Robert Seaborne

It's been a long time since I sat down and enjoyed reading a paper cover-to-cover as much as this. Some cracking work and experiments. www.science.org/doi/10.1126/...

1 week left to apply! We are recruiting a Post‑Doc in Skeletal Muscle Molecular Physiology, Oslo, Norway Join our EMMA multi‑omics project on mitochondrial epigenetic memory in human muscle ageing. 4‑year position. Start May 2026. Apply: www.jobbnorge.no/en/available...

We now have a lab website: muscleomicslab.github.io It has taken a while to write the code, update and is still a WIP, but it does a fair job of describing who we are, what we do and who funds us. We are always looking for collabs so please spread the word (& website)

Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you! Initial 12 months, but with a further 19months available for the right candidate! www.jobs.ac.uk/job/DPK467/p...

Final few days to apply for a postdoc pos. in our lab. If you have a passion for large data sets, data integration, sequencing and plenty of problem solving, then this could be for you! Initial 12 months, but with a further 19months available for the right candidate! www.jobs.ac.uk/job/DPK467/p...

Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...

Excited to present our recent work on myosin as a molecular target for genetic muscle diseases! Kudos to all authors, especially Elise, Fanny and @myofinlab.bsky.social @ucph.bsky.social

Please share far & wide. Looking for a #postdoc to get stuck in with a wide range of projects, with freedom to explore and lead the #computational #bioninformatics work 12 months to begin with, but for the right candidate we have funding for a further 19 months www.jobs.ac.uk/job/DPK467/p...

Recruiting a comp PDRA for the lab 🚨 Working on multiple projects using integrated multi omics in bulk & single cell level Passion for data, coding, bioinformatics & keen to lead our labs comp workflow 12 months in first instance but extendable for further 19 months my.corehr.com/pls/coreport...

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

🚨Second position available in the lab. Through MRC DTP programme we have a PhD opportunity working on brain-muscle axis, analysing shared/divergent molecular signatures across bulk tissue and single cell. Please spread the word! kcl-mrcdtp.com/project/the-...

Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

Denmark is a country very difficult not to fall in love with www.science.org/content/arti...

Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!

Congratulations to Dr Robert Seaborne @kingscollegelondon.bsky.social who has been awarded a New Investigator Grant from the Medical Research Council (MRC), which will support his work on understanding the role of skeletal muscle in motor neurone disease. Read more ➡️ www.kcl.ac.uk/news/dr-robe...

Kings Prize Fellowship is now open, awarding funds for 18-24 months to an outstanding postdoc. If keen to come to KCL and work on molecular dynamics of single myofibers in healthy/diseased contexts, drop me a message! www.kcl.ac.uk/assets/resea...

Fantastic opportunity for an ECR to establish their own group!

Save the date! On 25 June, Karolinska Institutet will be starting a major recruitment drive for 20 junior researchers with a focus on excellence and mobility news.ki.se/ki-to-recruit-junior-researchers-with-a-focus-on-excellence

Epigenetic effects of paternal environmental exposures and experiences on offspring phenotypes www.sciencedirect.com/science/arti....

A pleasure to play a very small part in a very large story (and just as big collaboration). From @nireynon.bsky.social team. Molecular landscape of sex- and modality-specific exercise adaptation in human skeletal muscle through large-scale multi-omics integration www.cell.com/cell-reports...

A wonderful time celebrating a fair few years of quality science! A few brain cells, papers, grants, experiments and beers developed, created and shared amongst these lads over the years!

Wow! Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease | NEJM www.nejm.org/doi/full/10....

Nice!

Another beautiful collaboration 🔬💪 Proof-of-principle of getting both functional and proteomics data from a single myofiber - even from our tiny nemaline myopathy ones! Thanks for all the fun times in the lab @robertseaborne.bsky.social

Excited to share another great collaborative effort — we successfully combined single muscle fiber proteomics with functional assays in the same fiber! This integrated approach allows a direct link between molecular composition and functional performance at the single cell/fiber level.

Integrated single-cell functional-proteomic profiling reveals a shift in myofibre specificity in human nemaline myopathy: A proof-of-principle study Another collab between the labs @droch.bsky.social @adeshmukh.bsky.social physoc.onlinelibrary.wiley.com/doi/10.1113/...

New collaborative paper from @droch.bsky.social group, combining SkM biopsy, single fascicle and single myofiber biophysical and molecular experiments in T2DM link.springer.com/article/10.1...

Our new very collaborative paper showing that muscle myosin has a reduced energy demand in diabetes. Big impact on weight control in our mind!!! Thank you to everyone involved and funders @lundbeckfonden.bsky.social @novo-nordisk.bsky.social @ucph.bsky.social @myoblue.bsky.social #diabetes

Big thanks to @acmedsci.bsky.social for the 2 year grant that will fund a programme of work on skeletal muscle ageing. Looking forward to getting stuck into it! #Springboard25 acmedsci.ac.uk/more/news/sp...

Computational analysis of DNA methylation from long-read sequencing www.nature.com/articles/s41...

It’s a timely process, building your own lab as a new PI. Especially with very, very limited start up funding. So this is a small step, but we now have our own, fully functioning lab room with everything we need (… nearly)

On the responsibilities of intellectuals and the rise of bullshit jobs in universities academic.oup.com/brain/articl...

www.nature.com/articles/s41...

A small part in a very big story. An exploration into drivers of heterogeneity in single muscle cells. A fantastic piece of work and a great collaboration. Human skeletal muscle fiber heterogeneity beyond myosin heavy chains | Nature Communications www.nature.com/articles/s41...

5-aza-2-deoxycytidine improves skeletal muscle function in a mouse model for recessive RYR1-related congenital myopathy academic.oup.com/hmg/advance-...

Kdm2a inhibition in skeletal muscle improves metabolic flexibility in obesity www.nature.com/articles/s42...

Link between fatty acid oxidation and senescence! www.science.org/doi/10.1126/...

If peer-review really qualitatively improved papers, then if I had read the preprint, I would subsequently go read the reviewed version. But usually, if I've read the preprint, the message doesn't change, and I don't read the final version. Sure, papers get better… but not by much. 3/3

Paper rejected. Grant submitted. Wine drunk. All in a days work…

www.nature.com/articles/s41...

www.nature.com/articles/s41...

For my second post; Anyone ever had a NIRG deemed fundable in a panel meeting and not be awarded due to funding restrictions, but held over to the following panel (5/6 months down the line) Only to be told the application is now deemed not fundable? Help! 🙃😬

As my inaugural post here, im pleased to share our latest work Single Myofiber Protein Function-Omics, a novel method enabling inspection of underlying proteome landscape, coupled with protein functionality - with all data derived from the same single SkM cell... www.biorxiv.org/content/10.1...