninstitute.org2026 Lake ConferenceJoin the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...

The deadline to apply for the Lake Conference on Modeling Life from Cells to Tissues is just few weeks away! Apply to attend by December 12: alleninstitute.org/events/aics-...

Still some doubts 😊here the list of speakers Alan Lowe, CZI Alex Schier, Biozentrum Allon Klein, Harvard Amy Shyer, The Rockefeller Arthur Lander, UCI Christina Theodoris, Gladstone Dana Pe’er, MSKCC Ewa Paluch, Cambridge Giovanni D’Angelo, EPFL James Briscoe, Crick

alleninstitute.org2026 Lake ConferenceJoin the Allen Institute for Cell Science and Circuit Neuroscience Basel in Seattle, Washington, April 20–22, 2026, for a 3 day conference, Modeling...

allen institute@alleninstitute.org

paveltomancak.bsky.social

Modeling Life from Cells to Tissues

Prisca Liberali reposted

@paveltomancak.bsky.social

21 Aug 2025

The last day of lectures at #LISH25 starts with Gustavo Medeiros presenting applications of light sheet microscopy to #organoid research. @priscaliberali.bsky.social lab. Gustavo is a physicist and a creative artist and the walk-up song delivers that message. Video in thread.

Prisca Liberali reposted

11 June 2025

🚨We're hiring! Join a global team at the @priscaliberali.bsky.social lab & the @alleninstitute.org to build cutting-edge image analysis workflows for complex biological datasets, including light-sheet microscopy images. Apply at: www.fmi.ch/education-ca...

Prisca Liberali reposted

12 June 2025

We're seeking a Research Associate in stem cell biology to join a global, interdisciplinary team investigating organoids and tissue organization. This unique role is part of a collaboration between the @priscaliberali.bsky.social lab & the @alleninstitute.org. Apply at: www.fmi.ch/education-ca...

Prisca Liberali reposted

fmi.chShaping the gut: how tissue mechanics drives intestinal organoids formationFMI researchers have shed light on how intestinal organoids form crypts, the pockets that house stem cells for gut regeneration and long-term stability. Their findings may have broader implications fo...

25 Mar 2025

In @naturephysics.bsky.social, researchers from @priscaliberali.bsky.social's lab and @ehannezo.bsky.social's group reveal how intestinal organoids form crypts, key to gut regeneration and stability. Their work could impact tissue engineering and regenerative medicine. www.fmi.ch/news-events/...

20 Mar 2025

Amazing work Irene and Tomo!

Irene Miguel-Aliaga@irenemiguel-aliaga.bsky.social

Epic effort led by Tomo Ameku in the lab, with contributions from the labs of Nick Bellono, Vassilis Pachnis, @francoisleulier.bsky.social, @schwarzergnoto.bsky.social, @priscaliberali.bsky.social, ‪@coxlabkcl.bsky.social,‬ @priscaliberali.bsky.social and Maria Rodriguez-Colman

12 Mar 2025

Super retreat! And don’t miss the paper on robustness in crypt morphogenesis 🤩

Edouard Hannezo@ehannezo.bsky.social

Fun group retreat in the Austrian alps with @priscaliberali.bsky.social! And perfect time to celebrate our new joint paper (from Shi-Lei Xue & Qiutan Yang) out on how mechanochemical bistability confers robustness to intestinal organoids! www.nature.com/articles/s41... - see 🧵! (1/n)

Prisca Liberali reposted

Edouard Hannezo

@ehannezo.bsky.social

10 Mar 2025

1 Feb 2025

Don’t forget to apply! This is an amazing opportunity!

FMI science@fmiscience.bsky.social

📣 Please share: We’re hiring a tenure-track Group Leader in Multicellular Systems to explore the molecular and cellular mechanisms driving the formation, maintenance, or destabilization of tissues, organs and organisms. Apply at: www.fmi.ch/education-ca...

biorxiv.orgCell heterogeneity and fate bistability drive tissue patterning during intestinal regenerationTissue regeneration relies on the ability of cells to undergo de novo patterning. While tissue patterning has been viewed as the transition from initially identical un-patterned cells to an arrangemen...

A perfect start in the new year! 🌱 Regenerating tissues are just an amazing spatio temporal controlled process! Our new manuscript explores how cell heterogeneity and bistability orchestrate intestinal regeneration. 🧵 biorxiv.org/cgi/content/...

And validated in vivo!

This shows that transient heterogeneity establishes a regulatory framework essential for proper intestinal regeneration and could be a general principle underlying a wide range of regenerative processes.

And FOXA1 role is essential to exit a default state of differentiation.

We developed mathematical models showing how YAP1 and FOXA1 drive bistable states, allowing cells to "lock in" their fates. A feedback loop ensures long-term pattern stability and confers memory to the system.

When tissue density hits a critical level, YAP1 activity becomes heterogeneously inactivated. This cell-to-cell variability is essential for triggering the first cell fate decisions via chromatic remodelling and Delta-Notch signalling.

YAP1 heterogeneity primes secretory progenitor cells, setting the stage for robust patterning. This involves chromatin remodelling, creating a favourable environment for FOXA1, a critical transcription factor.

We also made a Yap activity fluorescent reporter organoid line to look into the dynamics at the tissue scales!

And the movie!

Using in vitro organoids and in vivo mouse models, we uncovered that mechanosensor YAP1 acts as a molecular "pre-patterner" cue during regeneration.

Tissue regeneration is driven by cells transitioning from homogenous regenerative cells to a patterned crypt. But actually cell-to-cell variability plays a super important role for the return to homeostasis!

@lucagiorgetti.bsky.social

Amazing work @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social

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Luca Giorgetti lab @FMI

16 Dec 2024

Join us at FMI as a Junior Group Leader! A unique opportunity to set up your lab in a vibrant international research institute with world-class research groups and facilities, generous core funding, a collegial and inclusive culture - and great colleagues 🤓!

FMI science@fmiscience.bsky.social

16 Dec 2024

We have a new opening! Amazing environment colleagues and facility! Join us!

FMI science@fmiscience.bsky.social

15 Dec 2024

Do you want to know how tissue is coordinated across space and time? Don’t miss Laura’s talk!

lauracapolupo.bsky.social@lauracapolupo.bsky.social

If you are attending #CellBio2024 and are interested in understanding how the process of crypt morphogenesis is coordinated both in vivo and in organoids then come to my talk Wed Dec 18th in the subgroup “Organoids as tools to study the function of tissue in Health and Disease”

15 Dec 2024

Don’t miss Conny’s talk!!

Cornelia Schwayer@cschwayer.bsky.social

Have you ever wondered how cell heterogeneity can regulate tissue patterning and how such patterns are maintained? Then come to my talk at the ASCB meeting #cellbio2024 this Sunday afternoon ☺️